Concluding summary: Proceedings of the AAPS Biotec Open Forum on "Aggregation of Protein Therapeutics"

AAPS Journal

Volumn 8, Issue 4, 2006, Pages

  Shire, Steven J ^a   Cromwell, Mary ^a   Liu, Jun ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; SILICON DIOXIDE;

ANTIBODY RESPONSE; BIOPROCESS; BIOTECHNOLOGY; CELL CULTURE; CONFERENCE PAPER; DIAFILTRATION; ENVIRONMENTAL FACTOR; FIELD FLOW FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN QUALITY; QUANTITATIVE ANALYSIS; ULTRACENTRIFUGATION;

BIOTECHNOLOGY; CHEMISTRY, PHARMACEUTICAL; PROTEINS;

EID: 33845497766     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/aapsj080482     Document Type: Conference Paper

References (8)

1. Rosenberg AS. Effects of protein aggregates. An immunologic perspective. AAPS J. 2006;8:E501-E507.
2. Chi EY, Weickman J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci. 2005;94:256-274.
3. Cromwell MEM, Hilario E, Jacobson F. Protein aggregation and bioprocessing. AAPS J. 2006;8:E572-E579.
4. Philo JS. Is any measurement method optimal for all aggregate sizes and types? AAPS J. 2006;8:E564-E571.
5. Berkowitz SA. Role of analytical ultracentrifugation in assessing the aggregation of protein biopharmaceuticals. AAPS J. 2006;8:E590-E605.
6. Schuck P. Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophysical Journal. 2000;78:1606-1619.
7. Liu J, Andya JD, Shire SJ. A critical review of analytical ultracentrifugation and field flow fractionation methods for measuring protein aggregation. AAPS J. 2006;8:E580-E589.
8. Shire SJ. 2005 AAPS Biotechnology Conference Open Forum on Aggregation of Protein Therapeutics- Panel Discussion, June 5-8, 2005, San Francisco, CA. AAPS J. 2006;8:E644-E654.