Inhibition of cell proliferation by a selective inhibitor of the Ca2+-activated Cl- channel, Ano1

Biochemical and Biophysical Research Communications

Volumn 427, Issue 2, 2012, Pages 248-253

  Mazzone, Amelia ^a   Eisenman, Seth T ^a   Strege, Peter R ^a   Yao, Zhen ^b   Ordog, Tamas ^a   Gibbons, Simon J ^a   Farrugia, Gianrico ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer; GIST; ICC; Interstitial cells of Cajal; Intestine; TMEM16A

Indexed keywords

CALCIUM CHANNEL; PROTEIN ANO1; PROTEIN INHIBITOR; T16AINHA01; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INTERSTITIAL CELL OF CAJAL; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CHLORIDE CHANNELS; HEK293 CELLS; HUMANS; INTESTINE, SMALL; MICE; MICE, INBRED BALB C; MUSCLE, SMOOTH; NEOPLASM PROTEINS; PYRIMIDINES; THIAZOLES;

MUS;

EID: 84867872837     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.09.022     Document Type: Article

References (25)

1. Blackiston D.J., McLaughlin K.A., Levin M. Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle. Cell Cycle 2009, 8:3519-3528.
2. Jirsch J., Deeley R.G., Cole S.P., Stewart A.J., Fedida D. Inwardly rectifying K+ channels and volume-regulated anion channels in multidrug-resistant small cell lung cancer cells. Cancer Research 1993, 53:4156-4160.
3. Shuba Y.M., Prevarskaya N., Lemonnier L., Van Coppenolle F., Kostyuk P.G., Mauroy B., Skryma R. Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line. American Journal of Physiology. Cell Physiology 2000, 279:1144-1154.
4. Caputo A., Caci E., Ferrera L., Pedemonte N., Barsanti C., Sondo E., Pfeffer U., Ravazzolo R., Zegarra-Moran O., Galietta L.J. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 2008, 322:590-594.
5. Yang Y.D., Cho H., Koo J.Y., Tak M.H., Cho Y., Shim W.S., Park S.P., Lee J., Lee B., Kim B.M., Raouf R., Shin Y.K., Oh U. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 2008, 455:1210-1215.
6. Schroeder B.C., Cheng T., Jan Y.N., Jan L.Y. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 2008, 134:1019-1029.
7. Kashyap M.K., Marimuthu A., Kishore C.J., Peri S., Keerthikumar S., Prasad T.S., Mahmood R., Rao S., Ranganathan P., Sanjeeviah R.C., Vijayakumar M., Kumar K.V., Montgomery E.A., Kumar R.V., Pandey A. Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers. Cancer Biology & Therapy 2009, 8:36-46.
8. West R.B., Corless C.L., Chen X., Rubin B.P., Subramanian S., Montgomery K., Zhu S., Ball C.A., Nielsen T.O., Patel R., Goldblum J.R., Brown P.O., Heinrich M.C., van de Rijn M. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. The American Journal of Pathology 2004, 165:107-113.
9. Espinosa I., Lee C.H., Kim M.K., Rouse B.T., Subramanian S., Montgomery K., Varma S., Corless C.L., Heinrich M.C., Smith K.S., Wang Z., Rubin B., Nielsen T.O., Seitz R.S., Ross D.T., West R.B., Cleary M.L., van de Rijn M. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. The American Journal of Surgical Pathology 2008, 32:210-218.
10. Gomez-Pinilla P.J., Gibbons S.J., Bardsley M.R., Lorincz A., Pozo M.J., Pasricha P.J., Van de Rijn M., West R.B., Sarr M.G., Kendrick M.L., Cima R.R., Dozois E.J., Larson D.W., Ordog T., Farrugia G. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. American Journal of Physiology. Gastrointestinal and Liver Physiology 2009, 296:1370-1381.
11. Huang F., Rock J.R., Harfe B.D., Cheng T., Huang X., Jan Y.N., Jan L.Y. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:21413-21418.
12. Zhu M.H., Kim T.W., Ro S., Yan W., Ward S.M., Koh S.D., Sanders K.M. A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity. The Journal of Physiology 2009, 587:4905-4918.
13. Hwang S.J., Blair P.J., Britton F.C., O'Driscoll K.E., Hennig G., Bayguinov Y.R., Rock J.R., Harfe B.D., Sanders K.M., Ward S.M. Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. The Journal of Physiology 2009, 587:4887-4904.
14. Stanich J.E., Gibbons S.J., Eisenman S.T., Bardsley M.R., Rock J.R., Harfe B.D., Ordog T., Farrugia G. Ano1 as a regulator of proliferation. American Journal of Physiology Gastrointestinal and Liver Physiology 2011, 301:G1044-1051.
15. Duvvuri U., Shiwarski D.J., Xiao D., Bertrand C., Huang X., Edinger R.S., Rock J.R., Harfe B.D., Henson B.J., Kunzelmann K., Schreiber R., Seethala R.S., Egloff A.M., Chen X., Lui V.W., Grandis J.R., Gollin S.M. TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Research 2012, 72:3270-3281.
16. Schultz B.D., Singh A.K., Devor D.C., Bridges R.J. Pharmacology of CFTR chloride channel activity. Physiological Reviews 1999, 79:109-144.
17. Jordan V.C. Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. British Journal of Pharmacology 2006, 147(1):269-276.
18. Farrugia G., Rae J.L., Szurszewski J.H. Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates. The Journal of Physiology 1993, 468:297-310.
19. Liantonio A., Giannuzzi V., Picollo A., Babini E., Pusch M., Conte Camerino D. Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium. British Journal of Pharmacology 2007, 150:235-247.
20. Namkung W., Phuan P.W., Verkman A.S. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. The Journal of Biological Chemistry 2011, 286:2365-2374.
21. Wouters M.M., Gibbons S.J., Roeder J.L., Distad M., Ou Y., Strege P.R., Szurszewski J.H., Farrugia G. Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology 2007, 133:897-906.
22. Mazzone A., Bernard C.E., Strege P.R., Beyder A., Galietta L.J., Pasricha P.J., Rae J.L., Parkman H.P., Linden D.R., Szurszewski J.H., Ordog T., Gibbons S.J., Farrugia G. Altered expression of Ano1 variants in human diabetic gastroparesis. The Journal of Biological Chemistry 2011, 286:13393-13403.
23. Wouters M.M., Roeder J.L., Tharayil V.S., Stanich J.E., Strege P.R., Lei S., Bardsley M.R., Ordog T., Gibbons S.J., Farrugia G. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. The Journal of Biological Chemistry 2009, 284:21177-21184.
24. Bardsley M.R., Horvath V.J., Asuzu D.T., Lorincz A., Redelman D., Hayashi Y., Popko L.N., Young D.L., Lomberk G.A., Urrutia R.A., Farrugia G., Rubin B.P., Ordog T. Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology 2010, 139:942-952.
25. Wang M., Yang H., Zheng L.Y., Zhang Z., Tang Y.B., Wang G.L., Du Y.H., Lv X.F., Liu J., Zhou J.G., Guan Y.Y. Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation. Circulation 2012, 125:697-707.