Acerinol, a cyclolanstane triterpenoid from Cimicifuga acerina, reverses ABCB1-mediated multidrug resistance in HepG2/ADM and MCF-7/ADR cells

European Journal of Pharmacology

Volumn 733, Issue 1, 2014, Pages 34-44

  Liu, Dao Lu ^a   Li, Ying Jie ^a   Yao, Nan ^a   Xu, Jun ^a   Chen, Zhe Sheng ^b   Yiu, Anita ^c   Zhang, Cui Xian ^d   Ye, Wen Cai ^a   Zhang, Dong Mei ^a  

^a JINAN UNIVERSITY   (China)

^b ST JOHN'S UNIVERSITY   (United States)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

ABCB1; Acerinol; HepG2 ADM; MCF 7 ADR; Multidrug resistance

Indexed keywords

ACERINOL; CISPLATIN; CYTOCHROME P450 3A4; DOXORUBICIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; RHODAMINE 123; TRITERPENOID; UNCLASSIFIED DRUG; VERAPAMIL; VINCRISTINE; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BINDING; SMALL INTERFERING RNA; TRITERPENE;

ACTAEA; ARTICLE; CANCER RESISTANCE; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CIMICIFUGA ACERINA; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ENZYME SPECIFICITY; GENETICS; HEPG2 CELL LINE; ISOLATION AND PURIFICATION; MCF 7 CELL LINE; METABOLISM; MULTIDRUG RESISTANCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL SURVIVAL; CIMICIFUGA; CYTOCHROME P-450 CYP3A; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; P-GLYCOPROTEINS; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY; TRITERPENES;

EID: 84899008386     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.03.043     Document Type: Article

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