Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: Bioassay-directed isolation and characterization of active principles

Journal of Agricultural and Food Chemistry

Volumn 50, Issue 24, 2002, Pages 7022-7028

  Burdette, Joanna E ^a   Chen, Shao Nong ^a   Lu, Zhi Zhen ^a   Xu, Haiyan ^a   White, Bethany E P ^a   Fabricant, Daniel S ^a   Liu, Jianghua ^a   Fong, Harry H S ^a   Farnsworth, Norman R ^a   Constantinou, Andreas I ^a   Van Breemen, Richard B ^a   Pezzuto, John M ^a   Bolton, Judy L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antioxidant; Cimicifuga racemosa (black cohosh, Actaea racemosa); Menadione; Reactive oxygen species; Single cell gel electrophoresis assay (comet assay)

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; ANTIOXIDANT; CAFFEIC ACID DERIVATIVE; CIMICIFUGA RACEMOSA EXTRACT; DNA; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; FERULIC ACID; FUKINOLIC ACID; GALLIC ACID; MENADIONE; METHANOL; PICRIC ACID; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SCAVENGER; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BIOASSAY; BREAST CANCER; BREAST TUMOR; CANCER CELL CULTURE; CELL CULTURE; CHEMISTRY; CIMICIFUGA; COMET ASSAY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG EFFECT; ENZYME ASSAY; GEL ELECTROPHORESIS; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HUMAN; HUMAN CELL; ISOLATION AND PURIFICATION; MENOPAUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHYTOCHEMISTRY; PLANT ROOT; THIN LAYER CHROMATOGRAPHY; TRADITIONAL MEDICINE;

ANTIOXIDANTS; BREAST NEOPLASMS; CIMICIFUGA; DNA DAMAGE; ESTROGEN RECEPTOR ALPHA; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HUMANS; METHANOL; PICRATES; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; TRANSFECTION; TUMOR CELLS, CULTURED; VITAMIN K 3;

CAULOPHYLLUM; CIMICIFUGA; CIMICIFUGA DAHURICA; CIMICIFUGA RACEMOSA;

EID: 0037145929     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf020725h     Document Type: Article

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