Discovery and characterization of OC144-093, a novel inhibitor of P- glycoprotein-mediated multidrug resistance

Cancer Research

Volumn 60, Issue 11, 2000, Pages 2964-2972

  Newman, Michael J ^a   Rodarte, Jennifer C ^a   Benbatoul, Khalid D ^a,c   Romano, Suzanne J ^a   Zhang, Chengzhi ^a,d   Krane, Sonja ^a,e   Moran, Edmund J ^a,f   Uyeda, Roy T ^a   Dixon, Ross ^a   Guns, Emma S ^b   Mayer, Lawrence D ^b  

^a Ontogen Corporation   (United States)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c LIGAND PHARMACEUTICALS INC   (United States)

^d BAYER CORPORATION   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f Advanced Medicine Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; IMIDAZOLE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; OC 144093; PACLITAXEL; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; HUMAN CELL; LYMPHOMA; MALIGNANT NEOPLASTIC DISEASE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERUS CANCER;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DIVISION; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; KINETICS; MICE; MICE, SCID; P-GLYCOPROTEIN; PACLITAXEL; RATS; TIME FACTORS; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0034214366     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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