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Volumn 33, Issue 5, 2014, Pages 534-541

Quercetin protects rat hepatocytes from oxidative damage induced by ethanol and iron by maintaining intercellular liable iron pool

Author keywords

Alcohol; iron overload; labile iron pool; oxidative damage; quercetin

Indexed keywords

ALCOHOL; ASPARTATE AMINOTRANSFERASE; FERROUS GLUCONATE; GLUTATHIONE; LACTATE DEHYDROGENASE; LIVER ENZYME; MALONALDEHYDE; NITRILOTRIACETATE IRON; QUERCETIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

EID: 84898994681     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113499168     Document Type: Article
Times cited : (19)

References (43)
  • 1
    • 16544383147 scopus 로고    scopus 로고
    • Alcohol, oxidative stress, and free radical damag
    • Wu D, Cederbaum AI. Alcohol, oxidative stress, and free radical damag. Alcohol Res Health. 2003 ; 27 ((4)). 277-284
    • (2003) Alcohol Res Health , vol.27 , Issue.4 , pp. 277-284
    • Wu, D.1    Cederbaum, A.I.2
  • 2
    • 33644527617 scopus 로고    scopus 로고
    • Alcohol and oxidative liver injury
    • Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology. 2006 ; 43 (2 Suppl 1). S63 - S74
    • (2006) Hepatology , vol.43 , Issue.SUPPL. 1
    • Dey, A.1    Cederbaum, A.I.2
  • 3
    • 33845927120 scopus 로고    scopus 로고
    • Alcohol, oxidative stress and free radical damage
    • Albano E. Alcohol, oxidative stress and free radical damage. Proc Nutr Soc. 2006 ; 65 ((3)). 278-290
    • (2006) Proc Nutr Soc , vol.65 , Issue.3 , pp. 278-290
    • Albano, E.1
  • 4
    • 39749090649 scopus 로고    scopus 로고
    • Oxidative mechanisms in the pathogenesis of alcoholic liver disease
    • Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med. 2008 ; 29 ((1-2)). 9-16
    • (2008) Mol Aspects Med , vol.29 , Issue.12 , pp. 9-16
    • Albano, E.1
  • 5
    • 0014000359 scopus 로고
    • The assessment of total body iron stores using the chelating agent diethylene-triamine penta-acetic acid (D.T.P.A.). Its significance for human haemochromatosis
    • Powell LW.. The assessment of total body iron stores using the chelating agent diethylene-triamine penta-acetic acid (D.T.P.A.). Its significance for human haemochromatosis. Rev Med Chir Mal Foie. 1966 ; 41 ((6)). 271-280
    • (1966) Rev Med Chir Mal Foie , vol.41 , Issue.6 , pp. 271-280
    • Powell, L.W.1
  • 6
    • 2142809627 scopus 로고    scopus 로고
    • The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia
    • Ioannou GN, Dominitz JA, Weiss NS, et al. The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology. 2004 ; 126 ((5)). 1293-1301
    • (2004) Gastroenterology , vol.126 , Issue.5 , pp. 1293-1301
    • Ioannou, G.N.1    Dominitz, J.A.2    Weiss, N.S.3
  • 7
    • 0025157647 scopus 로고
    • The pathology of hepatic iron overload: A free radical-mediated process?
    • Bacon BR, Britton RS. The pathology of hepatic iron overload: a free radical-mediated process?. Hepatology. 1990 ; 11 ((1)). 127-137
    • (1990) Hepatology , vol.11 , Issue.1 , pp. 127-137
    • Bacon, B.R.1    Britton, R.S.2
  • 8
    • 0028919136 scopus 로고
    • Increase in cellular pool of low-molecular-weight iron during ethanol metabolism in rat hepatocyte cultures: Relationship with lipid peroxidation
    • Sergent O, Morel I, Cogrel P, et al. Increase in cellular pool of low-molecular-weight iron during ethanol metabolism in rat hepatocyte cultures: relationship with lipid peroxidation. Biol Trace Elem Res. 1995 ; 47 ((1-3)). 185-192
    • (1995) Biol Trace Elem Res , vol.47 , Issue.13 , pp. 185-192
    • Sergent, O.1    Morel, I.2    Cogrel, P.3
  • 9
    • 0031605490 scopus 로고    scopus 로고
    • Uptake, storage, and release of iron
    • Chasteen ND.. Uptake, storage, and release of iron. Met Ions Biol Syst. 1998 ; 35: 479-514
    • (1998) Met Ions Biol Syst , vol.35 , pp. 479-514
    • Chasteen, N.D.1
  • 10
    • 0344154421 scopus 로고    scopus 로고
    • Labile iron pool: The main determinant of cellular response to oxidative stress
    • Kruszewski M. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res. 2003 ; 531 ((1-2)). 81-92
    • (2003) Mutat Res , vol.531 , Issue.12 , pp. 81-92
    • Kruszewski, M.1
  • 11
    • 23144461217 scopus 로고    scopus 로고
    • Alcohol, iron-associated oxidative stress, and cancer
    • Petersen DR. Alcohol, iron-associated oxidative stress, and cancer. Alcohol. 2005 ; 35 ((3)). 243-249
    • (2005) Alcohol , vol.35 , Issue.3 , pp. 243-249
    • Petersen, D.R.1
  • 12
    • 1942473768 scopus 로고    scopus 로고
    • Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats
    • Anjaneyulu M, Chopra K. Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2004 ; 31 ((4)). 244-248
    • (2004) Clin Exp Pharmacol Physiol , vol.31 , Issue.4 , pp. 244-248
    • Anjaneyulu, M.1    Chopra, K.2
  • 13
    • 34347392509 scopus 로고    scopus 로고
    • Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways
    • Yao P, Nussler A, Liu L, et al. Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J Hepatol. 2007 ; 47 ((2)). 253-261
    • (2007) J Hepatol , vol.47 , Issue.2 , pp. 253-261
    • Yao, P.1    Nussler, A.2    Liu, L.3
  • 14
    • 76549135006 scopus 로고    scopus 로고
    • Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes
    • Liu S, Hou W, Yao P, et al. Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes. Toxicol In Vitro. 2010 ; 24 ((2)). 516-522
    • (2010) Toxicol in Vitro , vol.24 , Issue.2 , pp. 516-522
    • Liu, S.1    Hou, W.2    Yao, P.3
  • 15
    • 0142180034 scopus 로고    scopus 로고
    • Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin a bioflavonoid
    • Singh A, Naidu PS, Kulkarni SK. Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin a bioflavonoid. Free Radic Res. 2003 ; 37 ((11)). 1245-1252
    • (2003) Free Radic Res , vol.37 , Issue.11 , pp. 1245-1252
    • Singh, A.1    Naidu, P.S.2    Kulkarni, S.K.3
  • 16
    • 52649104870 scopus 로고    scopus 로고
    • Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats
    • Eybl V, Kotyzova D, Cerna P, et al. Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats. Hum Exp Toxicol. 2008 ; 27 ((4)). 347-353
    • (2008) Hum Exp Toxicol , vol.27 , Issue.4 , pp. 347-353
    • Eybl, V.1    Kotyzova, D.2    Cerna, P.3
  • 17
    • 33645381909 scopus 로고    scopus 로고
    • Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury
    • Zhang Y, Li H, Zhao Y, et al. Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury. Eur J Pharmacol. 2006 ; 535 ((1-3)). 263-269
    • (2006) Eur J Pharmacol , vol.535 , Issue.13 , pp. 263-269
    • Zhang, Y.1    Li, H.2    Zhao, Y.3
  • 18
    • 0018358875 scopus 로고
    • Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate: A model of experimental hemochromatosis
    • Awai M, Narasaki M, Yamanoi Y, et al. Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate: a model of experimental hemochromatosis. Am J Pathol. 1979 ; 95 ((3)). 663-673
    • (1979) Am J Pathol , vol.95 , Issue.3 , pp. 663-673
    • Awai, M.1    Narasaki, M.2    Yamanoi, Y.3
  • 19
    • 0032555782 scopus 로고    scopus 로고
    • Ethanol does not increase the hepatotoxicity of cocaine in primary rat hepatocyte culture
    • Figliomeni ML, Abdel-Rahman MS. Ethanol does not increase the hepatotoxicity of cocaine in primary rat hepatocyte culture. Toxicology. 1998 ; 129 ((2-3)). 125-135
    • (1998) Toxicology , vol.129 , Issue.23 , pp. 125-135
    • Figliomeni, M.L.1    Abdel-Rahman, M.S.2
  • 20
    • 0028849421 scopus 로고
    • Glutathione determination by the Tietze enzymatic recycling assay and its relationship to cellular radiation response
    • Eady JJ, Orta T, Dennis MF, et al. Glutathione determination by the Tietze enzymatic recycling assay and its relationship to cellular radiation response. Br J Canc. 1995 ; 72 ((5)). 1089-1095
    • (1995) Br J Canc , vol.72 , Issue.5 , pp. 1089-1095
    • Eady, J.J.1    Orta, T.2    Dennis, M.F.3
  • 21
    • 0017804313 scopus 로고
    • Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase
    • Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys. 1978 ; 186 ((1)). 189-195
    • (1978) Arch Biochem Biophys , vol.186 , Issue.1 , pp. 189-195
    • Kono, Y.1
  • 22
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979 ; 95 ((2)). 351-358
    • (1979) Anal Biochem , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 23
    • 0033756130 scopus 로고    scopus 로고
    • Association of serum bilirubin concentration with risk of coronary artery disease
    • Mayer M. Association of serum bilirubin concentration with risk of coronary artery disease. Clin Chem. 2000 ; 46 ((11)). 1723-1727
    • (2000) Clin Chem , vol.46 , Issue.11 , pp. 1723-1727
    • Mayer, M.1
  • 24
    • 0031570288 scopus 로고    scopus 로고
    • Fluorescence analysis of the labile iron pool of mammalian cells
    • Epsztejn S, Kakhlon O, Glickstein H, et al. Fluorescence analysis of the labile iron pool of mammalian cells. Anal Biochem. 1997 ; 248 ((1)). 31-40
    • (1997) Anal Biochem , vol.248 , Issue.1 , pp. 31-40
    • Epsztejn, S.1    Kakhlon, O.2    Glickstein, H.3
  • 25
    • 0031567095 scopus 로고    scopus 로고
    • The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
    • Richardson DR, Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997 ; 1331 ((1)). 1-40
    • (1997) Biochim Biophys Acta , vol.1331 , Issue.1 , pp. 1-40
    • Richardson, D.R.1    Ponka, P.2
  • 26
    • 33847729939 scopus 로고    scopus 로고
    • Alcohol intake and iron overload: Another role for hepcidin?
    • Kowdley KV. Alcohol intake and iron overload: another role for hepcidin?. Hepatology. 2007 ; 45 ((2)). 541-543
    • (2007) Hepatology , vol.45 , Issue.2 , pp. 541-543
    • Kowdley, K.V.1
  • 27
    • 0034065378 scopus 로고    scopus 로고
    • Liver iron is predictive of death in alcoholic cirrhosis: A multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: A prospective follow up study
    • Ganne-Carrie N, Christidis C, Chastang C, et al. Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study. Gut. 2000 ; 46 ((2)). 277-282
    • (2000) Gut , vol.46 , Issue.2 , pp. 277-282
    • Ganne-Carrie, N.1    Christidis, C.2    Chastang, C.3
  • 28
    • 41349120026 scopus 로고    scopus 로고
    • Intracellular iron transport and storage: From molecular mechanisms to health implications
    • Mackenzie EL, Iwasaki K, Tsuji Y. Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal. 2008 ; 10 ((6)). 997-1030
    • (2008) Antioxid Redox Signal , vol.10 , Issue.6 , pp. 997-1030
    • MacKenzie, E.L.1    Iwasaki, K.2    Tsuji, Y.3
  • 29
    • 58249117786 scopus 로고    scopus 로고
    • Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling
    • Harrison-Findik DD, Klein E, Evans J, et al. Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling. Am J Physiol Gastrointest Liver Physiol. 2009 ; 296 ((1)). G112
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , Issue.1 , pp. 112
    • Harrison-Findik, D.D.1    Klein, E.2    Evans, J.3
  • 30
    • 0042384674 scopus 로고    scopus 로고
    • Iron chelators and iron toxicity
    • Brittenham GM. Iron chelators and iron toxicity. Alcohol. 2003 ; 30 ((2)). 151-158
    • (2003) Alcohol , vol.30 , Issue.2 , pp. 151-158
    • Brittenham, G.M.1
  • 31
    • 79955642700 scopus 로고    scopus 로고
    • MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice
    • Mansouri A, Tarhuni A, Larosche I, et al. MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice. Dig Dis. 2010 ; 28 ((6)). 756-775
    • (2010) Dig Dis , vol.28 , Issue.6 , pp. 756-775
    • Mansouri, A.1    Tarhuni, A.2    Larosche, I.3
  • 32
    • 0032407621 scopus 로고    scopus 로고
    • Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1
    • Sakurai K, Cederbaum AI. Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Mol Pharmacol. 1998 ; 54 ((6)). 1024-1035
    • (1998) Mol Pharmacol , vol.54 , Issue.6 , pp. 1024-1035
    • Sakurai, K.1    Cederbaum, A.I.2
  • 33
    • 79952439249 scopus 로고    scopus 로고
    • Quercetin-iron chelates are transported via glucose transporters
    • Vlachodimitropoulou E, Sharp PA, Naftalin RJ. Quercetin-iron chelates are transported via glucose transporters. Free Radic Biol Med. 2011 ; 50 ((8)). 934-944
    • (2011) Free Radic Biol Med , vol.50 , Issue.8 , pp. 934-944
    • Vlachodimitropoulou, E.1    Sharp, P.A.2    Naftalin, R.J.3
  • 34
    • 29744466690 scopus 로고    scopus 로고
    • Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool
    • Sergent O, Tomasi A, Ceccarelli D, et al. Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool. Biometals. 2005 ; 18 ((6)). 567-575
    • (2005) Biometals , vol.18 , Issue.6 , pp. 567-575
    • Sergent, O.1    Tomasi, A.2    Ceccarelli, D.3
  • 35
    • 53449098862 scopus 로고    scopus 로고
    • Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis
    • Xiong S, She H, Zhang AS, et al. Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2008 ; 295 ((3)). G512
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , Issue.3 , pp. 512
    • Xiong, S.1    She, H.2    Zhang, A.S.3
  • 36
    • 0024367977 scopus 로고
    • Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates
    • Aruoma OI, Halliwell B, Gajewski E, et al. Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates. J Biol Chem. 1989 ; 264 ((34)). 20509-20512
    • (1989) J Biol Chem , vol.264 , Issue.34 , pp. 20509-20512
    • Aruoma, O.I.1    Halliwell, B.2    Gajewski, E.3
  • 37
    • 0024307575 scopus 로고
    • Early treatment with deferoxamine limits myocardial ischemic/reperfusion injury
    • Reddy BR, Kloner RA, Przyklenk K. Early treatment with deferoxamine limits myocardial ischemic/reperfusion injury. Free Radic Biol Med. 1989 ; 7 ((1)). 45-52
    • (1989) Free Radic Biol Med , vol.7 , Issue.1 , pp. 45-52
    • Reddy, B.R.1    Kloner, R.A.2    Przyklenk, K.3
  • 38
    • 84857046972 scopus 로고    scopus 로고
    • Quercetin attenuates ethanol-derived microsomal oxidative stress: Implication of haem oxygenase-1 induction
    • Tang YH, Gao C, Shi YR, et al. Quercetin attenuates ethanol-derived microsomal oxidative stress: implication of haem oxygenase-1 induction. Food Chem. 2012 ; 132 ((4)). 1769-1774
    • (2012) Food Chem , vol.132 , Issue.4 , pp. 1769-1774
    • Tang, Y.H.1    Gao, C.2    Shi, Y.R.3
  • 39
    • 55149104161 scopus 로고    scopus 로고
    • Quercetin: Potentials in the prevention and therapy of disease
    • Bischoff SC. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care. 2008 ; 11 ((6)). 733-740
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , Issue.6 , pp. 733-740
    • Bischoff, S.C.1
  • 40
    • 77951938250 scopus 로고    scopus 로고
    • Quercetin is a substrate for the transmembrane oxidoreductase Dcytb
    • Vlachodimitropoulou E, Naftalin RJ, Sharp PA. Quercetin is a substrate for the transmembrane oxidoreductase Dcytb. Free Radic Biol Med. 2010 ; 48 ((10)). 1366-1369
    • (2010) Free Radic Biol Med , vol.48 , Issue.10 , pp. 1366-1369
    • Vlachodimitropoulou, E.1    Naftalin, R.J.2    Sharp, P.A.3
  • 41
    • 79953036116 scopus 로고    scopus 로고
    • In vitro analysis of iron chelating activity of flavonoids
    • Mladenka P, Macakova K, Filipsky T, et al. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem. 2011 ; 105 (5). 693-701
    • (2011) J Inorg Biochem , vol.105 , Issue.5 , pp. 693-701
    • Mladenka, P.1    MacAkova, K.2    Filipsky, T.3
  • 42
    • 41849117298 scopus 로고    scopus 로고
    • Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron
    • Park SS, Bae I, Lee YJ. Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. J Cell Biochem. 2008 ; 103 ((6)). 1989-1998
    • (2008) J Cell Biochem , vol.103 , Issue.6 , pp. 1989-1998
    • Park, S.S.1    Bae, I.2    Lee, Y.J.3


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