Ethanol does not increase the hepatotoxicity of cocaine in primary rat hepatocyte culture

Toxicology

Volumn 129, Issue 2-3, 1998, Pages 125-135

  Figliomeni, Maria L ^a   Abdel Rahman, Mohamed S ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Cocaine; Hepatocytes; Lactate dehydrogenase

Indexed keywords

ALCOHOL; COCAINE; LACTATE DEHYDROGENASE; PHENOBARBITAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER CELL CULTURE; LIVER TOXICITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; COCAINE; DRUG SYNERGISM; ETHANOL; L-LACTATE DEHYDROGENASE; LIVER; MALE; PHENOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032555782     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(98)00081-X     Document Type: Article

References (41)

1. Barat S.A., Kardos S.A., Abdel-Rahman M.S. Development and validation of a high-performance liquid chromatography method for the determination of cocaine, its metabolites and lidocaine. J. Appl. Toxicol. 16(3):1996;215-219.
2. Boelsterli U.A., Atanasoski S., Goldlin C. Ethanol-induced enhancement of cocaine bioactivation and irreversible protein binding: evidence against a role of cytochrome P-450IIE1. Alcohol Clin. Exp. Res. 15(5):1991;779-784.
3. Boelsterli U.A., Lanzotti A., Goldlin C., Oertle M. Identification of cytochrome P-450 IIB1 as a cocaine-bioactivating isoform in rat hepatic microsomes and in cultured rat hepatocytes. Metab. Dispos. 20(1):1992;96-101.
4. Boelsterli U.A., Wolf A., Goldlin C. Oxygen free radical production mediated by cocaine and its ethanol-derived metabolite, cocaethylene, in rat hepatocytes. Hepatology. 18(5):1993;1154-1161.
5. Bouis P., Boelsterli U.A. Modulation of cocaine metabolism in primary rat hepatocyte cultures: effects on irreversible binding and protein biosynthesis. Toxicol. Appl. Pharmacol. 104:1990;429-439.
6. Boyer C.S., Petersen D.R. Potentiation of cocaine-mediated hepatoxicity by acute and chronic ethanol. Alcohol Clin. Exp. Res. 14(1):1990;28-31.
7. Boyer C.S., Petersen D.R. Hepatic biochemical changes as a result of acute cocaine administration in the mouse. Hepatology. 14:1991;1209-1216.
8. Boyer C.S., Petersen D.R. Enzymatic basis for the transesterification of cocaine in the presence of ethanol: evidence for the participation of microsomal carboxylesterases. J. Pharmacol. Exp. Ther. 260(3):1992;939-945.
9. Brody S.L., Slovis C.M., Wrenn K.D. Cocaine-related medical problems: consecutive series of 233 patients. Am. J. Med. 88:1990;325-331.
10. Chaisson R.E., Bacchetti P., Osmond D., Brodie B., Sande M.A., Moss A.R. Cocaine use and HIV infection in intravenous drug users in San Francisco. J. Am. Med. Assoc. 261(4):1989;561-565.
11. Connors S., Rankin D.R., Gandolfi A.J., Krumdieck C.L., Koep L.J., Brendel K. Cocaine hepatotoxicity in cultured liver slices: a species comparison. Toxicology. 61:1990;171-183.
12. Dean R.A., Christian C.D., Sample R.H.B., Bosron W.F. Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J. 5:1991;2735-2739.
13. Dean R.A., Harper E.T., Dumaual N., Stoeckel D.A., Bosron W.F. Effects of ethanol on cocaine metabolism: formation of cocaethylene and norcocaethylene. Toxicol. Appl. Pharmacol. 117:1992;1-8.
14. Farre M., De La Torre R., Llorente M., Lamas X., Ugena B., Segura J., Cami J. Alcohol and cocaine interactions in humans. J. Pharmacol. Exp. Ther. 266(3):1993;1364-1373.
15. Figliomeni M.L., Abdel-Rahman M.S. The role of ethanol exposure on cocaine metabolism in the rat hepatocyte. J. Appl. Toxicol. 17(2):1997a;105-112.
16. Figliomeni M.L., Abdel-Rahman M.S. The effect of ethanol exposure on cocaine toxicity in rat hepatocytes. Toxicol. In Vitro. 11(4):1997b;321-328.
17. Goldlin C.R., Boelsterli U.A. Reactive oxygen species and nonperoxidative mechanisms of cocaine-induced cytotoxicity in rat hepatocyte cultures. Toxicology. 69:1991;79-91.
18. Gottfried M.R., Kloss M.W., Graham D., Raukman E.J., Rosen G.M. Ultrastructure of experimental cocaine hepatotoxicity. Hepatology. 6(2):1986;299-304.
19. Grant B.F., Harford T.C. Concurrent and simultaneous use of alcohol and cocaine: results of national survey. Drug Alcohol Depend. 25:1990;97-104.
20. Jover R., Ponsoda X., Gomez-Lechon J.M., Castell J.V. Cocaine hepatotoxicity: two different toxicity mechanisms for phenobarbital-induced and non-induced rat hepatocytes. Biochem. Pharmacol. 46(11):1993;1967-1974.
21. Kanel G.C., Cassidy W., Shuster L., Reynolds T.B. Cocaine-induced liver cell injury: comparison of morphological features in man and in experimental models. Hepatology. 11:1990;646-651.
22. Kloss M.W., Rosen G.M., Rauckman J. N-demethylation of cocaine to norcocaine, evidence for participation by cytochrome P-450 and FAD-containing monooxygenase. Mol. Pharmacol. 23:1983;482-485.
23. Kloss M.W., Rosen G.M., Raukman E.J. Commentary: cocaine-mediated hepatoxicity, a critical review. Biochem Pharm. 33:1984;169-173.
24. Lange R.A., Flores E.D., Cigarroa R.G., Hillis L.D. Cocaine-induced myocardial ischemia and infarction. Cardiology. 7(8):1990;74-79.
25. Lau C.E. Determination of cocaethylene, cocaine and their metabolites in rat serum microsamples by high-performance liquid chromatography, and its application to pharmacokinetic studies in rodents. J. Chromatogr. 582:1992;167-172.
26. Lechevrel M., Wild C.P. Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: implications for the etiology of human oesophageal cancer. Arch. Toxicol. 71(11):1997;690-695.
27. Legrand C., Bour J.M., Jacob C., Capiaumont J., Martial A., Marc A., Wydtke M., Kretmer G., Demongel C., Duval D., Hache J. Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cells as a marker. J. Biotechnol. 25:1992;231-243.
28. Levine B.S., Tebbett I.R. Cocaine pharmacokinetics in ethanol-pretreated rats. Drug Metab. Dispos. 22(3):1994;498-500.
29. National Household Survey on Drug Abuse (NHSDA) 1992. Main findings (1992) US Department of Health and Human Services.
30. Perino L.E., Warren G.H., Levine J.S. Cocaine-induced hepatotoxicity in humans. Gastroenterology. 93:1987;176-180.
31. Roberts S.M., Pounds L.G., James R.C. Cocaine toxicity in cultured rat hepatocytes. Toxicol. Lett. 50:1990;283-288.
32. Roberts S.M., Munson J.W., James R.C., Harbison R.D. An assay for cocaethylene and other cocaine metabolites in liver using high-performance liquid chromatography. Anal. Biochem. 202:1992;256-261.
33. Roberts S.M., Harbison R.D., James R.C. Inhibition by ethanol of the metabolism of cocaine to benzoylecognine and ecognine methyl ester in mouse and human liver. Drug Metab. Dispos. 21(3):1993;537-541.
34. Roth L., Harbison R.D., James R.C., Tobin T., Roberts S.M. Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis. Hepatology. 15(5):1992;934-940.
35. Shuster L., Quimby F., Bates A., Thompson M.L. Liver damage from cocaine in mice. Life Sci. 20:1977;1035-1042.
36. Silva M.O., Roth D., Reddy K.R., Fernandez J.A., Albores-Saavedra J., Schiff E.R. Hepatic dysfunction accompanying acute cocaine intoxication. J. Hepatol. 12:1991;312-315.
37. Smith A.C., Freeman R.W., Harbison R.D. Ethanol enhancement of cocaine-induced hepatotoxicity. Biochem. Pharmacol. 30:1981;453-458.
38. Thompson M.L., Shuster L., Shaw K. Cocaine-induced hepatic necrosis in mice - the role of cocaine metabolism. Biochem. Pharm. 28:1979;2389-2395.
39. United States Department of Health and Human Services, 1996. Annual Medical Examiner Data 1994, DHHS Publ. No. (SMA) 96-3078. Government Printing Office, Washington D.C.
40. Wanless I.R., Dore S., Gopinath N., Tan J., Cameron R., Heathcote E.J., Blendis L.M., Levy G. Histopathology of cocaine hepatotoxicity. Gastroenterology. 98:1990;497-501.
41. Xu Z., Squires E.J., Bray T.M. Effects of dietary zinc deficiency on the expression of hepatic microsomal cytochrome P450 2E1 in rats. J. Nutr. Biochem. 5(6):1994;308-313.