The arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers

Journal of Biological Chemistry

Volumn 289, Issue 16, 2014, Pages 11556-11565

  Fye, Jason M ^a   Coffin, Stephanie R ^a   Orebaugh, Clinton D ^a   Hollis, Thomas ^a   Perrino, Fred W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

DIMER INTERFACE; DNA BINDING; EXONUCLEASE; FUNCTIONAL DIMER; KEY RESIDUES; PROTOMERS;

CATALYSIS;

ARGININE; DEOXYRIBONUCLEASE; DIMER; DOUBLE STRANDED DNA; PROTEIN TREX1; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA DEGRADATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RESIDUE ANALYSIS;

AUTOIMMUNE DISEASES; DIMER; DNA; DNASE; ENZYME MECHANISMS; EXONUCLEASE; NUCLEIC ACID; TREX1;

AMINO ACID SUBSTITUTION; ARGININE; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CATALYSIS; DNA, SINGLE-STRANDED; EXODEOXYRIBONUCLEASES; HUMANS; MUTATION, MISSENSE; NERVOUS SYSTEM MALFORMATIONS; PHOSPHOPROTEINS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS;

EID: 84898986513     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.559252     Document Type: Article

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