The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease

Journal of Biological Chemistry

Volumn 283, Issue 46, 2008, Pages 31649-31656

  Lehtinen, Duane A ^a   Harvey, Scott ^a   Mulcahy, Matthew J ^a   Hollis, Thomas ^a   Perrino, Fred W ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CELL DEATH; DNA; ENZYME ACTIVITY; ENZYMES; FERRITE DEVICES; GENES; NUCLEIC ACIDS; ORGANIC ACIDS;

AUTOIMMUNE DISEASES; COMMON FEATURES; DEATH PROCESSES; DEGRADATION ACTIVITIES; DNA DEGRADATIONS; EXONUCLEASE; HETERO DIMERS; HOMODIMER; IMMUNE RESPONSES; MUTANT ALLELES; SYSTEMIC LUPUS ERYTHEMATOSUS;

DEGRADATION;

DOUBLE STRANDED DNA; ENZYME; HOMODIMER; SINGLE STRANDED DNA; TREX1 ENZYME; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; COMPARATIVE STUDY; DNA DEGRADATION; GENE; GENE MUTATION; GENETICS; HETEROZYGOSITY; HOMOZYGOSITY; IMMUNE RESPONSE; PRIORITY JOURNAL; TREX1 GENE;

AUTOIMMUNE DISEASES; DNA; EXODEOXYRIBONUCLEASES; HUMANS; MODELS, MOLECULAR; MUTATION; PHOSPHOPROTEINS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 57649134251     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806155200     Document Type: Article

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