Migraine and genetic and acquired vasculopathies

Cephalalgia

Volumn 29, Issue 9, 2009, Pages 1006-1017

  Stam, A H ^a   Haan, J ^a,b   Van Den Maagdenberg, A M J M ^a   Ferrari, M D ^a   Terwindt, G M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RIJNLAND HOSPITAL   (Netherlands)

Author keywords

CADASIL; Comorbidity; Ischaemic stroke; Migraine; RVCL; TREX1

Indexed keywords

CADASIL; CEREBROVASCULAR ACCIDENT; ENDOTHELIAL DYSFUNCTION; GENETIC DISORDER; GENETIC SUSCEPTIBILITY; HEMIPARESIS; HEREDITARY INFANTILE HEMIPARESIS; HUMAN; ISCHEMIC HEART DISEASE; LEUKODYSTROPHY; MIGRAINE; RETINAL VASCULOPATHY WITH CEREBRAL LEUKODYSTROPHY; REVIEW; VASCULAR DISEASE;

BRAIN; HUMANS; MIGRAINE DISORDERS; VASCULAR DISEASES;

EID: 68249125680     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1111/j.1468-2982.2009.01940.x     Document Type: Review

References (114)

1. Goadsby PJ. The vascular theory of migraine - a great story wrecked by the facts. Brain 2009 132 : 6 7.
2. Schoonman GG, van der Grond J, Kortmann C, van der Geest RJ, Terwindt GM, Ferrari MD. Migraine headache is not associated with cerebral or meningeal vasodilatation - a 3T magnetic resonance angiography study. Brain 2008 131 : 2192 200.
3. Maassenvandenbrink A, Duncker DJ, Saxena PR. Migraine headache is not associated with cerebral or meningeal vasodilatation - a 3T magnetic resonance angiography study. Brain 2009 132 : e112.
4. Schoonman GG, Ferrari MD. Response to letter from MaassenVanDenBrink et al. Brain 2009 132 : e113.
5. Dreier JP, Kleeberg J, Petzold G, Priller J, Windmüller O, Orzechowski HD et al. Endothelin-1 potently induces Leao's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain 2002 125 : 102 12.
6. Dreier JP, Kleeberg J, Alam M, Major S, Kohl-Bareis M, Petzold GC et al. Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis. Exp Biol Med (Maywood) 2007 232 : 204 13.
7. Brennan KC, Beltran-Parrazal L, López-Valdés HE, Theriot J, Toga AW, Charles AC. Distinct vascular conduction with cortical spreading depression. J Neurophysiol 2007 97 : 4143 51.
8. Kurth T. Associations between migraine and cardiovascular disease. Expert Rev Neurother 2007 7 : 1097 104.
9. Tzourio C, Benslamia L, Guillon B, Aïdi S, Bertrand M, Berthet K, Bousser MG. Migraine and the risk of cervical artery dissection: a case-control study. Neurology 2002 59 : 435 7.
10. Goadsby PJ. Neurovascular headache and a midbrain vascular malformation: evidence for a role of the brainstem in chronic migraine. Cephalalgia 2002 22 : 107 11.
11. Kupersmith MJ, Vargas ME, Yashar A, Madrid M, Nelson K, Seton A et al. Occipital arteriovenous malformations: visual disturbances and presentation. Neurology 1996 46 : 953 7.
12. Kurita H, Ueki K, Shin M, Kawamoto S, Sasaki T, Tago M, Kirino T. Headaches in patients with radiosurgically treated occipital arteriovenous malformations. J Neurosurg 2000 93 : 224 8.
13. Calabrese LH, Dodick DW, Schwedt TJ, Singhal AB. Narrative review: reversible cerebral vasoconstriction syndromes. Ann Intern Med 2007 146 : 34 44.
14. Lesnik Oberstein SA, Haan J. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Panminerva Med 2004 46 : 265 76.
15. Richard A, Van den Maagdenberg AM, Jen JC, Kavanagh D, Bertram P, Spitzer D et al. Truncations in the carboxyl-terminus of human 3′-5′ DNA exonuclease TREX1 cause retinal vasculopathy with cerebral leukodystrophy. Nat Genet 2007 39 : 1068 70.
16. Terwindt GM, Haan J, Ophoff RA, Groenen SM, Storimans CW, Lanser JB et al. Clinical and genetic analysis of a large Dutch family with autosomal dominant vascular retinopathy, migraine and Raynaud's phenomenon. Brain 1998 121 : 303 16.
17. Vahedi K, Boukobza M, Massin P, Gould DB, Tournier-Laserve E, Bousser MG. Clinical and brain MRI follow-up study of a family with COL4A1 mutation. Neurology 2007 69 : 1564 8.
18. Parsons AA, Strijbos PJ. The neuronal versus vascular hypothesis of migraine and cortical spreading depression. Curr Opin Pharmacol 2003 3 : 73 7.
19. Wolff H. Headache and other pain. New York : Oxford Univeristy Press, 1948 : 59 97.
20. Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994 117 : 199 210.
21. Weiller C, May A, Limmroth V, Jüptner M, Kaube H, Schayck RV et al. Brain stem activation in spontaneous human migraine attacks. Nat Med 1995 1 : 658 60.
22. Goadsby PJ, Lipton RB, Ferrari MD. Migraine - current understanding and treatment. N Engl J Med 2002 346 : 257 70.
23. Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002 8 : 136 42.
24. Ferrari MD, Roon KI, Lipton RB, Goadsby PJ. Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 2001 358 : 1668 75.
25. Ho TW, Ferrari MD, Dodick DW, Galet V, Kost J, Fan X et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 2008 372 : 2115 23.
26. Gorji A, Scheller D, Straub H, Tegtmeier F, Köhling R, Höhling JM et al. Spreading depression in human neocortical slices. Brain Res 2001 906 : 74 83.
27. Milner PM. Note on a possible correspondence between the scotomas of migraine and spreading depression of Leao. Clin Neurophysiol 1958 10 : 705.
28. Hadjikhani N, Sanchez del Rio M, Wu O, Schwartz D, Bakker D, Fischl B et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA 2001 98 : 4687 92.
29. Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 1981 9 : 344 52.
30. Olesen J, Friberg L, Olsen TS, Iversen HK, Lassen NA, Andersen AR, Karle A. Timing and topography of cerebral blood flow, aura, and headache during migraine attacks. Ann Neurol 1990 28 : 791 8.
31. Cutrer FM, Sorensen AG, Weisskoff RM, Ostergaard L, Sanchez del Rio M, Lee EJ et al. Perfusion-weighted imaging defects during spontaneous migrainous aura. Ann Neurol 1998 43 : 25 31.
32. Tepper SJ, Sheftell FD, Bigal ME. The patent foramen ovale-migraine question. Neurol Sci 2007 28 (Suppl. 2 S118 S123.
33. Lesnik Oberstein SA, van den Boom R, Middelkoop HA, Ferrari MD, Knaap YM, van Houwelingen HC et al. Incipient CADASIL. Arch Neurol 2003 60 : 707 12.
34. Dichgans M, Mayer M, Uttner I, Brüning R, Müller-Höcker J, Rungger G et al. The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Ann Neurol 1998 44 : 731 9.
35. van den Boom R, Lesnik Oberstein SA, Ferrari MD, Haan J, van Buchem MA. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: MR imaging findings at different ages - 3rd-6th decades. Radiology 2003 229 : 683 90.
36. Lesnik Oberstein SA, van den Boom R, van Buchem MA, van Houwelingen HC, Bakker E, Vollebregt E et al. Cerebral microbleeds in CADASIL. Neurology 2001 57 : 1066 70.
37. Lesnik Oberstein SA, van Duinen SG, van den Boom R, Maat-Schieman ML, van Buchem MA, Van Houwelingen HC et al. Evaluation of diagnostic NOTCH3 immunostaining in CADASIL. Acta Neuropathol 2003 106 : 107 11.
38. Ruchoux MM, Maurage CA. Endothelial changes in muscle and skin biopsies in patients with CADASIL. Neuropathol Appl Neurobiol 1998 24 : 60 5.
39. Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996 383 : 707 10.
40. Joutel A, Andreux F, Gaulis S, Domenga V, Cecillon M, Battail N et al. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. J Clin Invest 2000 105 : 597 605.
41. Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O'Brien C et al. Notch and vascular smooth muscle cell phenotype. Circ Res 2008 103 : 1370 82.
42. Ruchoux MM, Domenga V, Brulin P, Maciazek J, Limol S, Tournier-Lasserve E et al. Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Am J Pathol 2003 162 : 329 42.
43. Monet M, Domenga V, Lemaire B, Souilhol C, Langa F, Babinet C et al. The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo. Hum Mol Genet 2007 16 : 982 92.
44. Opherk C, Peters N, Herzog J, Luedtke R, Dichgans M. Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients. Brain 2004 127 : 2533 9.
45. Opherk C, Peters N, Holtmannspötter M, Gschwendtner A, Müller-Myhsok B, Dichgans M. Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers. Stroke 2006 37 : 2684 9.
46. Grand MG, Kaine J, Fulling K, Atkinson J, Dowton SB, Farber M et al. Cerebroretinal vasculopathy. A new hereditary syndrome. Ophthalmology 1988 95 : 649 59.
47. Jen J, Cohen AH, Yue Q, Stout JT, Vinters HV, Nelson S, Baloh RW. Hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS). Neurology 1997 49 : 1322 30.
48. Ophoff RA, DeYoung J, Service SK, Joosse M, Caffo NA, Sandkuijl LA et al. Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3. Am J Hum Genet 2001 69 : 447 53.
49. Weil S, Reifenberger G, Dudel C, Yousry TA, Schriever S, Noachtar S. Cerebroretinal vasculopathy mimicking a brain tumor: a case of a rare hereditary syndrome. Neurology 1999 53 : 629 31.
50. Mazur DJ, Perrino FW. Excision of 3′ termini by the Trex1 and TREX2 3′ - >5′ exonucleases. Characterization of the recombinant proteins. J Biol Chem 2001 276 : 17022 9.
51. Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G et al. Gene-targeted mice lacking the Trex1 (DNase III) 3′ - >5′ DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol 2004 24 : 6719 27.
52. Martinvalet D, Zhu P, Lieberman J. Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity 2005 22 : 355 70.
53. Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B et al. The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell 2006 23 : 133 42.
54. Yang YG, Lindahl T, Barnes DE. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 2007 131 : 873 86.
55. Crow YJ, Hayward BE, Parmar R, Robins P, Leitch A, Ali M et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nat Genet 2006 38 : 917 20.
56. Rice G, Newman WG, Dean J, Patrick T, Parmar R, Flintoff K et al. Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. Am J Hum Genet 2007 80 : 811 5.
57. Lee-Kirsch MA, Chowdhury D, Harvey S, Gong M, Senenko L, Engel K et al. A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med 2007 85 : 531 7.
58. Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 2007 39 : 1065 7.
59. Lessa B, Santana A, Lima I, Almeida JM, Santiago M. Prevalence and classification of headache in patients with systemic lupus erythematosus. Clin Rheumatol 2006 25 : 850 3.
60. Hottenga JJ, Vanmolkot KR, Kors EE, Kheradmand Kia S, de Jong PT, Haan J et al. The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine. Cephalalgia 2005 25 : 1168 72.
61. Gould DB, Phalan FC, Breedveld GJ, van Mil SE, Smith RS, Schimenti JC et al. Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science 2005 308 : 1167 71.
62. Gould DB, Phalan FC, van Mil SE, Sundberg JP, Vahedi K, Massin P et al. Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med 2006 354 : 1489 96.
63. Vahedi K, Massin P, Guichard JP, Miocque S, Polivka M, Goutières F et al. Hereditary infantile hemiparesis, retinal arteriolar tortuosity, and leukoencephalopathy. Neurology 2003 60 : 57 63.
64. Mine M, Tournier-Lasserve E. Intracerebral hemorrhage and COL4A1 mutations, from preterm infants to adult patients. Ann Neurol 2009 65 : 1 2.
65. van der Knaap MS, Smit LM, Barkhof F, Pijnenburg YA, Zweegman S, Niessen HW et al. Neonatal porencephaly and adult stroke related to mutations in collagen IV A1. Ann Neurol 2006 59 : 504 11.
66. de Vries LS, Koopman C, Groenendaal F, Van Schooneveld M, Verheijen FW, Verbeek E et al. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Ann Neurol 2009 65 : 12 8.
67. Sibon I, Coupry I, Menegon P, Bouchet JP, Gorry P, Burgelin I et al. COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke. Ann Neurol 2007 62 : 177 84.
68. Plaisier E, Gribouval O, Alamowitch S, Mougenot B, Prost C, Verpont MC et al. COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. N Engl J Med 2007 357 : 2687 95.
69. Van Agtmael T, Schlötzer-Schrehardt U, McKie L, Brownstein DG, Lee AW, Cross SH et al. Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Hum Mol Genet 2005 14 : 3161 8.
70. Breedveld G, de Coo IF, Lequin MH, Arts WF, Heutink P, Gould DB et al. Novel mutations in three families confirm a major role of COL4A1 in hereditary porencephaly. J Med Gen 2006 43 : 490 5.
71. Launer LJ, Terwindt GM, Ferrari MD. The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology 1999 53 : 537 42.
72. Schwaag S, Evers S, Schirmacher A, Stögbauer F, Ringelstein EB, Kuhlenbäumer G. Genetic variants of the NOTCH3 gene in migraine - a mutation analysis and association study. Cephalalgia 2006 26 : 158 61.
73. Borroni B, Brambilla C, Liberini P, Rao R, Archetti S, Venturelli E et al. Investigating the association between Notch3 polymorphism and migraine. Headache 2006 46 : 317 21.
74. Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K. The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine. Am J Med Genet 2000 96 : 762 4.
75. Kowa H, Fusayasu E, Ijiri T, Ishizaki K, Yasui K, Nakaso K et al. Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura. Neurosci Lett 2005 374 : 129 31.
76. Lea RA, Ovcaric M, Sundholm J, Macmillan J, Griffiths LS. The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura. BMC Med 2004 2 : 3.
77. Paterna S, Di Pasquale P, D'Angelo A, Seidita G, Tuttolomondo A, Cardinale A et al. Angiotensin-converting enzyme gene deletion polymorphism determines an increase in frequency of migraine attacks in patients suffering from migraine without aura. Eur Neurol 2000 43 : 133 6.
78. Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H et al. Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol 2006 59 : 372 5.
79. Tzourio C, El Amrani M, Poirier O, Nicaud V, Bousser MG, Alpérovitch A. Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism. Neurology 2001 56 : 1273 7.
80. Borroni B, Rao R, Liberini P, Venturelli E, Cossandi M, Archetti S et al. Endothelial nitric oxide synthase (Glu298Asp) polymorphism is an independent risk factor for migraine with aura. Headache 2006 46 : 1575 9.
81. Lee ST, Chu K, Jung KH, Kim DH, Kim EH, Choe VN et al. Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology 2008 70 : 1510 7.
82. Vanmolkot FH, Van Bortel LM, de Hoon JN. Altered arterial function in migraine of recent onset. Neurology 2007 68 : 1563 70.
83. Yetkin E, Ozisik H, Ozcan C, Aksoy Y, Turhan H. Decreased endothelium-dependent vasodilatation in patients with migraine: a new aspect to vascular pathophysiology of migraine. Coron Artery Dis 2006 17 : 29 33.
84. Yetkin E, Ozisik H, Ozcan C, Aksoy Y, Turhan H. Increased dilator response to nitrate and decreased flow-mediated dilatation in migraineurs. Headache 2007 47 : 104 10.
85. Dubroca C, Lacombe P, Domenga V, Maciazek J, Levy B, Tournier-Lasserve E et al. Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. Stroke 2005 36 : 113 7.
86. Stenborg A, Kalimo H, Viitanen M, Terent A, Lind L. Impaired endothelial function of forearm resistance arteries in CADASIL patients. Stroke 2007 38 : 2692 7.
87. Peters N, Freilinger T, Opherk C, Pfefferkorn T, Dichgans M. Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL. J Neurol 2008 255 : 1203 8.
88. Liem MK, Lesnik Oberstein SA, Haan J, Boom R, Ferrari MD, Buchem MA, Grond JV. Reactivity C is a main determinant of white matter hyperintensity progression in CADASIL. AJNR Am J Neuroradiol 2009 30 : 1244 7.
89. van den Boom R, Lesnik Oberstein SA, Spilt A, Behloul F, Ferrari MD, Haan J et al. Cerebral hemodynamics and white matter hyperintensities in CADASIL. J Cereb Blood Flow Metab 2003 23 : 599 604.
90. Chabriat H, Pappata S, Ostergaard L, Clark CA, Pachot-Clouard M, Vahedi K et al. Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking. Stroke 2000 31 : 1904 12.
91. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ 2005 330 : 63.
92. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM et al. Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 2005 64 : 1020 6.
93. Kurth T, Gaziano JM, Cook NR, Bubes V, Logroscino G, Diener HC, Buring JE. Migraine and risk of cardiovascular disease in men. Arch Intern Med 2007 167 : 795 801. (Pubitemid 46658337)
94. MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, Kittner SJ. Probable migraine with visual aura and risk of ischemic stroke: the stroke prevention in young women study. Stroke 2007 38 : 2438 45.
95. Stang PE, Carson AP, Rose KM, Mo J, Ephross SA, Shahar E, Szkio M. Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study. Neurology 2005 64 : 1573 7.
96. Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE. Migraine and risk of cardiovascular disease in women. JAMA 2006 296 : 283 91.
97. Wammes-van der Heijden EA, Rahimtoola H, Leufkens HG, Tijssen CC, Egberts AC. Risk of ischemic complications related to the intensity of triptan and ergotamine use. Neurology 2006 67 : 1128 34.
98. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ. Migraine as a risk factor for subclinical brain lesions. JAMA 2004 291 : 427 34.
99. Kruit MC, Launer LJ, Ferrari MD, van Buchem MA. Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study. Brain 2005 128 : 2068 77.
100. Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders. 2nd edition. Cephalalgia 2004 24 : 1 160.
101. Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 2005 64 : 614 20.
102. Tietjen GE, Al-Qasmi MM, Athanas K, Utley C, Herial NA. Altered hemostasis in migraineurs studied with a dynamic flow system. Thromb Res 2007 119 : 217 22.
103. Liew G, Wang JJ, Mitchell P. Migraine and coronary heart disease mortality: a prospective cohort study. Cephalalgia 2007 27 : 368 71.
104. Kurth T, Schurks M, Logroscino G, Gaziano JM, Buring JE. Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 2008 337 : a636.
105. Kurth T, Ridker PM, Buring JE. Migraine and biomarkers of cardiovascular disease in women. Cephalalgia 2008 28 : 49 56.
106. Rubino E, Ferrero M, Rainero I, Binello E, Vaula G, Pinessi L. Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis. Cephalalgia 2007 advance online publication, 2007 Aug 21 (doi:10.1111/j.1468-2982.2007.01400.x).
107. De Bree A, Verschuren WM, Kromhout D, Kluijtmans LA, Blom HJ. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 2002 54 : 599 618.
108. Rubinstein SM, Peerdeman SM, van Tulder MW, Riphagen I, Haldeman S. A systematic review of the risk factors for cervical artery dissection. Stroke 2005 36 : 1575 80.
109. Pezzini A, Granella F, Grassi M, Bertolino C, Del Zotto E, Immovilli P et al. History of migraine and the risk of spontaneous cervical artery dissection. Cephalalgia 2005 25 : 575 80.
110. D'Anglejan-Chatillon J, Ribeiro V, Mas JL, Youl BD, Bousser MG. Migraine - a risk factor for dissection of cervical arteries. Headache 1989 29 : 560 1.
111. Guillon B, Berhet K, Benslamia L, Bertrand M, Bousser MG, Tzourio C. Infection and the risk of spontaneous cervical artery dissection: a case-control study. Stroke 2003 34 : e79 81
112. Law C, Bunyan D, Castle B, Day L, Simpson I, Westwood G, Keeton B. Clinical features in a family with an R460H mutation in transforming growth factor beta receptor 2 gene. J Med Genet 2006 43 : 908 16.
113. Afridi S, Goadsby PJ. New onset migraine with a brain stem cavernous angioma. J Neurol Neurosurg Psychiatry 2003 74 : 680 2.
114. Singhal AB, Caviness VS, Begleiter AF, Mark EJ, Rordorf G, Koroshetz WJ. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002 58 : 130 3.