메뉴 건너뛰기




Volumn 17, Issue 2, 2014, Pages 116-133

Mineralization of the connective tissue: A complex molecular process leading to age-related loss of function

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; BONE MORPHOGENETIC PROTEIN; COLLAGEN; FIBROBLAST GROWTH FACTOR; FRESOLIMUMAB; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; METELIMUMAB; PIOGLITAZONE; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; PROTEIN LYSINE 6 OXIDASE; MINERAL;

EID: 84898977454     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2013.1475     Document Type: Article
Times cited : (21)

References (121)
  • 1
    • 0033051415 scopus 로고    scopus 로고
    • High density micromass cultures of embryonic limb bud mesenchymal cells: An in vitro model of endochondral skeletal development
    • Mello MA, Tuan RS. High density micromass cultures of embryonic limb bud mesenchymal cells: An in vitro model of endochondral skeletal development. In Vitro Cell Dev Biol Anim 1999;35:262-269. (Pubitemid 29252105)
    • (1999) Vitro Cellular and Developmental Biology - Animal , vol.35 , Issue.5 , pp. 262-269
    • Mello, M.A.1    Tuan, R.S.2
  • 4
    • 0030043335 scopus 로고    scopus 로고
    • A histological study of the developing condylar cartilage of the fetal mouse mandible using coronal sections
    • Shibata S, Suzuki S, Tengan T, Ishii M, Kuroda T. A histological study of the developing condylar cartilage of the fetal mouse mandible using coronal sections. Arch Oral Biol 1996;41:47-54.
    • (1996) Arch Oral Biol , vol.41 , pp. 47-54
    • Shibata, S.1    Suzuki, S.2    Tengan, T.3    Ishii, M.4    Kuroda, T.5
  • 5
    • 84886100299 scopus 로고    scopus 로고
    • Vascular calcification: An update on mechanisms and callenges in treatment
    • published online March 1, 2013; doi 10.1007/s00223-013-9712-z
    • Wu M, Rementer C, Giachelli CM. Vascular calcification: An update on mechanisms and callenges in treatment. Calcif Tissue Int 2013; published online March 1, 2013; doi 10.1007/s00223-013-9712-z.
    • (2013) Calcif Tissue Int
    • Wu, M.1    Rementer, C.2    Giachelli, C.M.3
  • 6
    • 0028354771 scopus 로고
    • Coronary arterial calcification as an active process: A new perspective on an old problem
    • Doherty TM, Detrano RC. Coronary arterial calcification as an active process: A new perspective on an old problem. Calcif Tissue Int 1994;54:224-230. (Pubitemid 24076579)
    • (1994) Calcified Tissue International , vol.54 , Issue.3 , pp. 224-230
    • Doherty, T.M.1    Detrano, R.C.2
  • 8
    • 0026481868 scopus 로고
    • Evaluation of morphological changes of the atherosclerotic aorta by enhanced computed tomography
    • Takasu J, Takanashi K, Naito S, Onishi M, Miyazaki A, Aoyagi Y, et al. Evaluation of morphological changes of the atherosclerotic aorta by enhanced computed tomography. Atherosclerosis 1992;97:107-121.
    • (1992) Atherosclerosis , vol.97 , pp. 107-121
    • Takasu, J.1    Takanashi, K.2    Naito, S.3    Onishi, M.4    Miyazaki, A.5    Aoyagi, Y.6
  • 9
    • 84866539341 scopus 로고    scopus 로고
    • Detection of hydroxyapatite in calcified cardiovascular tissues
    • Lee JS, Morrisett JD, Tung CH. Detection of hydroxyapatite in calcified cardiovascular tissues. Atherosclerosis 2012;224: 340-347.
    • (2012) Atherosclerosis , vol.224 , pp. 340-347
    • Lee, J.S.1    Morrisett, J.D.2    Tung, C.H.3
  • 10
    • 16844380283 scopus 로고    scopus 로고
    • Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes
    • Sell DR, Biemel KM, Reihl O, Lederer MO, Strauch CM, Monnier VM. Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes. J Biol Chem 2005;280:12310-12315.
    • (2005) J Biol Chem , vol.280 , pp. 12310-12315
    • Sell, D.R.1    Biemel, K.M.2    Reihl, O.3    Lederer, M.O.4    Strauch, C.M.5    Monnier, V.M.6
  • 11
    • 0029893422 scopus 로고    scopus 로고
    • The role of glycation cross-links in diabetic vascular stiffening
    • DOI 10.1007/s001250050536
    • Sims TJ, Rasmussen LM, Oxlund H, Bailey AJ. The role of glycation cross-links in diabetic vascular stiffening. Diabetologia 1996;39:946-951. (Pubitemid 26249114)
    • (1996) Diabetologia , vol.39 , Issue.8 , pp. 946-951
    • Sims, T.J.1    Rasmussen, L.M.2    Oxlund, H.3    Bailey, A.J.4
  • 12
    • 10044280353 scopus 로고    scopus 로고
    • Elastin degradation and calcification in an abdominal aorta injury model: Role of matrix metalloproteinases
    • DOI 10.1161/01.CIR.0000148367.08413.E9
    • Basalyga DM, Simionescu DT, Xiong W, Baxter BT, Starcher BC, Vyavahare NR. Elastin degradation and calcification in an abdominal aorta injury model: Role of matrix metalloproteinases. Circulation 2004;110:3480-3487. (Pubitemid 39602227)
    • (2004) Circulation , vol.110 , Issue.22 , pp. 3480-3487
    • Basalyga, D.M.1    Simionescu, D.T.2    Xiong, W.3    Baxter, B.T.4    Starcher, B.C.5    Vyavahare, N.R.6
  • 14
    • 84886834727 scopus 로고    scopus 로고
    • Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: The osteoporotic fractures in men (MrOS) study
    • doi: 10.1002/jbmr.1985
    • Lane NE, Parimi N, Corr M, Yao W, Cauley JA, Nielson CM, et al. Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: The osteoporotic fractures in men (MrOS) study. J Bone Miner Res 2013;doi: 10.1002/jbmr.1985
    • (2013) J Bone Miner Res
    • Lane, N.E.1    Parimi, N.2    Corr, M.3    Yao, W.4    Cauley, J.A.5    Nielson, C.M.6
  • 15
    • 84866698708 scopus 로고    scopus 로고
    • Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice
    • Martin A, David V, Li H, Dai B, Feng JQ, Quarles LD. Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice. Mol Endocrinol 2012;26:1883- 1895.
    • (2012) Mol Endocrinol , vol.26 , pp. 1883-1895
    • Martin, A.1    David, V.2    Li, H.3    Dai, B.4    Feng, J.Q.5    Quarles, L.D.6
  • 16
    • 84864365432 scopus 로고    scopus 로고
    • Mutational analysis of PHEX, FGF23, DMP1, SLC34A3 and CLCN5 in patients with hypophosphatemic rickets
    • Beck-Nielsen SS, Brixen K, Gram J, Brusgaard K. Mutational analysis of PHEX, FGF23, DMP1, SLC34A3 and CLCN5 in patients with hypophosphatemic rickets. J Hum Genet 2012;57:453-458.
    • (2012) J Hum Genet , vol.57 , pp. 453-458
    • Beck-Nielsen, S.S.1    Brixen, K.2    Gram, J.3    Brusgaard, K.4
  • 18
    • 80052290776 scopus 로고    scopus 로고
    • A patient with hypophosphatemic rickets and ossification of posterior longitudinal ligament caused by a novel homozygous mutation in ENPP1 gene
    • Saito T, Shimizu Y, Hori M, Taguchi M, Igarashi T, Fukumoto S, et al. A patient with hypophosphatemic rickets and ossification of posterior longitudinal ligament caused by a novel homozygous mutation in ENPP1 gene. Bone 2011;49: 913-916.
    • (2011) Bone , vol.49 , pp. 913-916
    • Saito, T.1    Shimizu, Y.2    Hori, M.3    Taguchi, M.4    Igarashi, T.5    Fukumoto, S.6
  • 19
    • 84859556738 scopus 로고    scopus 로고
    • FGF23 and syndromes of abnormal renal phosphate handling
    • Bergwitz C, Juppner H. FGF23 and syndromes of abnormal renal phosphate handling. Adv Exp Med Biol 2012;728:41-64.
    • (2012) Adv Exp Med Biol , vol.728 , pp. 41-64
    • Bergwitz, C.1    Juppner, H.2
  • 20
    • 84872874858 scopus 로고    scopus 로고
    • Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro
    • Xiao L, Esliger A, Hurley MM. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res 2013;28:35-45.
    • (2013) J Bone Miner Res , vol.28 , pp. 35-45
    • Xiao, L.1    Esliger, A.2    Hurley, M.M.3
  • 21
    • 33645405335 scopus 로고    scopus 로고
    • Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia
    • Kobayashi K, Imanishi Y, Koshiyama H, Miyauchi A, Wakasa K, Kawata T, et al. Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. Life Sci 2006;78:2295-2301.
    • (2006) Life Sci , vol.78 , pp. 2295-2301
    • Kobayashi, K.1    Imanishi, Y.2    Koshiyama, H.3    Miyauchi, A.4    Wakasa, K.5    Kawata, T.6
  • 22
    • 84868601209 scopus 로고    scopus 로고
    • Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites
    • Dai B, David V, Alshayeb HM, Showkat A, Gyamlani G, Horst RL, et al. Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites. Kidney Int 2012;82:1061-1070.
    • (2012) Kidney Int , vol.82 , pp. 1061-1070
    • Dai, B.1    David, V.2    Alshayeb, H.M.3    Showkat, A.4    Gyamlani, G.5    Horst, R.L.6
  • 23
    • 84871858517 scopus 로고    scopus 로고
    • Unravelling of hidden secrets: The role of vitamin D in skin aging
    • Reichrath J. Unravelling of hidden secrets: The role of vitamin D in skin aging. Dermatoendocrinol 2012;4:241-244.
    • (2012) Dermatoendocrinol , vol.4 , pp. 241-244
    • Reichrath, J.1
  • 24
    • 84875254011 scopus 로고    scopus 로고
    • A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease
    • Quarles LD. A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease. Semin Nephrol 2013;33:130-142.
    • (2013) Semin Nephrol , vol.33 , pp. 130-142
    • Quarles, L.D.1
  • 25
    • 79952071106 scopus 로고    scopus 로고
    • Activation of vascular bone morphogenetic protein signaling in diabetes mellitus
    • Bostrom KI, Jumabay M, Matveyenko A, Nicholas SB, Yao Y. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res 2011;108:446-457.
    • (2011) Circ Res , vol.108 , pp. 446-457
    • Bostrom, K.I.1    Jumabay, M.2    Matveyenko, A.3    Nicholas, S.B.4    Yao, Y.5
  • 29
    • 79952397401 scopus 로고    scopus 로고
    • Contribution of bone morphogenetic protein- 2 to aortic valve calcification in aged rat
    • Seya K, Yu Z, Kanemaru K, Daitoku K, Akemoto Y, Shibuya H, et al. Contribution of bone morphogenetic protein- 2 to aortic valve calcification in aged rat. J Pharmacol Sci 2011;115:8-14.
    • (2011) J Pharmacol Sci , vol.115 , pp. 8-14
    • Seya, K.1    Yu, Z.2    Kanemaru, K.3    Daitoku, K.4    Akemoto, Y.5    Shibuya, H.6
  • 30
    • 84865124878 scopus 로고    scopus 로고
    • Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties
    • Mahlawat P, Ilangovan U, Biswas T, Sun LZ, Hinck AP. Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties. Biochemistry 2012;51:6328-6341.
    • (2012) Biochemistry , vol.51 , pp. 6328-6341
    • Mahlawat, P.1    Ilangovan, U.2    Biswas, T.3    Sun, L.Z.4    Hinck, A.P.5
  • 31
    • 34047095329 scopus 로고    scopus 로고
    • Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells
    • DOI 10.1016/j.cardiores.2006.09.014, PII S0008636306004317
    • Yao Y, Zebboudj AF, Torres A, Shao E, Bostrom K. Activinlike kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells. Cardiovasc Res 2007;74: 279-289. (Pubitemid 46517503)
    • (2007) Cardiovascular Research , vol.74 , Issue.2 , pp. 279-289
    • Yao, Y.1    Zebboudj, A.F.2    Torres, A.3    Shao, E.4    Bostrom, K.5
  • 32
    • 33845921834 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1
    • DOI 10.1074/jbc.M604239200
    • Yao Y, Zebboudj AF, Shao E, Perez M, Bostrom K. Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1. J Biol Chem 2006;281:33921-33930. (Pubitemid 46036604)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.45 , pp. 33921-33930
    • Yao, Y.1    Zebboudj, A.F.2    Shao, E.3    Perez, M.4    Bostrom, K.5
  • 33
    • 77956225591 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification
    • Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis AJ, et al. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res 2010;107:485-494.
    • (2010) Circ Res , vol.107 , pp. 485-494
    • Yao, Y.1    Bennett, B.J.2    Wang, X.3    Rosenfeld, M.E.4    Giachelli, C.5    Lusis, A.J.6
  • 34
    • 84868278414 scopus 로고    scopus 로고
    • Genetics in arterial calcification: Lessons learned from rare diseases
    • Nitschke Y, Rutsch F. Genetics in arterial calcification: lessons learned from rare diseases. Trends Cardiovasc Med 2012;22:145-149.
    • (2012) Trends Cardiovasc Med , vol.22 , pp. 145-149
    • Nitschke, Y.1    Rutsch, F.2
  • 36
    • 34748813185 scopus 로고    scopus 로고
    • The long-term consequence of anterior cruciate ligament and meniscus injuries: Osteoarthritis
    • DOI 10.1177/0363546507307396
    • Lohmander LS, Englund PM, Dahl LL, Roos EM. The longterm consequence of anterior cruciate ligament and meniscus injuries: Osteoarthritis. Am J Sports Med 2007;35: 1756-1769. (Pubitemid 47476065)
    • (2007) American Journal of Sports Medicine , vol.35 , Issue.10 , pp. 1756-1769
    • Lohmander, L.S.1    Englund, P.M.2    Dahl, L.L.3    Roos, E.M.4
  • 38
    • 37449025069 scopus 로고    scopus 로고
    • A quantitative study of the microstructure and biochemistry of the medial meniscal horn attachments
    • DOI 10.1007/s10439-007-9403-x
    • Villegas DF, Hansen TA, Liu DF, Donahue TL. A quantitative study of the microstructure and biochemistry of the medial meniscal horn attachments. Ann Biomed Eng 2008; 36:123-131. (Pubitemid 50002701)
    • (2008) Annals of Biomedical Engineering , vol.36 , Issue.1 , pp. 123-131
    • Villegas, D.F.1    Hansen, T.A.2    Liu, D.F.3    Haut Donahue, T.L.4
  • 39
    • 84876416544 scopus 로고    scopus 로고
    • Bone ingrowth potential of electron beam and selective laser melting produced trabecular-like implant surfaces with and without a biomimetic coating
    • Biemond JE, Hannink G, Verdonschot N, Buma P. Bone ingrowth potential of electron beam and selective laser melting produced trabecular-like implant surfaces with and without a biomimetic coating. J Mater Sci Mater Med 2013;24:745-753.
    • (2013) J Mater Sci Mater Med , vol.24 , pp. 745-753
    • Biemond, J.E.1    Hannink, G.2    Verdonschot, N.3    Buma, P.4
  • 40
    • 67649678424 scopus 로고    scopus 로고
    • Vascular calcification: The killer of patients with chronic kidney disease
    • Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 2009;20:1453-1464.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1453-1464
    • Mizobuchi, M.1    Towler, D.2    Slatopolsky, E.3
  • 41
    • 77955172689 scopus 로고    scopus 로고
    • Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo
    • Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, et al. Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Circ Res 2010;107:252-262.
    • (2010) Circ Res , vol.107 , pp. 252-262
    • Yang, J.1    Li, X.2    Al-Lamki, R.S.3    Southwood, M.4    Zhao, J.5    Lever, A.M.6
  • 42
    • 33745962708 scopus 로고    scopus 로고
    • Molecular mechanisms of vascular calcification: Lessons learned from the aorta
    • DOI 10.1161/01.ATV.0000220441.42041.20, PII 0004360520060700000005
    • Shao JS, Cai J, Towler DA. Molecular mechanisms of vascular calcification: Lessons learned from the aorta. Arterioscler Thromb Vasc Biol 2006;26:1423-1430. (Pubitemid 44288965)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.7 , pp. 1423-1430
    • Shao, J.-S.1    Cai, J.2    Towler, D.A.3
  • 43
    • 84864088681 scopus 로고    scopus 로고
    • Osteoblastspecific transcription factor Osterix (Osx) and HIF-1alpha cooperatively regulate gene expression of vascular endothelial growth factor (VEGF)
    • Chen D, Tian W, Li Y, Tang W, Zhang C. Osteoblastspecific transcription factor Osterix (Osx) and HIF-1alpha cooperatively regulate gene expression of vascular endothelial growth factor (VEGF). Biochem Biophys Res Commun 2012;424:176-181.
    • (2012) Biochem Biophys Res Commun , vol.424 , pp. 176-181
    • Chen, D.1    Tian, W.2    Li, Y.3    Tang, W.4    Zhang, C.5
  • 44
    • 84861495270 scopus 로고    scopus 로고
    • Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium
    • Yao Y, Jumabay M, Ly A, Radparvar M, Wang AH, Abdmaulen R, et al. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood 2012;119:5037-5047.
    • (2012) Blood , vol.119 , pp. 5037-5047
    • Yao, Y.1    Jumabay, M.2    Ly, A.3    Radparvar, M.4    Wang, A.H.5    Abdmaulen, R.6
  • 46
    • 70350580660 scopus 로고    scopus 로고
    • Notch1 represses osteogenic pathways in aortic valve cells
    • Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol 2009;47: 828-834.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 828-834
    • Nigam, V.1    Srivastava, D.2
  • 48
    • 47249157776 scopus 로고    scopus 로고
    • Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling
    • Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley- Usmar VM, et al. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem 2008;283: 15319-15327.
    • (2008) J Biol Chem , vol.283 , pp. 15319-15327
    • Byon, C.H.1    Javed, A.2    Dai, Q.3    Kappes, J.C.4    Clemens, T.L.5    Darley- Usmar, V.M.6
  • 49
    • 84865515845 scopus 로고    scopus 로고
    • Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification
    • Sun Y, Byon CH, Yuan K, Chen J, Mao X, Heath JM, et al. Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification. Circ Res 2012;111:543-552.
    • (2012) Circ Res , vol.111 , pp. 543-552
    • Sun, Y.1    Byon, C.H.2    Yuan, K.3    Chen, J.4    Mao, X.5    Heath, J.M.6
  • 52
    • 84875262394 scopus 로고    scopus 로고
    • Renal and extrarenal actions of Klotho
    • Hu MC, Kuro-o M, Moe OW. Renal and extrarenal actions of Klotho. Semin Nephrol 2013;33:118-129.
    • (2013) Semin Nephrol , vol.33 , pp. 118-129
    • Hu, M.C.1    Kuro-O, M.2    Moe, O.W.3
  • 53
    • 84871916859 scopus 로고    scopus 로고
    • Measurement of serum soluble Klotho levels in CKD 5D patients: Useful tool or dispensable biomarker?
    • Fliser D, Seiler S, Heine GH, Ketteler M. Measurement of serum soluble Klotho levels in CKD 5D patients: useful tool or dispensable biomarker? Nephrol Dial Transplant 2012;27:1702-1703.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 1702-1703
    • Fliser, D.1    Seiler, S.2    Heine, G.H.3    Ketteler, M.4
  • 54
    • 84878375467 scopus 로고    scopus 로고
    • Coronary artery calcification and outcomes in diabetic patients with and without chronic kidney disease
    • Russo D, Morrone LF, Imbriaco M, Pota A, Russo L, Scognamiglio B, et al. Coronary artery calcification and outcomes in diabetic patients with and without chronic kidney disease. Blood Purif 2013;36:17-20.
    • (2013) Blood Purif , vol.36 , pp. 17-20
    • Russo, D.1    Morrone, L.F.2    Imbriaco, M.3    Pota, A.4    Russo, L.5    Scognamiglio, B.6
  • 55
    • 18044399154 scopus 로고    scopus 로고
    • Vascular calcifications in chronic kidney disease: Are there new treatments?
    • DOI 10.2174/1570161053586877
    • Negri AL. Vascular calcifications in chronic kidney disease: Are there new treatments? Curr Vasc Pharmacol 2005;3: 181-184. (Pubitemid 40601586)
    • (2005) Current Vascular Pharmacology , vol.3 , Issue.2 , pp. 181-184
    • Negri, A.L.1
  • 57
    • 84870710841 scopus 로고    scopus 로고
    • Relationship between aortic mineral elements and osteodystrophy in mice with chronic kidney disease
    • Matsumoto T, Fukushima S, Kanasaki T, Hagino S. Relationship between aortic mineral elements and osteodystrophy in mice with chronic kidney disease. Biol Trace Elem Res 2012;150:278-284.
    • (2012) Biol Trace Elem Res , vol.150 , pp. 278-284
    • Matsumoto, T.1    Fukushima, S.2    Kanasaki, T.3    Hagino, S.4
  • 58
    • 84862226919 scopus 로고    scopus 로고
    • Vanin-1 pantetheinase drives smooth muscle cell activation in postarterial injury neointimal hyperplasia
    • Dammanahalli KJ, Stevens S, Terkeltaub R. Vanin-1 pantetheinase drives smooth muscle cell activation in postarterial injury neointimal hyperplasia. PLoS One 2012; 7:e39106.
    • (2012) PLoS One , vol.7
    • Dammanahalli, K.J.1    Stevens, S.2    Terkeltaub, R.3
  • 62
    • 84879123915 scopus 로고    scopus 로고
    • Dkk1 and Msx2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells
    • Cheng SL, Shao JS, Behrmann A, Krchma K, Towler DA. Dkk1 and Msx2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells. Arterioscler Thromb Vasc Biol 2013;33:1679-1689.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1679-1689
    • Cheng, S.L.1    Shao, J.S.2    Behrmann, A.3    Krchma, K.4    Towler, D.A.5
  • 63
    • 0347379905 scopus 로고    scopus 로고
    • Teriparatide (Human Parathyroid Hormone (1-34)) Inhibits Osteogenic Vascular Calcification in Diabetic Low Density Lipoprotein Receptor-deficient Mice
    • DOI 10.1074/jbc.M308825200
    • Shao JS, Cheng SL, Charlton-Kachigian N, Loewy AP, Towler DA. Teriparatide (human parathyroid hormone (1- 34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice. J Biol Chem 2003;278:50195-50202. (Pubitemid 37548859)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.50 , pp. 50195-50202
    • Shao, J.-S.1    Cheng, S.-L.2    Charlton-Kachigian, N.3    Loewy, A.P.4    Towler, D.A.5
  • 65
    • 79958700007 scopus 로고    scopus 로고
    • The pharmacological management of osteoporosis
    • Riek AE, Towler DA. The pharmacological management of osteoporosis. Missouri Med 2011;108:118-123.
    • (2011) Missouri Med , vol.108 , pp. 118-123
    • Riek, A.E.1    Towler, D.A.2
  • 66
    • 62549151245 scopus 로고    scopus 로고
    • Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential
    • Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathol 2009;174:1109-1119.
    • (2009) Am J Pathol , vol.174 , pp. 1109-1119
    • Chen, J.H.1    Yip, C.Y.2    Sone, E.D.3    Simmons, C.A.4
  • 68
    • 79956011495 scopus 로고    scopus 로고
    • A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis
    • Trachtman H, Fervenza FC, Gipson DS, Heering P, Jayne DR, Peters H, et al. A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney Int 2011;79:1236-1243.
    • (2011) Kidney Int , vol.79 , pp. 1236-1243
    • Trachtman, H.1    Fervenza, F.C.2    Gipson, D.S.3    Heering, P.4    Jayne, D.R.5    Peters, H.6
  • 70
    • 85027958993 scopus 로고    scopus 로고
    • Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products
    • Li F, Cai Z, Chen F, Shi X, Zhang Q, Chen S, et al. Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products. Basic Res Cardiol 2012;107:306.
    • (2012) Basic Res Cardiol , vol.107 , pp. 306
    • Li, F.1    Cai, Z.2    Chen, F.3    Shi, X.4    Zhang, Q.5    Chen, S.6
  • 71
    • 84866975779 scopus 로고    scopus 로고
    • The nuclear hormone receptor PPARgamma counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells
    • Woldt E, Terrand J, Mlih M, Matz RL, Bruban V, Coudane F, et al. The nuclear hormone receptor PPARgamma counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells. Nat Commun 2012;3:1077.
    • (2012) Nat Commun , vol.3 , pp. 1077
    • Woldt, E.1    Terrand, J.2    Mlih, M.3    Matz, R.L.4    Bruban, V.5    Coudane, F.6
  • 72
    • 84868283392 scopus 로고    scopus 로고
    • Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease
    • Sun L, Chandra S, Sucosky P. Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS One 2012;7:e48843.
    • (2012) PLoS One , vol.7
    • Sun, L.1    Chandra, S.2    Sucosky, P.3
  • 73
    • 73449123020 scopus 로고    scopus 로고
    • Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes
    • Mori K, Jono S, Emoto M, Kawagishi T, Yasumoto H, Konishi T, et al. Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes. Angiology 2010;61:86-91.
    • (2010) Angiology , vol.61 , pp. 86-91
    • Mori, K.1    Jono, S.2    Emoto, M.3    Kawagishi, T.4    Yasumoto, H.5    Konishi, T.6
  • 74
    • 84871307196 scopus 로고    scopus 로고
    • Advances in molecular imaging of atherosclerosis and myocardial infarction: Shedding new light on in vivo cardiovascular biology
    • Phinikaridou A, Andia ME, Shah AM, Botnar RM. Advances in molecular imaging of atherosclerosis and myocardial infarction: Shedding new light on in vivo cardiovascular biology. Am J Physiol Heart Circ Physiol 2012;303:H1397-H1410.
    • (2012) Am J Physiol Heart Circ Physiol , vol.303
    • Phinikaridou, A.1    Andia, M.E.2    Shah, A.M.3    Botnar, R.M.4
  • 75
    • 84877049014 scopus 로고    scopus 로고
    • Novel applications of contrast-enhanced ultrasound imaging in vascular medicine
    • Staub D, Partovi S, Imfeld S, Uthoff H, Baldi T, Aschwanden M, et al. Novel applications of contrast-enhanced ultrasound imaging in vascular medicine. Vasa 2013;42: 17-31.
    • (2013) Vasa , vol.42 , pp. 17-31
    • Staub, D.1    Partovi, S.2    Imfeld, S.3    Uthoff, H.4    Baldi, T.5    Aschwanden, M.6
  • 77
    • 84863876597 scopus 로고    scopus 로고
    • Fluorescence lifetime imaging - Techniques and applications
    • Becker W. Fluorescence lifetime imaging - techniques and applications. J Microsc 2012;247:119-136.
    • (2012) J Microsc , vol.247 , pp. 119-136
    • Becker, W.1
  • 79
    • 0035038929 scopus 로고    scopus 로고
    • Immunomodulatory effects of interferon-1b in patients with multiple sclerosis
    • DOI 10.1016/S1567-5769(01)00039-X, PII S156757690100039X
    • Ossege LM, Sindern E, Patzold T, Malin JP. Immunomodulatory effects of interferon-beta-1b in patients with multiple sclerosis. Int Immunopharmacol 2001;1: 1085-1100. (Pubitemid 32434426)
    • (2001) International Immunopharmacology , vol.1 , Issue.6 , pp. 1085-1100
    • Ossege, L.M.1    Sindern, E.2    Patzold, T.3    Malin, J.-P.4
  • 84
    • 79953897155 scopus 로고    scopus 로고
    • Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass
    • Bone HG, Bolognese MA, Yuen CK, Kendler DL, Miller PD, Yang YC, et al. Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass. J Clin Endocrinol Metab 2011;96:972-980.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 972-980
    • Bone, H.G.1    Bolognese, M.A.2    Yuen, C.K.3    Kendler, D.L.4    Miller, P.D.5    Yang, Y.C.6
  • 87
    • 33745963397 scopus 로고    scopus 로고
    • A phase III randomized trial of BAY 12-9566 (tanomastat) as maintenance therapy in patients with advanced ovarian cancer responsive to primary surgery and paclitaxel/platinum containing chemotherapy: A National Cancer Institute of Canada Clinical Trials Group Study
    • DOI 10.1016/j.ygyno.2005.12.020, PII S0090825805011224
    • Hirte H, Vergote IB, Jeffrey JR, Grimshaw RN, Coppieters S, Schwartz B, et al. A phase III randomized trial of BAY 12- 9566 (tanomastat) as maintenance therapy in patients with advanced ovarian cancer responsive to primary surgery and paclitaxel/platinum containing chemotherapy: A National Cancer Institute of Canada Clinical Trials Group Study. Gynecol Oncol 2006;102:300-308. (Pubitemid 44056259)
    • (2006) Gynecologic Oncology , vol.102 , Issue.2 , pp. 300-308
    • Hirte, H.1    Vergote, I.B.2    Jeffrey, J.R.3    Grimshaw, R.N.4    Coppieters, S.5    Schwartz, B.6    Tu, D.7    Sadura, A.8    Brundage, M.9    Seymour, L.10
  • 88
    • 0031848158 scopus 로고    scopus 로고
    • Phase i study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites
    • Beattie GJ, Smyth JF. Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites. Clin Cancer Res 1998;4:1899-1902. (Pubitemid 28369173)
    • (1998) Clinical Cancer Research , vol.4 , Issue.8 , pp. 1899-1902
    • Beattie, G.J.1    Smyth, J.F.2
  • 93
    • 77954570926 scopus 로고    scopus 로고
    • Efficacy and safety of muraglitazar: A double-blind, 24-week, doseranging study in patients with type 2 diabetes
    • Rubin CJ, Viraswami-Appanna K, Fiedorek FT. Efficacy and safety of muraglitazar: A double-blind, 24-week, doseranging study in patients with type 2 diabetes. Diab Vasc Dis Res 2009;6:205-215.
    • (2009) Diab Vasc Dis Res , vol.6 , pp. 205-215
    • Rubin, C.J.1    Viraswami-Appanna, K.2    Fiedorek, F.T.3
  • 94
    • 24944536256 scopus 로고    scopus 로고
    • A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy
    • DOI 10.1111/j.1523-1755.2005.00416.x, PII 4494587
    • Agarwal R, Saha C, Battiwala M, Vasavada N, Curley T, Chase SD, et al. A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy. Kidney Int 2005;68:285-292. (Pubitemid 43181387)
    • (2005) Kidney International , vol.68 , Issue.1 , pp. 285-292
    • Agarwal, R.1    Saha, C.2    Battiwala, M.3    Vasavada, N.4    Curley, T.5    Chase, S.D.6    Sachs, N.7    Semret, M.H.8
  • 95
    • 77950474638 scopus 로고    scopus 로고
    • Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: The assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history trial
    • Gerstein HC, Ratner RE, Cannon CP, Serruys PW, Garcia- Garcia HM, van Es GA, et al. Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: The assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history trial. Circulation 2010;121:1176-1187.
    • (2010) Circulation , vol.121 , pp. 1176-1187
    • Gerstein, H.C.1    Ratner, R.E.2    Cannon, C.P.3    Serruys, P.W.4    Garcia- Garcia, H.M.5    Van Es, G.A.6
  • 96
    • 34948858370 scopus 로고    scopus 로고
    • The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes
    • DOI 10.3132/dvdr.2007.041
    • Goke B, Gause-Nilsson I, Persson A, Group GS. The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes. Diab Vasc Dis Res 2007;4:204-213. (Pubitemid 47529210)
    • (2007) Diabetes and Vascular Disease Research , vol.4 , Issue.3 , pp. 204-213
    • Goke, B.1    Gause-Nilsson, I.2    Persson, A.3
  • 98
    • 79955730238 scopus 로고    scopus 로고
    • Efficacy and safety of the PPARgamma partial agonist balaglitazone compared with pioglitazone and placebo: A phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy
    • Henriksen K, Byrjalsen I, Qvist P, Beck-Nielsen H, Hansen G, Riis BJ, et al. Efficacy and safety of the PPARgamma partial agonist balaglitazone compared with pioglitazone and placebo: a phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy. Diabetes Metab Res Rev 2011;27:392-401.
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 392-401
    • Henriksen, K.1    Byrjalsen, I.2    Qvist, P.3    Beck-Nielsen, H.4    Hansen, G.5    Riis, B.J.6
  • 99
    • 77952521297 scopus 로고    scopus 로고
    • A 26-week, placebo- and pioglitazone-controlled, dose-ranging study of rivoglitazone, a novel thiazolidinedione for the treatment of type 2 diabetes
    • Truitt KE GR, Rosenstock J, Chou HS, Merante D, Triscari J, Wang AC. A 26-week, placebo- and pioglitazone-controlled, dose-ranging study of rivoglitazone, a novel thiazolidinedione for the treatment of type 2 diabetes. Curr Med Res Opin 2010;26:1321-1331.
    • (2010) Curr Med Res Opin , vol.26 , pp. 1321-1331
    • Truitt, K.E.G.R.1    Rosenstock, J.2    Chou, H.S.3    Merante, D.4    Triscari, J.5    Wang, A.C.6
  • 100
    • 19444377563 scopus 로고    scopus 로고
    • Pain measurements and side effect profile of the novel cannabinoid ajulemic acid
    • DOI 10.1016/j.neuropharm.2005.02.010, PII S0028390805000870
    • Salim K SU, Burstein S, Hoy L, Karst M. Pain measurements and side effect profile of the novel cannabinoid ajulemic acid. Neuropharmacology 2005;48:1164-1171. (Pubitemid 40725989)
    • (2005) Neuropharmacology , vol.48 , Issue.8 , pp. 1164-1171
    • Salim, K.1    Schneider, U.2    Burstein, S.3    Hoy, L.4    Karst, M.5
  • 102
    • 33645324424 scopus 로고    scopus 로고
    • Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions ollowing allergen challenge in mild asthmatics: A randomized, double-blind, lacebo-controlled clinical cross-over-trial
    • Beeh KM BJ, Meyer M, Buhl R, Zahlten R, Wolff G. Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions ollowing allergen challenge in mild asthmatics: a randomized, double-blind, lacebo-controlled clinical cross-over-trial. Pulm Pharmacol Ther 2005;19:233-241.
    • (2005) Pulm Pharmacol Ther , vol.19 , pp. 233-241
    • Beeh, K.M.B.J.1    Meyer, M.2    Buhl, R.3    Zahlten, R.4    Wolff, G.5
  • 103
    • 50049134725 scopus 로고    scopus 로고
    • Phase i trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma
    • Riechelmann H SA, Golze W, Hanft G, Schroen C, Hoermann K, Erhardt T, Gronau S. Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. Oral Oncol 2008;44:823-829.
    • (2008) Oral Oncol , vol.44 , pp. 823-829
    • Riechelmann, H.S.A.1    Golze, W.2    Hanft, G.3    Schroen, C.4    Hoermann, K.5    Erhardt, T.6    Gronau, S.7
  • 106
  • 108
    • 0024195620 scopus 로고
    • Cardiovascular side effects of diethylstilbestrol, cyproterone acetate, medroxyprogesterone acetate and estramustine phosphate used for the treatment of advanced prostatic cancer: Results from European Organization for Research on Treatment of Cancer Trials 30761 and 30762
    • deVoogt HJ P-MM, Sylvester R, Schröder FH. Cardiovascular side effects of diethylstilbestrol, cyproterone acetate, medroxyprogesterone acetate and estramustine phosphate used for the treatment of advanced prostatic cancer: results from European Organization for Research on Treatment of Cancer Trials 30761 and 30762. J Urol 1988;140:1557.
    • (1988) J Urol , vol.140 , pp. 1557
    • Devoogt, H.J.P.-M.M.1    Sylvester, R.2    Schröder, F.H.3
  • 109
    • 4644311821 scopus 로고    scopus 로고
    • Alvimopan Postoperative Ileus Study Group. Alvimopan A Novel, Peripherally Acting Mu Opioid Antagonist: Results of A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Trial of Major Abdominal Surgery and Postoperative Ileus
    • Wolff BG MF, Gerkin TM, Techner L, Gabriel K, Du W, Wallin BA. Alvimopan Postoperative Ileus Study Group. Alvimopan, a novel, peripherally acting mu opioid antagonist: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus. Ann Surg 2004;240:728-734.
    • (2004) Ann Surg , vol.240 , pp. 728-734
    • Wolff, B.G.M.F.1    Gerkin, T.M.2    Techner, L.3    Gabriel, K.4    Du, W.5    Wallin, B.A.6
  • 110
    • 0026658639 scopus 로고
    • Plicamycin and pamidronate in symptomatic tumor-related hypercalcemia: A prospective randomized crossover trial
    • Thü rlimann B WR, Senn HJ, Thiébaud D. Plicamycin and pamidronate in symptomatic tumor-related hypercalcemia: A prospective randomized crossover trial. Ann Oncol 1992; 3:619-623.
    • (1992) Ann Oncol , vol.3 , pp. 619-623
    • Thü Rlimann, B.W.R.1
  • 111
    • 84875151927 scopus 로고    scopus 로고
    • Warfarin accelerates ectopic mineralization in Abcc6 (- /-) mice: Clinical relevance to pseudoxanthoma elasticum
    • Li Q, Guo H, Chou DW, Harrington DJ, Schurgers LJ, Terry SF, et al. Warfarin accelerates ectopic mineralization in Abcc6 (- /-) mice: Clinical relevance to pseudoxanthoma elasticum. Am J Pathol 2013;182:1139-1150.
    • (2013) Am J Pathol , vol.182 , pp. 1139-1150
    • Li, Q.1    Guo, H.2    Chou, D.W.3    Harrington, D.J.4    Schurgers, L.J.5    Terry, S.F.6
  • 112
    • 84876180059 scopus 로고    scopus 로고
    • The vascular phenotype in pseudoxanthoma elasticum and related disorders: Contribution of a genetic disease to the understanding of vascular calcification
    • Leftheriotis G, Omarjee L, Le Saux O, Henrion D, Abraham P, Prunier F, et al. The vascular phenotype in pseudoxanthoma elasticum and related disorders: Contribution of a genetic disease to the understanding of vascular calcification. Front Genet 2013;4:4.
    • (2013) Front Genet , vol.4 , pp. 4
    • Leftheriotis, G.1    Omarjee, L.2    Le Saux, O.3    Henrion, D.4    Abraham, P.5    Prunier, F.6
  • 114
    • 84879007303 scopus 로고    scopus 로고
    • Autosomal dominant polycystic kidney disease: New insights into treatment
    • Helal I. Autosomal dominant polycystic kidney disease: New insights into treatment. Saudi J Kidney Dis Transpl 2013;24:230-234.
    • (2013) Saudi J Kidney Dis Transpl , vol.24 , pp. 230-234
    • Helal, I.1
  • 115
    • 84864339688 scopus 로고    scopus 로고
    • The role of FGF23 in CKD - With or without Klotho
    • Komaba H, Fukagawa M. The role of FGF23 in CKD - with or without Klotho. Nat Rev Nephrol 2012;8:484-490.
    • (2012) Nat Rev Nephrol , vol.8 , pp. 484-490
    • Komaba, H.1    Fukagawa, M.2
  • 116
    • 84859642325 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and adverse clinical outcomes in chronic kidney disease
    • Isakova T. Fibroblast growth factor 23 and adverse clinical outcomes in chronic kidney disease. Curr Opin Nephrol Hypertens 2012;21:334-340.
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 334-340
    • Isakova, T.1
  • 117
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon B, Ugel S, Del Pozzo F, Soldani C, Zilio S, Avella D, et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med 2011;208: 1949-1962.
    • (2011) J Exp Med , vol.208 , pp. 1949-1962
    • Molon, B.1    Ugel, S.2    Del Pozzo, F.3    Soldani, C.4    Zilio, S.5    Avella, D.6
  • 118
    • 63249129731 scopus 로고    scopus 로고
    • FGF2 induced expression of the pyrophosphate generating enzyme, PC-1, is mediated by Runx2 and Msx2
    • Hatch NE, Franceschi RT. FGF2 induced expression of the pyrophosphate generating enzyme, PC-1, is mediated by Runx2 and Msx2. J Musculoskelet Neuronal Interact 2008; 8:318-320.
    • (2008) J Musculoskelet Neuronal Interact , vol.8 , pp. 318-320
    • Hatch, N.E.1    Franceschi, R.T.2
  • 120
    • 79955002353 scopus 로고    scopus 로고
    • FGF signaling in craniofacial biological control and pathological craniofacial development
    • Hatch NE. FGF signaling in craniofacial biological control and pathological craniofacial development. Crit Rev Eukaryot Gene Expr 2010;20:295-311.
    • (2010) Crit Rev Eukaryot Gene Expr , vol.20 , pp. 295-311
    • Hatch, N.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.