Discovery of small molecule vanin inhibitors: New tools to study metabolism and disease

ACS Chemical Biology

Volumn 8, Issue 3, 2013, Pages 530-534

  Jansen, Patrick A M ^a   Van Diepen, Janna A ^b   Ritzen, Bas ^c   Zeeuwen, Patrick L J M ^a   Cacciatore, Ivana ^d   Cornacchia, Catia ^d   Van Vlijmen Willems, Ivonne M J J ^a   De Heuvel, Erik ^e   Botman, Peter N M ^e   Blaauw, Richard H ^e   Hermkens, Pedro H H ^c   Rutjes, Floris P J T ^c   Schalkwijk, Joost ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d UNIVERSITY OF CHIETI   (Italy)

^e CHIRALIX B V   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; ENZYME INHIBITOR; LIPID; RR 6; UNCLASSIFIED DRUG; VANIN; AMIDASE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; MOLECULAR LIBRARY; PANTETHEINASE; PANTETHEINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; IC 50; LIPID BLOOD LEVEL; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; WISTAR RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINAE; CHEMICAL STRUCTURE; CHEMISTRY; DISEASES; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDOHYDROLASES; ANIMALS; CATTLE; DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FEMALE; GPI-LINKED PROTEINS; HUMANS; MALE; MOLECULAR STRUCTURE; PANTETHEINE; RATS; RATS, WISTAR; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875184941     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb3006424     Document Type: Article

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