-
1
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
10.1056/NEJMoa065044, 17215529
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007, 356(2):115-124. 10.1056/NEJMoa065044, 17215529.
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
-
2
-
-
14644415949
-
Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
-
10.1200/JCO.2005.01.186, 15534359
-
Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 2005, 23(5):1028-1043. 10.1200/JCO.2005.01.186, 15534359.
-
(2005)
J Clin Oncol
, vol.23
, Issue.5
, pp. 1028-1043
-
-
Rini, B.I.1
Small, E.J.2
-
3
-
-
33646107369
-
VEGF receptor signalling - in control of vascular function
-
10.1038/nrm1911, 16633338
-
Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 2006, 7:359-371. 10.1038/nrm1911, 16633338.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 359-371
-
-
Olsson, A.K.1
Dimberg, A.2
Kreuger, J.3
Claesson-Welsh, L.4
-
4
-
-
34249073831
-
Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor
-
10.1158/1078-0432.CCR-06-0919, 17473195
-
Norden-Zfoni A, Desai J, Manola J, Beaudry P, Force J, Maki R, Folkman J, Bello CL, Baum CM, Deprimo SE, et al. Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor. Clin Cancer Res 2007, 13:2643-2650. 10.1158/1078-0432.CCR-06-0919, 17473195.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2643-2650
-
-
Norden-Zfoni, A.1
Desai, J.2
Manola, J.3
Beaudry, P.4
Force, J.5
Maki, R.6
Folkman, J.7
Bello, C.L.8
Baum, C.M.9
Deprimo, S.E.10
-
5
-
-
34547779489
-
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins
-
10.1186/1479-5876-5-32, 1939830, 17605814
-
Deprimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, Michaelson MD, Motzer RJ. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. Journal of translational medicine 2007, 5:32. 10.1186/1479-5876-5-32, 1939830, 17605814.
-
(2007)
Journal of translational medicine
, vol.5
, pp. 32
-
-
Deprimo, S.E.1
Bello, C.L.2
Smeraglia, J.3
Baum, C.M.4
Spinella, D.5
Rini, B.I.6
Michaelson, M.D.7
Motzer, R.J.8
-
6
-
-
36749052895
-
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
-
10.1073/pnas.0708148104, 2040401, 17942672
-
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci USA 2007, 104:17069-17074. 10.1073/pnas.0708148104, 2040401, 17942672.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17069-17074
-
-
Ebos, J.M.1
Lee, C.R.2
Christensen, J.G.3
Mutsaers, A.J.4
Kerbel, R.S.5
-
7
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
10.1200/JCO.2005.02.2574, 16330672
-
Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, DePrimo SE, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006, 24(1):16-24. 10.1200/JCO.2005.02.2574, 16330672.
-
(2006)
J Clin Oncol
, vol.24
, Issue.1
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
DePrimo, S.E.10
-
8
-
-
0038299462
-
Elevated numbers of circulating endothelial cells in renal transplant recipients
-
10.1097/01.TP.0000074569.65127.26, 12865778
-
Woywodt A, Schroeder M, Gwinner W, Mengel M, Jaeger M, Schwarz A, Haller H, Haubitz M. Elevated numbers of circulating endothelial cells in renal transplant recipients. Transplantation 2003, 76(1):1-4. 10.1097/01.TP.0000074569.65127.26, 12865778.
-
(2003)
Transplantation
, vol.76
, Issue.1
, pp. 1-4
-
-
Woywodt, A.1
Schroeder, M.2
Gwinner, W.3
Mengel, M.4
Jaeger, M.5
Schwarz, A.6
Haller, H.7
Haubitz, M.8
-
9
-
-
0344520447
-
Circulating endothelial cells are a novel marker of cyclosporine-induced endothelial damage
-
10.1161/01.HYP.0000052948.64125.AB, 12623986
-
Woywodt A, Schroeder M, Mengel M, Schwarz A, Gwinner W, Haller H, Haubitz M. Circulating endothelial cells are a novel marker of cyclosporine-induced endothelial damage. Hypertension 2003, 41(3 Pt 2):720-723. 10.1161/01.HYP.0000052948.64125.AB, 12623986.
-
(2003)
Hypertension
, vol.41
, Issue.3 PART 2
, pp. 720-723
-
-
Woywodt, A.1
Schroeder, M.2
Mengel, M.3
Schwarz, A.4
Gwinner, W.5
Haller, H.6
Haubitz, M.7
-
10
-
-
1942456726
-
Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation
-
10.1182/blood-2003-10-3479, 14715625
-
Woywodt A, Scheer J, Hambach L, Buchholz S, Ganser A, Haller H, Hertenstein B, Haubitz M. Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation. Blood 2004, 103(9):3603-3605. 10.1182/blood-2003-10-3479, 14715625.
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3603-3605
-
-
Woywodt, A.1
Scheer, J.2
Hambach, L.3
Buchholz, S.4
Ganser, A.5
Haller, H.6
Hertenstein, B.7
Haubitz, M.8
-
11
-
-
0033135720
-
Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells
-
Mutin M, Canavy I, Blann A, Bory M, Sampol J, Dignat-George F. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood 1999, 93(9):2951-2958.
-
(1999)
Blood
, vol.93
, Issue.9
, pp. 2951-2958
-
-
Mutin, M.1
Canavy, I.2
Blann, A.3
Bory, M.4
Sampol, J.5
Dignat-George, F.6
-
12
-
-
4344589419
-
Circulating endothelial cells in cancer patients do not express tissue factor
-
10.1016/j.canlet.2004.04.019, 15327840
-
Beerepoot LV, Mehra N, Linschoten F, Jorna AS, Lisman T, Verheul HM, Voest EE. Circulating endothelial cells in cancer patients do not express tissue factor. Cancer Lett 2004, 213:241-248. 10.1016/j.canlet.2004.04.019, 15327840.
-
(2004)
Cancer Lett
, vol.213
, pp. 241-248
-
-
Beerepoot, L.V.1
Mehra, N.2
Linschoten, F.3
Jorna, A.S.4
Lisman, T.5
Verheul, H.M.6
Voest, E.E.7
-
13
-
-
42949148257
-
Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
10.1200/JCO.2007.14.5375, 18347007
-
Burstein HJ, Elias AD, Rugo HS, Cobleigh MA, Wolff AC, Eisenberg PD, Lehman M, Adams BJ, Bello CL, Deprimo SE, et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2008, 26:1810-1816. 10.1200/JCO.2007.14.5375, 18347007.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1810-1816
-
-
Burstein, H.J.1
Elias, A.D.2
Rugo, H.S.3
Cobleigh, M.A.4
Wolff, A.C.5
Eisenberg, P.D.6
Lehman, M.7
Adams, B.J.8
Bello, C.L.9
Deprimo, S.E.10
-
14
-
-
33645961574
-
Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol
-
10.1111/j.1538-7836.2006.01794.x, 16460450
-
Woywodt A, Blann AD, Kirsch T, Erdbruegger U, Banzet N, Haubitz M, Dignat-George F. Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J Thromb Haemost 2006, 4(3):671-677. 10.1111/j.1538-7836.2006.01794.x, 16460450.
-
(2006)
J Thromb Haemost
, vol.4
, Issue.3
, pp. 671-677
-
-
Woywodt, A.1
Blann, A.D.2
Kirsch, T.3
Erdbruegger, U.4
Banzet, N.5
Haubitz, M.6
Dignat-George, F.7
-
15
-
-
0036344495
-
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
-
Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002, 8(8):831-840.
-
(2002)
Nat Med
, vol.8
, Issue.8
, pp. 831-840
-
-
Luttun, A.1
Tjwa, M.2
Moons, L.3
Wu, Y.4
Angelillo-Scherrer, A.5
Liao, F.6
Nagy, J.A.7
Hooper, A.8
Priller, J.9
De Klerck, B.10
-
16
-
-
0035254646
-
Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans
-
10.1182/blood.V97.3.785, 11157498
-
Sawano A, Iwai S, Sakurai Y, Ito M, Shitara K, Nakahata T, Shibuya M. Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 2001, 97(3):785-791. 10.1182/blood.V97.3.785, 11157498.
-
(2001)
Blood
, vol.97
, Issue.3
, pp. 785-791
-
-
Sawano, A.1
Iwai, S.2
Sakurai, Y.3
Ito, M.4
Shitara, K.5
Nakahata, T.6
Shibuya, M.7
-
17
-
-
35448934762
-
Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study
-
10.1016/S1470-2045(07)70285-1, 17959415
-
Rixe O, Bukowski RM, Michaelson MD, Wilding G, Hudes GR, Bolte O, Motzer RJ, Bycott PW, Liau KF, Freddo J, et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol 2007, 8:975-984. 10.1016/S1470-2045(07)70285-1, 17959415.
-
(2007)
Lancet Oncol
, vol.8
, pp. 975-984
-
-
Rixe, O.1
Bukowski, R.M.2
Michaelson, M.D.3
Wilding, G.4
Hudes, G.R.5
Bolte, O.6
Motzer, R.J.7
Bycott, P.W.8
Liau, K.F.9
Freddo, J.10
-
18
-
-
55349087484
-
Circulating endothelial cells are a potential biomarker for patients with renal cell carcinoma (RCC) with and without von Hippel Lindau (VHL) syndrome
-
Bhatt RS, Norden-Zfoni A, O'Neill A, Zurita AJ, Wu H, Prox D, Atkins MB, Heymach JV. Circulating endothelial cells are a potential biomarker for patients with renal cell carcinoma (RCC) with and without von Hippel Lindau (VHL) syndrome. J Clin Oncol 2008, 26(Suppl):Abstr 5098.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL
-
-
Bhatt, R.S.1
Norden-Zfoni, A.2
O'Neill, A.3
Zurita, A.J.4
Wu, H.5
Prox, D.6
Atkins, M.B.7
Heymach, J.V.8
-
19
-
-
0035383784
-
Resting and activated endothelial cells are increased in the peripheral blood of cancer patients
-
10.1182/blood.V97.11.3658, 11369666
-
Mancuso P, Burlini A, Pruneri G, Goldhirsch A, Martinelli G, Bertolini F. Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood 2001, 97(11):3658-3661. 10.1182/blood.V97.11.3658, 11369666.
-
(2001)
Blood
, vol.97
, Issue.11
, pp. 3658-3661
-
-
Mancuso, P.1
Burlini, A.2
Pruneri, G.3
Goldhirsch, A.4
Martinelli, G.5
Bertolini, F.6
-
20
-
-
0035360833
-
Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma
-
Monestiroli S, Mancuso P, Burlini A, Pruneri G, Dell'Agnola C, Gobbi A, Martinelli G, Bertolini F. Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma. Cancer Res 2001, 61:4341-4344.
-
(2001)
Cancer Res
, vol.61
, pp. 4341-4344
-
-
Monestiroli, S.1
Mancuso, P.2
Burlini, A.3
Pruneri, G.4
Dell'Agnola, C.5
Gobbi, A.6
Martinelli, G.7
Bertolini, F.8
-
21
-
-
0034687663
-
Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood
-
10.1073/pnas.97.26.14608, 18966, 11121063
-
Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci USA 2000, 97:14608-14613. 10.1073/pnas.97.26.14608, 18966, 11121063.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 14608-14613
-
-
Chang, Y.S.1
di Tomaso, E.2
McDonald, D.M.3
Jones, R.4
Jain, R.K.5
Munn, L.L.6
-
22
-
-
20944436688
-
Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity
-
10.1158/1078-0432.CCR-04-2271, 15867254
-
Beaudry P, Force J, Naumov GN, Wang A, Baker CH, Ryan A, Soker S, Johnson BE, Folkman J, Heymach JV. Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. Clin Cancer Res 2005, 11:3514-3522. 10.1158/1078-0432.CCR-04-2271, 15867254.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3514-3522
-
-
Beaudry, P.1
Force, J.2
Naumov, G.N.3
Wang, A.4
Baker, C.H.5
Ryan, A.6
Soker, S.7
Johnson, B.E.8
Folkman, J.9
Heymach, J.V.10
-
23
-
-
61449179073
-
Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib
-
10.1007/s10456-009-9133-9, 19212818
-
Vroling L, van der Veldt AA, de Haas RR, Haanen JB, Schuurhuis GJ, Kuik DJ, van Cruijsen H, Verheul HM, van den Eertwegh AJ, Hoekman K, et al. Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib. Angiogenesis 2009, 12(1):69-79. 10.1007/s10456-009-9133-9, 19212818.
-
(2009)
Angiogenesis
, vol.12
, Issue.1
, pp. 69-79
-
-
Vroling, L.1
van der Veldt, A.A.2
de Haas, R.R.3
Haanen, J.B.4
Schuurhuis, G.J.5
Kuik, D.J.6
van Cruijsen, H.7
Verheul, H.M.8
van den Eertwegh, A.J.9
Hoekman, K.10
-
24
-
-
55349124241
-
Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor
-
Hutson TE, Davis ID, Machiels JH, de Souza PL, Baker K, Bordogna W, Westlund R, Crofts T, Pandite L, Figlin RA. Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor. J Clin Oncol 2008, 26(Suppl):Abstr 5046.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.H.3
de Souza, P.L.4
Baker, K.5
Bordogna, W.6
Westlund, R.7
Crofts, T.8
Pandite, L.9
Figlin, R.A.10
-
25
-
-
53249111806
-
Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival
-
10.1158/1078-0432.CCR-08-0656, 18794101
-
van Cruijsen H, van der Veldt AA, Vroling L, Oosterhoff D, Broxterman HJ, Scheper RJ, Giaccone G, Haanen JB, van den Eertwegh AJ, Boven E, et al. Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival. Clin Cancer Res 2008, 14(18):5884-5892. 10.1158/1078-0432.CCR-08-0656, 18794101.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.18
, pp. 5884-5892
-
-
van Cruijsen, H.1
van der Veldt, A.A.2
Vroling, L.3
Oosterhoff, D.4
Broxterman, H.J.5
Scheper, R.J.6
Giaccone, G.7
Haanen, J.B.8
van den Eertwegh, A.J.9
Boven, E.10
-
26
-
-
35548990498
-
Phase II trial of sunitinib in bevacizumab-refractory metastatic renal cell carcinoma (mRCC): Updated results and analysis of circulating biomarkers
-
George DJ, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Margolin K, Hutson TE, Rini BI. Phase II trial of sunitinib in bevacizumab-refractory metastatic renal cell carcinoma (mRCC): Updated results and analysis of circulating biomarkers. J Clin Oncol ASCO Annual Meeting Proceedings Part I 2007, 25(18s):Abstr 5035.
-
(2007)
J Clin Oncol ASCO Annual Meeting Proceedings Part I
, vol.25
, Issue.18 S
-
-
George, D.J.1
Michaelson, M.D.2
Rosenberg, J.E.3
Bukowski, R.M.4
Sosman, J.A.5
Stadler, W.M.6
Margolin, K.7
Hutson, T.E.8
Rini, B.I.9
-
27
-
-
0033999142
-
Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes
-
Mallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM, Tedgui A. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000, 101:841-843.
-
(2000)
Circulation
, vol.101
, pp. 841-843
-
-
Mallat, Z.1
Benamer, H.2
Hugel, B.3
Benessiano, J.4
Steg, P.G.5
Freyssinet, J.M.6
Tedgui, A.7
-
28
-
-
33846224940
-
Analysis of circulating biomarkers of sunitinib malate in patients with unresectable neuroendocrine tumors (NET): VEGF, IL-8, and soluble VEGF receptors 2 and 3
-
Bello CL, Deprimo SE, Friece C, Smeraglia J, Sherman L, Tye L, Baum CM, Meropol NJ, Lenz H, Kulke MH. Analysis of circulating biomarkers of sunitinib malate in patients with unresectable neuroendocrine tumors (NET): VEGF, IL-8, and soluble VEGF receptors 2 and 3. J Clin Oncol ASCO Annual Meeting Proceedings Part I 2006, 24(18s):abstr 4045.
-
(2006)
J Clin Oncol ASCO Annual Meeting Proceedings Part I
, vol.24
, Issue.18 S
-
-
Bello, C.L.1
Deprimo, S.E.2
Friece, C.3
Smeraglia, J.4
Sherman, L.5
Tye, L.6
Baum, C.M.7
Meropol, N.J.8
Lenz, H.9
Kulke, M.H.10
-
29
-
-
65949124367
-
Sunitinib in combination with gefitinib in patients (pts) with metastatic renal cell carcinoma (mRCC): Updated results from a phase I/II study
-
Redman BG, Hudes GR, Kim ST, Chen I, Motzer RJ. Sunitinib in combination with gefitinib in patients (pts) with metastatic renal cell carcinoma (mRCC): Updated results from a phase I/II study. J Clin Oncol 2008, 26(Suppl):Abstr 16014.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL
-
-
Redman, B.G.1
Hudes, G.R.2
Kim, S.T.3
Chen, I.4
Motzer, R.J.5
|