Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters

Genes Chromosomes and Cancer

Volumn 34, Issue 1, 2002, Pages 58-68

  Kondo, Keiichi ^a   Yao, Masahiro ^a   Yoshida, Minoru ^a   Kishida, Takeshi ^a   Shuin, Taro ^a   Miura, Takeshi ^b   Moriyama, Masatoshi ^c   Kobayashi, Kazuki ^a   Sakai, Naoki ^a   Kaneko, Shigeki ^a   Kawakami, Satoshi ^a   Baba, Masaya ^a   Nakaigawa, Noboru ^a   Nagashima, Yoji ^a   Nakatani, Yukio ^d   Hosaka, Masahiko ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b KANAGAWA CANCER CENTER   (Japan)

^c AKITA UNIVERSITY   (Japan)

^d YOKOHAMA CITY UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; CANCER GRADING; CANCER STAGING; CARCINOGENESIS; CONTROLLED STUDY; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; GERM LINE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METHYLATION; MUTATIONAL ANALYSIS; PATHOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; SOUTHERN BLOTTING; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR VOLUME; VON HIPPEL LINDAU DISEASE;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; BLOTTING, SOUTHERN; CARCINOMA, RENAL CELL; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENE REARRANGEMENT; HUMANS; KIDNEY NEOPLASMS; LIGASES; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 18344396226     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10054     Document Type: Article

References (40)

1. Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
2. Sarcomatoid renal cell carcinoma: The chromophobe connection
3. Lessons from hereditary colorectal cancer. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 uhiquitin ligase activity
4. Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in European kidney cancers
5. Renal tumors
6. VHL alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation
7. Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene
8. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
9. Germline mutations in the von Hippel-Lindau disease (VHL) gene in Japanese VHL
10. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
11. Sarcomatoid renal carcinoma: The final common dedifferentiation pathway of renal epithelial malignancies
12. Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma
13. Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC
14. Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: Implications for the potential organization of the human von Hippel-Lindau disease gene
15. Mutations of the VHL tumour suppressor gene in renal carcinoma
16. TNM staging of renal cell carcinoma: Workgroup No. 3
17. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
18. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
19. Tumour suppression by the human von Hippel-Lindau gene product
20. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
21. Isolation and characterization of 19 dinucleotide repeat polymorphisms on chromosome 3p
22. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
23. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
24. Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas
25. Lessons from hereditary colorectal cancer
26. Identification of the von Hippel-Lindau disease tumor suppressor gene
27. Three polymorphic dinucleotide repeats near the von Hippel-Lindau (VHL) disease gene on human chromosome 3: D3S587; D3S1317; D3S1435
28. Novel mutations of the von Hippel-Lindau tumor-suppressor gene and rare DNA hypermethylation in renal-cell carcinoma cell lines of the clear cell type
29. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
30. Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes
31. Renal cell carcinoma in young and old patients. Comparison of prognostic pathologic variables (cell type, tumor grade and stage, and DNA ploidy pattern) and their impact on disease outcome
32. Renal adenocarcinoma in young adults
33. A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor
34. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
35. Structure of the VHL-Elongin C-Elongin B complex: Implications for VHL tumor suppressor function
36. Classification of renal cell carcinoma: Workgroup No. 1
37. Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product
38. Comparative sequence analysis of the VHL tumor suppressor gene
39. Novel somatic mutations in the VHL gene in Swedish archived sporadic renal cell carcinomas
40. Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan