-
1
-
-
41349099104
-
Cancer statistics, 2008
-
Jemal A, Siegel R, Ward E, et al.: Cancer statistics, 2008. CA Cancer J Clin 2008, 58:71-96.
-
(2008)
CA Cancer J Clin
, vol.58
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
0033978220
-
Systemic therapy for renal cell carcinoma
-
Motzer RJ, Russo P: Systemic therapy for renal cell carcinoma. J Urol 2000, 163:408-417.
-
(2000)
J Urol
, vol.163
, pp. 408-417
-
-
Motzer, R.J.1
Russo, P.2
-
3
-
-
0035048096
-
Cytokine therapy for metastatic renal cell carcinoma
-
Bukowski RM: Cytokine therapy for metastatic renal cell carcinoma. Semin Urol Oncol 2001, 19:148-154.
-
(2001)
Semin Urol Oncol
, vol.19
, pp. 148-154
-
-
Bukowski, R.M.1
-
4
-
-
0032772880
-
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
-
Motzer RJ, Mazumdar M, Bacik J, et al.: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999, 17: 2530-2540.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2530-2540
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
-
5
-
-
41149091197
-
Using molecular biology to develop drugs for renal cell carcinoma
-
Cowey C, Rathmell WK: Using molecular biology to develop drugs for renal cell carcinoma. Expert Opin Drug Discov 2008, 3:311-327.
-
(2008)
Expert Opin Drug Discov
, vol.3
, pp. 311-327
-
-
Cowey, C.1
Rathmell, W.K.2
-
6
-
-
33846879810
-
The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
-
Kaelin WG Jr: The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 2007, 13(2 Pt 2): 680s-684s.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.2 PART 2
-
-
Kaelin Jr., W.G.1
-
7
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al.: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007, 356:115-124.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
8
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al.: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356:125-134.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
9
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al.: Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007, 356:2271-2281.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
11
-
-
0027240519
-
Identification of the von Hippel-Lindau disease tumor suppressor gene
-
Latif F, Tory K, Gnarra J, et al.: Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993, 260:1317-1320.
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.3
-
12
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos O, Levy AP, Jiang C, et al.: Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci U S A 1996, 93:10595-10599.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
-
13
-
-
0033607291
-
Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
-
Iwai K, Yamanaka K, Kamura T, et al.: Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A 1999, 96:12436-12441.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 12436-12441
-
-
Iwai, K.1
Yamanaka, K.2
Kamura, T.3
-
14
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, et al.: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
15
-
-
0035394516
-
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas
-
Wiesener MS, Munchenhagen PM, Berger I, et al.: Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001, 61:5215-5222.
-
(2001)
Cancer Res
, vol.61
, pp. 5215-5222
-
-
Wiesener, M.S.1
Munchenhagen, P.M.2
Berger, I.3
-
16
-
-
0029090338
-
Tumour suppression by the human von Hippel-Lindau gene product
-
Iliopoulos O, Kibel A, Gray S, et al.: Tumour suppression by the human von Hippel-Lindau gene product. Nat Med 1995, 1:822-826.
-
(1995)
Nat Med
, vol.1
, pp. 822-826
-
-
Iliopoulos, O.1
Kibel, A.2
Gray, S.3
-
17
-
-
0028805059
-
Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene
-
Chen F, Kishida T, Duh FM, et al.: Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res 1995, 55:4804-4807.
-
(1995)
Cancer Res
, vol.55
, pp. 4804-4807
-
-
Chen, F.1
Kishida, T.2
Duh, F.M.3
-
18
-
-
16144365122
-
Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan
-
Zbar B, Kishida T, Chen F, et al.: Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan. Hum Mutat 1996, 8:348-357.
-
(1996)
Hum Mutat
, vol.8
, pp. 348-357
-
-
Zbar, B.1
Kishida, T.2
Chen, F.3
-
19
-
-
0035054565
-
Genotype-phenotype correlation in von Hippel-Lindau syndrome
-
Friedrich CA: Genotype-phenotype correlation in von Hippel-Lindau syndrome. Hum Mol Genet 2001, 10:763-767.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 763-767
-
-
Friedrich, C.A.1
-
20
-
-
57049125129
-
VHL type 2B mutations retain VBC form and function
-
Hacker KE, Lee CM, Rathmell WK: VHL type 2B mutations retain VBC form and function. PLoS ONE 2008, 3:e3801.
-
(2008)
PLoS ONE
, vol.3
-
-
Hacker, K.E.1
Lee, C.M.2
Rathmell, W.K.3
-
21
-
-
34547174217
-
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations
-
Li L, Zhang L, Zhang X, et al.: Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Mol Cell Biol 2007, 27:5381-5392.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 5381-5392
-
-
Li, L.1
Zhang, L.2
Zhang, X.3
-
22
-
-
0028587585
-
Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma
-
Foster K, Prowse A, van den Berg A, et al.: Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma. Hum Mol Genet 1994, 3:2169-2173.
-
(1994)
Hum Mol Genet
, vol.3
, pp. 2169-2173
-
-
Foster, K.1
Prowse, A.2
van den Berg, A.3
-
23
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, et al.: Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994, 7:85-90.
-
(1994)
Nat Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
24
-
-
0028235907
-
Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
-
Shuin T, Kondo K, Torigoe S, et al.: Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 1994, 54:2852-2855.
-
(1994)
Cancer Res
, vol.54
, pp. 2852-2855
-
-
Shuin, T.1
Kondo, K.2
Torigoe, S.3
-
25
-
-
51049084870
-
Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
-
Nickerson ML, Jaeger E, Shi Y, et al.: Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res 2008, 14:4726-4734.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4726-4734
-
-
Nickerson, M.L.1
Jaeger, E.2
Shi, Y.3
-
26
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman JG, Latif F, Weng Y, et al.: Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A 1994, 91:9700-9704.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
-
27
-
-
0031776704
-
Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
-
Clifford SC, Prowse AH, Affara NA, et al.: Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis. Genes Chromosomes Cancer 1998, 22:200-209.
-
(1998)
Genes Chromosomes Cancer
, vol.22
, pp. 200-209
-
-
Clifford, S.C.1
Prowse, A.H.2
Affara, N.A.3
-
28
-
-
3042538398
-
Promoter hypermethylation profile of kidney cancer
-
Dulaimi E, Ibanez de Caceres I, Uzzo RG, et al.: Promoter hypermethylation profile of kidney cancer. Clin Cancer Res 2004, 10(12 Pt 1):3972-3979.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.12 PART 1
, pp. 3972-3979
-
-
Dulaimi, E.1
Ibanez de Caceres, I.2
Uzzo, R.G.3
-
29
-
-
16744366213
-
VHL alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation
-
Brauch H, Weirich G, Brieger J, et al.: VHL alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation. Cancer Res 2000, 60:1942-1948.
-
(2000)
Cancer Res
, vol.60
, pp. 1942-1948
-
-
Brauch, H.1
Weirich, G.2
Brieger, J.3
-
30
-
-
0036154040
-
VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma
-
Schraml P, Struckmann K, Hatz F, et al.: VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma. J Pathol 2002, 196:186-193.
-
(2002)
J Pathol
, vol.196
, pp. 186-193
-
-
Schraml, P.1
Struckmann, K.2
Hatz, F.3
-
31
-
-
44949119410
-
Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma
-
Patard JJ, Fergelot P, Karakiewicz PI, et al.: Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma. Int J Cancer 2008, 123:395-400.
-
(2008)
Int J Cancer
, vol.123
, pp. 395-400
-
-
Patard, J.J.1
Fergelot, P.2
Karakiewicz, P.I.3
-
32
-
-
0037120977
-
VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma
-
Yao M, Yoshida M, Kishida T, et al.: VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. J Natl Cancer Inst 2002, 94:1569-1575.
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1569-1575
-
-
Yao, M.1
Yoshida, M.2
Kishida, T.3
-
33
-
-
18344396226
-
Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters
-
Kondo K, Yao M, Yoshida M, et al.: Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters. Genes Chromosomes Cancer 2002, 34:58-68.
-
(2002)
Genes Chromosomes Cancer
, vol.34
, pp. 58-68
-
-
Kondo, K.1
Yao, M.2
Yoshida, M.3
-
34
-
-
38949093560
-
Genetic and epigenetic alterations in the von hippel-lindau gene: The influence on renal cancer prognosis
-
Smits KM, Schouten LJ, van Dijk BA, et al.: Genetic and epigenetic alterations in the von hippel-lindau gene: The influence on renal cancer prognosis. Clin Cancer Res 2008, 14:782-787.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 782-787
-
-
Smits, K.M.1
Schouten, L.J.2
van Dijk, B.A.3
-
35
-
-
33646347130
-
Determination of vhl gene mutations in sporadic renal cell carcinoma
-
Gimenez-Bachs JM, Salinas-Sanchez AS, Sanchez-Sanchez F, et al.: Determination of vhl gene mutations in sporadic renal cell carcinoma. Eur Urol 2006, 49: 1051-1057.
-
(2006)
Eur Urol
, vol.49
, pp. 1051-1057
-
-
Gimenez-Bachs, J.M.1
Salinas-Sanchez, A.S.2
Sanchez-Sanchez, F.3
-
36
-
-
18844386435
-
Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy
-
Upton MP, Parker RA, Youmans A, et al.: Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy. J Immunother 2005, 28:488-495.
-
(2005)
J Immunother
, vol.28
, pp. 488-495
-
-
Upton, M.P.1
Parker, R.A.2
Youmans, A.3
-
37
-
-
25144503984
-
Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma
-
Kim JH, Jung CW, Cho YH, et al.: Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma. Oncol Rep 2005, 13:859-864.
-
(2005)
Oncol Rep
, vol.13
, pp. 859-864
-
-
Kim, J.H.1
Jung, C.W.2
Cho, Y.H.3
-
38
-
-
48649098245
-
von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
-
discussion 865-866
-
Choueiri TK, Vaziri SA, Jaeger E, et al.: Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008, 180:860-865; discussion 865-866.
-
(2008)
J Urol
, vol.180
, pp. 860-865
-
-
Choueiri, T.K.1
Vaziri, S.A.2
Jaeger, E.3
-
39
-
-
33748526494
-
Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Impact of patient characteristics and Von Hippel-Lindau gene status
-
Rini BI, Jaeger E, Weinberg V, et al.: Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Impact of patient characteristics and Von Hippel-Lindau gene status. BJU Int 2006, 98:756-762.
-
(2006)
BJU Int
, vol.98
, pp. 756-762
-
-
Rini, B.I.1
Jaeger, E.2
Weinberg, V.3
-
40
-
-
33846164401
-
Somatic von Hippel-Lindau (VHL) gene analysis and clinical outcome under antiangiogenic treatment in metastatic renal cell carcinoma: Preliminary results
-
Gad S, Sultan-Amar V, Meric JB, et al.: Somatic von Hippel-Lindau (VHL) gene analysis and clinical outcome under antiangiogenic treatment in metastatic renal cell carcinoma: Preliminary results. Targeted Oncol 2007, 2:3-6.
-
(2007)
Targeted Oncol
, vol.2
, pp. 3-6
-
-
Gad, S.1
Sultan-Amar, V.2
Meric, J.B.3
-
41
-
-
33846866035
-
The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
-
Cho D, Signoretti S, Regan M, et al.: The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer. Clin Cancer Res 2007, 13(2 Pt 2):758s-763s.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.2 PART 2
-
-
Cho, D.1
Signoretti, S.2
Regan, M.3
-
42
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al.: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004, 350:2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
43
-
-
27944473690
-
VEGF as a key mediator of angiogenesis in cancer
-
Carmeliet P: VEGF as a key mediator of angiogenesis in cancer. Oncology 2005, 69(Suppl 3):4-10.
-
(2005)
Oncology
, vol.69
, Issue.SUPPL. 3
, pp. 4-10
-
-
Carmeliet, P.1
-
44
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K, Wang M, Gralow J, et al.: Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007, 357:2666-2676.
-
(2007)
N Engl J Med
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
45
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al.: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350:2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
46
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al.: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359:378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
|