Generalized and specific neurocognitive deficits in psychotic disorders: Utility for evaluating pharmacological treatment effects and as intermediate phenotypes for gene discovery

Schizophrenia Bulletin

Volumn 40, Issue 3, 2014, Pages 516-522

  Reilly, James L ^a   Sweeney, John A ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

bipolar disorder; cognition; endophenotype; neuropsychology; schizoaffective disorder; schizophrenia; treatment effects

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CLINICAL FEATURE; CLINICAL RESEARCH; COGNITIVE DEFECT; GENETIC ANALYSIS; HEREDITY; HUMAN; MENTAL DISEASE; PHARMACEUTICAL CARE; PHENOTYPE; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCIENTIFIC LITERATURE; COGNITION DISORDERS; ENDOPHENOTYPE; GENETIC PREDISPOSITION; GENETICS; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGY; PSYCHOTIC DISORDERS;

BIPOLAR DISORDER; COGNITION DISORDERS; ENDOPHENOTYPES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84898955514     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbu013     Document Type: Article

References (72)

1. Rosen C, Marvin R, Reilly JL, et al. Phenomenology of firstepisode psychosis in schizophrenia, bipolar disorder, and unipolar depression: A comparative analysis. Clin Schizophr Relat Psychoses. 2012;6:145-151.
2. Berrettini W. Evidence for shared susceptibility in bipolar disorder and schizophrenia. Am J Med Genet C Semin Med Genet. 2003;123C:59-64.
3. Ivleva EI, Morris DW, Moates AF, Suppes T, Thaker GK, Tamminga CA. Genetics and intermediate phenotypes of the schizophrenia-bipolar disorder boundary. Neurosci Biobehav Rev. 2010;34:897-921.
4. Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, et al. Genetic relationship between five psychiatric disorders estimated from genomewide SNPs. Nat Genet. 2013;45:984-994.
5. Bowie CR, Reichenberg A, McClure MM, Leung WL, Harvey PD. Age-Associated differences in cognitive performance in older community dwelling schizophrenia patients: Differential sensitivity of clinical neuropsychological and experimental information processing tests. Schizophr Res. 2008;106:50-58.
6. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996;153:321-330.
7. Bowie CR, Harvey PD. Cognitive deficits and functional outcome in schizophrenia. Neuropsychiatr Dis Treat. 2006;2:531-536.
8. Hill SK, Schuepbach D, Herbener ES, Keshavan MS, Sweeney JA. Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic- naïve patients with schizophrenia. Schizophr Res. 2004;68:149-163.
9. Keefe RS, Sweeney JA, Gu H, et al. Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: A randomized, double-blind 52-week comparison. Am J Psychiatry. 2007;164:1061-1071.
10. Gray BE, McMahon RP, Gold JM. General intellectual ability does not explain the general deficit in schizophrenia. Schizophr Res. 2013;147:315-319.
11. Ivleva EI, Morris DW, Osuji J, et al. Cognitive endophenotypes of psychosis within dimension and diagnosis. Psychiatry Res. 2012;196:38-44.
12. Hill SK, Reilly JL, Keefe RS, et al. Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. Am J Psychiatry. 2013;170:1275-1284.
13. Lewandowski KE, Cohen BM, Ongur D. Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder. Psychol Med. 2011;41:225-241.
14. Hill SK, Reilly JL, Harris MS, et al. A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia. Schizophr Res. 2009;113:167-175.
15. Barch DM. Neuropsychological abnormalities in schizophrenia and major mood disorders: Similarities and differences. Curr Psychiatry Rep. 2009;11:313-319.
16. Sweeney JA, Kmiec JA, Kupfer DJ. Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery. Biol Psychiatry. 2000;48:674-684.
17. Hill SK, Bishop JR, Palumbo D, Sweeney JA. Effect of second-generation antipsychotics on cognition: Current issues and future challenges. Expert Rev Neurother. 2010;10:43-57.
18. Greenwood TA, Braff DL, Light GA, et al. Initial heritability analyses of endophenotypic measures for schizophrenia: The consortium on the genetics of schizophrenia. Arch Gen Psychiatry. 2007;64:1242-1250.
19. Chapman LJ, Chapman JP. Disordered thought in schizophrenia. Psychol Bull. 1973;79:380-385.
20. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology. 1998;12:426-445.
21. Dickinson D, Ramsey ME, Gold JM. Overlooking the obvious: A meta-Analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Arch Gen Psychiatry. 2007;64:532-542.
22. Reichenberg A. The assessment of neuropsychological functioning in schizophrenia. Dialogues Clin Neurosci. 2010;12:383-392.
23. Dickinson D, Ragland JD, Gold JM, Gur RC. General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biol Psychiatry. 2008;64:823-827.
24. Green MF, Horan WP, Sugar CA. Has the generalized deficit become the generalized criticism? Schizophr Bull. 2013;39:257-262.
25. Gold JM, Dickinson D. 'Generalized cognitive deficit' in schizophrenia: Overused or underappreciated? Schizophr Bull. 2013;39:263-265.
26. Barrett SL, Mulholland CC, Cooper SJ, Rushe TM. Patterns of neurocognitive impairment in first-episode bipolar disorder and schizophrenia. Br J Psychiatry. 2009;195:67-72.
27. Reichenberg A, Harvey PD, Bowie CR, et al. Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull. 2009;35:1022-1029.
28. Schretlen DJ, Cascella NG, Meyer SM, et al. Neuropsychological functioning in bipolar disorder and schizophrenia. Biol Psychiatry. 2007;62:179-186.
29. McIntosh AM, Harrison LK, Forrester K, Lawrie SM, Johnstone EC. Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives. Br J Psychiatry. 2005;186:378-385.
30. Altshuler LL, Ventura J, van Gorp WG, Green MF, Theberge DC, Mintz J. Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjects. Biol Psychiatry. 2004;56:560-569.
31. Dickerson F, Boronow JJ, Stallings C, Origoni AE, Cole SK, Yolken RH. Cognitive functioning in schizophrenia and bipolar disorder: Comparison of performance on the Repeatable Battery for the Assessment of Neuropsychological Status. Psychiatry Res. 2004;129:45-53.
32. Tabarés-Seisdedos R, Balanzá-Martinez V, Salazar-Fraile J, Selva-Vera G, Leal-Cercós C, Gómez-Beneyto M. Specific executive/attentional deficits in patients with schizophrenia or bipolar disorder who have a positive family history of psychosis. J Psychiatr Res. 2003;37:479-486.
33. Mojtabai R, Bromet EJ, Harvey PD, Carlson GA, Craig TJ, Fennig S. Neuropsychological differences between first-Admission schizophrenia and psychotic affective disorders. Am J Psychiatry. 2000;157:1453-1460.
34. Rossi A, Arduini L, Daneluzzo E, Bustini M, Prosperini P, Stratta P. Cognitive function in euthymic bipolar patients, stabilized schizophrenic patients, and healthy controls. J Psychiatr Res. 2000;34:333-339.
35. Seidman LJ, Lanca M, Kremen WS, Faraone SV, Tsuang MT. Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: Effects of duration of illness. J Clin Exp Neuropsychol. 2003;25:949-964.
36. Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT. A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr Res. 2002;53:31-44.
37. Simonsen C, Sundet K, Vaskinn A, et al. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull. 2011;37:73-83.
38. Sánchez-Morla EM, Barabash A, Martínez-Vizcaíno V, et al. Comparative study of neurocognitive function in euthymic bipolar patients and stabilized schizophrenic patients. Psychiatry Res. 2009;169:220-228.
39. Depp CA, Moore DJ, Sitzer D, et al. Neurocognitive impairment in middle-Aged and older adults with bipolar disorder: Comparison to schizophrenia and normal comparison subjects. J Affect Disord. 2007;101:201-209.
40. Balanzá-Martínez V, Tabarés-Seisdedos R, Selva-Vera G, et al. Persistent cognitive dysfunctions in bipolar I disorder and schizophrenic patients: A 3-year follow-up study. Psychother Psychosom. 2005;74:113-119.
41. McGrath J, Chapple B, Wright M. Working memory in schizophrenia and mania: Correlation with symptoms during the acute and subacute phases. Acta Psychiatr Scand. 2001;103:181-188.
42. Smith MJ, Barch DM, Csernansky JG. Bridging the gap between schizophrenia and psychotic mood disorders: Relating neurocognitive deficits to psychopathology. Schizophr Res. 2009;107:69-75.
43. Tam WC, Liu Z. Comparison of neurocognition between drug-free patients with schizophrenia and bipolar disorder. J Nerv Ment Dis. 2004;192:464-470.
44. McClellan J, Prezbindowski A, Breiger D, McCurry C. Neuropsychological functioning in early onset psychotic disorders. Schizophr Res. 2004;68:21-26.
45. Glahn DC, Bearden CE, Cakir S, et al. Differential working memory impairment in bipolar disorder and schizophrenia: Effects of lifetime history of psychosis. Bipolar Disord. 2006;8:117-123.
46. Glahn DC, Bearden CE, Barguil M, et al. The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry. 2007;62:910-916.
47. Martinez-Aran A, Torrent C, Tabares-Seisdedos R, et al. Neurocognitive impairment in bipolar patients with and without history of psychosis. J Clin Psychiatry. 2008;69:233-239.
48. Green MF, Nuechterlein KH. The MATRICS initiative: Developing a consensus cognitive battery for clinical trials. Schizophr Res. 2004;72:1-3.
49. Nuechterlein KH, Green MF, Kern RS, et al. The MATRICS Consensus Cognitive Battery, part 1: Test selection, reliability, and validity. Am J Psychiatry. 2008;165:203-213.
50. Keefe RS, Fox KH, Harvey PD, Cucchiaro J, Siu C, Loebel A. Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial. Schizophr Res. 2011;125:161-168.
51. Hill SK, Sweeney JA, Hamer RM, et al. Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia. J Int Neuropsychol Soc. 2008;14:209-221.
52. Arnsten AFT. Catecholamine influences on dorsolateral prefrontal cortical networks. Biol Psychiatry. 2011;69:e89-e99.
53. Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nat Neurosci. 2007;10:376-384.
54. Reilly JL, Harris MS, Keshavan MS, Sweeney JA. Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-Treated schizophrenia. Biol Psychiatry. 2005;57:145-154.
55. Harris MS, Reilly JL, Keshavan MS, Sweeney JA. Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophrenia. Psychol Med. 2006;36:485-494.
56. Reilly JL, Harris MS, Khine TT, Keshavan MS, Sweeney JA. Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia. Biol Psychiatry. 2008;63:776-783.
57. Reilly JL, Harris MS, Khine TT, Keshavan MS, Sweeney JA. Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia. Biol Psychiatry. 2007;62:818-821.
58. Reilly JL, Harris MS, Keshavan MS, Sweeney JA. Adverse effects of risperidone on spatial working memory in first-episode schizophrenia. Arch Gen Psychiatry. 2006;63:1189-1197.
59. Hill SK, Reilly JL, Harris MSH, Khine T, Sweeney JA. Oculomotor and neuropsychological effects of antipsychotic treatment for schizophrenia. Schizophr Bull. 2008;34:494-506.
60. Goldberg TE, Keefe RS, Goldman RS, Robinson DG, Harvey PD. Circumstances under which practice does not make perfect: A review of the practice effect literature in schizophrenia and its relevance to clinical treatment studies. Neuropsychopharmacology. 2010;35:1053-1062.
61. Goldberg TE, Goldman RS, Burdick KE, et al. Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: Is it a practice effect? Arch Gen Psychiatry. 2007;64:1115-1122.
62. Castner SA, Williams GV, Goldman-Rakic PS. Reversal of antipsychotic-induced working memory deficits by short-Term dopamine D1 receptor stimulation. Science. 2000;287:2020-2022.
63. Carter CS, Barch DM. Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: The CNTRICS initiative. Schizophr Bull. 2007;33:1131-1137.
64. Gold JM, Barch DM, Carter CS, et al. Clinical, functional, and intertask correlations of measures developed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia Consortium. Schizophr Bull. 2012;38:144-152.
65. Sheffield JM, Gold JM, Strauss ME, et al. Common and specific cognitive deficits in schizophrenia: Relationships to function. Cogn Affect Behav Neurosci. 2013:1-14.
66. Barch DM, Carter CS, Dakin SC, et al. The clinical translation of a measure of gain control: The contrast-contrast effect task. Schizophr Bull. 2012;38:135-143.
67. Silverstein SM, Keane BP, Barch DM, et al. Optimization and validation of a visual integration test for schizophrenia research. Schizophr Bull. 2012;38:125-134.
68. Ragland JD, Ranganath C, Barch DM, et al. Relational and Item-Specific Encoding (RISE): Task development and psychometric characteristics. Schizophr Bull. 2012;38:114-124.
69. Henderson D, Poppe AB, Barch DM, et al. Optimization of a goal maintenance task for use in clinical applications. Schizophr Bull. 2012;38:104-113.
70. Owoso A, Carter CS, Gold JM, et al. Cognition in schizophrenia and schizo-Affective disorder: Impairments that are more similar than different. Psychol Med. 2013;43:2535-2545.
71. Gottesman II, Gould TD. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry. 2003;160:636-645.
72. Reilly JL, Frankovich K, Hill S, et al. Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories. Schizophr Bull. 2013:1-11.