Evidence for Shared Susceptibility in Bipolar Disorder and Schizophrenia

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 123 C, Issue 1, 2003, Pages 59-64

  Berrettini, Wade ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bipolar disorder; Schizophrenia; Unipolar disorders

Indexed keywords

BIPOLAR DISORDER; FAMILY; GENETIC LINKAGE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOME; HEREDITY; HERITABILITY; HUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SCHIZOPHRENIA;

EID: 0242385651     PISSN: 15524868     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.c.20014     Document Type: Review

References (65)

1. Angst J, Frey R, Lohmeyer R, Zerben-Rubin E. 1980. Bipolar manic depressive psychoses: results of a genetic investigation. Hum Genet 55:237-254.
2. Badner J, Gershon ES. 2002. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405-411.
3. Baron M, Gruen R, Anis L, Kane J. 1983. Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission. Acta Psychiatr Scand 65:253-262.
4. Baron M, Gruen D, Ranier JD, Kane J, Asnis L, Lord A. 1985. A family study of schizophrenia and normal control probands: implications for the spectrum concept of schizophrenia. Am J Psychiatry 142:447-455.
5. Bennett P, Segurado R, Jones I, Bort S, McCandless R, Lamberr D, Heron J, Comerford C, Middle F, Corvin A, Pelios G, Kirov G, Larsen B, Mulcahy T, Williams N, O'Connell R, O'Mahony E, Pane A, Owen M, Holmans P, Craddock N, Gill M. 2002. The Wellcome trust UK-Irish bipolar affective disorder sibling pair genome screen: first stage report. Mol Psychiatry 7:189-200.
6. Berrettini WH. 2002. Bipolar disorders: review of molecular genetic studies. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology. The Fifth Generation of Progress. Philadelphia: Lippincott. p 1027-1038.
7. Berrettini W, Ferraro T, Goldin L, Weeks D, Detera-Wadleigh SD, Nurnberger JI Jr, Gershon E. 1994. Chromosome 18 DNA markers and manic depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 91:5918-5921.
8. Berrettini W, Ferraro T, Choi H, Goldin L, Detera-Wadleigh SD, Muniec D, Hsieh W-T, Hoehe M, Guroff J, Kazuba D, Nurnberger JI Jr, Gershon E. 1997. Linkage studies of bipolar illness. Arch Gen Psychiatry 54:32-39.
9. Blackwood DHR, He L, Morris SW, McLean A, Whitton C, Thomson M, Walker MT, Woodburn K, Sharp CM, Wright AF, Shibasaki Y, St. Clair DM, Porteous DJ, Muir WJ. 1996. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 12:427-430.
10. Blouin J-L, Dombroski B, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, et al. 1998. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 20:70-73.
11. Brzustowicz LM, Honer WG, Chow EWC, Little D, Hogan J, Hodgkinson K, Bassett AS. 1999. Linkage of famlial schizophrenia to chromosome 13q32. Am J Hum Genet 65:1096-1103.
12. Carlson C, Papolos D, Pandita RK, Faedda GL, Veit S, Goldberg R, Shprintzen R, Kucherlapati R, Morrow B. 1997. Molecular analysis of VCFS patients with psychiatric disorders. Am J Med Genet 60:851-859.
13. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouelette G, Fortier I, Realson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D. 2002. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 99:13675-13680.
14. Coryell W, Zimmerman M. 1988. The heritability of schizophrenia and schizoaffective disorder: a family study. Arch Gen Psychiatry 42:770-779.
15. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G, Rolins DY, Moses T, Sanders AR, Karkera JD, Esterling LE, Zeng J, Ferraro TN, Guroff JJ, Kazuba D, Maxwell ME, Nurnberger JI Jr, Gershon ES. 1999. Evidence for a bipolar susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 96:5604-5609.
16. Edenberg H, Foroud T, Conneally M, Sorbel J, et al. 1997. Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. Neuropsychiatr Genet 74:238-246.
17. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98:6917-6922.
18. Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, Hampe C, Zambuto CT, Schmitt K, Meyer J, Markel P, Lee H, Harkavy-Friedman J, Kaufmann C, Cloninger CR, Tsuang MT. 1998. Genome scan of European-American schizophrenia kindreds: results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet 81:290-295.
19. Gershon ES, Hamovit J, Guroff JJ, Dibble E, Leckman JF, Sceery W, Targum SD, Nurnberger JI Jr, Goldin LR, Bunney WE Jr. 1982. A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch Gen Psychiatry 39:1157-1167.
20. Gershon ES, DeLisi LE, Hamovit J, Nurnberger JI Jr, Maxwell ME, Schreiber J, Dauphinais D, et al. 1988. A controlled family study of chronic psychoses. Arch Gen Pscyhiatry 45:328-336.
21. Gill M, Vallada H, Collier D, Sham P, et al. 1996. A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Am J Med Genet 67:40-45.
22. Goldin LR, Gershon ES, Berrettini WH, Stine OC, DePaulo R, McMahon F, Meyers D, Nothen M, Propping P, Cichon S, Fimmers R, Baur M, Albus M, Franzek E, Kreiner R, Maier W, Rietschel M, Baron M, Knowles J, Gilliam C, Endicott J, Gurling H, Curtis D, Smyth C, Kelsoe J. 1997. Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets. Genet Epidemiol 14:563-568.
23. Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D. 1999. Initial genome wide parametric genetic linkage analysis of schizophrenia and schizophrenia spectrum disorders finds LOD scores above 3.00 on four chromosomes at 1q22-23, 5q22-35, 8p21-23 and 11q14-24. Mol Psychiatry 4(suppl):S4.
24. Hattori E, Liu C, Badner JA, Bonner TL, Christian SL, Maheshwari M, Detera-Wadleigh S, Gibbs RA, Gershon ES. 2003. Polymorphisms at the G72/G30 gene locus on 13q33 are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72:1131-1140.
25. Helzer JE, Winokur G. 1974. A family interview study of male manic-depressives. Arch Gen Psychiatry 31:73-77.
26. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI. 2000. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163-175.
27. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's Disease. Nature 411:599-603.
28. James NM, Chapman CJ. 1975. A genetic study of bipolar affective disorder. Br J Psychiatry 126:449-456.
29. Johnson GFS, Leeman MM. 1977. Analysis of familial factors in bipolar affective illness. Arch Gen Psychiatry 34:1074-1083.
30. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, et al. 2001. A genome survey indicates a susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98:585-590.
31. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. 1993. The Roscommon Family Study. IV. Affective illness, anxiety disorders, and alcoholism in relatives. Arch Gen Psychiatry 50:952-960.
32. Lachman HM, Kelsoe JR, Remick RA, Sadovnick AD, Rapaport MH, Lin M, Pazur BA, Roe AA, Saito T, Papolos DF. 1996. Linkage studies support a possible locus for bipolar disorder in the velocardiofacial syndrome region on chromosome 22. Am J Med Genet 74:121-128.
33. Levinson DF, and the Schizophrenia Linkage Colaborative Group. 1996. Additional support for schizophrenia linkage for chromosomes 6 and 8. A multicenter study. Am J Med Genet (Neuropsychiatr Genet) 67:580-594.
34. Levinson DF, Lewis CM, Wise LH, et al. 2002. Meta-analysis of genome scans for schizophrenia. Am J Med Genet 114:700-701.
35. Lewis CM, Wise LH, Levinson DF. 2002. Meta-analyses of genome searches: methods. Am J Med Genet 114:700.
36. Lin JP, Bale SJ. 1997. Parental transmission and D18S37 allele sharing in bipolar affective disorder. Genet Epidemiol 14:665-668.
37. Liu H, Abecasis GR, Health SC, Knowles A. Demars S, Chen YJ, Roos JL, Rapoport JL, Gogos JA, Karayiorgou M. 2002. Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc Natl Acad Sci USA 99:16859-16864.
38. Maier W, Lichtermann D, Minges J, Hallmayer J, Heun R, Benkert O, Levinson DF. 1993. Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Arch Gen Psychiatry 50:871-883.
39. Maier W, Lichtermann D, Franke P, Heun R, Falkai P, Rietschel M. 2002. The dichotomy of schizophrenia and affective disorders in extended pedigrees. Schizophr Res 57:259-266.
40. Maj M, Starace F, Pirozzi R. 1991. A family study of DSM-III-R schizoaffective disorder, depressive type, compared with schizophrenia and psychotic and non-psychotic depression. Am J Psychiatry 148:612-616.
41. Mujaheed M, Corbex M, Lichtenberg P, Levinson DF, Deleuze JF, Mallet J, Ebstein RP. 2000. Evidence for linkage by transmission disequilibrium test analysis of a chromosome 22 microsatellite marker D22S278 and bipolar disorder in a Palestinian Arab population. Am J Med Genet 96:836-838.
42. Niculescu AB3rd, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. 2000. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol Genomics 4:83-91.
43. Nothen MM, Cichon S, Rohleder H, Hemmer S, Franzek E, Fritze J, Albus M, Borrmann-Hassenbach M, Kreiner R, Weigelt B, Minges J, Lichtermann D, Maier W, Craddock N, Fimmers R, Holler T, Bauer MP, Rietschel M, Propping R. 1999. Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families. Mol Psychiatry 4:76.
44. Numberger JL Jr, Berrettini WH. 1998. Psychiatric genetics. London: Chapman and Hall. p 57-58.
45. Ophoff RA, Escamilla MA, Service SK, Spesny M, Meshi DB, Poon W, Molina J, Fournier E, Gallegos A, Mathews C, Neylan T, Batki SL, Roche E, Ramirez M, Silva S, De Mille MC, Dong P, Leon PE, Reus VI, Sandkuijl LA, Freimer NB. 2002. Genome-wide linkage disequilibrium mapping of severe bipolar disorder in a population isolate. Am J Hum Genet 71:565-574.
46. Papolos DF, Faedda GL, Veit S, Goldberg R, Morrow B, Kucherlapati R, Shprintzen RJ. 1996. Bipolar spectrum disorders in patients diagnosed with VCFS: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry 153:1541-1547.
47. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, Antonarakis S, Housman D, Kazazian HH, Meyers D. 1994a. Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: part 1. Am J Med Genet 54:36-43.
48. Pulver AE, Nestadt G, Goldberg R, Shprintzen RJ, Lamacz M, Wolyniec PS, Morrow B, Karayiorgou M, Antonarakis SE, Housman D, et al. 1994b. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 182:476-478.
49. Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, Cohen Z, Delmonte T, Kocher K, Miller K, Guschwan S, Kulbokas E, O'Leary S, Winchester E, Dewar K, Green T, Stone V, Chow C, Cohen A, Langelier D, Lapointe G, Gaudet D, Faith J, Branco N, Bull SB, McLeod RS, Griffith AM, Bitton A, Greenberg GR, Lander ES, Siminovitch KA, Hudson TJ. 2001. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility in Crohn's disease. Nat Genet 29:223-228.
50. Schwab SG, Hallmayer J, Lerer B, Albus M, Borrmann M, Honig S, Strauss M, Segman R, Lichtermann D, Knapp M, Trixler M, Maier W, Wildenauer DB. 1998. Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. Am J Hum Genet 63:1139.
51. Schwab SG, Hallmayer J, Albus M, Lerer B, Eckstein GN, Borrmann M, Segman RH, Hanses C, Freymann J, Yakir A, Trixler M, Falkai P, Rietschel M, Maier W, Wildenauer DB. 2000. A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6. Mol Psychiatry 5:638-649.
52. Segurado R, Detera-Wadliegh S, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder: part III, bipolar disorder. Am J Hum Genet 73:49-62.
53. Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Beckmann JS, Yakir B, Risch N, Zak NB, Darvasi A. 2002. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 71:1296-1302.
54. Somnath CP, Reddy YCJ, Jain S. 2002. Is there a familial overlap between schizophrenia and bipolar disorder? J Affective Disord 72:243-247.
55. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K. 2002. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71:877-892.
56. Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C, Clark CD, McInnis MG, Simpson SG, Breschel TS, Vishio E, Riskin K, Feilotter H, Chen E, Shen S, Folstein S, Meyers DA, Botstein D, Marr TG, DePaulo JR. 1995. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 57:1384-1394.
57. Straub RE, MacLean CJ, Martin RB, Ma Y, Myakishev MV, Harris-Kerr C, Webb BT, O'Neill A, Walsh D, Kendler KS. 1998. A schizophrenia locus may be located in region 10p15-p11. Am J Med Genet (Neuropsychiatr Genet) 81:296-301.
58. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, Cesare AJ, Gibberman A, Wang X, O'Neill FA, Walsh D, Kendler KS. 2002. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 71:337-348.
59. Tohen M, Ketter TA, Zarate CA, Suppes T, Frye M, Altshuler L, Zajecka J, Schuh LM, Risser RC, Brown E, Baker RW. 2003. Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study. Am J Psychiatry 160:1263-1271.
60. Tsuang MT, Own MJ. 2002. Molecular and population genetics of schizophrena. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology, the fifth generation of progress. Philadelphia: Lippincott. p 671-687.
61. Turecki G, Grof P, Cavazzoni R, Duffy A, Grof E, Martin R, Joober R, Rouleau GA, Alda M. 1999. Lithium responsive bipolar disorder, unilineality and chromosome 18: a linkage study. Am J Med Genet 88:411-415.
62. Weissman MM, Gershon ES, Kidd KK, Prusoff BA, Leckman JF, Dibble E, Hamovit J, Thompson WD, Pauls DL, Guroff JJ. 1984. Psychiatric disorders in the relatives of probands with affective disorder. Arch Gen Psychiatry 41:13-21.
63. Winokur G, Tsuang MT, Crowe RR. 1982. The Iowa 500: affective disorder in relatives of manic and depressed patients. Am J Psychiatry 139:209-212.
64. Winokur G, Coryell W, Keller M, Endicott J, Leon A. 1995. A family study of manic-depressive (bipolar I) disease. Is it a distinct illness separable from primary unipolar depression? Arch Gen Psychiatry 52:367-373.
65. Yoshikawa T, Kikuchi M, Saito K, Watanabe A, Yamada K, Shibuya H, Nankai M, Kurumaji A, Hattori E, Ishiguro H, Shimizu H, Okubo Y, Toru M, Detera-Wadleigh SD. 2001. Evidence for association of the myoinositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. Mol Psychiatry 6:202-210.