Immunomodulatory effects of adipose-derived mesenchymal stem cells on the gene expression of major transcription factors of T cell subsets

International Immunopharmacology

Volumn 20, Issue 2, 2014, Pages 316-321

  Mohammadzadeh, Adel ^a   Pourfathollah, Ali Akbar ^a   Shahrokhi, Somayeh ^b   Hashemi, Seyed Mahmoud ^c,d   Moradi, Sadegh Lotf Alah ^d   Soleimani, Masoud ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d STEM CELL TECHNOLOGY RESEARCH CENTER   (Iran)

Author keywords

AD MSCs; Autoimmunity; Cell subsets; Immunomodulation

Indexed keywords

5' NUCLEOTIDASE; BETA1 INTEGRIN; CD11B ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; ENDOGLIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR ROR GAMMA T; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE;

ADIPOSE DERIVED MESENCHYMAL STEM CELL; ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; IMMUNOMODULATION; MESENCHYMAL STEM CELL; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; UPREGULATION; ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; CELL COMMUNICATION; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MESENCHYMAL STROMA CELL; METABOLISM; SPLEEN;

ADIPOSE TISSUE; ANIMALS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; IMMUNOMODULATION; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTORS;

EID: 84898948565     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.03.003     Document Type: Article

References (36)

1. A. Corcione, F. Benvenuto, E. Ferretti, D. Giunti, V. Cappiello, and F. Cazzanti et al. Human mesenchymal stem cells modulate B-cell functions Blood 1 2006 367 372
2. D.G. Phinney, K. Hill, C. Michelson, M. DuTreil, C. Hughes, and S. Humphries et al. Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy Stem Cells 1 2006 186 198
3. Lda S. Meirelles, A.M. Fontes, D.T. Covas, and A.I. Caplan Mechanisms involved in the therapeutic properties of mesenchymal stem cells Cytokine Growth Factor Rev 5-6 2009 419 427
4. S. Pillai, and A. Cariappa The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow-derived B lymphocytes Immunol Cell Biol 1 2009 16 19
5. C.T. Weaver, R.D. Hatton, P.R. Mangan, and L.E. Harrington IL-17 family cytokines and the expanding diversity of effector T cell lineages Annu Rev Immunol 2007 821 852
6. L. Bai, D.P. Lennon, V. Eaton, K. Maier, A.I. Caplan, and S.D. Miller et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis Glia 11 2009 1192 1203
7. M.A. Gonzalez, E. Gonzalez-Rey, L. Rico, D. Buscher, and M. Delgado Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells Arthritis Rheum 4 2009 1006 1019
8. J.W. Chang, S.P. Hung, H.H. Wu, W.M. Wu, A.H. Yang, and H.L. Tsai et al. Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis Cell Transplant 2 2011 245 257
9. R. Hass, C. Kasper, S. Bohm, and R. Jacobs Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC Cell Commun Signal: CCS 2011 12
10. O. Joffre, T. Santolaria, D. Calise, T. Al Saati, D. Hudrisier, and P. Romagnoli et al. Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes Nat Med 1 2008 88 92
11. J.C. Crispin, and G.C. Tsokos Interleukin-17-producing T cells in lupus Curr Opin Rheumatol 5 2010 499 503
12. E. Gonzalez-Rey, M.A. Gonzalez, N. Varela, F. O'Valle, P. Hernandez-Cortes, and L. Rico et al. Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis Ann Rheum Dis 1 2010 241 248
13. L. Sun, D. Wang, J. Liang, H. Zhang, X. Feng, and H. Wang et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus Arthritis Rheum 8 2010 2467 2475
14. C. Prevosto, M. Zancolli, P. Canevali, M.R. Zocchi, and A. Poggi Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction Haematologica 7 2007 881 888
15. S. Fu, N. Zhang, A.C. Yopp, D. Chen, M. Mao, and H. Zhang et al. TGF-beta induces Foxp3+ T-regulatory cells from CD4+CD25 - precursors Am J Transplant 10 2004 1614 1627
16. R. Tatara, K. Ozaki, Y. Kikuchi, K. Hatanaka, I. Oh, and A. Meguro et al. Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation Cytotherapy 6 2011 686 694
17. T.R. Mosmann, and R.L. Coffman TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties Annu Rev Immunol 1989 145 173
18. P. Muranski, and N.P. Restifo Essentials of Th17 cell commitment and plasticity Blood 121 2013 2402 2414
19. W. Chen, W. Jin, N. Hardegen, K.J. Lei, L. Li, and N. Marinos et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3 J Exp Med 12 2003 1875 1886
20. S.G. Zheng, J.H. Wang, J.D. Gray, H. Soucier, and D.A. Horwitz Natural and induced CD4+CD25+ cells educate CD4 +CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10 J Immunol 9 2004 5213 5221
21. L. Zhou, I.I. Ivanov, R. Spolski, R. Min, K. Shenderov, and T. Egawa et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 9 2007 967 974
22. W.E. Paul, and R.A. Seder Lymphocyte responses and cytokines Cell 2 1994 241 251
23. L. Gorelik, P.E. Fields, and R.A. Flavell Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression J Immunol 9 2000 4773 4777
24. L.E. Harrington, R.D. Hatton, P.R. Mangan, H. Turner, T.L. Murphy, and K.M. Murphy et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat Immunol 11 2005 1123 1132
25. E.S. Hwang, S.J. Szabo, P.L. Schwartzberg, and L.H. Glimcher T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3 Science 5708 2005 430 433
26. N.J. Wilson, K. Boniface, J.R. Chan, B.S. McKenzie, W.M. Blumenschein, and J.D. Mattson et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells Nat Immunol 9 2007 950 957
27. S.M. Hashemi, Z.M. Hassan, A.A. Pourfathollah, S. Soudi, A. Shafiee, and M. Soleimani Comparative immunomodulatory properties of adipose-derived mesenchymal stem cells conditioned media from BALB/c, C57BL/6, and DBA mouse strains J Cell Biochem 4 2013 955 965
28. M.W. Pfaffl, G.W. Horgan, and L. Dempfle Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Nucleic Acids Res 9 2002 e36
29. J.C. Ra, S.K. Kang, I.S. Shin, H.G. Park, S.A. Joo, and J.G. Kim et al. Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells J Transl Med 2011 181
30. P.J. Khandelwal, A.M. Herman, and C.E. Moussa Inflammation in the early stages of neurodegenerative pathology J Neuroimmunol 1-2 2011 1 11
31. K. Zhou, H. Zhang, O. Jin, X. Feng, G. Yao, and Y. Hou et al. Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice Cell Mol Immunol 6 2008 417 424
32. V. Viglietta, C. Baecher-Allan, H.L. Weiner, and D.A. Hafler Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J Exp Med 7 2004 971 979
33. A. Uccelli, L. Moretta, and V. Pistoia Mesenchymal stem cells in health and disease Nat Rev Immunol 9 2008 726 736
34. T. Olsson Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis Immunol Rev 1995 245 268
35. P. Connick, M. Kolappan, R. Patani, M.A. Scott, C. Crawley, and X.L. He et al. The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test:post-test study with blinded outcome assessments Trials 2011 62
36. M. Rafei, E. Birman, K. Forner, and J. Galipeau Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis Mol Ther 10 2009 1799 1803