-
1
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
2
-
-
0030846212
-
Alterations in DNA methylation: A fundamental aspect of neoplasia
-
Baylin, S. B., Herman, J. G., Graff, J. R., Vertino, P. M. & Issa, J. P. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72, 141-196 (1998).
-
(1998)
Adv Cancer Res
, vol.72
, pp. 141-196
-
-
Baylin, S.B.1
Herman, J.G.2
Graff, J.R.3
Vertino, P.M.4
Issa, J.P.5
-
3
-
-
0021950948
-
Hypomethylation of DNA from benign and malignant human colon neoplasms
-
Goelz, S. E., Vogelstein, B., Hamilton, S. R. & Feinberg, A. P. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228, 187-190 (1985).
-
(1985)
Science
, vol.228
, pp. 187-190
-
-
Goelz, S.E.1
Vogelstein, B.2
Hamilton, S.R.3
Feinberg, A.P.4
-
4
-
-
0032960181
-
Cancer epigenetics comes of age
-
doi:10.1038/5947
-
Jones, P. A. & Laird, P. W. Cancer epigenetics comes of age. Nat Genet 21, 163-167, doi:10.1038/5947 (1999).
-
(1999)
Nat Genet
, vol.21
, pp. 163-167
-
-
Jones, P.A.1
Laird, P.W.2
-
5
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
-
doi:10.1016/S1470-2045(09)70003-8
-
Fenaux, P. et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 10, 223-232, doi:10.1016/S1470-2045(09)70003-8 (2009).
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
-
6
-
-
40849124009
-
DNA methylation markers and early recurrence in stage i lung cancer
-
doi:10.1056/NEJMoa0706550
-
Brock, M. V. et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 358, 1118-1128, doi:10.1056/NEJMoa0706550 (2008).
-
(2008)
N Engl J Med
, vol.358
, pp. 1118-1128
-
-
Brock, M.V.1
-
7
-
-
0032532092
-
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia
-
Esteller, M. et al. Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia. Cancer Res 58, 4515-4518 (1998).
-
(1998)
Cancer Res
, vol.58
, pp. 4515-4518
-
-
Esteller, M.1
-
8
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
doi:10.1056/NEJM200011093431901
-
Esteller, M. et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343, 1350-1354, doi:10.1056/NEJM200011093431901 (2000).
-
(2000)
N Engl J Med
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
-
9
-
-
77949536178
-
DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
-
doi:10.1182/blood-2009-04-214668
-
Milani, L. et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood 115, 1214-1225, doi:10.1182/blood-2009-04-214668 (2010).
-
(2010)
Blood
, vol.115
, pp. 1214-1225
-
-
Milani, L.1
-
10
-
-
18544406053
-
DNA methylation in serum of breast cancer patients: An independent prognostic marker
-
Muller, H. M. et al. DNA methylation in serum of breast cancer patients: an independent prognostic marker. Cancer Res 63, 7641-7645 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 7641-7645
-
-
Muller, H.M.1
-
11
-
-
79955773267
-
Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients
-
doi:10.1093/carcin/bgr020
-
Rawson, J. B. et al. Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. Carcinogenesis 32, 741-747, doi:10.1093/carcin/ bgr020 (2011).
-
(2011)
Carcinogenesis
, vol.32
, pp. 741-747
-
-
Rawson, J.B.1
-
12
-
-
84869209119
-
DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer
-
doi:10.1158/0008-5472.CAN-12-2309
-
Nikolaidis, G. et al. DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. Cancer Res 72, 5692-5701, doi:10.1158/0008-5472.CAN-12-2309 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 5692-5701
-
-
Nikolaidis, G.1
-
13
-
-
0035870248
-
A gene hypermethylation profile of human cancer
-
Esteller, M., Corn, P. G., Baylin, S. B. & Herman, J. G. A gene hypermethylation profile of human cancer. Cancer Res 61, 3225-3229 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 3225-3229
-
-
Esteller, M.1
Corn, P.G.2
Baylin, S.B.3
Herman, J.G.4
-
14
-
-
33845443302
-
Epigenetic diagnostics of cancer-The application of DNA methylation markers
-
doi:10.1007/BF03194647
-
Paluszczak, J. & Baer-Dubowska, W. Epigenetic diagnostics of cancer-the application of DNA methylation markers. J Appl Genet 47, 365-375, doi:10.1007/BF03194647 (2006).
-
(2006)
J Appl Genet
, vol.47
, pp. 365-375
-
-
Paluszczak, J.1
Baer-Dubowska, W.2
-
15
-
-
79952384705
-
Cancer epigenetics reaches mainstream oncology
-
doi:10.1038/nm.2305
-
Rodriguez-Paredes, M. & Esteller, M. Cancer epigenetics reaches mainstream oncology. Nat Med 17, 330-339, doi:10.1038/nm.2305 (2011).
-
(2011)
Nat Med
, vol.17
, pp. 330-339
-
-
Rodriguez-Paredes, M.1
Esteller, M.2
-
16
-
-
44049105041
-
Methylation-specific PCR
-
Chapter 10, Unit 10 16; doi:10.1002/0471142905.hg1006s16
-
Herman, J. G. & Baylin, S. B. Methylation-specific PCR. Curr Protoc Hum Genet Chapter 10, Unit 10 16; doi:10.1002/0471142905.hg1006s16 (2001).
-
(2001)
Curr Protoc Hum Genet
-
-
Herman, J.G.1
Baylin, S.B.2
-
17
-
-
0035710246
-
DNA methylation analysis by Methy Light technology
-
doi:10.1006/meth.2001.1268
-
Trinh, B. N., Long, T. I. & Laird, P. W. DNA methylation analysis by Methy Light technology. Methods 25, 456-462, doi:10.1006/meth.2001.1268 (2001).
-
(2001)
Methods
, vol.25
, pp. 456-462
-
-
Trinh, B.N.1
Long, T.I.2
Laird, P.W.3
-
18
-
-
0034654669
-
Methy light: A high-throughput assay to measure DNA methylation
-
Eads, C. A. et al. Methy Light: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 28, E32 (2000).
-
(2000)
Nucleic Acids Res
, vol.28
-
-
Eads, C.A.1
-
19
-
-
63049098369
-
Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays
-
doi:10.1371/journal.pone.0004830
-
Kron, K. et al. Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays. PLoS One 4, e4830, doi:10.1371/journal.pone.0004830 (2009).
-
(2009)
PLoS One
, vol.4
-
-
Kron, K.1
-
20
-
-
77954159684
-
DNA methylation of HOXD3 as a marker of prostate cancer progression
-
doi:10.1038/labinvest.2010.57
-
Kron, K. J. et al. DNA methylation of HOXD3 as a marker of prostate cancer progression. Lab Invest 90, 1060-1067, doi:10.1038/labinvest.2010.57 (2010).
-
(2010)
Lab Invest
, vol.90
, pp. 1060-1067
-
-
Kron, K.J.1
-
21
-
-
79959885041
-
Association of tissue promoter methylation levels of APC, TGFbeta2, HOXD3 and RASSF1A with prostate cancer progression
-
doi:10.1002/ijc.25908
-
Liu, L. et al. Association of tissue promoter methylation levels of APC, TGFbeta2, HOXD3 and RASSF1A with prostate cancer progression. Int J Cancer 129, 2454-2462, doi:10.1002/ijc.25908 (2011).
-
(2011)
Int J Cancer
, vol.129
, pp. 2454-2462
-
-
Liu, L.1
-
22
-
-
29244490041
-
Analysis of repetitive element DNA methylation by Methy Light
-
doi:10.1093/nar/gki987
-
Weisenberger, D. J. et al. Analysis of repetitive element DNA methylation by Methy Light. Nucleic Acids Res 33, 6823-6836, doi:10.1093/nar/gki987 (2005).
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 6823-6836
-
-
Weisenberger, D.J.1
-
23
-
-
0030851627
-
The elimination of primer-dimer accumulation in PCR
-
Brownie, J. et al. The elimination of primer-dimer accumulation in PCR. Nucleic Acids Res 25, 3235-3241 (1997).
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3235-3241
-
-
Brownie, J.1
-
24
-
-
0001459569
-
Synthesis of novel 29,39-linked bicyclic thymine ribonucleosides
-
Koshkin, A. A. & Wengel, J. Synthesis of Novel 29,39-Linked Bicyclic Thymine Ribonucleosides. J Org Chem 63, 2778-2781 (1998).
-
(1998)
J Org Chem
, vol.63
, pp. 2778-2781
-
-
Koshkin, A.A.1
Wengel, J.2
-
25
-
-
33745160325
-
Evaluation of probe chemistries and platforms to improve the detection limit of real-time PCR
-
doi:10.1016/j.mimet.2005.11.006
-
Reynisson, E., Josefsen, M. H., Krause, M. & Hoorfar, J. Evaluation of probe chemistries and platforms to improve the detection limit of real-time PCR. J Microbiol Methods 66, 206-216, doi:10.1016/j.mimet.2005.11.006 (2006).
-
(2006)
J Microbiol Methods
, vol.66
, pp. 206-216
-
-
Reynisson, E.1
Josefsen, M.H.2
Krause, M.3
Hoorfar, J.4
-
26
-
-
37549001314
-
Aligation assay for multiplex analysis of CpG methylation using bisulfite-treated DNA
-
doi:10.1093/nar/gkm984
-
Dahl, C.&Guldberg, P. Aligation assay for multiplex analysis of CpG methylation using bisulfite-treated DNA. Nucleic Acids Res 35, e144, doi:10.1093/nar/gkm984 (2007).
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Dahl, C.1
Guldberg, P.2
-
27
-
-
63649141835
-
Identification of CpG methylation of the SNRPN gene by methylation-specific multiplex PCR
-
doi:10.1002/elps.200800225
-
Hung, C. C. et al. Identification of CpG methylation of the SNRPN gene by methylation-specific multiplex PCR. Electrophoresis 30, 410-416, doi:10.1002/elps.200800225 (2009).
-
(2009)
Electrophoresis
, vol.30
, pp. 410-416
-
-
Hung, C.C.1
-
28
-
-
70349325786
-
Improved PCR-BSP assay for multiplex methylation pattern analysis in minimal amount of DNA
-
doi:10.1007/s12033-009-9169-5
-
Wang, J., Yu, M., Li, K., Xiao, J.&Zhou, Y. Improved PCR-BSP assay for multiplex methylation pattern analysis in minimal amount of DNA. Mol Biotechnol 42, 333-340, doi:10.1007/s12033-009-9169-5 (2009).
-
(2009)
Mol Biotechnol
, vol.42
, pp. 333-340
-
-
Wang, J.1
Yu, M.2
Li, K.3
Xiao, J.4
Zhou, Y.5
-
29
-
-
77954143654
-
Multiplex detection of CpG methylation using microarray combining with target-selection-padlock probe
-
doi:10.1016/j.cca.2010.03.026
-
Shi, X., Tang, C., Zhou, D., Zhao, H. & Lu, Z. Multiplex detection of CpG methylation using microarray combining with target-selection-padlock probe. Clin Chim Acta 411, 1187-1194, doi:10.1016/j.cca.2010.03.026 (2010).
-
(2010)
Clin Chim Acta
, vol.411
, pp. 1187-1194
-
-
Shi, X.1
Tang, C.2
Zhou, D.3
Zhao, H.4
Lu, Z.5
-
30
-
-
77955234573
-
Methylation-specific loop-mediated isothermal amplification for detecting hypermethylatedDNAin simplex and multiplex formats
-
doi:10.1373/clinchem.2010.143545
-
Zerilli, F. et al. Methylation-specific loop-mediated isothermal amplification for detecting hypermethylatedDNAin simplex and multiplex formats. Clin Chem 56, 1287-1296, doi:10.1373/clinchem.2010.143545 (2010).
-
(2010)
Clin Chem
, vol.56
, pp. 1287-1296
-
-
Zerilli, F.1
-
31
-
-
80255122747
-
Methylation-specific ligation detection reaction (msLDR): A new approach for multiplex evaluation of methylation patterns
-
doi:10.1007/s00438-011-0645-9
-
Bormann, F. et al. Methylation-specific ligation detection reaction (msLDR): a new approach for multiplex evaluation of methylation patterns. Mol Genet Genomics 286, 279-291, doi:10.1007/s00438-011-0645-9 (2011).
-
(2011)
Mol Genet Genomics
, vol.286
, pp. 279-291
-
-
Bormann, F.1
-
32
-
-
84868380146
-
Development of a non-invasive method, multiplex methylation specific PCR (MMSP), for early diagnosis of nasopharyngeal carcinoma
-
doi:10.1371/journal.pone.0045908
-
Zhang, Z. et al. Development of a non-invasive method, multiplex methylation specific PCR (MMSP), for early diagnosis of nasopharyngeal carcinoma. PLoS One 7, e45908, doi:10.1371/journal.pone.0045908 (2012).
-
(2012)
PLoS One
, vol.7
-
-
Zhang, Z.1
-
33
-
-
84856391668
-
Quantification of methylated markers with amultiplex methylationspecific technology
-
doi:10.1373/clinchem.2011.171264
-
Zou, H. et al. Quantification of methylated markers with amultiplex methylationspecific technology. Clin Chem 58, 375-383, doi:10.1373/clinchem. 2011.171264 (2012).
-
(2012)
Clin Chem
, vol.58
, pp. 375-383
-
-
Zou, H.1
-
34
-
-
84873165888
-
MNAzyme qPCR with superior multiplexing capacity
-
doi:10.1373/clinchem.2012.192930
-
Mokany, E., Tan, Y. L., Bone, S. M., Fuery, C. J. & Todd, A. V. MNAzyme qPCR with superior multiplexing capacity. Clin Chem 59, 419-426, doi:10.1373/clinchem.2012.192930 (2013).
-
(2013)
Clin Chem
, vol.59
, pp. 419-426
-
-
Mokany, E.1
Tan, Y.L.2
Bone, S.M.3
Fuery, C.J.4
Todd, A.V.5
-
35
-
-
84879095890
-
A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA
-
doi:10.1016/j.ygyno.2013.04.048
-
Zhang, Q. et al. A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA. Gynecol Oncol 130, 132-139, doi:10.1016/j.ygyno.2013.04.048 (2013).
-
(2013)
Gynecol Oncol
, vol.130
, pp. 132-139
-
-
Zhang, Q.1
-
36
-
-
84883472774
-
A 3-plex methylation assay combined with the FGFR3 mutation assay sensitively detects recurrent bladder cancer in voided urine
-
doi:10.1158/1078-0432.CCR-12-3276
-
Kandimalla, R. et al. A 3-Plex Methylation Assay Combined with the FGFR3 Mutation Assay Sensitively Detects Recurrent Bladder Cancer in Voided Urine. Clin Cancer Res, doi:10.1158/1078-0432.CCR-12-3276 (2013).
-
(2013)
Clin Cancer Res
-
-
Kandimalla, R.1
-
37
-
-
3042825295
-
Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer
-
doi:10.1158/0008-5472.CAN-03-3341
-
Fackler, M. J. et al. Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Res 64, 4442-4452, doi:10.1158/0008-5472.CAN-03-3341 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 4442-4452
-
-
Fackler, M.J.1
-
38
-
-
77956143206
-
Development of a multiplex Methy Light assay for the detection of multigene methylation in human colorectal cancer
-
doi:10.1016/j.cancergencyto.2010.05.018
-
He, Q. et al. Development of a multiplex Methy Light assay for the detection of multigene methylation in human colorectal cancer. Cancer Genet Cytogenet 202, 1-10, doi:10.1016/j.cancergencyto.2010.05.018 (2010).
-
(2010)
Cancer Genet Cytogenet
, vol.202
, pp. 1-10
-
-
He, Q.1
-
39
-
-
84869881661
-
Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape
-
doi:10.1186/1471-2407-12-551
-
Snellenberg, S. et al. Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape. BMC Cancer 12, 551; doi:10.1186/1471-2407-12-551 (2012).
-
(2012)
BMC Cancer
, vol.12
, pp. 551
-
-
Snellenberg, S.1
-
40
-
-
84861802954
-
A tissue biopsy-based epigenetic multiplex PCR assay for prostate cancer detection
-
doi:10.1186/1471-2490-12-16
-
Van Neste, L. et al. A tissue biopsy-based epigenetic multiplex PCR assay for prostate cancer detection. BMC Urol 12, 16; doi:10.1186/1471-2490-12-16 (2012).
-
(2012)
BMC Urol
, vol.12
, pp. 16
-
-
Van Neste, L.1
-
41
-
-
49249091385
-
DNA methylation analysis by digital bisulfite genomic sequencing and digital Methy Light
-
doi:10.1093/nar/gkn455
-
Weisenberger, D. J. et al. DNA methylation analysis by digital bisulfite genomic sequencing and digital Methy Light. Nucleic Acids Res 36, 4689-4698, doi:10.1093/nar/gkn455 (2008).
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4689-4698
-
-
Weisenberger, D.J.1
-
42
-
-
84862520692
-
Epigenetic biomarkers in colorectal cancer diagnostics
-
doi:10.1586/erm.12.39
-
Rawson, J. B. & Bapat, B. Epigenetic biomarkers in colorectal cancer diagnostics. Expert Rev Mol Diagn 12, 499-509, doi:10.1586/erm.12.39 (2012).
-
(2012)
Expert Rev Mol Diagn
, vol.12
, pp. 499-509
-
-
Rawson, J.B.1
Bapat, B.2
-
43
-
-
70349656779
-
Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer
-
doi:10.1158/1078-0432.CCR-09-0111
-
Lee, B. B. et al. Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer. Clin Cancer Res 15, 6185-6191, doi:10.1158/1078-0432.CCR-09-0111 (2009).
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6185-6191
-
-
Lee, B.B.1
-
44
-
-
84866090183
-
Quantitative DNA methylation analysis of genes coding for kallikrein-related peptidases 6 and 10 as biomarkers for prostate cancer
-
doi:10.4161/epi.21524
-
Olkhov-Mitsel, E. et al. Quantitative DNA methylation analysis of genes coding for kallikrein-related peptidases 6 and 10 as biomarkers for prostate cancer. Epigenetics 7, 1037-1045, doi:10.4161/epi.21524 (2012).
-
(2012)
Epigenetics
, vol.7
, pp. 1037-1045
-
-
Olkhov-Mitsel, E.1
|