Gastrodin inhibits glutamate-induced apoptosis of pc12 cells via inhibition of CaMKII/ASK-1/p38 MAPK/p53 signaling cascade

Cellular and Molecular Neurobiology

Volumn 34, Issue 4, 2014, Pages 591-602

  Jiang, Genling ^a   Wu, Haiyun ^a   Hu, Yuqin ^b   Li, Jun ^a   Li, Qinling ^a,c  

^a ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c Anqing Medical and Pharmaceutical College   (China)

Author keywords

Apoptosis; Apoptosis signaling regulating kinase 1 (ASK 1); Calmodulin dependent kinase II (CaMKII); Gastrodin; Glutamate

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; BENZYL ALCOHOL DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYTOCHROME C; GASTRODIN; GLUCOSIDE; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53;

ANIMAL; APOPTOSIS; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PC12 CELL LINE; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BENZYL ALCOHOLS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL SURVIVAL; CYTOCHROMES C; GLUCOSIDES; GLUTAMIC ACID; MAP KINASE KINASE KINASE 5; MEMBRANE POTENTIAL, MITOCHONDRIAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; RATS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84898862540     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-014-0043-z     Document Type: Article

References (50)

1. +-induced cytotoxicity in human dopaminergic SH-SY5Y cells. J Ethnopharmacol 130:290-298
2. Arundine M, Tymianski M (2003) Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 34:524-537
3. Azadmehr A, Oghyanous KA, Hajiaghaee R (2013) Antioxidant and neuroprotective effects of scrophularia striata extract against oxidative stress-induced neurotoxicity. Cell Mol Neurobiol 33:1135-1141
4. Birben E, Sahiner UM, Sackesen C et al (2012) Oxidative stress and antioxidant defense. World Allergy Organ J 5:9-19
5. Boronkai A, Bellyei S, Szigeti A et al (2009) Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAPkinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophagecells. Eur J Cell Biol 88:753-763
6. CalìT Ottolini D, Brini M (2011) Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease. BioFactors 37:228-240
7. Chae S, Lee AY, Lee H-W et al (2008) Three phenolic glycosides from Gastrodia elata. J Appl Biol Chem 51:61-65
8. Chen W, Li X, Jia LQ (2013) Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells. Br J Pharmacol 169:1140-1152
9. +-elicited apoptosis. Neurosci Res 63:52-58
10. Christophe M, Nicolas S (2006) Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion. Curr Pharm Des 12:739-757
11. Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695
12. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911
13. Hirata Y, Yamamoto H, Atta MSM et al (2011) Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor. J Neurochem 119:839-847
14. Jiang GZ, Li JC (2014) Protective effects of ginsenoside Rg1 against colistin sulfate-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol 34:167-172
15. Kim SJ, Ju JW, Oh CD et al (2002) ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status. J Biol Chem 277:1332-1339
16. Kim IS, Choi D-K, Jung HJ (2011) Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules 16:5349-5361
17. Kim BW, Koppula S, Kim JW et al (2012) Modulation of LPS-stimulated neuroinflammation in BV-2 microglia by Gastrodia elata: 4-hydroxybenzyl alcohol is the bioactive candidate. J Ethnopharmacol 139:549-557
18. Kumar H, Kim IS, More SV et al (2013) Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson's disease model. Evid Based Complement Altern Med 2013:514095
19. Lau A, Tymianski M (2010) Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch Eur J Physiol 460:525-542
20. Li N, Liu B, Dluzen DE et al (2007) Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. J Ethnopharmacol 111:458-463
21. Li G, Ma R, Huang C (2008) Protective effect of erythropoietin on b-amyloid-induced PC12 cell death through antioxidant mechanisms. Neurosci Lett 442:143-147
22. Liu Y, Templeton DM (2007) Cadmium activates CaMK-II and initiates CaMK-II- dependent apoptosis in mesangial cells. FEBS Lett 581:1481-1486
23. 2+ influx. Neurotoxicology 33:59-69
24. Means AR, Dedman JR (1980) Calmodulin - an intracellular calcium receptor. Nature 285:73-77
25. Nagai H, Noguchi T, Takeda K et al (2007) Pathophysiological roles of ASK1-MAP kinase signaling pathways. J Biochem Mol Biol 40:1-6
26. Ojemann LM, Nelson WL, Shin DS et al (2006) Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions. Epilepsy Behav 8:376-383
27. Olanow CW, Tatton WG (1999) Etiology and pathogenesis of Parkinson's disease. Annu Rev Neurosci 22:123-144
28. Orrenius S, Zhivotovsky B, Nicotera P (2003) Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4:552-565
29. Peng TI, Jou MJ (2010) Oxidative stress caused by mitochondrial calcium overload. Ann N Y Acad Sci 1201:183-188
30. Rokhlin OW, Taghiyev AF, Bayer KU (2007) Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival. Cancer Biol Ther 6:732-742
31. Salas MA, Valverde CA, Sánchez G et al (2010) The signaling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury. J Mol Cell Cardiol 48:1298-1306
32. Satpute RM, Kashyap RS, Deopujari JY (2009) Protection of PC12 cells from chemical ischemia induced oxidative stress by Fagonia arabica. Food Chem Toxicol 47:2689-2695
33. Sheldon AL, Robinson MB (2007) The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int 51:333-355
34. Shu C, Chen C, Zhang DP et al (2012) Gastrodin protects against cardiac hypertrophy and fibrosis. Mol Cell Biochem 359:9-16
35. Soga M, Matsuzawa A, Ichijo H (2012) Oxidative stress-induced diseases via the ASK1 signaling pathway. Int J Cell Biol 2012:439587
36. 2+-induced p38 MAP kinase activation. EMBO Rep 5:161-166
37. Tan JW, Tham CL, Israf DA et al (2013) Neuroprotective effects of biochanin a against glutamate-induced cytotoxicity in PC12 cells via apoptosis inhibition. Neurochem Res 38:512-518
38. Thompson LM (2008) Neurodegeneration: a question of balance. Nature 452:707-708
39. Uberti D, Grilli M, Memo M (2000) Induction of p53 in the glutamate-induced cell death program. Amino Acids 19:253-261
40. Wakamatsu TH, Dogru M, Tsubota K (2008) Tearful relations: oxidative stress, inflammation and eye diseases. Arq Bras Oftalmol 71:72-79
41. Wang X, Zhu G, Yang S et al (2011) Paeonol prevents excitotoxicity in rat pheochromocytoma PC12 cells via down-regulation of ERK activation and inhibition of apoptosis. Planta Med 77:1695-1701
42. Wu H, Jiang G, Li Q (2012) Protection of gastrodin on PC12 cell injury induced by glutamate via inhibition of cell apoptosis. Chin J Clin Pharmacol Ther 17:1361-1367
43. Xiao X, Liu J, Hu J et al (2008) Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca(2+) antagonism and antioxidant mechanisms. Eur J Pharmacol 591:21-27
44. Xu X, Lu Y, Bie X (2007) Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta Med 73:650-654
45. Yang XD, Zhu J, Yang R et al (2007) Phenolic constituents from the rhizomes of Gastrodia elata. Nat Prod Res 21:180-186
46. Yang X, Wang Y, Luo J et al (2011) Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cell Mol Neurobiol 31:303-311
47. Yong W, Xing TR, Wang S et al (2009) Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus. Planta Med 75:1112-1117
48. Yu X, Li X, Jiang G et al (2013) Isradipine prevents rotenone-induced intracellular calcium rise that accelerates senescence in human neuroblastoma SH-SY5Y cells. Neuroscience 246:243-253
49. Zeng X, Zhang S, Zhang L et al (2006) A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Med 72:1359-1365
50. Zhang C, Du F, Shi M et al (2012) Ginsenoside Rd protects neurons against glutamate-induced excitotoxicity by inhibiting ca(2+) influx. Cell Mol Neurobiol 32:121-128