메뉴 건너뛰기




Volumn 77, Issue 15, 2011, Pages 1695-1701

Paeonol prevents excitotoxicity in rat pheochromocytoma PC12 cells via downregulation of ERK activation and inhibition of apoptosis

Author keywords

apoptosis; ERK1 2; glutamate; Paeonia moutan; Paeoniaceae; paeonol

Indexed keywords

CASPASE 3; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PEONOL; TRYPAN BLUE;

EID: 84930486751     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1271033     Document Type: Article
Times cited : (38)

References (34)
  • 1
    • 0026596478 scopus 로고
    • Molecular neurobiology of glutamate receptors
    • Gasic G P., Hollmann M. Molecular neurobiology of glutamate receptors. Annu Rev Physiol 1992 54 507-536
    • (1992) Annu Rev Physiol , vol.54 , pp. 507-536
    • Gasic, G.P.1    Hollmann, M.2
  • 2
    • 34247230363 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    • DOI 10.1016/j.jep.2006.12.015, PII S0378874106006611
    • Li N, Liu B, Dluzen D E., Jin Y. Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. J Ethnopharmacol 2007 111 458-463 (Pubitemid 46617084)
    • (2007) Journal of Ethnopharmacology , vol.111 , Issue.3 , pp. 458-463
    • Li, N.1    Liu, B.2    Dluzen, D.E.3    Jin, Y.4
  • 3
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle J T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993 262 689-695 (Pubitemid 23350687)
    • (1993) Science , vol.262 , Issue.5134 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 4
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton S A., Rosenberg P A. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994 330 613-622
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 5
    • 0028971169 scopus 로고
    • 17-beta Estradiol protects neurons from oxidative stress-induced cell death in vitro
    • Behl C, Widmann M, Trapp T, Holsboer F. 17-beta Estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 1995 216 473-482
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 473-482
    • Behl, C.1    Widmann, M.2    Trapp, T.3    Holsboer, F.4
  • 6
    • 0028206292 scopus 로고
    • Cytotoxic effects of glutamic acid on PC12 cells
    • DOI 10.1016/0197-0186(94)90096-5
    • Froissard P, Duval D. Cytotoxic effects of glutamic acid on PC12 cells. Neurochem Int 1994 24 485-493 (Pubitemid 24169907)
    • (1994) Neurochemistry International , vol.24 , Issue.5 , pp. 485-493
    • Froissard, P.1    Duval, D.2
  • 7
    • 0032055973 scopus 로고    scopus 로고
    • Neuronal cell death
    • DOI 10.1016/S0896-6273(00)81004-1
    • Pettmann B, Henderson C E. Neuronal cell death. Neuron 1998 20 633-647 (Pubitemid 28199044)
    • (1998) Neuron , vol.20 , Issue.4 , pp. 633-647
    • Pettmann, B.1    Henderson, C.E.2
  • 9
    • 55349109231 scopus 로고    scopus 로고
    • Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats
    • Chen X, Liu J, Gu X, Ding F. Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. Brain Res 2008 1238 189-198
    • (2008) Brain Res , vol.1238 , pp. 189-198
    • Chen, X.1    Liu, J.2    Gu, X.3    Ding, F.4
  • 10
    • 0026939298 scopus 로고
    • Role of excitotoxicity in human neurological disease
    • Beal M F. Role of excitotoxicity in human neurological disease. Curr Opin Neurobiol 1992 2 657-662
    • (1992) Curr Opin Neurobiol , vol.2 , pp. 657-662
    • Beal, M.F.1
  • 11
    • 0034711236 scopus 로고    scopus 로고
    • Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death
    • DOI 10.1074/jbc.M002361200
    • Atlante A, Calissano P, Bobba A, Azzariti A, Marra E, Passarella S. Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. J Biol Chem 2000 275 37159-37166 (Pubitemid 32002134)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 37159-37166
    • Atlante, A.1    Calissano, P.2    Bobba, A.3    Azzariti, A.4    Marra, E.5    Passarella, S.6
  • 12
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • DOI 10.1023/A:1009616228304
    • Simon H U., Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000 5 415-418 (Pubitemid 32162623)
    • (2000) Apoptosis , vol.5 , Issue.5 , pp. 415-418
    • Simon, H.-U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 13
    • 0026637624 scopus 로고
    • A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion
    • Kato S, Negishi K, Mawatari K, Kuo C H. A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion. Neuroscience 1992 48 903-914
    • (1992) Neuroscience , vol.48 , pp. 903-914
    • Kato, S.1    Negishi, K.2    Mawatari, K.3    Kuo, C.H.4
  • 14
    • 58149269501 scopus 로고    scopus 로고
    • Inhibitory effect of paeonol on hydrogen peroxide-induced apoptosis in PC12 cells
    • Xu D H., Zhou C H., Wu T, Xu B L. Inhibitory effect of paeonol on hydrogen peroxide-induced apoptosis in PC12 cells. Chin J Pharmacol Toxicol 2008 22 401-405
    • (2008) Chin J Pharmacol Toxicol , vol.22 , pp. 401-405
    • Xu, D.H.1    Zhou, C.H.2    Wu, T.3    Xu, B.L.4
  • 15
    • 39149086351 scopus 로고    scopus 로고
    • Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats
    • DOI 10.1055/s-2007-993775
    • Nizamutdinova I T., Jin Y C., Kim J S., Yean M H., Kang S S., Kim Y S., Lee J H., Seo H G., Kim H J., Chang K C. Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats. Planta Med 2008 74 14-18 (Pubitemid 351251377)
    • (2008) Planta Medica , vol.74 , Issue.1 , pp. 14-18
    • Nizamutdinova, I.T.1    Yong, C.J.2    Ju, S.K.3    Min, H.Y.4    Sam, S.K.5    Yeong, S.K.6    Jae, H.L.7    Han, C.S.8    Hye, J.K.9    Ki, C.C.10
  • 17
    • 0041667974 scopus 로고    scopus 로고
    • Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia
    • Chou T C. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol 2003 139 1146-1152
    • (2003) Br J Pharmacol , vol.139 , pp. 1146-1152
    • Chou, T.C.1
  • 18
    • 63649092828 scopus 로고    scopus 로고
    • Protective effect of paeonol on beta-amyloid 25-35-induced toxicity in PC12 cells
    • Xu D H., Zhou C H., Xu B L., Luo S Y. Protective effect of paeonol on beta-amyloid 25-35-induced toxicity in PC12 cells. Neural Regen Res 2008 3 863-866
    • (2008) Neural Regen Res , vol.3 , pp. 863-866
    • Xu, D.H.1    Zhou, C.H.2    Xu, B.L.3    Luo, S.Y.4
  • 19
    • 36549042393 scopus 로고    scopus 로고
    • Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation injury
    • Wu J B., Song N N., Wei X B., Guan H S., Zhang X M. Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation injury. J Neurol Sci 2008 264 50-55
    • (2008) J Neurol Sci , vol.264 , pp. 50-55
    • Wu, J.B.1    Song, N.N.2    Wei, X.B.3    Guan, H.S.4    Zhang, X.M.5
  • 21
    • 1642483509 scopus 로고    scopus 로고
    • Neurodegenerative diseases and oxidative stress
    • DOI 10.1016/j.biopha.2003.11.004
    • Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 2004 58 39-46 (Pubitemid 38117047)
    • (2004) Biomedicine and Pharmacotherapy , vol.58 , Issue.1 , pp. 39-46
    • Emerit, J.1    Edeas, M.2    Bricaire, F.3
  • 22
    • 0034796353 scopus 로고    scopus 로고
    • Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment
    • Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 2001 18 685-716 (Pubitemid 32948277)
    • (2001) Drugs and Aging , vol.18 , Issue.9 , pp. 685-716
    • Halliwell, B.1
  • 23
    • 3242664824 scopus 로고    scopus 로고
    • Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes
    • DOI 10.1111/j.1600-079X.2004.00140.x
    • Jou M J., Peng T I., Reiter R J., Jou S B., Wu H Y., Wen S T. Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. J Pineal Res 2004 37 55-70 (Pubitemid 38969021)
    • (2004) Journal of Pineal Research , vol.37 , Issue.1 , pp. 55-70
    • Jou, M.-J.1    Peng, T.-I.2    Reiter, R.J.3    Jou, S.-B.4    Wu, H.-Y.5    Wen, S.-T.6
  • 24
    • 78650753023 scopus 로고    scopus 로고
    • Antioxidative properties of flavonoids from Cheilanthes anceps Swartz
    • Chowdhary S, Verma D L., Pande R, Kumar H. Antioxidative properties of flavonoids from Cheilanthes anceps Swartz. J Am Sci 2010 6 203-207
    • (2010) J Am Sci , vol.6 , pp. 203-207
    • Chowdhary, S.1    Verma, D.L.2    Pande, R.3    Kumar, H.4
  • 25
  • 26
    • 0036669527 scopus 로고    scopus 로고
    • Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation
    • DOI 10.1016/S0753-3322(02)00182-8, PII S0753332202001828
    • Watanabe S, Uesugi S, Kikuchi Y. Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation. Biomed Pharmacother 2002 56 302-312 (Pubitemid 35245314)
    • (2002) Biomedicine and Pharmacotherapy , vol.56 , Issue.6 , pp. 302-312
    • Watanabe, S.1    Uesugi, S.2    Kikuchi, Y.3
  • 27
    • 0041884769 scopus 로고    scopus 로고
    • Protective effect of flavonoids against aging- and lipopolysaccharide- induced cognitive impairment in mice
    • DOI 10.1159/000072357
    • Patil C S., Singh V P., Satyanarayan P S., Jain N K., Singh A, Kulkarni S K. Protective effect of flavonoids against aging- and lipopolysaccharide- induced cognitive impairment in mice. Pharmacology 2003 69 59-67 (Pubitemid 37034425)
    • (2003) Pharmacology , vol.69 , Issue.2 , pp. 59-67
    • Patil, C.S.1    Singh, V.P.2    Satyanarayan, P.S.V.3    Jain, N.K.4    Singh, A.5    Kulkarni, S.K.6
  • 28
    • 36549042393 scopus 로고    scopus 로고
    • Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation-induced injury
    • Wu J B., Song N N., Wei X B., Guan H S., Zhang X M. Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation-induced injury. J Neurol Sci 2008 264 50-55
    • (2008) J Neurol Sci , vol.264 , pp. 50-55
    • Wu, J.B.1    Song, N.N.2    Wei, X.B.3    Guan, H.S.4    Zhang, X.M.5
  • 29
    • 63649092828 scopus 로고    scopus 로고
    • Protective effect of paeonol on beta-amyloid 25-35-induced toxicity in PC12 cells
    • Xu D H., Zhou C H., Xu B L., Luo S Y. Protective effect of paeonol on beta-amyloid 25-35-induced toxicity in PC12 cells. Neural Regen Res 2008 3 863-866
    • (2008) Neural Regen Res , vol.3 , pp. 863-866
    • Xu, D.H.1    Zhou, C.H.2    Xu, B.L.3    Luo, S.Y.4
  • 30
    • 58149305975 scopus 로고    scopus 로고
    • Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice
    • Zhong S Z., Ge Q H., Qu R, Li Q, Ma S P. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. J Neurol Sci 2009 277 58-64
    • (2009) J Neurol Sci , vol.277 , pp. 58-64
    • Zhong, S.Z.1    Ge, Q.H.2    Qu, R.3    Li, Q.4    Ma, S.P.5
  • 31
    • 0029834669 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival
    • DOI 10.1074/jbc.271.34.20713
    • Creedon D J., Johnson E M., Lawrence J C. Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival. J Biol Chem 1996 271 20713-20718 (Pubitemid 26281854)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.34 , pp. 20713-20718
    • Creedon, D.J.1    Johnson Jr., E.M.2    Lawrence Jr., J.C.3
  • 33
    • 0032530577 scopus 로고    scopus 로고
    • Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism
    • Runden E, Seglen P O., Haug F M., Ottersen O P., Wieloch T, Shamloo M, Laake J H. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J Neurosci 1998 18 7296-7305 (Pubitemid 28425814)
    • (1998) Journal of Neuroscience , vol.18 , Issue.18 , pp. 7296-7305
    • Runden, E.1    Seglen, P.O.2    Haug, F.-M.3    Ottersen, O.P.4    Wieloch, T.5    Shamloo, M.6    Laake, J.H.7
  • 34
    • 0029328342 scopus 로고
    • Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus
    • Karin M, Hunter T. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol 1995 5 747-757
    • (1995) Curr Biol , vol.5 , pp. 747-757
    • Karin, M.1    Hunter, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.