Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca2+ antagonism and antioxidant mechanisms

European Journal of Pharmacology

Volumn 591, Issue 1-3, 2008, Pages 21-27

  Xiao, Xianghua ^a,b,c   Liu, Juntian ^a   Hu, Jingwen ^a   Zhu, Xiuping ^b,c   Yang, Hua ^b,c   Wang, Chaoyun ^a   Zhang, Yuanhui ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b Shaanxi Provincial Key Laboratory of Ophthalmology   (China)

^c XI AN NO 1 HOSPITAL   (China)

Author keywords

Apoptosis; Calcium; Hydrogen peroxide; Mitochondria; Oxidative stress; Protopine

Indexed keywords

CALCIUM ION; CASPASE 3; CATALASE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MALONALDEHYDE; PROTOPINE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM ANTAGONISM; CALCIUM CELL LEVEL; CELL CULTURE; CELL PROTECTION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG MECHANISM; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BENZOPHENANTHRIDINES; BERBERINE ALKALOIDS; CALCIUM; CASPASE 3; CELL SURVIVAL; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDANTS; OXIDATIVE STRESS; PC12 CELLS; RATS;

EID: 48749107430     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.045     Document Type: Article

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