The Toll-Like Receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Long, Huaicong ^a,b   O'Connor, Brian P ^a,c   Zemans, Rachel L ^a,d   Zhou, Xiaofang ^b   Yang, Ivana V ^a,d   Schwartz, David A ^a,c,d  

^a DEPARTMENT OF MEDICINE   (United States)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; COMPLEMENTARY DNA; ENHANCED GREEN FLUORESCENT PROTEIN; GLYCINE; INTERLEUKIN 8; ISOLEUCINE; LENTIVIRUS VECTOR; LIPOPOLYSACCHARIDE; PHOSPHOPROTEIN; THREONINE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ALLELE; ARTICLE; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE ACTIVATION; GENE CONSTRUCT; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; MUTANT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMORPHISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL LINE; GENETIC POLYMORPHISM; GENETICS; METABOLISM;

ASPARTIC ACID; CELL LINE; GLYCINE; HUMANS; ISOLEUCINE; NF-KAPPA B; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION; THREONINE; TOLL-LIKE RECEPTOR 4;

EID: 84898862526     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093550     Document Type: Article

References (40)

1. Vogel SN, Fenton M (2003) Toll-like receptor 4 signalling: new perspectives on a complex signal-transduction problem. Biochem Soc Trans 31: 664-668. (Pubitemid 36750752)
2. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F (1999) Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274: 10689-10692.
3. Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, et al. (2001) Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69: 1477-1482. (Pubitemid 32187597)
4. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, et al. (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1: 398-401.
5. Bulut Y, Faure E, Thomas L, Karahashi H, Michelsen KS, et al. (2002) Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 168: 1435-1440. (Pubitemid 34094516)
6. Kuhns DB, Nelson EL, Alvord WG, Gallin JI (2001) Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl- phenylalanine or leukotriene B(4). J Immunol 167: 2869-2878. (Pubitemid 32768921)
7. Smiley ST, King JA, Hancock WW (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167: 2887-2894. (Pubitemid 32768923)
8. Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, et al. (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276: 10229-10233.
9. Jiang D, Liang J, Fan J, Yu S, Chen S, et al. (2005) Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11: 1173-1179. (Pubitemid 43093664)
10. Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, et al. (2002) Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 195: 99-111. (Pubitemid 34074500)
11. Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, et al. (2002) Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 168: 5989-5992. (Pubitemid 34620010)
12. Tsan MF, Gao B (2004) Cytokine function of heat shock proteins. Am J Physiol Cell Physiol 286: C739-744.
13. Gay NJ, Gangloff M (2007) Structure and function of Toll receptors and their ligands. Annu Rev Biochem 76: 141-165.
14. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, et al. (1990) Structure and function of lipopolysaccharide binding protein. Science 249: 1429-1431. (Pubitemid 120034117)
15. Tobias PS, Mathison JC, Ulevitch RJ (1988) A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem 263: 13479-13481.
16. Tobias PS, Soldau K, Ulevitch RJ (1989) Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein. J Biol Chem 264: 10867-10871. (Pubitemid 19161662)
17. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433.
18. Alexander C, Rietschel ET (2001) Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 7: 167-202. (Pubitemid 32894573)
19. Lorenz E, Frees KL, Schwartz DA (2001) Determination of the TLR4 genotype using allele-specific PCR. Biotechniques 31: 22-24. (Pubitemid 32645902)
20. Ferwerda B, McCall MB, Alonso S, Giamarellos-Bourboulis EJ, Mouktaroudi M, et al. (2007) TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A 104: 16645-16650. (Pubitemid 350211070)
21. Lorenz E, Mira J, Frees K, Schwartz D (2002) Relevance of mutations in the TLR4 receptor in patients with Gram negative septic shock. Arch Int Med 162: 1028-1032. (Pubitemid 34492532)
22. Arbour NC, Lorenz E, Schutte B, Zabner J, Kline J, et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25: 187-191. (Pubitemid 30394990)
23. Bhuvanendran S, Hussin HM, Meran LP, Anthony AA, Zhang L, et al. (2011) Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay population in Malaysia. Microbes Infect 13: 844-851.
24. Montes AH, Asensi V, Alvarez V, Valle E, Ocana MG, et al. (2006) The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis. Clin Exp Immunol 143: 404-413.
25. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, et al. (2002) Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347: 185-192. (Pubitemid 34764822)
26. Tulic MK, Hurrelbrink RJ, Prele CM, Laing IA, Upham JW, et al. (2007) TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide. J Immunol 179: 132-140. (Pubitemid 46986527)
27. Rallabhandi P, Bell J, Boukhvalova MS, Medvedev A, Lorenz E, et al. (2006) Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol 177: 322-332. (Pubitemid 43939144)
28. Ohto U, Yamakawa N, Akashi-Takamura S, Miyake K, Shimizu T (2012) Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I. J Biol Chem.
29. Fageras Bottcher M, Hmani-Aifa M, Lindstrom A, Jenmalm MC, Mai XM, et al. (2004) A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. J Allergy Clin Immunol 114: 561-567. (Pubitemid 39194929)
30. Norata GD, Garlaschelli K, Ongari M, Raselli S, Grigore L, et al. (2005) Effect of the Toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPS. J Intern Med 258: 21-27. (Pubitemid 40904929)
31. Guo J, Loke J, Zheng F, Hong F, Yea S, et al. (2009) Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses. Hepatology 49: 960-968.
32. McGettrick AF, O'Neill LA (2010) Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol 22: 20-27.
33. Lundberg A, Wikberg LA, Ilonen J, Vaarala O, Bottcher MF (2008) Lipopolysaccharide-induced immune responses in relation to the TLR4(Asp299Gly) gene polymorphism. Clin Vaccine Immunol 15: 1878-1883.
34. Prohinar P, Rallabhandi P, Weiss JP, Gioannini TL (2010) Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4. J Immunol 184: 4362-4367.
35. Balistreri CR, Caruso C, Listi F, Colonna-Romano G, Lio D, et al. (2011) LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects. Mech Ageing Dev 132: 86-92.
36. Candore G, Aquino A, Balistreri CR, Bulati M, Di Carlo D, et al. (2006) Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4. Ann N Y Acad Sci 1067: 282-287. (Pubitemid 43806335)
37. Senthilselvan A, Dosman JA, Chenard L, Burch LH, Predicala BZ, et al. (2009) Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility. J Allergy Clin Immunol 123: 1034-1040, 1040 e1031-1032.
38. Figueroa L, Xiong Y, Song C, Piao W, Vogel SN, et al. (2012) The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol 188: 4506-4515.
39. Rallabhandi P, Awomoyi A, Thomas KE, Phalipon A, Fujimoto Y, et al. (2008) Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling. J Immunol 180: 1139-1147.
40. Liadaki K, Petinaki E, Skoulakis C, Tsirevelou P, Klapsa D, et al. (2011) Toll-like receptor 4 gene (TLR4), but not TLR2, polymorphisms modify the risk of tonsillar disease due to Streptococcus pyogenes and Haemophilus influenzae. Clin Vaccine Immunol 18: 217-222.