Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility

Journal of Allergy and Clinical Immunology

Volumn 123, Issue 5, 2009, Pages

  Senthilselvan, Ambikaipakan ^a   Dosman, James A ^b   Chénard, Liliane ^b   Burch, Lauranell H ^d   Predicala, Bernardo Z ^e   Sorowski, Randine ^b   Schneberger, David ^b   Hurst, Tom ^f   Kirychuk, Shelley ^b   Gerdts, Volker ^c   Cormier, Yvon ^g   Rennie, Donna C ^b   Schwartz, David A ^h  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e PRAIRIE SWINE CENTRE INC   (Canada)

^f UNIVERSITY OF SASKATCHEWAN   (Canada)

^g UNIVERSITÉ LAVAL   (Canada)

^h DEPARTMENT OF MEDICINE   (United States)

Author keywords

Airway hyperresponsiveness; blood counts; cytokines; endotoxin; gene environment interaction; lung function; swine confinement facility; Toll like receptor 4 variants

Indexed keywords

ENDOTOXIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

ADULT; AIRWAY CONDUCTANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FORCED EXPIRATORY VOLUME; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MALE; PIG FARMING; PRIORITY JOURNAL; RECEPTOR GENE; TLR4 GENE; VITAL CAPACITY; WILD TYPE;

AIR POLLUTANTS, OCCUPATIONAL; ALLERGENS; ANIMALS; CYTOKINES; ENDOTOXINS; FEMALE; HOUSING, ANIMAL; HUMANS; HYPERSENSITIVITY; INHALATION EXPOSURE; LEUKOCYTE COUNT; LUNG; MALE; POLYMORPHISM, GENETIC; SUS SCROFA; TOLL-LIKE RECEPTOR 4; YOUNG ADULT;

EID: 67349282256     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.02.019     Document Type: Article

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