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Volumn 19, Issue 1, 2014, Pages 113-125

Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment

Author keywords

Akt; Embelin; Pancreatic cancer; Sonic hedgehog

Indexed keywords

BENZOQUINONE DERIVATIVE; EMBELIN;

EID: 84898807499     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4198     Document Type: Article
Times cited : (30)

References (42)
  • 1
    • 2342448582 scopus 로고    scopus 로고
    • Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database
    • Z. Nikolovska-Coleska, L. Xu, Z. Hu, Y. Tomita, P. Li, P. P. Roller, R. Wang, X. Fang, R. Guo, M. Zhang, M. E. Lippman, D. Yang and S. Wang: Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem, 47(10), 2430-40 (2004)
    • (2004) J Med Chem , vol.47 , Issue.10 , pp. 2430-2440
    • Nikolovska-Coleska, Z.1    Xu, L.2    Hu, Z.3    Tomita, Y.4    Li, P.5    Roller, P.P.6    Wang, R.7    Fang, X.8    Guo, R.9    Zhang, M.10    Lippman, M.E.11    Yang, D.12    Wang, S.13
  • 2
    • 27844580749 scopus 로고    scopus 로고
    • Embelin derivatives and their anticancer activity through microtubule disassembly
    • M. Xu, J. Cui, H. Fu, P. Proksch, W. Lin and M. Li: Embelin derivatives and their anticancer activity through microtubule disassembly. Planta Med, 71(10), 944-8 (2005)
    • (2005) Planta Med , vol.71 , Issue.10 , pp. 944-948
    • Xu, M.1    Cui, J.2    Fu, H.3    Proksch, P.4    Lin, W.5    Li, M.6
  • 5
    • 84872765772 scopus 로고    scopus 로고
    • Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades
    • S. W. Kim, S. M. Kim, H. Bae, D. Nam, J. H. Lee, S. G. Lee, B. S. Shim, S. H. Kim, K. S. Ahn, S. H. Choi and G. Sethi: Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades. Prostate, 73(3), 296-305 (2013)
    • (2013) Prostate , vol.73 , Issue.3 , pp. 296-305
    • Kim, S.W.1    Kim, S.M.2    Bae, H.3    Nam, D.4    Lee, J.H.5    Lee, S.G.6    Shim, B.S.7    Kim, S.H.8    Ahn, K.S.9    Choi, S.H.10    Sethi, G.11
  • 7
    • 67650080174 scopus 로고    scopus 로고
    • The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP
    • M. D. Siegelin, T. Gaiser and Y. Siegelin: The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP. Neurochem Int, 55(6), 423-30 (2009)
    • (2009) Neurochem Int , vol.55 , Issue.6 , pp. 423-430
    • Siegelin, M.D.1    Gaiser, T.2    Siegelin, Y.3
  • 10
    • 0035409102 scopus 로고    scopus 로고
    • Molecular epidemiology of pancreatic cancer
    • D. Li: Molecular epidemiology of pancreatic cancer. Cancer J, 7(4), 259-65 (2001)
    • (2001) Cancer J , vol.7 , Issue.4 , pp. 259-265
    • Li, D.1
  • 11
    • 0031911012 scopus 로고    scopus 로고
    • Epidemiology of and risk factors for pancreatic cancer
    • E. B. Gold and S. B. Goldin: Epidemiology of and risk factors for pancreatic cancer. Surg Oncol Clin N Am, 7(1), 67-91 (1998)
    • (1998) Surg Oncol Clin N Am , vol.7 , Issue.1 , pp. 67-91
    • Gold, E.B.1    Goldin, S.B.2
  • 14
    • 77950635816 scopus 로고    scopus 로고
    • Pancreatic cancer: Pathobiology, treatment options, and drug delivery
    • J. Li, M. G. Wientjes and J. L. Au: Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J, 12(2), 223-32 (2010)
    • (2010) AAPS J , vol.12 , Issue.2 , pp. 223-232
    • Li, J.1    Wientjes, M.G.2    Au, J.L.3
  • 16
    • 80054105872 scopus 로고    scopus 로고
    • Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy
    • A. L. Kennedy, P. D. Adams and J. P. Morton: Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy. Small GTPases, 2(5), 264-267 (2011)
    • (2011) Small GTPases , vol.2 , Issue.5 , pp. 264-267
    • Kennedy, A.L.1    Adams, P.D.2    Morton, J.P.3
  • 18
    • 79551617718 scopus 로고    scopus 로고
    • Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition
    • S. Shankar, D. Nall, S. N. Tang, D. Meeker, J. Passarini, J. Sharma and R. K. Srivastava: Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One, 6(1), e16530 (2011)
    • (2011) PLoS One , vol.6 , Issue.1
    • Shankar, S.1    Nall, D.2    Tang, S.N.3    Meeker, D.4    Passarini, J.5    Sharma, J.6    Srivastava, R.K.7
  • 19
    • 34548306769 scopus 로고    scopus 로고
    • Patching the gaps in Hedgehog signalling
    • R. Rohatgi and M. P. Scott: Patching the gaps in Hedgehog signalling. Nat Cell Biol, 9(9), 1005-9 (2007)
    • (2007) Nat Cell Biol , vol.9 , Issue.9 , pp. 1005-1009
    • Rohatgi, R.1    Scott, M.P.2
  • 20
    • 0023930186 scopus 로고
    • The GLI gene is a member of the Kruppel family of zinc finger proteins
    • K. W. Kinzler, J. M. Ruppert, S. H. Bigner and B. Vogelstein: The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature, 332(6162), 371-4 (1988)
    • (1988) Nature , vol.332 , Issue.6162 , pp. 371-374
    • Kinzler, K.W.1    Ruppert, J.M.2    Bigner, S.H.3    Vogelstein, B.4
  • 21
    • 41749102898 scopus 로고    scopus 로고
    • Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor
    • S. Shankar, Q. Chen and R. K. Srivastava: Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor. J Mol Signal, 3, 7 (2008)
    • (2008) J Mol Signal , vol.3 , pp. 7
    • Shankar, S.1    Chen, Q.2    Srivastava, R.K.3
  • 22
    • 36448962451 scopus 로고    scopus 로고
    • EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer
    • S. Shankar, S. Ganapathy, S. R. Hingorani and R. K. Srivastava: EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Front Biosci, 13, 440-52 (2008)
    • (2008) Front Biosci , vol.13 , pp. 440-452
    • Shankar, S.1    Ganapathy, S.2    Hingorani, S.R.3    Srivastava, R.K.4
  • 23
    • 84866651554 scopus 로고    scopus 로고
    • A new view of the lethal apoptotic pore
    • G. Basanez, L. Soane and J. M. Hardwick: A new view of the lethal apoptotic pore. PLoS Biol, 10(9), e1001399 (2012)
    • (2012) PLoS Biol , vol.10 , Issue.9
    • Basanez, G.1    Soane, L.2    Hardwick, J.M.3
  • 24
    • 0034525374 scopus 로고    scopus 로고
    • The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability
    • M. H. Harris and C. B. Thompson: The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ, 7(12), 1182-91 (2000)
    • (2000) Cell Death Differ , vol.7 , Issue.12 , pp. 1182-1191
    • Harris, M.H.1    Thompson, C.B.2
  • 25
    • 0033258120 scopus 로고    scopus 로고
    • Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
    • M. G. Vander Heiden and C. B. Thompson: Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol, 1(8), E209-16 (1999)
    • (1999) Nat Cell Biol , vol.1 , Issue.8
    • Vander Heiden, M.G.1    Thompson, C.B.2
  • 26
    • 0345276617 scopus 로고    scopus 로고
    • Apoptosis regulators
    • H. Harada and S. Grant: Apoptosis regulators. Rev Clin Exp Hematol, 7(2), 117-38 (2003)
    • (2003) Rev Clin Exp Hematol , vol.7 , Issue.2 , pp. 117-138
    • Harada, H.1    Grant, S.2
  • 27
    • 1842471880 scopus 로고    scopus 로고
    • Angiogenesis and proteins of the hemostatic system
    • J. Folkman: Angiogenesis and proteins of the hemostatic system. J Thromb Haemost, 1(8), 1681-2 (2003)
    • (2003) J Thromb Haemost , vol.1 , Issue.8 , pp. 1681-1682
    • Folkman, J.1
  • 29
    • 84863707423 scopus 로고    scopus 로고
    • Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment
    • C. Palena, D. H. Hamilton and R. I. Fernando: Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. Future Oncol, 8(6), 713-22 (2012)
    • (2012) Future Oncol , vol.8 , Issue.6 , pp. 713-722
    • Palena, C.1    Hamilton, D.H.2    Fernando, R.I.3
  • 30
    • 79960952144 scopus 로고    scopus 로고
    • IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    • R. I. Fernando, M. D. Castillo, M. Litzinger, D. H. Hamilton and C. Palena: IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res, 71(15), 5296-306 (2011)
    • (2011) Cancer Res , vol.71 , Issue.15 , pp. 5296-5306
    • Fernando, R.I.1    Castillo, M.D.2    Litzinger, M.3    Hamilton, D.H.4    Palena, C.5
  • 31
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • P. S. Steeg: Tumor metastasis: mechanistic insights and clinical challenges. Nat Med, 12(8), 895-904 (2006)
    • (2006) Nat Med , vol.12 , Issue.8 , pp. 895-904
    • Steeg, P.S.1
  • 33
    • 80555145216 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms
    • B. N. Singh, J. Fu, R. K. Srivastava and S. Shankar: Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One, 6(11), e27306 (2011)
    • (2011) PLoS One , vol.6 , Issue.11
    • Singh, B.N.1    Fu, J.2    Srivastava, R.K.3    Shankar, S.4
  • 35
    • 24944564679 scopus 로고    scopus 로고
    • A new mouse model of pancreatic cancer: PTEN gets its Akt together
    • A. Maitra and R. H. Hruban: A new mouse model of pancreatic cancer: PTEN gets its Akt together. Cancer Cell, 8(3), 171-2 (2005)
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 171-172
    • Maitra, A.1    Hruban, R.H.2
  • 37
    • 84871805095 scopus 로고    scopus 로고
    • Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
    • S. H. Li, J. Fu, D. N. Watkins, R. K. Srivastava and S. Shankar: Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. Mol Cell Biochem, 373(1-2), 217-27 (2013)
    • (2013) Mol Cell Biochem , vol.373 , Issue.1-2 , pp. 217-227
    • Li, S.H.1    Fu, J.2    Watkins, D.N.3    Srivastava, R.K.4    Shankar, S.5
  • 38
    • 84867018979 scopus 로고    scopus 로고
    • Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal
    • M. Rodova, J. Fu, D. N. Watkins, R. K. Srivastava and S. Shankar: Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PLoS One, 7(9), e46083 (2012)
    • (2012) PLoS One , vol.7 , Issue.9
    • Rodova, M.1    Fu, J.2    Watkins, D.N.3    Srivastava, R.K.4    Shankar, S.5
  • 39
    • 77955641868 scopus 로고    scopus 로고
    • The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
    • S. N. Tang, C. Singh, D. Nall, D. Meeker, S. Shankar and R. K. Srivastava: The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal, 5, 14 (2010)
    • (2010) J Mol Signal , vol.5 , pp. 14
    • Tang, S.N.1    Singh, C.2    Nall, D.3    Meeker, D.4    Shankar, S.5    Srivastava, R.K.6
  • 40
    • 84872803741 scopus 로고    scopus 로고
    • Hedgehog signaling pathway regulates human pancreatic cancer cell proliferation and metastasis
    • K. Hao, X. D. Tian, C. F. Qin, X. H. Xie and Y. M. Yang: Hedgehog signaling pathway regulates human pancreatic cancer cell proliferation and metastasis. Oncol Rep, 29(3), 1124-32 (2013)
    • (2013) Oncol Rep , vol.29 , Issue.3 , pp. 1124-1132
    • Hao, K.1    Tian, X.D.2    Qin, C.F.3    Xie, X.H.4    Yang, Y.M.5
  • 41
    • 79957794952 scopus 로고    scopus 로고
    • Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells
    • R. K. Srivastava, S. N. Tang, W. Zhu, D. Meeker and S. Shankar: Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells. Front Biosci (Elite Ed), 3, 515-28 (2011)
    • (2011) Front Biosci (Elite Ed) , vol.3 , pp. 515-528
    • Srivastava, R.K.1    Tang, S.N.2    Zhu, W.3    Meeker, D.4    Shankar, S.5
  • 42
    • 84860214416 scopus 로고    scopus 로고
    • Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
    • S. N. Tang, J. Fu, D. Nall, M. Rodova, S. Shankar and R. K. Srivastava: Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics. Int J Cancer, 131(1), 30-40 (2012)
    • (2012) Int J Cancer , vol.131 , Issue.1 , pp. 30-40
    • Tang, S.N.1    Fu, J.2    Nall, D.3    Rodova, M.4    Shankar, S.5    Srivastava, R.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.