Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice

Journal of Hepatology

Volumn 60, Issue 5, 2014, Pages 1046-1054

  Zhu, Li Hua ^a,b   Wang, Aibing ^c   Luo, Pengcheng ^a,d   Wang, Xinan ^a,b   Jiang, Ding Sheng ^a,b   Deng, Wei ^a,b   Zhang, Xiaofei ^b   Wang, Tao ^a,b   Liu, Yi ^b   Gao, Lu ^e   Zhang, Shumin ^a,b   Zhang, Xiaodong ^b   Zhang, Jie ^a,d   Li, Hongliang ^a,b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c HUNAN AGRICULTURAL UNIVERSITY   (China)

^d HUBEI POLYTECHNIC UNIVERSITY   (China)

^e HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Fatty liver; Insulin resistance; PPAR ; Spondin 2

Indexed keywords

MINDIN; MUTANT PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RECOMBINANT PROTEIN; SCLEROPROTEIN;

ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DEFICIENCY; GENE SILENCING; GENETICS; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIPID DIET; LIPID METABOLISM; LIVER; METABOLISM; MOUSE; MOUSE MUTANT; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; DIET, HIGH-FAT; EXTRACELLULAR MATRIX PROTEINS; GENE KNOCKDOWN TECHNIQUES; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; MICE, TRANSGENIC; MUTANT PROTEINS; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; PPAR ALPHA; RECOMBINANT PROTEINS;

EID: 84898828288     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.01.011     Document Type: Article

References (33)

1. M. Roden Mechanisms of disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance Nat Clin Pract Endocrinol Metab 2 2006 335 348
2. M. Narce, J. Bellenger, M. Rialland, and S. Bellenger Recent advances on stearoyl-Coa desaturase regulation in fatty liver diseases Curr Drug Metab 13 2012 1454 1463
3. J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 2004 147 152
4. V.T. Samuel, Z.X. Liu, X. Qu, B.D. Elder, S. Bilz, and D. Befroy et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J Biol Chem 279 2004 32345 32353
5. T. Aoyama, J.M. Peters, N. Iritani, T. Nakajima, K. Furihata, and T. Hashimoto et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha) J Biol Chem 273 1998 5678 5684
6. S. Tyagi, P. Gupta, A.S. Saini, C. Kaushal, and S. Sharma The peroxisome proliferator-activated receptor: a family of nuclear receptors role in various diseases J Adv Pharm Technol Res 2 2011 236 240
7. G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 2006 860 867
8. C.K. Glass, and J.M. Olefsky Inflammation and lipid signaling in the etiology of insulin resistance Cell Metab 15 2012 635 645
9. A.M. Jetten Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism Nucl Recept Signal 7 2009 e003
10. L.A. Solt, and T.P. Burris Action of RORs and their ligands in (patho)physiology Trends Endocrinol Metab 23 2012 619 627
11. K. Tan, M. Duquette, J.H. Liu, J. Lawler, and J.H. Wang The crystal structure of the heparin-binding reelin-N domain of f-spondin J Mol Biol 381 2008 1213 1223
12. Y.W. He, H. Li, J. Zhang, C.L. Hsu, E. Lin, and N. Zhang et al. The extracellular matrix protein Mindin is a pattern-recognition molecule for microbial pathogens Nat Immunol 5 2004 88 97
13. W. Jia, H. Li, and Y.W. He The extracellular matrix protein Mindin serves as an integrin ligand and is critical for inflammatory cell recruitment Blood 106 2005 3854 3859
14. H. Li, T. Oliver, W. Jia, and Y.W. He Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein Mindin EMBO J 25 2006 4097 4107
15. W. Jia, H. Li, and Y.W. He Pattern recognition molecule Mindin promotes intranasal clearance of influenza viruses J Immunol 180 2008 6255 6261
16. Y. Feinstein, V. Borrell, C. Garcia, T. Burstyn-Cohen, V. Tzarfaty, and A. Frumkin et al. F-spondin and Mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons Development 126 1999 3637 3648
17. Y. Feinstein, and A. Klar The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities Int J Biochem Cell Biol 36 2004 975 980
18. R. Parry, D. Schneider, D. Hudson, D. Parkes, J.A. Xuan, and A. Newton et al. Identification of a novel prostate tumor target, Mindin/RG-1, for antibody-based radiotherapy of prostate cancer Cancer Res 65 2005 8397 8405
19. S.E. Shoelson, J. Lee, and A.B. Goldfine Inflammation and insulin resistance J Clin Invest 116 2006 1793 1801
20. N.R. Qi, J. Wang, V. Zidek, V. Landa, P. Mlejnek, and L. Kazdová et al. A new transgenic rat model of hepatic steatosis and the metabolic syndrome Hypertension 45 2005 1004 1011
21. L. Yan, X. Wei, Q.Z. Tang, J. Feng, Y. Zhang, and C. Liu et al. Cardiac-specific Mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling Cardiovasc Res 92 2011 85 94
22. Z.Y. Bian, X. Wei, S. Deng, Q.Z. Tang, J. Feng, and Y. Zhang et al. Disruption of Mindin exacerbates cardiac hypertrophy and fibrosis J Mol Med 90 2012 895 910
23. L. Wang, Y. Lu, X. Zhang, Y. Zhang, D. Jiang, and X. Dong et al. Mindin is a critical mediator of ischemic brain injury in an experimental stroke model Exp Neurol 247 2013 506 516
24. S. Mandard, M. Müller, and S. Kersten Peroxisome proliferator-activated receptor alpha target genes Cell Mol Life Sci 61 2004 393 416
25. P. Lefebvre, G. Chinetti, J.C. Fruchart, and B. Staels Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis J Clin Invest 116 2006 571 580
26. F. Djouadi, C.J. Weinheimer, J.E. Saffitz, C. Pitchford, J. Bastin, and F.J. Gonzalez et al. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice J Clin Invest 102 1998 1083 1091
27. M.A. Abdelmegeed, S.H. Yoo, L.E. Henderson, F.J. Gonzalez, K.J. Woodcroft, and B.J. Song PPARalpha expression protects male mice from high fat-induced non-alcoholic fatty liver J Nutr 141 2011 603 610
28. M. Guerre-Millo, C. Rouault, P. Poulain, J. André, V. Poitout, and J.M. Peters et al. PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance Diabetes 50 2001 2809 2814
29. G. Marchesini, M. Brizi, A.M. Morselli-Labate, G. Bianchi, E. Bugianesi, and A.J. McCullough et al. Association of non-alcoholic fatty liver disease with insulin resistance Am J Med 107 1999 450 455
30. S.H. Koo, H. Satoh, S. Herzig, C.H. Lee, S. Hedrick, and R. Kulkarni et al. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3 Nat Med 10 2004 530 534
31. M.F. Gregor, and G.S. Hotamisligil Inflammatory mechanisms in obesity Annu Rev Immunol 29 2011 415 445
32. R. Stienstra, S. Mandard, D. Patsouris, C. Maass, S. Kersten, and M. Müller Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation Endocrinology 148 2007 2753 2763
33. G. Solinas, and M. Karin JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction FASEB J 24 2010 2596 2611