메뉴 건너뛰기




Volumn 86, Issue 2, 2012, Pages 1001-1009

Polyfunctional t cells accumulate in large human cytomegalovirus-specific t cell responses

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD40 LIGAND; CD45RA ANTIGEN; CYTOMEGALOVIRUS ANTIGEN PP65; GAMMA INTERFERON; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84856822945     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00873-11     Document Type: Article
Times cited : (82)

References (50)
  • 1
    • 67650581553 scopus 로고    scopus 로고
    • Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    • Almeida JR, et al. 2009. Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 113: 6351-6360.
    • (2009) Blood , vol.113 , pp. 6351-6360
    • Almeida, J.R.1
  • 2
    • 55949116720 scopus 로고    scopus 로고
    • Phenotype and function of human T lymphocyte subsets: consensus and issues
    • Appay V, van Lier RA, Sallusto F, Roederer M. 2008. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 73:975-983.
    • (2008) Cytometry A , vol.73 , pp. 975-983
    • Appay, V.1    van Lier, R.A.2    Sallusto, F.3    Roederer, M.4
  • 3
    • 33646686040 scopus 로고    scopus 로고
    • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    • Betts MR, et al. 2006. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107:4781-4789.
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1
  • 4
    • 20244377843 scopus 로고    scopus 로고
    • Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells
    • Bunde T, et al. 2005. Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells. J. Exp. Med. 201:1031-1036.
    • (2005) J. Exp. Med , vol.201 , pp. 1031-1036
    • Bunde, T.1
  • 5
    • 33845875194 scopus 로고    scopus 로고
    • Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
    • Casazza JP, et al. 2006. Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J. Exp. Med. 203:2865-2877.
    • (2006) J. Exp. Med , vol.203 , pp. 2865-2877
    • Casazza, J.P.1
  • 6
    • 2442580881 scopus 로고    scopus 로고
    • Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood
    • Chen SF, et al. 2004. Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. J. Infect. Dis. 189: 1619-1627.
    • (2004) J. Infect. Dis , vol.189 , pp. 1619-1627
    • Chen, S.F.1
  • 7
    • 59249090000 scopus 로고    scopus 로고
    • Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
    • Chidrawar S, et al. 2009. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin. Exp. Immunol. 155:423-432.
    • (2009) Clin. Exp. Immunol , vol.155 , pp. 423-432
    • Chidrawar, S.1
  • 8
    • 58149269499 scopus 로고    scopus 로고
    • Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication
    • Ciuffreda D, et al. 2008. Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication. Eur. J. Immunol. 38:2665-2677.
    • (2008) Eur. J. Immunol , vol.38 , pp. 2665-2677
    • Ciuffreda, D.1
  • 9
    • 34250303350 scopus 로고    scopus 로고
    • Multifunctional TH1 cells define a correlate of vaccinemediated protection against Leishmania major
    • Darrah PA, et al. 2007. Multifunctional TH1 cells define a correlate of vaccinemediated protection against Leishmania major. Nat. Med. 13:843-850.
    • (2007) Nat. Med , vol.13 , pp. 843-850
    • Darrah, P.A.1
  • 10
    • 78049489351 scopus 로고    scopus 로고
    • Hallmark features of immunosenescence are absent in familial longevity
    • Derhovanessian E, et al. 2010. Hallmark features of immunosenescence are absent in familial longevity. J. Immunol. 185:4618-4624.
    • (2010) J. Immunol , vol.185 , pp. 4618-4624
    • Derhovanessian, E.1
  • 11
    • 42249096487 scopus 로고    scopus 로고
    • Polyfunctional T cell responses are a hallmark of HIV-2 infection
    • Duvall MG, et al. 2008. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur. J. Immunol. 38:350-363.
    • (2008) Eur. J. Immunol , vol.38 , pp. 350-363
    • Duvall, M.G.1
  • 12
    • 14944372561 scopus 로고    scopus 로고
    • PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis
    • Elias D, Akuffo H, Britton S. 2005. PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis. Trans. R. Soc. Trop. Med. Hyg. 99:363-368.
    • (2005) Trans. R. Soc. Trop. Med. Hyg , vol.99 , pp. 363-368
    • Elias, D.1    Akuffo, H.2    Britton, S.3
  • 13
    • 0242416961 scopus 로고    scopus 로고
    • Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T cells recognizing CMVpp65 are present but display functional impairment
    • Engstrand M, et al. 2003. Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T cells recognizing CMVpp65 are present but display functional impairment. Clin. Exp. Immunol. 132:96-104.
    • (2003) Clin. Exp. Immunol , vol.132 , pp. 96-104
    • Engstrand, M.1
  • 14
    • 32044433093 scopus 로고    scopus 로고
    • Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly
    • Hadrup SR, et al. 2006. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J. Immunol. 176:2645-2653.
    • (2006) J. Immunol , vol.176 , pp. 2645-2653
    • Hadrup, S.R.1
  • 15
    • 0030691757 scopus 로고    scopus 로고
    • Phenotypic and functional separation of memory and effector human CD8+ T cells
    • Hamann D, et al. 1997. Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 186:1407-1418.
    • (1997) J. Exp. Med , vol.186 , pp. 1407-1418
    • Hamann, D.1
  • 16
    • 1042300031 scopus 로고    scopus 로고
    • Continuous cytomegalovirus seroconversion in a large group of healthy blood donors
    • Hecker M, Qiu D, Marquardt K, Bein G, Hackstein H. 2004. Continuous cytomegalovirus seroconversion in a large group of healthy blood donors. Vox Sang. 86:41-44.
    • (2004) Vox Sang , vol.86 , pp. 41-44
    • Hecker, M.1    Qiu, D.2    Marquardt, K.3    Bein, G.4    Hackstein, H.5
  • 17
    • 34547773111 scopus 로고    scopus 로고
    • Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells
    • Kannanganat S, Ibegbu C, Chennareddi L, Robinson HL, Amara RR. 2007. Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells. J. Virol. 81:8468-8476.
    • (2007) J. Virol , vol.81 , pp. 8468-8476
    • Kannanganat, S.1    Ibegbu, C.2    Chennareddi, L.3    Robinson, H.L.4    Amara, R.R.5
  • 18
    • 0037442113 scopus 로고    scopus 로고
    • Memory inflation: continuous accumulation of antiviral CD8+ T cells over time
    • Karrer U, et al. 2003. Memory inflation: continuous accumulation of antiviral CD8+ T cells over time. J. Immunol. 170:2022-2029.
    • (2003) J. Immunol , vol.170 , pp. 2022-2029
    • Karrer, U.1
  • 19
    • 0037097657 scopus 로고    scopus 로고
    • Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals
    • Kern F, et al. 2002. Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J. Infect. Dis. 185:1709-1716.
    • (2002) J. Infect. Dis , vol.185 , pp. 1709-1716
    • Kern, F.1
  • 20
    • 0034093051 scopus 로고    scopus 로고
    • Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides
    • Kern F, et al. 2000. Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides. Eur. J. Immunol. 30:1676-1682.
    • (2000) Eur. J. Immunol , vol.30 , pp. 1676-1682
    • Kern, F.1
  • 21
    • 33947696311 scopus 로고    scopus 로고
    • T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection
    • Khan N, et al. 2007. T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection. J. Immunol. 178:4455-4465.
    • (2007) J. Immunol , vol.178 , pp. 4455-4465
    • Khan, N.1
  • 22
    • 10344257508 scopus 로고    scopus 로고
    • Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection
    • Khan N, et al. 2004. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J. Immunol. 173:7481-7489.
    • (2004) J. Immunol , vol.173 , pp. 7481-7489
    • Khan, N.1
  • 23
    • 21844461573 scopus 로고    scopus 로고
    • Rapid assessment of recognition efficiency and functional capacity of antigen-specific T-cell responses
    • Kohrt HE, et al. 2005. Rapid assessment of recognition efficiency and functional capacity of antigen-specific T-cell responses. J. Immunother. 28:297-305.
    • (2005) J. Immunother , vol.28 , pp. 297-305
    • Kohrt, H.E.1
  • 24
    • 68149179573 scopus 로고    scopus 로고
    • Immunosenescence: what does it mean to health outcomes in older adults? Curr
    • McElhaney JE, Effros RB. 2009. Immunosenescence: what does it mean to health outcomes in older adults? Curr. Opin. Immunol. 21:418-424.
    • (2009) Opin. Immunol , vol.21 , pp. 418-424
    • McElhaney, J.E.1    Effros, R.B.2
  • 25
    • 34249788420 scopus 로고    scopus 로고
    • Viral interference with antigen presentation does not alter acute or chronic CD8 T cell im-munodominance in murine cytomegalovirus infection
    • Munks MW, Pinto AK, Doom CM, Hill AB. 2007. Viral interference with antigen presentation does not alter acute or chronic CD8 T cell im-munodominance in murine cytomegalovirus infection. J. Immunol. 178: 7235-7241.
    • (2007) J. Immunol , vol.178 , pp. 7235-7241
    • Munks, M.W.1    Pinto, A.K.2    Doom, C.M.3    Hill, A.B.4
  • 27
    • 55949127402 scopus 로고    scopus 로고
    • Polyfunctional cytomegalovirus-specific CD4+ and pp65 CD8+ T cells protect against high-level replication after liver transplantation
    • Nebbia G, et al. 2008. Polyfunctional cytomegalovirus-specific CD4+ and pp65 CD8+ T cells protect against high-level replication after liver transplantation. Am. J. Transplant. 8:2590-2599.
    • (2008) Am. J. Transplant , vol.8 , pp. 2590-2599
    • Nebbia, G.1
  • 28
    • 73449137923 scopus 로고    scopus 로고
    • Polyfunctional T lymphocytes are in the peripheral blood of donors naturally immune to coccidioidomycosis and are not induced by dendritic cells
    • Nesbit L, Johnson SM, Pappagianis D, Ampel NM. 2010. Polyfunctional T lymphocytes are in the peripheral blood of donors naturally immune to coccidioidomycosis and are not induced by dendritic cells. Infect. Immun. 78:309-315.
    • (2010) Infect. Immun , vol.78 , pp. 309-315
    • Nesbit, L.1    Johnson, S.M.2    Pappagianis, D.3    Ampel, N.M.4
  • 29
    • 0042206627 scopus 로고    scopus 로고
    • Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
    • Ouyang Q, et al. 2003. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp. Gerontol. 38:911-920.
    • (2003) Exp. Gerontol , vol.38 , pp. 911-920
    • Ouyang, Q.1
  • 30
    • 0036824696 scopus 로고    scopus 로고
    • Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype? Eur
    • Ouyang Q, Wagner WM, Wikby A, Remarque E, Pawelec G. 2002. Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype? Eur. Cytokine Netw. 13:392-394.
    • (2002) Cytokine Netw , vol.13 , pp. 392-394
    • Ouyang, Q.1    Wagner, W.M.2    Wikby, A.3    Remarque, E.4    Pawelec, G.5
  • 31
    • 0037825764 scopus 로고    scopus 로고
    • Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominantCMVepitope in the very old
    • Ouyang Q, et al. 2003. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominantCMVepitope in the very old. J. Clin. Immunol. 23:247-257.
    • (2003) J. Clin. Immunol , vol.23 , pp. 247-257
    • Ouyang, Q.1
  • 32
    • 1642503829 scopus 로고    scopus 로고
    • Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly
    • Ouyang Q, et al. 2004. Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly. Exp. Gerontol. 39:607-613.
    • (2004) Exp. Gerontol , vol.39 , pp. 607-613
    • Ouyang, Q.1
  • 33
    • 76549107658 scopus 로고    scopus 로고
    • Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors
    • Pita-Lopez ML, et al. 2009. Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors. Immun. Ageing 6:11.
    • (2009) Immun. Ageing , vol.6 , pp. 11
    • Pita-Lopez, M.L.1
  • 34
    • 34447260501 scopus 로고    scopus 로고
    • The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire
    • Pourgheysari B, et al. 2007. The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire. J. Virol. 81:7759-7765.
    • (2007) J. Virol , vol.81 , pp. 7759-7765
    • Pourgheysari, B.1
  • 35
    • 78650596159 scopus 로고    scopus 로고
    • Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire
    • Quigley MF, et al. 2010. Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire. Proc. Natl. Acad. Sci. U. S. A. 107:19414-19419.
    • (2010) Proc. Natl. Acad. Sci. U. S. A , vol.107 , pp. 19414-19419
    • Quigley, M.F.1
  • 36
    • 0033998352 scopus 로고    scopus 로고
    • Development of virus-specific CD4(+) T cells during primary cytomegalovirus infection
    • Rentenaar RJ, et al. 2000. Development of virus-specific CD4(+) T cells during primary cytomegalovirus infection. J. Clin. Invest. 105:541-548.
    • (2000) J. Clin. Invest , vol.105 , pp. 541-548
    • Rentenaar, R.J.1
  • 37
    • 57649235503 scopus 로고    scopus 로고
    • Age-related appearance of a CMV-specific high-avidity CD8+T cell clonotype which does not occur in young adults
    • Schwanninger A, et al. 2008. Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults. Immun. Ageing 5:14.
    • (2008) Immun. Ageing , vol.5 , pp. 14
    • Schwanninger, A.1
  • 38
    • 0041381363 scopus 로고    scopus 로고
    • Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
    • Seder RA, Ahmed R. 2003. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat. Immunol. 4:835-842.
    • (2003) Nat. Immunol , vol.4 , pp. 835-842
    • Seder, R.A.1    Ahmed, R.2
  • 39
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: implications for vaccine design
    • Seder RA, Darrah PA, Roederer M. 2008. T-cell quality in memory and protection: implications for vaccine design. Nat. Rev. Immunol. 8:247-258.
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 40
    • 0036198286 scopus 로고    scopus 로고
    • Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus
    • Sester M, et al. 2002. Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus. J. Virol. 76:3748-3755.
    • (2002) J. Virol , vol.76 , pp. 3748-3755
    • Sester, M.1
  • 41
    • 20544466061 scopus 로고    scopus 로고
    • Differences in CMV-specific T-cell levels and longterm susceptibility to CMV infection after kidney, heart and lung transplantation
    • Sester U, et al. 2005. Differences in CMV-specific T-cell levels and longterm susceptibility to CMV infection after kidney, heart and lung transplantation. Am. J. Transplant. 5:1483-1489.
    • (2005) Am. J. Transplant , vol.5 , pp. 1483-1489
    • Sester, U.1
  • 42
    • 47249101105 scopus 로고    scopus 로고
    • PD-1 expression and IL-2 loss of cytomegalovirusspecific T cells correlates with viremia and reversible functional anergy
    • Sester U, et al. 2008. PD-1 expression and IL-2 loss of cytomegalovirusspecific T cells correlates with viremia and reversible functional anergy. Am. J. Transplant. 8:1486-1497.
    • (2008) Am. J. Transplant , vol.8 , pp. 1486-1497
    • Sester, U.1
  • 43
    • 70349320168 scopus 로고    scopus 로고
    • CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection
    • Snyder CM, et al. 2009. CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection. J. Immunol. 183:3932-3941.
    • (2009) J. Immunol , vol.183 , pp. 3932-3941
    • Snyder, C.M.1
  • 44
    • 77954173564 scopus 로고    scopus 로고
    • CMV-specific T-cell immunity, viral load, and clinical outcome in seropositive renal transplant recipients: a pilot study
    • Sund F, et al. 2010. CMV-specific T-cell immunity, viral load, and clinical outcome in seropositive renal transplant recipients: a pilot study. Clin. Transplant. 24:401-409.
    • (2010) Clin. Transplant , vol.24 , pp. 401-409
    • Sund, F.1
  • 45
    • 24344489044 scopus 로고    scopus 로고
    • Broadly targeted human cytomegalovirusspecific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    • Sylwester AW, et al. 2005. Broadly targeted human cytomegalovirusspecific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 202:673-685.
    • (2005) J. Exp. Med , vol.202 , pp. 673-685
    • Sylwester, A.W.1
  • 46
    • 77957240274 scopus 로고    scopus 로고
    • Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
    • Turner JE, et al. 2010. Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain Behav. Immun. 24:1362-1370.
    • (2010) Brain Behav. Immun , vol.24 , pp. 1362-1370
    • Turner, J.E.1
  • 47
    • 0030002902 scopus 로고    scopus 로고
    • Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
    • Valitutti S, Muller S, Dessing M, Lanzavecchia A. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917-1921.
    • (1996) J. Exp. Med , vol.183 , pp. 1917-1921
    • Valitutti, S.1    Muller, S.2    Dessing, M.3    Lanzavecchia, A.4
  • 48
    • 1842331510 scopus 로고    scopus 로고
    • Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation
    • Valitutti S, Muller S, Salio M, Lanzavecchia A. 1997. Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation. J. Exp. Med. 185:1859-1864.
    • (1997) J. Exp. Med , vol.185 , pp. 1859-1864
    • Valitutti, S.1    Muller, S.2    Salio, M.3    Lanzavecchia, A.4
  • 49
    • 35748936769 scopus 로고    scopus 로고
    • Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects
    • Vescovini R, et al. 2007. Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects. J. Immunol. 179:4283-4291.
    • (2007) J. Immunol , vol.179 , pp. 4283-4291
    • Vescovini, R.1
  • 50
    • 0023124471 scopus 로고
    • Modulation of CD4 by antigenic activation
    • Weyand CM, Goronzy J, Fathman CG. 1987. Modulation of CD4 by antigenic activation. J. Immunol. 138:1351-1354.
    • (1987) J. Immunol. , vol.138 , pp. 1351-1354
    • Weyand, C.M.1    Goronzy, J.2    Fathman, C.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.