Clinical application of ghrelin administration for gastric cancer patients undergoing gastrectomy

Gastric Cancer

Volumn 17, Issue 2, 2014, Pages 200-205

  Takiguchi, Shuji ^a   Takata, Akihiro ^a   Murakami, Kohei ^a   Miyazaki, Yasuhiro ^a   Yanagimoto, Yoshitomo ^a   Kurokawa, Yukinori ^a   Takahashi, Tsuyoshi ^a   Mori, Masaki ^a   Doki, Yuichiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Gastrectomy; Gastric cancer; Ghrelin; Weight loss

Indexed keywords

GHRELIN;

DRUG EFFECTS; GASTRECTOMY; HUMAN; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; STOMACH NEOPLASMS; WEIGHT REDUCTION;

GASTRECTOMY; GHRELIN; HUMANS; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; STOMACH NEOPLASMS; WEIGHT LOSS;

EID: 84898816182     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-013-0300-8     Document Type: Review

References (66)

1. Demas GE, Drazen DL, Nelson RJ. Reductions in total body fat decrease humoral immunity. Proc Biol Sci. 2003;270:905-11. (Pubitemid 36561025)
2. Marinho LA, Rettori O, Vieira-Matos AN. Body weight loss as an indicator of breast cancer recurrence. Acta Oncol. 2001;40:832-7. (Pubitemid 34081663)
3. Tsugane S, Sasaki S, Tsubono Y. Under- and overweight impact on mortality among middle-aged Japanese men and women: a 10-y follow-up of JPHC study cohort I. Int J Obes Relat Metab Disord. 2002;26:529-37. (Pubitemid 34407266)
4. Bae JM, Park JW, Yang HK, Kim JP. Nutritional status of gastric cancer patients after total gastrectomy. World J Surg. 1998;22:254-60.
5. Friess H, Bohm J, Muller MW, et al. Maldigestion after total gastrectomy is associated with pancreatic insufficiency. Am J Gastroenterol. 1996;91:341-7. (Pubitemid 26067346)
6. Melissas J, Kampitakis E, Schoretsanitis G, et al. Does reduction in gastric acid secretion in bariatric surgery increase diet-induced thermogenesis? Obes Surg. 2002;12:236-40. (Pubitemid 34442085)
7. Adachi S, Takeda T, Fukao K. Evaluation of esophageal bile reflux after total gastrectomy by gastrointestinal and hepatobiliary dual scintigraphy. Surg Today. 1999;29:301-6. (Pubitemid 29194210)
8. Armbrecht U, Lundell L, Stockbruegger RW. Nutrient malassimilation after total gastrectomy and possible intervention. Digestion. 1987;37(Suppl 1):56-60. (Pubitemid 17096241)
9. Iesato H, Ohya T, Ohwada S, et al. Jejunal pouch interposition with an antiperistaltic conduit as a pyloric ring substitute after standard distal gastrectomy: a comparison with the use of an isoperistaltic conduit. Hepatogastroenterology. 2000;47:756-60. (Pubitemid 30417289)
10. Bergh C, Sjostedt S, Hellers G, et al. Meal size, satiety and cholecystokinin in gastrectomized humans. Physiol Behav. 2003;78:143-7. (Pubitemid 36110563)
11. Braga M, Zuliani W, Foppa L, et al. Food intake and nutritional status after total gastrectomy: results of a nutritional follow-up. Br J Surg. 1988;75:477-80.
12. Fein M, Fuchs KH, Thalheimer A, et al. Long-term benefits of Roux-en-Y pouch reconstruction after total gastrectomy: a randomized trial. Ann Surg. 2008;247:759-65. (Pubitemid 351591510)
13. Liedman B. Symptoms after total gastrectomy on food intake, body composition, bone metabolism, and quality of life in gastric cancer patients-is reconstruction with a reservoir worthwhile? Nutrition. 1999;15:677-82. (Pubitemid 29385562)
14. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656-60. (Pubitemid 129516334)
15. Date Y, Kojima M, Hosoda H, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000;141:4255-61.
16. Leite-Moreira AF, Soares JB. Physiological, pathological and potential therapeutic roles of ghrelin. Drug Discov Today. 2007;12:276-88. (Pubitemid 46467484)
17. Shintani M, Ogawa Y, Ebihara K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes. 2001;50: 227-32. (Pubitemid 32127276)
18. Masuda Y, Tanaka T, Inomata N, et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun. 2000;276:905-8.
19. Davies JS, Kotokorpi P, Eccles SR, et al. Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol. 2009;23:914-24.
20. Wu R, Dong W, Zhou M, et al. Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Am J Respir Crit Care Med. 2007;176:805-13. (Pubitemid 47598482)
21. Yang J, Brown MS, Liang G, et al. Identification of the acyl-transferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008;132:387-96. (Pubitemid 351192001)
22. Gutierrez JA, Solenberg PJ, Perkins DR, et al. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA. 2008;105:6320-5. (Pubitemid 351758344)
23. Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and desacyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun. 2000;279:909-13. (Pubitemid 32042875)
24. Neary NM, Small CJ, Wren AM, et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab. 2004;89:2832-6. (Pubitemid 38766373)
25. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86:5992.
26. Nagaya N, Moriya J, Yasumura Y, et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation. 2004;110:3674-9. (Pubitemid 39665256)
27. Nagaya N, Itoh T, Murakami S, et al. Treatment of cachexia with ghrelin in patients with COPD. Chest. 2005;128:1187-93. (Pubitemid 41324394)
28. Strasser F, Lutz TA, Maeder MT, et al. Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, doubleblind, double-crossover study. Br J Cancer. 2008;98:300-8. (Pubitemid 351161246)
29. Hiura Y, Takiguchi S, Yamamoto K, et al. Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study. Cancer. 2012;118:4785-94.
30. Karamanakos SN, Vagenas K, Kalfarentzos F, Alexandrides TK. Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study. Ann Surg. 2008;247:401-7.
31. Jeon TY, Lee S, Kim HH, et al. Long-term changes in gut hormones, appetite and food intake 1 year after subtotal gastrectomy with normal body weight. Eur J Clin Nutr. 2010;64:826-31.
32. Jeon TY, Lee S, Kim HH, et al. Changes in plasma ghrelin concentration immediately after gastrectomy in patients with early gastric cancer. J Clin Endocrinol Metab. 2004;89:5392-6. (Pubitemid 39518414)
33. Kamiji MM, Troncon LE, Suen VM, de Oliveira RB. Gastrointestinal transit, appetite, and energy balance in gastrectomized patients. Am J Clin Nutr. 2009;89:231-9.
34. Kim S, Lee JH, Heo JS, et al. Serum obestatin/ghrelin ratio is altered in patients after distal gastrectomy. Dig Surg. 2009;26:143-8.
35. Takachi K, Doki Y, Ishikawa O, et al. Postoperative ghrelin levels and delayed recovery from body weight loss after distal or total gastrectomy. J Surg Res. 2006;130:1-7. (Pubitemid 43028556)
36. Wang HT, Lu QC, Wang Q, et al. Role of the duodenum in regulation of plasma ghrelin levels and body mass index after subtotal gastrectomy. World J Gastroenterol. 2008;14:2425-9. (Pubitemid 351877618)
37. Zub-Pokrowiecka A, Rembiasz K, Konturek PC, et al. Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy. World J Gastroenterol. 2011;17:449-58.
38. Langer FB, Reza Hoda MA, Bohdjalian A, et al. Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg. 2005;15:1024-9. (Pubitemid 41116888)
39. Teive MB, Russi RF, Vieira DS, et al. Quantitative immunohistochemical analysis of duodenal ghrelin cells after sleeve gastrectomy in Wistar rats. Acta Cir Bras. 2012;27:595-9.
40. Hosoda H, Kangawa K. The autonomic nervous system regulates gastric ghrelin secretion in rats. Regul Pept. 2008;146:12-8.
41. Doki Y, Takachi K, Ishikawa O, et al. Ghrelin reduction after esophageal substitution and its correlation to postoperative body weight loss in esophageal cancer patients. Surgery. 2006;139:797-805. (Pubitemid 43902916)
42. Yamamoto K, Takiguchi S, Miyata H, et al. Reduced plasma ghrelin levels on day 1 after esophagectomy: a new predictor of prolonged systemic inflammatory response syndrome. Surg Today. 2013;43:48-54.
43. Pekic S, Pesko P, Djurovic M, et al. Plasma ghrelin levels of gastrectomized and vagotomized patients are not affected by glucose administration. Clin Endocrinol (Oxf). 2006;64:684-8. (Pubitemid 43775008)
44. Takeno R, Okimura Y, Iguchi G, et al. Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects. Eur J Endocrinol. 2004;151:447-50. (Pubitemid 39430261)
45. le Roux CW, Neary NM, Halsey TJ, et al. Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrinol Metab. 2005;90:4521-4. (Pubitemid 41159336)
46. Arnold M, Mura A, Langhans W, Geary N. Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci. 2006;26:11052-60. (Pubitemid 44772195)
47. Adachi S, Takiguchi S, Okada K, et al. Effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study. Gastroenterology. 2010;138:1312-20.
48. Yamamoto K, Takiguchi S, Miyata H, et al. Randomized phase II study of clinical effects of ghrelin after esophagectomy with gastric tube reconstruction. Surgery. 2010;148:31-8.
49. Takiguchi S, Hiura Y, Takahashi T, et al. Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy. Gastric Cancer. 2012;. doi:10.1007/s10120-012-0164-3 (Epub 2012/08/17 PubMed PMID: 22895614).
50. Yeh AH, Jeffery PL, Duncan RP, et al. Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer. Clin Cancer Res. 2005;11:8295-303. (Pubitemid 41746940)
51. Duxbury MS, Waseem T, Ito H, et al. Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun. 2003;309:464-8. (Pubitemid 37025913)
52. Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest. 2006;29:781-90. (Pubitemid 44869422)
53. Jeffery PL, Murray RE, Yeh AH, et al. Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines. Endocr Relat Cancer. 2005;12:839-50. (Pubitemid 41815779)
54. Mottershead M, Karteris E, Barclay JY, et al. Immunohistochemical and quantitative mRNA assessment of ghrelin expression in gastric and oesophageal adenocarcinoma. J Clin Pathol. 2007;60:405-9. (Pubitemid 46596560)
55. Garin MC, Burns CM, Kaul S, Cappola AR. The human experience with ghrelin administration. J Clin Endocrinol Metab. 2013;98:1826-37.
56. Murphy G, Kamangar F, Dawsey SM, et al. The relationship between serum ghrelin and the risk of gastric and esophagogastric junctional adenocarcinomas. J Natl Cancer Inst. 2011;103:1123-9.
57. Murphy G, Kamangar F, Albanes D, et al. Serum ghrelin is inversely associated with risk of subsequent oesophageal squamous cell carcinoma. Gut. 2012;61:1533-7.
58. Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, et al. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology. 2004;145:2607-12. (Pubitemid 38686204)
59. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes. 2001;50:2438-43. (Pubitemid 33642759)
60. Gibney J, Healy ML, Sonksen PH. The growth hormone/insulin-like growth factor-I axis in exercise and sport. Endocr Rev. 2007;28:603-24. (Pubitemid 47610444)
61. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE Jr, Clasey JL, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149:601-11.
62. Velloso CP. Regulation of muscle mass by growth hormone and IGF-I. Br J Pharmacol. 2008;154:557-68. (Pubitemid 351744951)
63. Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation. 2004;109:2221-6. (Pubitemid 38625400)
64. Waseem T, Duxbury M, Ito H, Ashley SW, Robinson MK. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery. 2008;143:334-42.
65. Delhanty PJ, van der Lely AJ. Ghrelin and glucose homeostasis. Peptides. 2011;32:2309-18.
66. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25:426-57. (Pubitemid 38780667)