메뉴 건너뛰기




Volumn 176, Issue 8, 2007, Pages 805-813

Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats

Author keywords

Cytokine; Nuclear factor B; Peptide

Indexed keywords

CYTOKINE; GHRELIN; GHRELIN RECEPTOR ANTAGONIST; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROSPHERE; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

EID: 35348960888     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200604-511OC     Document Type: Article
Times cited : (190)

References (51)
  • 2
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-1310.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 3
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-1349.
    • (2000) N Engl J Med , vol.342 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 4
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-150.
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 8
    • 0029787027 scopus 로고    scopus 로고
    • Nuclear factor-κB is activated in alveolar macrophages from patients with acute respiratory distress syndrome
    • Schwartz MD, Moore EE, Moore FA, Shenkar R, Moine P, Haenel JB, Abraham E. Nuclear factor-κB is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med 1996;24:1285-1292.
    • (1996) Crit Care Med , vol.24 , pp. 1285-1292
    • Schwartz, M.D.1    Moore, E.E.2    Moore, F.A.3    Shenkar, R.4    Moine, P.5    Haenel, J.B.6    Abraham, E.7
  • 10
    • 0038132126 scopus 로고    scopus 로고
    • Early alterations in neutrophil activation are associated with outcome in acute lung injury
    • Yang KY, Arcaroli JJ, Abraham E. Early alterations in neutrophil activation are associated with outcome in acute lung injury. Am J Respir Crit Care Med 2003;167:1567-1574.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1567-1574
    • Yang, K.Y.1    Arcaroli, J.J.2    Abraham, E.3
  • 11
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 13
    • 2542453815 scopus 로고    scopus 로고
    • Ghrelin: Satisfying a hunger for the mechanism
    • Cowley MA, Grove KL. Ghrelin: satisfying a hunger for the mechanism. Endocrinology 2004;145:2604-2606.
    • (2004) Endocrinology , vol.145 , pp. 2604-2606
    • Cowley, M.A.1    Grove, K.L.2
  • 14
    • 1642354552 scopus 로고    scopus 로고
    • Ghrelin: Integrative neuroendocrine peptide in health and disease
    • Wu JT, Kral JG. Ghrelin: integrative neuroendocrine peptide in health and disease. Ann Surg 2004;239:464-474.
    • (2004) Ann Surg , vol.239 , pp. 464-474
    • Wu, J.T.1    Kral, J.G.2
  • 16
    • 4143111272 scopus 로고    scopus 로고
    • Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
    • Wu R, Zhou M, Cui X, Simms HH, Wang P. Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. Am J Physiol Heart Circ Physiol 2004;287:H1296-H1302.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Wu, R.1    Zhou, M.2    Cui, X.3    Simms, H.H.4    Wang, P.5
  • 17
    • 26444572289 scopus 로고    scopus 로고
    • Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1
    • Wu R, Dong W, Zhou M, Cui X, Hank SH, Wang P. Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1. Cardiovasc Res 2005;68:318-326.
    • (2005) Cardiovasc Res , vol.68 , pp. 318-326
    • Wu, R.1    Dong, W.2    Zhou, M.3    Cui, X.4    Hank, S.H.5    Wang, P.6
  • 20
    • 0035964986 scopus 로고    scopus 로고
    • The role of lipopolysaccharide in stimulating adrenomedullin production during polymicrobial sepsis
    • Yang S, Zhou M, Chaudry IH, Wang P. The role of lipopolysaccharide in stimulating adrenomedullin production during polymicrobial sepsis. Biochim Biophys Acta 2001;1537:167-174.
    • (2001) Biochim Biophys Acta , vol.1537 , pp. 167-174
    • Yang, S.1    Zhou, M.2    Chaudry, I.H.3    Wang, P.4
  • 21
    • 0020322373 scopus 로고
    • Structural alterations of lung parenchyma in the adult respiratory distress syndrome
    • Bachofen M, Weibel ER. Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med 1982;3:35-56.
    • (1982) Clin Chest Med , vol.3 , pp. 35-56
    • Bachofen, M.1    Weibel, E.R.2
  • 22
    • 2442487903 scopus 로고    scopus 로고
    • Differential expression of cytochrome P450 isoforms in the lungs of septic animals
    • Cui X, Wu R, Zhou M, Simms HH, Wang P. Differential expression of cytochrome P450 isoforms in the lungs of septic animals. Crit Care Med 2004;32:1186-1191.
    • (2004) Crit Care Med , vol.32 , pp. 1186-1191
    • Cui, X.1    Wu, R.2    Zhou, M.3    Simms, H.H.4    Wang, P.5
  • 23
    • 8444227751 scopus 로고    scopus 로고
    • Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro
    • Saeed RW, Varma S, Peng T, Tracey KJ, Sherry B, Metz CN. Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. J Immunol 2004;173:6376-6383.
    • (2004) J Immunol , vol.173 , pp. 6376-6383
    • Saeed, R.W.1    Varma, S.2    Peng, T.3    Tracey, K.J.4    Sherry, B.5    Metz, C.N.6
  • 25
  • 27
    • 0034841199 scopus 로고    scopus 로고
    • GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils
    • Hattori N, Saito T, Yagyu T, Jiang BH, Kitagawa K, Inagaki CGH. GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab 2001;86:4284-4291.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4284-4291
    • Hattori, N.1    Saito, T.2    Yagyu, T.3    Jiang, B.H.4    Kitagawa, K.5    Inagaki, C.G.H.6
  • 29
    • 0034741715 scopus 로고    scopus 로고
    • 9]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: Up-regulation of receptors with athersclerosis
    • 9]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis. Br J Pharmacol 2001;134:143-149.
    • (2001) Br J Pharmacol , vol.134 , pp. 143-149
    • Katugampola, S.D.1    Pallikaros, Z.2    Davenport, A.P.3
  • 32
    • 3242725318 scopus 로고    scopus 로고
    • Ghrelin clearance is reduced at the late stage of polymicrobial sepsis
    • Wu R, Zhou M, Cui X, Simms HH, Wang P. Ghrelin clearance is reduced at the late stage of polymicrobial sepsis. Int J Mol Med 2003;12:777-781.
    • (2003) Int J Mol Med , vol.12 , pp. 777-781
    • Wu, R.1    Zhou, M.2    Cui, X.3    Simms, H.H.4    Wang, P.5
  • 33
    • 1142299409 scopus 로고    scopus 로고
    • Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    • Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004;202:145-156.
    • (2004) J Pathol , vol.202 , pp. 145-156
    • Bhatia, M.1    Moochhala, S.2
  • 35
    • 0025916516 scopus 로고
    • Interleukin-6 and its relation to the humoral immune response and clinical parameters in burned patients
    • Nijsten MWN, Hack CE, Helle M, Ten Duis HJ, Klasen HJ, Aarden LA. Interleukin-6 and its relation to the humoral immune response and clinical parameters in burned patients. Surgery 1991;109:761-767.
    • (1991) Surgery , vol.109 , pp. 761-767
    • Nijsten, M.W.N.1    Hack, C.E.2    Helle, M.3    Ten Duis, H.J.4    Klasen, H.J.5    Aarden, L.A.6
  • 37
    • 0036595292 scopus 로고    scopus 로고
    • Six at six: Interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days
    • Remick DG, Bolgos GR, Siddiqui J, Shin J, Nemzek JA. Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days. Shock 2002;17:463-467.
    • (2002) Shock , vol.17 , pp. 463-467
    • Remick, D.G.1    Bolgos, G.R.2    Siddiqui, J.3    Shin, J.4    Nemzek, J.A.5
  • 38
    • 0028860550 scopus 로고
    • Inflammatory cytokines in the BAL of patients with ARDS: Persistent elevation over time predicts poor outcome
    • Meduri GU, Kohler G, Headley S, Tolley E, Stentz F, Postlethwaite A. Inflammatory cytokines in the BAL of patients with ARDS: persistent elevation over time predicts poor outcome. Chest 1995;108:1303-1314.
    • (1995) Chest , vol.108 , pp. 1303-1314
    • Meduri, G.U.1    Kohler, G.2    Headley, S.3    Tolley, E.4    Stentz, F.5    Postlethwaite, A.6
  • 41
    • 0026576815 scopus 로고
    • Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation
    • Wang P, Ba ZF, Ayala A, Chaudry IH. Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation. J Trauma 1992;32:389-397.
    • (1992) J Trauma , vol.32 , pp. 389-397
    • Wang, P.1    Ba, Z.F.2    Ayala, A.3    Chaudry, I.H.4
  • 42
    • 0031183766 scopus 로고    scopus 로고
    • The role of nuclear factor-κB in cytokine gene regulation
    • Blackwell TS, Christman JW. The role of nuclear factor-κB in cytokine gene regulation. Am J Respir Cell Mol Biol 1997;17:3-9.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 3-9
    • Blackwell, T.S.1    Christman, J.W.2
  • 43
    • 0025260779 scopus 로고
    • Regulation of tumor necrosis factor alpha transcription in macrophages: Involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB
    • Collart MA, Baeuerle P, Vassalli P. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol Cell Biol 1990;10:1498-1506.
    • (1990) Mol Cell Biol , vol.10 , pp. 1498-1506
    • Collart, M.A.1    Baeuerle, P.2    Vassalli, P.3
  • 46
    • 0029597434 scopus 로고
    • NF-βB is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment
    • Manning AM, Bell FP, Rosenbloom CL, Chosay JG, Simmons CA, Northrup JL, Shebuski RJ, Dunn CJ, Anderson DC. NF-βB is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment. J Inflamm 1995;45:283-296.
    • (1995) J Inflamm , vol.45 , pp. 283-296
    • Manning, A.M.1    Bell, F.P.2    Rosenbloom, C.L.3    Chosay, J.G.4    Simmons, C.A.5    Northrup, J.L.6    Shebuski, R.J.7    Dunn, C.J.8    Anderson, D.C.9
  • 47
    • 34247640178 scopus 로고    scopus 로고
    • Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve
    • Wu R, Dong W, Cui X, Zhou M, Simms HH, Ravikumar TS, Wang P. Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve. Ann Surg 2007;245:480-486.
    • (2007) Ann Surg , vol.245 , pp. 480-486
    • Wu, R.1    Dong, W.2    Cui, X.3    Zhou, M.4    Simms, H.H.5    Ravikumar, T.S.6    Wang, P.7
  • 48
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • Tracey KJ. The inflammatory reflex. Nature 2002;420:853-859.
    • (2002) Nature , vol.420 , pp. 853-859
    • Tracey, K.J.1
  • 50
    • 33846817498 scopus 로고    scopus 로고
    • Physiology and immunology of the cholinergic antiinflammatory pathway
    • Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest 2007;117:289-296.
    • (2007) J Clin Invest , vol.117 , pp. 289-296
    • Tracey, K.J.1
  • 51
    • 2342620868 scopus 로고    scopus 로고
    • Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats
    • Lin Y, Matsumura K, Fukuhara M, Kagiyama S, Fujii K, Iida M. Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension 2004;43:977-982.
    • (2004) Hypertension , vol.43 , pp. 977-982
    • Lin, Y.1    Matsumura, K.2    Fukuhara, M.3    Kagiyama, S.4    Fujii, K.5    Iida, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.