A microdevice for parallelized pulmonary permeability studies

Biomedical Microdevices

Volumn 16, Issue 2, 2014, Pages 277-285

  Bol, Ludivine ^a,b   Galas, Jean Christophe ^c   Hillaireau, Hervé ^a,b   Le Potier, Isabelle ^a,b   Nicolas, Valérie ^a,d   Haghiri Gosnet, Anne Marie ^c   Fattal, Elias ^a,b   Taverna, Myriam ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIV PARIS SUD   (France)

^c UNIV PARIS SUD   (France)

^d IPSIT   (France)

Author keywords

Calu 3 cells; Cell culture microdevice; High throughput; Permeability assays; Pulmonary epithelial barrier; Transwell

Indexed keywords

CELL CULTURE; PETROLEUM RESERVOIR ENGINEERING; SUGAR (SUCROSE);

AIR LIQUID INTERFACES; DRUG PERMEABILITIES; ELECTRICAL RESISTANCES; EPITHELIAL BARRIER; HIGH-THROUGHPUT; MICRO-DEVICE; PULMONARY ADMINISTRATIONS; TRANSWELL;

CELLS;

SUCROSE; SWEETENING AGENT;

CELL LINE; CULTURE TECHNIQUE; CYTOLOGY; DEVICES; HUMAN; IMPEDANCE; LUNG GAS EXCHANGE; METABOLISM; MICROFLUIDIC ANALYSIS; PERMEABILITY; PROCEDURES;

BLOOD-AIR BARRIER; CELL CULTURE TECHNIQUES; CELL LINE; ELECTRIC IMPEDANCE; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; PERMEABILITY; SUCROSE; SWEETENING AGENTS;

EID: 84898814912     PISSN: 13872176     EISSN: 15728781     Source Type: Journal    
DOI: 10.1007/s10544-013-9831-3     Document Type: Article

References (44)

1. R.U. Agu, M.I. Ugwoke, M. Armand et al., The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir. Res. 2, 198-209 (2001)
2. L. Baginski, F. Tewes, S.T. Buckley et al., Investigations into the fate of inhaled salmon calcitonin at the respiratory epithelial barrier. Pharm. Res. 29, 332-341 (2012)
3. R. Baudoin, L. Griscom, M. Monge et al., Development of a renal microchip for in vitro distal tubule models. Biotechnol. Prog. 23, 1245-1253 (2007)
4. R. Booth, H. Kim, Characterization of amicrofluidic in vitro model of the blood-brain barrier (μBBB). Lab Chip 12, 1784-1792 (2012)
5. E.M.M. Del Valle, M.A. Galan, R.G. Carbonell, Drug delivery technologies: the way forward in the new decade. Ind. Eng. Chem. Res. 48, 2475-2486 (2009)
6. N.J. Douville, P. Zamankhan, Y.-C. Tung et al., Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model. Lab Chip 11, 609-619 (2011)
7. C. Ehrhardt, J. Fiegel, S. Fuchs et al., Drug absorption by the respiratory mucosa: cell culture models and particulate drug carriers. J. Aerosol Med. 15, 131-139 (2002)
8. M. Felder, P. Sallin, L. Barbe et al., Microfluidic wound-healing assay to assess the regenerative effect of HGF on wounded alveolar epithelium. Lab Chip 12, 640-646 (2012)
9. J. Fiegel, C. Ehrhardt, U.F. Schaefer et al., Large porous particle impingement on lung epithelial cell monolayers-toward improved particle characterization in the lung. Pharm. Res. 20, 788-796 (2003)
10. B.I. Florea, M.L. Cassara, H.E. Junginger et al., Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. J. Control. Release 87, 131-138 (2003)
11. B.I. Florea, M. Thanou, H.E. Junginger et al., Enhancement of bronchial octreotide absorption by chitosan and N-trimethyl chitosan shows linear in vitro /in vivo correlation. J. Control. Release 110, 353-361 (2006)
12. B. Forbes, Human airway epithelial cell lines for in vitro drug transport and metabolism studies. Pharm. Sci. Technol. Today 3, 18-27 (2000)
13. K.A. Foster, M.L. Avery, M. Yazdanian et al., Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery. Int. J. Pharm. 208, 1-11 (2000)
14. D. Gao, H. Liu, J.M. Lin et al., Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device. Lab Chip 13, 978-985 (2013)
15. R.W. Godfrey, Human airway epithelial tight junctions. Microsc. Res. Tech. 38, 488-499 (1997)
16. C.I. Grainger, L.L. Greenwell, D.J. Lockley et al., Culture of calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. Pharm. Res. 23, 1482-1490 (2006)
17. M. Haghi, P.M. Young, D. Traini et al., Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. Drug Dev. Ind. Pharm. 36, 1207-1214 (2010)
18. D. Huh, H. Fujioka, Y.C. Tung et al., Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proc. Natl. Acad. Sci. 104, 18886-18891 (2007)
19. D. Huh, B.D. Matthews, A. Mammoto et al., Reconstituting organ-level lung functions on a chip. Science 328, 1662-1668 (2010)
20. Y. Imura, Y. Asano, K. Sato et al., A microfluidic system to evaluate intestinal absorption. Anal. Sci. Int. J. Jpn. Soc. Anal. Chem. 25, 1403-1407 (2009)
21. H. Kimura, T. Yamamoto, H. Sakai et al., An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models. Lab Chip 8, 741 (2008)
22. A. Lewis, F. Jordan, L. Illum, CriticalSorb™: enabling systemic delivery of macromolecules via the nasal route. Drug Deliv. Transl. Res. 3, 26-32 (2013)
23. N.R. Mathias, J. Timoszyk, P.I. Stetsko et al., Permeability characteristics of calu-3 human bronchial epithelial cells: in vitro -in vivo correlation to predict lung absorption in rats. J. Drug Target. 10, 31-40 (2002)
24. L. Müller, M. Riediker, P. Wick et al., Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cellmonocultures and an advanced three-dimensionalmodel of the human epithelial airways. J. R. Soc. Interface. 7, 27-41 (2010)
25. S.Mura, H.Hillaireau, J. Nicolas et al., Biodegradable nanoparticles meet the bronchial airway barrier: how surface properties affect their interaction with mucus and epithelial cells. Biomacromolecules 12, 4136-4143 (2011a)
26. S. Mura, H. Hillaireau, J. Nicolas et al., Influence of surface charge on the potential toxicity of PLGA nanoparticules towards Calu-3 cells. Int. J. Nanomedicine 6, 2591-2605 (2011b)
27. D.D. Nalayanda, Q. Wang, W.B. Fulton et al., Engineering an artificial alveolar-capillary membrane: a novel continuously perfused model within microchannels. J. Pediatr. Surg. 45, 45-51 (2010)
28. J.S. Patton,Mechanisms of macromolecule absorption by the lungs. Adv. Drug Deliv. Rev. 19, 3-36 (1996)
29. J.S. Patton, C.S. Fishburn, J.G. Weers, The lungs as a portal of entry for systemic drug delivery. Proc. Am. Thorac. Soc. 1, 338-344 (2004)
30. I. Pezron, R. Mitra, D. Pal et al., Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3). J. Pharm. Sci. 91, 1135-1146 (2002)
31. B. Prabhakarpandian, M.-C. Shen, J.B. Nichols et al., SyM-BBB: a microfluidic blood brain barrier model. Lab Chip 13, 1093-1101 (2012)
32. B.M. Rothen-Rutishauser, S.G. Kiama, P. Gehr, A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am. J. Respir. Cell Mol. Biol. 32, 281-289 (2005)
33. J. Shao, L.Wu, J.Wu et al.,Amicrofluidic chip for permeability assays of endothelial monolayer. Biomed. Microdevices 12, 81-88 (2010)
34. A. Stentebjerg-Andersen, I.V. Notlevsen, B. Brodin et al., Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances. Eur. J. Pharm. Biopharm. 78, 19-26 (2011)
35. H. Tavana, P. Zamankhan, P.J. Christensen et al., Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model. Biomed. Microdevices 13, 731-742 (2011)
36. D. Teijeiro-Osorio, C. Remuñán-López, M.J. Alonso, Chitosan/ cyclodextrin nanoparticles can efficiently transfect the airway epithelium in vitro . Eur. J. Pharm. Biopharm. 71, 257-263 (2009)
37. R. Tréhin,U.Krauss, A.G. Beck-Sickinger et al., Cellular uptake but Low permeation of human calcitonin-derived cell penetrating peptides and tat(47-57) through well-differentiated epithelialmodels. Pharm. Res. 21, 1248-1256 (2004)
38. D. Vllasaliu, R. Fowler, M. Garnett et al., Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison. Biochem. Biophys. Res. Commun. 415, 579-585 (2011)
39. D. Vllasaliu, C. Alexander, M. Garnett et al., Fc-mediated transport of nanoparticles across airway epithelial cell layers. J. Control. Release 158, 479-486 (2012)
40. S. Wang, M.S.S. Chow, Z. Zuo, An approach for rapid development of nasal delivery of analgesics-Identification of relevant features, in vitro screening and in vivo verification. Int. J. Pharm. 420, 43-50 (2011)
41. M.-H. Wu, S.B. Huang, G.-B. Lee, Microfluidic cell culture systems for drug research. Lab Chip 10, 939-956 (2010)
42. L.Y. Yeo, H.C. Chang, P.P.Y. Chan et al., Microfluidic devices for bioapplications. Small 7, 12-48 (2011)
43. J. Yeon, D. Na, K. Choi et al., Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures. Biomed. Microdevices 14, 1-8 (2012)
44. E.W.K. Young, M.W.L.Watson, S. Srigunapalan, Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Anal. Chem. 82, 808-816 (2010)