How useful are clinical liver function tests in in vitro human hepatotoxicity assays?

Toxicology in Vitro

Volumn 28, Issue 5, 2014, Pages 784-795

  Borlak, Jürgen ^a   Chougule, Anil ^a   Singh, Prafull Kumar ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Aminotransferases; Ammonia detoxification; Drug induced liver injury; Hepatotoxicity testing; Human hepatocyte cultures; Urea

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; AMINO ACID; AMIODARONE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; PARACETAMOL; RIFAMPICIN; SUCCINATE DEHYDROGENASE; UREA; ALBUMINOID; PLANT EXTRACT;

AMINO ACID METABOLISM; ARTICLE; CELL VIABILITY; CYTOLYSIS; DETOXIFICATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER CELL DAMAGE; LIVER FUNCTION TEST; LIVER TOXICITY; METABOLIC STRESS; PREDICTION; TOXIC HEPATITIS; BIOASSAY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; HEPG2 CELL LINE; METABOLISM; PETASITES; TOXICITY;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ALBUMINS; ALKALINE PHOSPHATASE; AMIODARONE; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL ASSAY; DRUG-INDUCED LIVER INJURY; GAMMA-GLUTAMYLTRANSFERASE; HEP G2 CELLS; HEPATOCYTES; HUMANS; L-LACTATE DEHYDROGENASE; LIVER FUNCTION TESTS; PETASITES; PLANT EXTRACTS; RIFAMPIN; UREA;

EID: 84898785535     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.03.006     Document Type: Article

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