Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety

Toxicological Sciences

Volumn 112, Issue 2, 2009, Pages 507-520

  Anderson, Nora ^a   Meier, Tatjana ^a   Borlak, Jürgen ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Hepatotoxicity; Human and rat hepatocyte cultures; Petasin; Petasites hybridus extract; Rat in vivo organisation for economic co operation and development guideline study; Toxicogenomics

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ALBUMIN; ANDROSTENEDIONE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILIRUBIN; CYTOCHROME P450; GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE DEHYDROGENASE; LACTATE DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PETASITES HYBRIDUS EXTRACT; TESTOSTERONE; UREA; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GLUCOSE METABOLISM; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM; LIVER CELL; LIVER CELL CULTURE; LIVER TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MIGRAINE; NONHUMAN; OXIDATIVE STRESS; PETASITES; PETASITES HYBRIDUS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTOSTERONE SYNTHESIS; TOXICITY TESTING; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHEMISTRY; DNA MICROARRAY; DRUG EFFECT; GENOMICS; HEPATOBILIARY SYSTEM; LIVER; METABOLISM; WISTAR RAT;

PETASITES; PETASITES HYBRIDUS; RATTUS;

ANIMALS; BILIARY TRACT; BLOTTING, WESTERN; CELLS, CULTURED; ENERGY METABOLISM; FEMALE; GENOMICS; HEPATOCYTES; HUMANS; LIPID METABOLISM; LIVER; MALE; MIGRAINE DISORDERS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PETASITES; PLANT EXTRACTS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 74949127361     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp216     Document Type: Article

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