Study of cholesterol metabolism in Huntington′s disease

Biochemical and Biophysical Research Communications

Volumn 446, Issue 3, 2014, Pages 697-701

  Leoni, Valerio ^a   Caccia, Claudio ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

Biomarker; Lipids; Mass spectrometry; Neurodegeneration; Oxysterols

Indexed keywords

CHOLESTEROL; HUNTINGTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LANOSTEROL; LATHOSTEROL; MYELIN BASIC PROTEIN; OXYSTEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN;

BIOSYNTHESIS; BRAIN ATROPHY; BRAIN CORTEX; BRAIN MATURATION; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CORPUS STRIATUM; DISEASE COURSE; GENE EXPRESSION; HUMAN; HUNTINGTON CHOREA; LIPID METABOLISM; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REVIEW; UPREGULATION;

BIOMARKER; LIPIDS; MASS SPECTROMETRY; NEURODEGENERATION; OXYSTEROLS;

ANIMALS; BRAIN; CHOLESTEROL; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTON DISEASE; HYDROXYCHOLESTEROLS; MICE; MUTATION; NERVE TISSUE PROTEINS;

EID: 84898776283     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.188     Document Type: Review

References (30)

1. A.R. Koudinov, and N.V. Koudinova Cholesterol homeostasis failure as a unifying cause of synaptic degeneration J. Neurol. Sci. 229-230 2005 233 240
2. F.W. Pfrieger, and N. Ungerer Cholesterol metabolism in neurons and astrocytes Prog. Lipid Res. 50 2011 357 371
3. J.M. Dietschy, and S.D. Turley Thematic review series, brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal J. Lipid Res. 45 2004 1375 1397
4. N.R. Matthan, M. Raeini-Sarjaz, and A.H. Lichtenstein et al. Deuterium uptake and plasma cholesterol precursor levels correspond as methods for measurement of endogenous cholesterol synthesis in hypercholesterolemic women Lipids 35 2000 1037 1044
5. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131
6. G. Bu Apolipoprotein E and its receptors in Alzheimer's disease, pathways, pathogenesis and therapy Nat. Rev. Neurosci. 10 2009 333 344
7. I. Björkhem, A. Cedazo-Minguez, and V. Leoni et al. Oxysterols and neurodegenerative diseases Mol. Aspects Med. 30 2009 171 179
8. K. Abildayeva, P.J. Jansen, and V. Hirsch-Reinshagen et al. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux J. Biol. Chem. 281 2006 12799 12808
9. T. Tsunemi, and A.R. La Spada PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond Prog. Neurobiol. 97 2012 142 151
10. E.H. Aylward Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease Brain Res. Bull. 72 2007 152 158
11. J.M. Gil, and A.C. Rego Mechanisms of neurodegeneration in Huntington's disease Eur. J. Neurosci. 27 2008 2803 2820
12. M. Valenza, D. Rigamonti, and D. Goffredo et al. Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease J. Neurosci. 25 2005 9932 9939
13. M. Valenza, V. Leoni, A. Tarditi, C. Mariotti, I. Bjorkhem, S. Di Donato, and E. Cattaneo Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease Neurobiol. Dis. 28 2007 133 142
14. M. Valenza, V. Leoni, and J.M. Karasinska et al. Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes J. Neurosci. 30 2010 10844 10850
15. M. Valenza, J.B. Carroll, and V. Leoni et al. Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation Hum. Mol. Genet. 16 2007 2187 2198
16. J.J. Ritch, A. Valencia, and J. Alexander et al. Multiple phenotypes in Huntington disease mouse neural stem cells Mol. Cell Neurosci. 50 2012 70 81
17. M. Marullo, M. Valenza, and V. Leoni et al. Pitfalls in the detection of cholesterol in Huntington's disease models PLoS Curr. 4 2012 10.1371/505886e9a1968 e505886e9a1968
18. Z. Xiang, M. Valenza, L. Cui, V. Leoni, H.K. Jeong, E. Brilli, J. Zhang, Q. Peng, W. Duan, S.A. Reeves, E. Cattaneo, and D. Krainc Peroxisome- proliferator-activated receptor gamma coactivator 1 á contributes to dysmyelination in experimental models of Huntington's disease J. Neurosci. 31 2011 9544 9553
19. M. Valenza, and E. Cattaneo Emerging roles for cholesterol in Huntington's disease Trends Neurosci. 34 2011 474 486
20. J.M. Karasinska, and M.R. Hayden Cholesterol metabolism in Huntington disease Nat. Rev. Neurol. 7 2011 561 572 Review
21. T.C. Leone, J.J. Lehman, and B.N. Finck et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis PloS Biol. 3 2005 e101
22. M. Futter, H. Schoenmakers, and O. Sadiq et al. Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors J. Med. Genet. 46 2009 438 446
23. E. Trushina, R.D. Singh, R.B. Dyer, S. Cao, V.H. Shah, R.G. Parton, R.E. Pagano, and C.T. McMurray Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo Hum. Mol. Genet. 15 2006 3578 3591
24. D. del Toro, X. Xifró, and A. Pol et al. Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease J. Neurochem. 115 2010 153 167
25. M. Markianos, M. Panas, and N. Kalfakis et al. Low plasma total cholesterol in patients with Huntington's disease and first-degree relatives Mol. Genet. Metab. 93 2008 341 346
26. V. Leoni, C. Mariotti, and L. Nanetti et al. Whole body cholesterol metabolism is impaired in Huntington's disease Neurosci. Lett. 494 2011 245 249
27. V. Leoni, C. Mariotti, and S.J. Tabrizi et al. Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease Brain 131 2008 2851 2859
28. V. Leoni, J.D. Long, and J.A. Mills et al. Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression Neurobiol. Dis. 55 2013 37 43
29. V. Leoni, and C. Caccia 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases Biochimie 95 2013 595 612
30. G. Lupattelli, S. De Vuono, and E. Mandarino Patterns of cholesterol metabolism: pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome Nutr. Metab. Cardiovasc. Dis. 21 2011 620 627