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Volumn 1561, Issue , 2014, Pages 23-34

Minocycline mitigates motor impairments and cortical neuronal loss induced by focal ischemia in rats chronically exposed to ethanol during adolescence

Author keywords

Adolescence; Cerebral ischemia; Ethanol; Minocycline; Motor Cortex; Motor deficits; Neuroinflammation

Indexed keywords

ALCOHOL; ENDOTHELIN 1; MINOCYCLINE; SODIUM CHLORIDE; WATER; CENTRAL DEPRESSANT AGENT; NEUROPROTECTIVE AGENT;

EID: 84898770844     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.03.005     Document Type: Article
Times cited : (43)

References (68)
  • 3
    • 79958844606 scopus 로고    scopus 로고
    • Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain
    • S. Alfonso-Loeches, and C. Guerri Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain Crit. Rev. Clin. Lab. Sci. 48 2011 19 47
    • (2011) Crit. Rev. Clin. Lab. Sci. , vol.48 , pp. 19-47
    • Alfonso-Loeches, S.1    Guerri, C.2
  • 5
    • 36048943866 scopus 로고    scopus 로고
    • Ethanol intake enhances inflammatory mediators in brain: Role of glial cells and TLR4/IL-1RI receptors
    • A.M. Blanco, and C. Guerri Ethanol intake enhances inflammatory mediators in brain: role of glial cells and TLR4/IL-1RI receptors Front. Biosci. 12 2007 2616 2630
    • (2007) Front. Biosci. , vol.12 , pp. 2616-2630
    • Blanco, A.M.1    Guerri, C.2
  • 6
    • 33644948465 scopus 로고    scopus 로고
    • The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress
    • P. Blandino Jr., C.J. Barnum, and T. Deak The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress J. Neuroimmunol. 173 2006 87 95
    • (2006) J. Neuroimmunol. , vol.173 , pp. 87-95
    • Blandino Jr., P.1    Barnum, C.J.2    Deak, T.3
  • 7
    • 70349142541 scopus 로고    scopus 로고
    • Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress
    • P. Blandino Jr., C.J. Barnum, L.G. Solomon, Y. Larish, B.S. Lankow, and T. Deak Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress Brain Behav. Immun. 23 2009 958 968
    • (2009) Brain Behav. Immun. , vol.23 , pp. 958-968
    • Blandino Jr., P.1    Barnum, C.J.2    Solomon, L.G.3    Larish, Y.4    Lankow, B.S.5    Deak, T.6
  • 8
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • M.L. Block, L. Zecca, and J.S. Hong Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat. Rev. Neurosci. 8 2007 57 69
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 9
    • 0026567697 scopus 로고
    • Epidemiology of stroke
    • R. Bonita Epidemiology of stroke Lancet 339 1992 342 344
    • (1992) Lancet , vol.339 , pp. 342-344
    • Bonita, R.1
  • 10
    • 84873270095 scopus 로고    scopus 로고
    • Microglia play a role in ethanol-induced oxidative stress and apoptosis in developing hypothalamic neurons
    • N.I. Boyadjieva, and D.K. Sarkar Microglia play a role in ethanol-induced oxidative stress and apoptosis in developing hypothalamic neurons Alcohol Clin. Exp. Res. 37 2013 252 262
    • (2013) Alcohol Clin. Exp. Res. , vol.37 , pp. 252-262
    • Boyadjieva, N.I.1    Sarkar, D.K.2
  • 11
    • 0036260089 scopus 로고    scopus 로고
    • Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis
    • V. Brundula, N.B. Rewcastle, L.M. Metz, C.C. Bernard, and V.W. Yong Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis Brain 125 2002 1297 1308
    • (2002) Brain , vol.125 , pp. 1297-1308
    • Brundula, V.1    Rewcastle, N.B.2    Metz, L.M.3    Bernard, C.C.4    Yong, V.W.5
  • 12
    • 84872911901 scopus 로고    scopus 로고
    • Minocycline treatment and bone marrow mononuclear cell transplantation after endothelin-1 induced striatal ischemia
    • M.M. Cardoso, E.C. Franco, C.C. de Souza, M.C. da Silva, A. Gouveia, and W. Gomes-Leal Minocycline treatment and bone marrow mononuclear cell transplantation after endothelin-1 induced striatal ischemia Inflammation 36 2013 197 205
    • (2013) Inflammation , vol.36 , pp. 197-205
    • Cardoso, M.M.1    Franco, E.C.2    De Souza, C.C.3    Da Silva, M.C.4    Gouveia, A.5    Gomes-Leal, W.6
  • 14
    • 84860146607 scopus 로고    scopus 로고
    • Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury
    • S. Casha, D. Zygun, M.D. McGowan, I. Bains, V.W. Yong, and R.J. Hurlbert Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury Brain 135 2012 1224 1236
    • (2012) Brain , vol.135 , pp. 1224-1236
    • Casha, S.1    Zygun, D.2    McGowan, M.D.3    Bains, I.4    Yong, V.W.5    Hurlbert, R.J.6
  • 15
    • 0038149645 scopus 로고    scopus 로고
    • Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability
    • R.A. Chambers, J.R. Taylor, and M.N. Potenza Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability Am. J. Psychiatry 160 2003 1041 1052
    • (2003) Am. J. Psychiatry , vol.160 , pp. 1041-1052
    • Chambers, R.A.1    Taylor, J.R.2    Potenza, M.N.3
  • 21
    • 70449732755 scopus 로고    scopus 로고
    • Critical role of TLR4 response in the activation of microglia induced by ethanol
    • S. Fernandez-Lizarbe, M. Pascual, and C. Guerri Critical role of TLR4 response in the activation of microglia induced by ethanol J. Immunol. 183 2009 4733 4744
    • (2009) J. Immunol. , vol.183 , pp. 4733-4744
    • Fernandez-Lizarbe, S.1    Pascual, M.2    Guerri, C.3
  • 22
    • 84860335451 scopus 로고    scopus 로고
    • Modulation of microglial activation enhances neuroprotection and functional recovery derived from bone marrow mononuclear cell transplantation after cortical ischemia
    • E.C. Franco, M.M. Cardoso, A. Gouvêia, A. Pereira, and W. Gomes-Leal Modulation of microglial activation enhances neuroprotection and functional recovery derived from bone marrow mononuclear cell transplantation after cortical ischemia Neurosci. Res. 73 2012 122 132
    • (2012) Neurosci. Res. , vol.73 , pp. 122-132
    • Franco, E.C.1    Cardoso, M.M.2    Gouvêia, A.3    Pereira, A.4    Gomes-Leal, W.5
  • 23
    • 24944454194 scopus 로고    scopus 로고
    • Stroke units, tissue plasminogen activator, aspirin and neuroprotection: Which stroke intervention could provide the greatest community benefit?
    • A.K. Gilligan, A.G. Thrift, J.W. Sturm, H.M. Dewey, R.A. Macdonell, and G.A. Donnan Stroke units, tissue plasminogen activator, aspirin and neuroprotection: which stroke intervention could provide the greatest community benefit? Cerebrovasc. Dis. 20 2005 239 244
    • (2005) Cerebrovasc. Dis. , vol.20 , pp. 239-244
    • Gilligan, A.K.1    Thrift, A.G.2    Sturm, J.W.3    Dewey, H.M.4    Macdonell, R.A.5    Donnan, G.A.6
  • 25
    • 29044451027 scopus 로고    scopus 로고
    • Systematic analysis of axonal damage and inflammatory response in different white matter tracts of acutely injured rat spinal cord
    • W. Gomes-Leal, D.J. Corkill, and C.W. Picanço-Diniz Systematic analysis of axonal damage and inflammatory response in different white matter tracts of acutely injured rat spinal cord Brain Res. 1066 2005 57 70
    • (2005) Brain Res. , vol.1066 , pp. 57-70
    • Gomes-Leal, W.1    Corkill, D.J.2    Picanço-Diniz, C.W.3
  • 26
    • 84880089425 scopus 로고    scopus 로고
    • Microglial physiopathology: How to explain the dual role of microglia after acute neural disorders?
    • W. Gomes-Leal Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders? Brain Behav. 2 2012 345 356
    • (2012) Brain Behav. , vol.2 , pp. 345-356
    • Gomes-Leal, W.1
  • 28
  • 30
    • 41249088005 scopus 로고    scopus 로고
    • Delayed treatment with minocycline ameliorates neurologic impairment through activated micróglia expressing a high-mobility group box1-inhibiting mechanism
    • K. Hayakawa, K. Mishima, M. Nozako, M. Hazekawa, S. Mishima, M. Fujioka, K. Orito, N. Egashira, K. Iwasaki, and M. Fujiwara Delayed treatment with minocycline ameliorates neurologic impairment through activated micróglia expressing a high-mobility group box1-inhibiting mechanism Stroke 39 2008 951 958
    • (2008) Stroke , vol.39 , pp. 951-958
    • Hayakawa, K.1    Mishima, K.2    Nozako, M.3    Hazekawa, M.4    Mishima, S.5    Fujioka, M.6    Orito, K.7    Egashira, N.8    Iwasaki, K.9    Fujiwara, M.10
  • 31
    • 41349093774 scopus 로고    scopus 로고
    • Increased MCP-1 and microglia in various regions of the human alcoholic brain
    • J. He, and F.T. Crews Increased MCP-1 and microglia in various regions of the human alcoholic brain Exp. Neurol. 210 2008 349 358
    • (2008) Exp. Neurol. , vol.210 , pp. 349-358
    • He, J.1    Crews, F.T.2
  • 32
    • 20344375241 scopus 로고    scopus 로고
    • Huntington's disease and minocycline
    • A.K. Hodl, and R.M. Bonelli Huntington's disease and minocycline Mov. Disord. 20 2005 510 511
    • (2005) Mov. Disord. , vol.20 , pp. 510-511
    • Hodl, A.K.1    Bonelli, R.M.2
  • 33
    • 77952972556 scopus 로고    scopus 로고
    • Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: A twelve-week follow-up study
    • S. Homsi, T. Piaggio, N. Croci, F. Noble, M. Plotkine, C. Marchand-Leroux, and M. Jafarian-Tehrani Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study J. Neurotrauma 27 2010 911 921
    • (2010) J. Neurotrauma , vol.27 , pp. 911-921
    • Homsi, S.1    Piaggio, T.2    Croci, N.3    Noble, F.4    Plotkine, M.5    Marchand-Leroux, C.6    Jafarian-Tehrani, M.7
  • 35
    • 85172620239 scopus 로고    scopus 로고
    • II Levantamento Nacional de Àlcool e Drogas (LENAD). (accessed 01.08.13)
    • Instituto Nacional de Ciência e Tecnologia para Políticas Públicas de Àlcool e outras Drogas (INPAD), 2013. II Levantamento Nacional de Àlcool e Drogas (LENAD). 〈http://inpad.org.br/wp- content/uploads/2013/04/LENAD-PressRelease-Alcohol-RVW.pdf〉 (accessed 01.08.13).
    • (2013)
  • 36
    • 2142771205 scopus 로고    scopus 로고
    • Alcohol consumption and risk of stroke among middle-aged men: The JPHC Study Cohort I
    • H. Iso, S. Baba, T. Mannami, S. Sasaki, K. Okada, M. Konishi, and S. Tsugane Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I Stroke 35 2004 1124 1129
    • (2004) Stroke , vol.35 , pp. 1124-1129
    • Iso, H.1    Baba, S.2    Mannami, T.3    Sasaki, S.4    Okada, K.5    Konishi, M.6    Tsugane, S.7
  • 38
    • 77954177287 scopus 로고    scopus 로고
    • Stroke incidence is decreasing in whites but not in blacks: A population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati/Northern Kentucky Stroke Study
    • D.O. Kleindorfer, J. Khoury, C.J. Moomaw, K. Alwell, D. Woo, M.L. Flaherty, P. Khatri, O. Adeoye, S. Ferioli, J.P. Broderick, and B.M. Kissela Stroke incidence is decreasing in whites but not in blacks: a population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati/Northern Kentucky Stroke Study Stroke 41 2010 1326 1331
    • (2010) Stroke , vol.41 , pp. 1326-1331
    • Kleindorfer, D.O.1    Khoury, J.2    Moomaw, C.J.3    Alwell, K.4    Woo, D.5    Flaherty, M.L.6    Khatri, P.7    Adeoye, O.8    Ferioli, S.9    Broderick, J.P.10    Kissela, B.M.11
  • 39
    • 23244453399 scopus 로고    scopus 로고
    • Antioxidant properties of minocycline: Neuroprotection in an oxidative stress assay and direct radical-scavenging activity
    • R.L. Kraus, R. Pasieczny, K. Lariosa-Willingham, M.S. Turner, A. Jiang, and J.W. Trauger Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity J. Neurochem. 94 2005 819 827
    • (2005) J. Neurochem. , vol.94 , pp. 819-827
    • Kraus, R.L.1    Pasieczny, R.2    Lariosa-Willingham, K.3    Turner, M.S.4    Jiang, A.5    Trauger, J.W.6
  • 40
    • 33847785649 scopus 로고    scopus 로고
    • Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    • M. Lalancette-Hebert, G. Gowing, A. Simard, Y.C. Weng, and J. Kriz Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain J. Neurosci. 27 2007 2596 2605
    • (2007) J. Neurosci. , vol.27 , pp. 2596-2605
    • Lalancette-Hebert, M.1    Gowing, G.2    Simard, A.3    Weng, Y.C.4    Kriz, J.5
  • 42
    • 84874513844 scopus 로고    scopus 로고
    • Adolescent alcohol exposure alters the rat adult hypothalamic-pituitary- adrenal axis responsiveness in a sex-specific manner
    • M.L. Logrip, C. Rivier, C. Lau, S. Im, J. Vaughan, and S. Lee Adolescent alcohol exposure alters the rat adult hypothalamic-pituitary-adrenal axis responsiveness in a sex-specific manner Neuroscience 235 2013 174 186
    • (2013) Neuroscience , vol.235 , pp. 174-186
    • Logrip, M.L.1    Rivier, C.2    Lau, C.3    Im, S.4    Vaughan, J.5    Lee, S.6
  • 44
    • 0035103190 scopus 로고    scopus 로고
    • Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat
    • S.E. Maier, and J.R. West Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat Alcohol 23 2001 49 57
    • (2001) Alcohol , vol.23 , pp. 49-57
    • Maier, S.E.1    West, J.R.2
  • 45
    • 84858601163 scopus 로고    scopus 로고
    • Risk factors for stroke
    • M. Mandić, and N. Rancić Risk factors for stroke Med. Pregl. 64 2011 600 605
    • (2011) Med. Pregl. , vol.64 , pp. 600-605
    • Mandić, M.1    Rancić, N.2
  • 47
    • 77955487488 scopus 로고    scopus 로고
    • The science of stroke: Mechanisms in search of treatments
    • M.A. Moskowitz, E.H. Lo, and C. Iadecola The science of stroke: mechanisms in search of treatments Neuron 67 2010 181 198
    • (2010) Neuron , vol.67 , pp. 181-198
    • Moskowitz, M.A.1    Lo, E.H.2    Iadecola, C.3
  • 48
  • 50
    • 44949248404 scopus 로고    scopus 로고
    • Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: A new mechanism of CNS immune privilege
    • J. Neumann, S. Sauerzweig, R. Rönicke, F. Gunzer, K. Dinkel, O. Ullrich, M. Gunzer, and K.G. Reymann Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege J. Neurosci. 28 2008 5965 5975
    • (2008) J. Neurosci. , vol.28 , pp. 5965-5975
    • Neumann, J.1    Sauerzweig, S.2    Rönicke, R.3    Gunzer, F.4    Dinkel, K.5    Ullrich, O.6    Gunzer, M.7    Reymann, K.G.8
  • 52
    • 34249787628 scopus 로고    scopus 로고
    • Etiologic subtypes of ischemic stroke in young adults aged 18 to 45 years: A study of a series of 93 patients
    • M.M. Otero Palleiro, and L.C. Barbagelata López Etiologic subtypes of ischemic stroke in young adults aged 18 to 45 years: a study of a series of 93 patients Rev. Clin. Esp. 207 2007 158 165
    • (2007) Rev. Clin. Esp. , vol.207 , pp. 158-165
    • Otero Palleiro, M.M.1    Barbagelata López, L.C.2
  • 54
    • 84862255818 scopus 로고    scopus 로고
    • Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration
    • L. Qin, and F.T. Crews Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration J. Neuroinflamm. 9 2012 130
    • (2012) J. Neuroinflamm. , vol.9 , pp. 130
    • Qin, L.1    Crews, F.T.2
  • 55
    • 84855570853 scopus 로고    scopus 로고
    • NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
    • L. Qin, and F.T. Crews NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration J. Neuroinflamm. 9 2012 5
    • (2012) J. Neuroinflamm. , vol.9 , pp. 5
    • Qin, L.1    Crews, F.T.2
  • 56
    • 34247229202 scopus 로고    scopus 로고
    • What we drink when we drink? The role of the acetaldehyde in the alcohol consumption
    • C. Sanchis, and C.M. Aragón What we drink when we drink? The role of the acetaldehyde in the alcohol consumption Adicciones 19 2007 5 11
    • (2007) Adicciones , vol.19 , pp. 5-11
    • Sanchis, C.1    Aragón, C.M.2
  • 57
    • 0032821690 scopus 로고    scopus 로고
    • Acute inflammatory responses to mechanical lesions in the CNS: Difference between brain and spinal cord
    • L. Schnell, S. Fearn, H. Klasse, M.E. Schwab, and H. Perry Acute inflammatory responses to mechanical lesions in the CNS: difference between brain and spinal cord Eur. J. Neurosci. 11 1999 3648 3658
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 3648-3658
    • Schnell, L.1    Fearn, S.2    Klasse, H.3    Schwab, M.E.4    Perry, H.5
  • 58
    • 59249097875 scopus 로고    scopus 로고
    • Alcohol-use disorders
    • M.A. Schuckit Alcohol-use disorders Lancet 373 2009 492 501
    • (2009) Lancet , vol.373 , pp. 492-501
    • Schuckit, M.A.1
  • 60
    • 70349260133 scopus 로고    scopus 로고
    • Neurobehavioral impairments, generation of oxidative stress and release of pro-apoptotic factors after chronic exposure to sulphur mustard in mouse brain
    • D.J. Sharma, A. Sunkaria, A. Bal, Y.D. Bhutia, R. Vijayaraghavan, S.J.S. Flora, and K.D. Gill Neurobehavioral impairments, generation of oxidative stress and release of pro-apoptotic factors after chronic exposure to sulphur mustard in mouse brain Toxicol. Appl. Pharmacol. 240 2009 208 218
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 208-218
    • Sharma, D.J.1    Sunkaria, A.2    Bal, A.3    Bhutia, Y.D.4    Vijayaraghavan, R.5    Flora, S.J.S.6    Gill, K.D.7
  • 61
    • 3042799770 scopus 로고    scopus 로고
    • Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal models
    • C.J. Slawecki, A. Thorsell, and C.L. Ehlers Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal models Ann. NY Acad. Sci. 1021 2004 448 452
    • (2004) Ann. NY Acad. Sci. , vol.1021 , pp. 448-452
    • Slawecki, C.J.1    Thorsell, A.2    Ehlers, C.L.3
  • 62
    • 1442326012 scopus 로고    scopus 로고
    • Minocycline: Neuroprotective mechanisms in Parkinson's disease
    • M. Thomas, and W.D. Le Minocycline: neuroprotective mechanisms in Parkinson's disease Curr. Pharm. Des. 10 2004 679 686
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 679-686
    • Thomas, M.1    Le, W.D.2
  • 63
    • 3042715836 scopus 로고    scopus 로고
    • Hippocampal function during adolescence: A unique target of ethanol
    • A.M. White, and H.S. Swartzwelder Hippocampal function during adolescence: a unique target of ethanol Ann. NY Acad. Sci. 1021 2004 206 220
    • (2004) Ann. NY Acad. Sci. , vol.1021 , pp. 206-220
    • White, A.M.1    Swartzwelder, H.S.2
  • 66
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • J. Yrjanheikki, T. Tikka, R. Keinanen, G. Goldsteins, P.H. Chan, and J. Koistinaho A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Proc. Natl. Acad. Sci. USA 96 1999 13496 13500
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 67
    • 84867085950 scopus 로고    scopus 로고
    • Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure
    • Y.N. Zhao, F. Wang, Y.X. Fan, G.F. Ping, J.Y. Yang, and C.F. Wu Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure Behav. Brain Res. 236 2012 270 282
    • (2012) Behav. Brain Res. , vol.236 , pp. 270-282
    • Zhao, Y.N.1    Wang, F.2    Fan, Y.X.3    Ping, G.F.4    Yang, J.Y.5    Wu, C.F.6
  • 68
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • S. Zhu, I. Stavrovskaya, M. Drozda, B. Kim, V. Ona, and M. Li Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice Nature 417 2002 74 78 Nível Superior
    • (2002) Nature , vol.417 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.2    Drozda, M.3    Kim, B.4    Ona, V.5    Li, M.6


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