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Volumn 37, Issue 2, 2013, Pages 252-262

Microglia Play a Role in Ethanol-Induced Oxidative Stress and Apoptosis in Developing Hypothalamic Neurons

Author keywords

Fetal Alcohol; Hypothalamus; Microglia; Neuronal Apoptosis; Oxidative Stress

Indexed keywords

ALCOHOL; CATALASE; GLUTATHIONE PEROXIDASE; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

EID: 84873270095     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01889.x     Document Type: Article
Times cited : (59)

References (50)
  • 2
    • 0029024582 scopus 로고
    • Effect of prenatal ethanol and stress on levels of beta-endorphin in different brain regions of the rat
    • Baker RA, Shoemaker WJ (1995) Effect of prenatal ethanol and stress on levels of beta-endorphin in different brain regions of the rat. Alcohol Clin Exp Res 19:727-734.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 727-734
    • Baker, R.A.1    Shoemaker, W.J.2
  • 3
    • 79952275879 scopus 로고    scopus 로고
    • Galanin and consummatory behavior: special relationship with dietary fat, alcohol and circulating lipids
    • Barson JR, Morganstern I, Leibowitz SF (2010) Galanin and consummatory behavior: special relationship with dietary fat, alcohol and circulating lipids. EXS 102:87-111.
    • (2010) EXS , vol.102 , pp. 87-111
    • Barson, J.R.1    Morganstern, I.2    Leibowitz, S.F.3
  • 6
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 7
    • 64549149000 scopus 로고    scopus 로고
    • Beta-endorphin neuronal cell transplant reduces corticotropin releasing hormone hyperresponse to lipopolysaccharide and eliminates natural killer cell functional deficiencies in fetal alcohol exposed rats
    • Boyadjieva NI, Ortigüela M, Arjona A, Cheng X, Sarkar DK (2009) Beta-endorphin neuronal cell transplant reduces corticotropin releasing hormone hyperresponse to lipopolysaccharide and eliminates natural killer cell functional deficiencies in fetal alcohol exposed rats. Alcohol Clin Exp Res 33:931-937.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 931-937
    • Boyadjieva, N.I.1    Ortigüela, M.2    Arjona, A.3    Cheng, X.4    Sarkar, D.K.5
  • 8
    • 78049256367 scopus 로고    scopus 로고
    • Role of microglia in ethanol's apoptotic action on hypothalamic neuronal cells in primary cultures
    • Boyadjieva NI, Sarkar DK (2010) Role of microglia in ethanol's apoptotic action on hypothalamic neuronal cells in primary cultures. Alcohol Clin Exp Res 34:1835-1842.
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. 1835-1842
    • Boyadjieva, N.I.1    Sarkar, D.K.2
  • 9
    • 77955085839 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration and mechanisms of microglial killing of neurons
    • Brown GC, Neher JJ (2010) Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 41:242-247.
    • (2010) Mol Neurobiol , vol.41 , pp. 242-247
    • Brown, G.C.1    Neher, J.J.2
  • 10
    • 0004046754 scopus 로고    scopus 로고
    • An Introduction to Neuroendocrinology
    • Cambridge University Press, New York, NY.
    • Brown RE (1998) An Introduction to Neuroendocrinology, pp 41-43. Cambridge University Press, New York, NY.
    • (1998) , pp. 41-43
    • Brown, R.E.1
  • 11
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK (1992) Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149:2736-2741.
    • (1992) J Immunol , vol.149 , pp. 2736-2741
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Shaskan, E.G.4    Peterson, P.K.5
  • 12
    • 33646097212 scopus 로고    scopus 로고
    • Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus
    • Chen CP, Kuhn P, Advis JP, Sarkar DK (2006) Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. J Neurochem 97:1026-1033.
    • (2006) J Neurochem , vol.97 , pp. 1026-1033
    • Chen, C.P.1    Kuhn, P.2    Advis, J.P.3    Sarkar, D.K.4
  • 14
    • 0037221722 scopus 로고    scopus 로고
    • Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans
    • Cohen-Kerem R, Koren G (2003) Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans. Neurotoxicol Teratol 25:1-9.
    • (2003) Neurotoxicol Teratol , vol.25 , pp. 1-9
    • Cohen-Kerem, R.1    Koren, G.2
  • 15
    • 0023642584 scopus 로고
    • Production of superoxide anions by a CNS macrophage, the microglia
    • Colton CA, Gilbert DL (1987) Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 223:284-288.
    • (1987) FEBS Lett , vol.223 , pp. 284-288
    • Colton, C.A.1    Gilbert, D.L.2
  • 16
    • 0033080919 scopus 로고    scopus 로고
    • Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
    • Combs CK, Johnson DE, Cannady SB, Lehman TM, Landreth GE (1999) Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci 19:928-939.
    • (1999) J Neurosci , vol.19 , pp. 928-939
    • Combs, C.K.1    Johnson, D.E.2    Cannady, S.B.3    Lehman, T.M.4    Landreth, G.E.5
  • 17
    • 0027993025 scopus 로고
    • Cyclic AMP and ethanol interact to control apoptosis and differentiation in hypothalamic beta-endorphin neurons
    • De A, Boyadjieva NI, Pastorcic M, Reddy BV, Sarkar DK (1994) Cyclic AMP and ethanol interact to control apoptosis and differentiation in hypothalamic beta-endorphin neurons. J Biol Chem 269:26697-26705.
    • (1994) J Biol Chem , vol.269 , pp. 26697-26705
    • De, A.1    Boyadjieva, N.I.2    Pastorcic, M.3    Reddy, B.V.4    Sarkar, D.K.5
  • 18
    • 0032974143 scopus 로고    scopus 로고
    • The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells
    • Dringen R, Kussmaul L, Gutterer JM, Hirrlinger J, Hamprecht B (1999) The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells. J Neurochem 72:2523-2530.
    • (1999) J Neurochem , vol.72 , pp. 2523-2530
    • Dringen, R.1    Kussmaul, L.2    Gutterer, J.M.3    Hirrlinger, J.4    Hamprecht, B.5
  • 19
    • 0023618311 scopus 로고
    • Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells
    • Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A (1987) Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells. Eur J Immunol 17:1271-1278.
    • (1987) Eur J Immunol , vol.17 , pp. 1271-1278
    • Frei, K.1    Siepl, C.2    Groscurth, P.3    Bodmer, S.4    Schwerdel, C.5    Fontana, A.6
  • 20
    • 0028868238 scopus 로고
    • Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes
    • García-Ruiz C, Morales A, Colell A, Ballesta A, Rodés J, Kaplowitz N, Fernández-Checa JC (1995) Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology 21:207-214.
    • (1995) Hepatology , vol.21 , pp. 207-214
    • García-Ruiz, C.1    Morales, A.2    Colell, A.3    Ballesta, A.4    Rodés, J.5    Kaplowitz, N.6    Fernández-Checa, J.C.7
  • 22
    • 0025957211 scopus 로고
    • Long-term deficits in cerebellar growth and rotarod performance of rats following "binge-like" alcohol exposure during the neonatal brain growth spurt
    • Goodlett CR, Thomas JD, West Jr. (1991) Long-term deficits in cerebellar growth and rotarod performance of rats following "binge-like" alcohol exposure during the neonatal brain growth spurt. Neurotoxicol Teratol 13:69-74.
    • (1991) Neurotoxicol Teratol , vol.13 , pp. 69-74
    • Goodlett, C.R.1    Thomas, J.D.2    West, J.R.3
  • 23
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: where are we now?
    • Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634-1658.
    • (2006) J Neurochem , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 24
    • 0035947221 scopus 로고    scopus 로고
    • Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
    • Jung C, Rong Y, Doctrow S, Baudry M, Malfroy B, Xu Z (2001) Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci Lett 304:157-160.
    • (2001) Neurosci Lett , vol.304 , pp. 157-160
    • Jung, C.1    Rong, Y.2    Doctrow, S.3    Baudry, M.4    Malfroy, B.5    Xu, Z.6
  • 25
    • 0033753802 scopus 로고    scopus 로고
    • Increased activity of the hypothalamic-pituitary-adrenal axis of rats exposed to alcohol in utero: role of altered pituitary and hypothalamic function
    • Lee S, Schmidt D, Tilders F, Rivier C (2000) Increased activity of the hypothalamic-pituitary-adrenal axis of rats exposed to alcohol in utero: role of altered pituitary and hypothalamic function. Mol Cell Neurosci 16:515-528.
    • (2000) Mol Cell Neurosci , vol.16 , pp. 515-528
    • Lee, S.1    Schmidt, D.2    Tilders, F.3    Rivier, C.4
  • 26
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 27
    • 41149119994 scopus 로고    scopus 로고
    • Glutathione content as a potential mediator of the vulnerability of cultured fetal cortical neurons to ethanol-induced apoptosis
    • Maffi SK, Rathinam ML, Cherian PP, Pate W, Hamby-Mason R, Schenker S, Henderson GI (2008) Glutathione content as a potential mediator of the vulnerability of cultured fetal cortical neurons to ethanol-induced apoptosis. J Neurosci Res 86:1064-1076.
    • (2008) J Neurosci Res , vol.86 , pp. 1064-1076
    • Maffi, S.K.1    Rathinam, M.L.2    Cherian, P.P.3    Pate, W.4    Hamby-Mason, R.5    Schenker, S.6    Henderson, G.I.7
  • 28
    • 0031562673 scopus 로고    scopus 로고
    • Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites
    • Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G (1997) Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites. Cell Immunol 177:62-68.
    • (1997) Cell Immunol , vol.177 , pp. 62-68
    • Malfroy, B.1    Doctrow, S.R.2    Orr, P.L.3    Tocco, G.4    Fedoseyeva, E.V.5    Benichou, G.6
  • 29
    • 0019313317 scopus 로고
    • Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissues
    • McCarthy KD, de Vellis J (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissues. J Cell Biol 85:890-902.
    • (1980) J Cell Biol , vol.85 , pp. 890-902
    • McCarthy, K.D.1    de Vellis, J.2
  • 30
    • 0030961544 scopus 로고    scopus 로고
    • Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
    • McDonald DR, Brunden KR, Landreth GE (1997) Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 17:2284-2294.
    • (1997) J Neurosci , vol.17 , pp. 2284-2294
    • McDonald, D.R.1    Brunden, K.R.2    Landreth, G.E.3
  • 31
    • 0025337827 scopus 로고
    • Numbers of neurons and glia in mature rat somatosensory cortex: effects of prenatal exposure to ethanol
    • Miller MW, Potempa G (1990) Numbers of neurons and glia in mature rat somatosensory cortex: effects of prenatal exposure to ethanol. J Comp Neurol 293:92-102.
    • (1990) J Comp Neurol , vol.293 , pp. 92-102
    • Miller, M.W.1    Potempa, G.2
  • 32
    • 0344495393 scopus 로고    scopus 로고
    • Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species
    • Min KJ, Jou I, Joe E (2003) Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species. Biochem Biophys Res Commun 312:969-974.
    • (2003) Biochem Biophys Res Commun , vol.312 , pp. 969-974
    • Min, K.J.1    Jou, I.2    Joe, E.3
  • 34
    • 0034042319 scopus 로고    scopus 로고
    • The pro-oxidative activity of SOD and nitroxide SOD mimics
    • Offer T, Russo A, Samuni A (2000) The pro-oxidative activity of SOD and nitroxide SOD mimics. FASEB J 14:1215-1223.
    • (2000) FASEB J , vol.14 , pp. 1215-1223
    • Offer, T.1    Russo, A.2    Samuni, A.3
  • 35
    • 0034972410 scopus 로고    scopus 로고
    • In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal
    • Ramachandran V, Perez A, Chen J, Senthil D, Schenker S, Henderson GI (2001) In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal. Alcohol Clin Exp Res 25:862-871.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 862-871
    • Ramachandran, V.1    Perez, A.2    Chen, J.3    Senthil, D.4    Schenker, S.5    Henderson, G.I.6
  • 36
    • 0242330832 scopus 로고    scopus 로고
    • Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons
    • Ramachandran V, Watts LT, Maffi SK, Chen J, Schenker S, Henderson G (2003) Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons. J Neurosci Res 74:577-588.
    • (2003) J Neurosci Res , vol.74 , pp. 577-588
    • Ramachandran, V.1    Watts, L.T.2    Maffi, S.K.3    Chen, J.4    Schenker, S.5    Henderson, G.6
  • 38
    • 0023488842 scopus 로고
    • Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro
    • Reinke LA, Lai EK, DuBose CM, McCay PB (1987) Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro. Proc Natl Acad Sci U S A 84:9223-9227.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9223-9227
    • Reinke, L.A.1    Lai, E.K.2    DuBose, C.M.3    McCay, P.B.4
  • 39
    • 0032693933 scopus 로고    scopus 로고
    • Morphological changes produced by acute prenatal exposure to ethanol on the immunoreactive vasoactive intestinal polypeptide cells of the suprachiasmatic nucleus of the rat
    • Rojas JC, Vigueras RM, Reyes G, Rojas P, Cintra L, Aguilar-Roblero R (1999) Morphological changes produced by acute prenatal exposure to ethanol on the immunoreactive vasoactive intestinal polypeptide cells of the suprachiasmatic nucleus of the rat. Proc West Pharmacol Soc 42:75-76.
    • (1999) Proc West Pharmacol Soc , vol.42 , pp. 75-76
    • Rojas, J.C.1    Vigueras, R.M.2    Reyes, G.3    Rojas, P.4    Cintra, L.5    Aguilar-Roblero, R.6
  • 40
    • 0033578309 scopus 로고    scopus 로고
    • EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
    • Rong Y, Doctrow SR, Tocco G, Baudry M (1999) EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci U S A 96:9897-9902.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 9897-9902
    • Rong, Y.1    Doctrow, S.R.2    Tocco, G.3    Baudry, M.4
  • 41
    • 34250904380 scopus 로고    scopus 로고
    • Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function
    • Sarkar DK, Kuhn P, Marano J, Chen C, Boyadjieva N (2007) Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function. Endocrinology 148:2828-2834.
    • (2007) Endocrinology , vol.148 , pp. 2828-2834
    • Sarkar, D.K.1    Kuhn, P.2    Marano, J.3    Chen, C.4    Boyadjieva, N.5
  • 42
    • 0033016131 scopus 로고    scopus 로고
    • Dose- and time-dependent effects of ethanol on plasma antioxidant system in rat
    • Schlorff EC, Husain K, Somani SM (1999) Dose- and time-dependent effects of ethanol on plasma antioxidant system in rat. Alcohol 17:97-105.
    • (1999) Alcohol , vol.17 , pp. 97-105
    • Schlorff, E.C.1    Husain, K.2    Somani, S.M.3
  • 43
    • 0028900618 scopus 로고
    • Acute prenatal ethanol exposure and luteinizing hormone-releasing hormone messenger RNA expression in the fetal mouse brain
    • Scott HC, Zoeller RT, Rudeen PK (1995) Acute prenatal ethanol exposure and luteinizing hormone-releasing hormone messenger RNA expression in the fetal mouse brain. Alcohol Clin Exp Res 19:153-159.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 153-159
    • Scott, H.C.1    Zoeller, R.T.2    Rudeen, P.K.3
  • 44
    • 79954633466 scopus 로고    scopus 로고
    • Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period
    • Stettner GM, Kubin L, Volgin DV (2011) Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period. Behav Brain Res 221:324-328.
    • (2011) Behav Brain Res , vol.221 , pp. 324-328
    • Stettner, G.M.1    Kubin, L.2    Volgin, D.V.3
  • 45
    • 7744224673 scopus 로고    scopus 로고
    • Microglia and neuroinflammation: a pathological perspective
    • Streit WJ, Mrak RE, Griffin WS (2004) Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 1:14.
    • (2004) J Neuroinflammation , vol.1 , pp. 14
    • Streit, W.J.1    Mrak, R.E.2    Griffin, W.S.3
  • 46
    • 39549084919 scopus 로고    scopus 로고
    • Free radical production in CA1 neurons induces MIP-1alpha expression, microglia recruitment, and delayed neuronal death after transient forebrain ischemia
    • Wang HK, Park UJ, Kim SY, Lee JH, Kim SU, Gwag BJ, Lee YB (2008) Free radical production in CA1 neurons induces MIP-1alpha expression, microglia recruitment, and delayed neuronal death after transient forebrain ischemia. J Neurosci 28:1721-1727.
    • (2008) J Neurosci , vol.28 , pp. 1721-1727
    • Wang, H.K.1    Park, U.J.2    Kim, S.Y.3    Lee, J.H.4    Kim, S.U.5    Gwag, B.J.6    Lee, Y.B.7
  • 47
    • 21244477904 scopus 로고    scopus 로고
    • Astrocytes protect neurons from ethanol-induced oxidative stress and apoptotic death
    • Watts LT, Rathinam ML, Schenker S, Henderson GI (2005) Astrocytes protect neurons from ethanol-induced oxidative stress and apoptotic death. J Neurosci Res 80:655-666.
    • (2005) J Neurosci Res , vol.80 , pp. 655-666
    • Watts, L.T.1    Rathinam, M.L.2    Schenker, S.3    Henderson, G.I.4
  • 48
    • 0021317905 scopus 로고
    • Prenatal and early postnatal exposure to ethanol permanently alters the rat hippocampus
    • West JR, Dewey SL, Pierce DR, Black AC Jr. (1984) Prenatal and early postnatal exposure to ethanol permanently alters the rat hippocampus. Ciba Found Symp 105:8-25.
    • (1984) Ciba Found Symp , vol.105 , pp. 8-25
    • West, J.R.1    Dewey, S.L.2    Pierce, D.R.3    Black Jr., A.C.4
  • 49
    • 0035053740 scopus 로고    scopus 로고
    • Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1
    • Wu D, Cederbaum AI (2001) Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1. Alcohol Clin Exp Res 25:619-628.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 619-628
    • Wu, D.1    Cederbaum, A.I.2
  • 50
    • 77951535281 scopus 로고    scopus 로고
    • Induction of innate immune gene expression cascades in brain slice cultures by ethanol: key role of NF-κB and proinflammatory cytokines
    • Zou J, Crews F (2010) Induction of innate immune gene expression cascades in brain slice cultures by ethanol: key role of NF-κB and proinflammatory cytokines. Alcohol Clin Exp Res 34:777-789.
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. 777-789
    • Zou, J.1    Crews, F.2


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