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Volumn 15, Issue 11, 2013, Pages

Epigenetics in rheumatoid arthritis: A primer for rheumatologists

Author keywords

DNAmethylation; Epigenetics; Histone acetylation; Histonemodification; MicroRNA; Rheumatoid arthritis

Indexed keywords

ANTIRHEUMATIC AGENT; HISTONE; HISTONE DEACETYLASE INHIBITOR; MICRORNA;

EID: 84893758625     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-013-0372-9     Document Type: Article
Times cited : (67)

References (77)
  • 1
    • 70449657126 scopus 로고    scopus 로고
    • Rheumatoid arthritis genetics: 2009 update
    • Plenge RM. Rheumatoid arthritis genetics: 2009 update. Curr Rheumatol Rep. 2009;11:351-6
    • (2009) Curr Rheumatol Rep , vol.11 , pp. 351-356
    • Plenge, R.M.1
  • 2
    • 78649733694 scopus 로고    scopus 로고
    • Prevention of autoimmune rheumatic disease: State of the art and future perspectives
    • Klareskog L, Gregersen PK, Huizinga TW. Prevention of autoimmune rheumatic disease: state of the art and future perspectives. Ann Rheum Dis. 2010;69:2062-6
    • (2010) Ann Rheum Dis , vol.69 , pp. 2062-2066
    • Klareskog, L.1    Gregersen, P.K.2    Huizinga, T.W.3
  • 3
    • 84871778727 scopus 로고    scopus 로고
    • Duality of fibroblast-like synoviocytes in RA: Passive responders and imprinted aggressors
    • Bottini N, Firestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013;9:24-33
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 24-33
    • Bottini, N.1    Firestein, G.S.2
  • 4
    • 84877602531 scopus 로고    scopus 로고
    • The ascent of acetylation in the epigenetics of rheumatoid arthritis
    • Grabiec AM, Reedquist KA. The ascent of acetylation in the epigenetics of rheumatoid arthritis. Nat Rev Rheumatol. 2013;9: 311-8
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 311-318
    • Grabiec, A.M.1    Reedquist, K.A.2
  • 5
    • 84875129831 scopus 로고    scopus 로고
    • DNA methylation dynamics in health and disease
    • Bergman Y, Cedar H. DNA methylation dynamics in health and disease. Nat Struct Mol Biol. 2013;20:274-81
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 274-281
    • Bergman, Y.1    Cedar, H.2
  • 6
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 1990;33:1665-73
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 7
    • 0025736912 scopus 로고
    • 5- Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmunerheumatic diseases
    • Corvetta A, Della Bitta R, Luchetti MM, Pomponio G. 5- Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmunerheumatic diseases. J Chromatogr. 1991;566:481-91
    • (1991) J Chromatogr , vol.566 , pp. 481-491
    • Corvetta, A.1    Della Bitta, R.2    Luchetti, M.M.3    Pomponio, G.4
  • 9
    • 78751703609 scopus 로고    scopus 로고
    • Global DNA methylation, DNMT1, andMBD2 in patients with rheumatoid arthritis
    • Liu CC, Fang TJ, Ou TT,Wu CC, Li RN, Lin YC, et al. Global DNA methylation, DNMT1, andMBD2 in patients with rheumatoid arthritis. Immunol Lett. 2011;135:96-9
    • (2011) Immunol Lett , vol.135 , pp. 96-99
    • Liu, C.C.1    Fang, T.J.2    Ou, T.T.3    Wu, C.C.4    Li, R.N.5    Lin, Y.C.6
  • 10
    • 49449106856 scopus 로고    scopus 로고
    • Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
    • Nile CJ, Read RC, AkilM, Duff GW,Wilson AG.Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum. 2008;58: 2686-93
    • (2008) Arthritis Rheum , vol.58 , pp. 2686-2693
    • Nile, C.J.1    Read, R.C.2    Akil, M.3    Duff, G.W.4    Wilson, A.G.5
  • 11
    • 84863685954 scopus 로고    scopus 로고
    • Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis
    • Ishida K, Kobayashi T, Ito S, Komatsu Y, Yokoyama T, Okada M, et al. Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis. J Periodontol. 2012;83:917-25
    • (2012) J Periodontol , vol.83 , pp. 917-925
    • Ishida, K.1    Kobayashi, T.2    Ito, S.3    Komatsu, Y.4    Yokoyama, T.5    Okada, M.6
  • 12
    • 84864799962 scopus 로고    scopus 로고
    • CD40L demethylation in CD4(+) Tcells from women with rheumatoid arthritis
    • Liao J, Liang G, Xie S, Zhao H, Zuo X, Li F, et al. CD40L demethylation in CD4(+) Tcells from women with rheumatoid arthritis. Clin Immunol. 2012;145:13-8
    • (2012) Clin Immunol , vol.145 , pp. 13-18
    • Liao, J.1    Liang, G.2    Xie, S.3    Zhao, H.4    Zuo, X.5    Li, F.6
  • 14
    • 84873576566 scopus 로고    scopus 로고
    • Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
    • The first integrated genome wide analysis of DNA methylation and singlenucleotide polymorphisms (SNPs). It identifies alterations of DNA methylation as responsible for the associations between SNPs in the MHC region and rheumatoid arthritis
    • Liu Y, Aryee MJ, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, et al. Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol. 2013;31:142-7. The first integrated genome wide analysis of DNA methylation and singlenucleotide polymorphisms (SNPs). It identifies alterations of DNA methylation as responsible for the associations between SNPs in the MHC region and rheumatoid arthritis
    • (2013) Nat Biotechnol , vol.31 , pp. 142-147
    • Liu, Y.1    Aryee, M.J.2    Padyukov, L.3    Fallin, M.D.4    Hesselberg, E.5    Runarsson, A.6
  • 15
    • 0034541591 scopus 로고    scopus 로고
    • Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: Association with genomic DNA hypomethylation and influence on gene expression
    • DOI 10.1002/1529-0131 (200012) 43:12<2634::AID-ANR3>3.0.CO;2-1
    • NeidhartM, Rethage J, Kuchen S, Kunzler P, Crowl RM, Billingham ME, et al. Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum. 2000;43: 2634-47 (Pubitemid 32001729)
    • (2000) Arthritis and Rheumatism , vol.43 , Issue.12 , pp. 2634-2647
    • Neidhart, M.1    Rethage, J.2    Kuchen, S.3    Knzler, P.4    Crowl, R.M.5    Billingham, M.E.6    Gay, R.E.7    Gay, S.8
  • 18
    • 84872713887 scopus 로고    scopus 로고
    • Regulation of DNA methylation in rheumatoid arthritis synoviocytes
    • Nakano K, Boyle DL, Firestein GS. Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J Immunol. 2013;190:1297-303
    • (2013) J Immunol , vol.190 , pp. 1297-1303
    • Nakano, K.1    Boyle, D.L.2    Firestein, G.S.3
  • 19
    • 82555192432 scopus 로고    scopus 로고
    • DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts
    • Karouzakis E, Rengel Y, Jungel A, Kolling C, Gay RE, Michel BA, et al. DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. Genes Immunol. 2011;12: 643-52
    • (2011) Genes Immunol , vol.12 , pp. 643-652
    • Karouzakis, E.1    Rengel, Y.2    Jungel, A.3    Kolling, C.4    Gay, R.E.5    Michel, B.A.6
  • 20
    • 33644890154 scopus 로고    scopus 로고
    • Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells
    • Takami N, Osawa K, Miura Y, Komai K, Taniguchi M, Shiraishi M, et al. Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells. Arthritis Rheum. 2006;54:779-87
    • (2006) Arthritis Rheum , vol.54 , pp. 779-787
    • Takami, N.1    Osawa, K.2    Miura, Y.3    Komai, K.4    Taniguchi, M.5    Shiraishi, M.6
  • 22
    • 84871525988 scopus 로고    scopus 로고
    • MeCP2modulates the canonicalWnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast- like synoviocytes in rats
    • Miao CG, Huang C, Huang Y, Yang YY, He X, Zhang L, et al. MeCP2modulates the canonicalWnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast- like synoviocytes in rats. Cell Signal. 2013;25:598-608
    • (2013) Cell Signal , vol.25 , pp. 598-608
    • Miao, C.G.1    Huang, C.2    Huang, Y.3    Yang, Y.Y.4    He, X.5    Zhang, L.6
  • 23
    • 84871050696 scopus 로고    scopus 로고
    • DNA methylome signature in rheumatoid arthritis
    • The first genome-wide DNA methylation analysis in RA FLS. It identifies signature alterations of DNA methylome in RA FLS in key pathways
    • Nakano K,Whitaker JW, Boyle DL,WangW, Firestein GS. DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis. 2013;72:110-7. The first genome-wide DNA methylation analysis in RA FLS. It identifies signature alterations of DNA methylome in RA FLS in key pathways
    • (2013) Ann Rheum Dis. , vol.72 , pp. 110-117
    • Nakano, K.1    Whitaker, J.W.2    Boyle, D.L.3    Wang, W.4    Firestein, G.S.5
  • 25
    • 84875943253 scopus 로고    scopus 로고
    • Identification of novelmarkers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression
    • de la Rica L, Urquiza JM, Gomez-Cabrero D, Islam AB, Lopez- Bigas N, Tegner J, et al. Identification of novelmarkers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression. J Autoimmun. 2013;41:6-16
    • (2013) J Autoimmun , vol.41 , pp. 6-16
    • De La Rica, L.1    Urquiza, J.M.2    Gomez-Cabrero, D.3    Islam, A.B.4    Lopez- Bigas, N.5    Tegner, J.6
  • 26
    • 84861829515 scopus 로고    scopus 로고
    • Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts
    • One of the few models explaining what causes alterations of DNA methylation in RA FLS
    • Karouzakis E, Gay RE, Gay S, Neidhart M. Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2012;64:1809-One of the few models explaining what causes alterations of DNA methylation in RA FLS
    • (2012) Arthritis Rheum. , vol.64 , pp. 1809-1817
    • Karouzakis, E.1    Gay, R.E.2    Gay, S.3    Neidhart, M.4
  • 28
    • 78049240315 scopus 로고    scopus 로고
    • Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
    • Xiao Y, Li B, Zhou Z, Hancock WW, Zhang H, Greene MI. Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr Opin Immunol. 2010;22:583-91
    • (2010) Curr Opin Immunol , vol.22 , pp. 583-591
    • Xiao, Y.1    Li, B.2    Zhou, Z.3    Hancock, W.W.4    Zhang, H.5    Greene, M.I.6
  • 29
    • 84859492923 scopus 로고    scopus 로고
    • HDAC inhibitor therapy in autoimmunity and transplantation
    • Hancock WW, Akimova T, Beier UH, Liu Y, Wang L. HDAC inhibitor therapy in autoimmunity and transplantation. Ann Rheum Dis. 2012;71 Suppl 2:i46-54
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 2
    • Hancock, W.W.1    Akimova, T.2    Beier, U.H.3    Liu, Y.4    Wang, L.5
  • 30
    • 77951925741 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue
    • Grabiec AM, Krausz S, de JagerW, Burakowski T, Groot D, Sanders ME, et al. Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J Immunol. 2010;184:2718-28
    • (2010) J Immunol , vol.184 , pp. 2718-2728
    • Grabiec, A.M.1    Krausz, S.2    De Jager, W.3    Burakowski, T.4    Groot, D.5    Sanders, M.E.6
  • 31
    • 84857233842 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay
    • Demonstrates the effect of HDACi on key target cytokine for therapy of RA
    • Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA. Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. Ann Rheum Dis. 2012;71:424-31. Demonstrates the effect of HDACi on key target cytokine for therapy of RA
    • (2012) Ann Rheum Dis. , vol.71 , pp. 424-431
    • Grabiec, A.M.1    Korchynskyi, O.2    Tak, P.P.3    Reedquist, K.A.4
  • 32
    • 84863395477 scopus 로고    scopus 로고
    • Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients
    • Gillespie J, Savic S,Wong C, Hempshall A, InmanM, Emery P, et al. Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Rheum. 2012;64:418-22
    • (2012) Arthritis Rheum , vol.64 , pp. 418-422
    • Gillespie, J.1    Savic, S.2    Wong, C.3    Hempshall, A.4    Inman, M.5    Emery, P.6
  • 33
    • 80052453175 scopus 로고    scopus 로고
    • SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
    • Niederer F, Ospelt C, Brentano F, HottigerMO, Gay RE, Gay S, et al. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis. 2011;70:1866-73
    • (2011) Ann Rheum Dis , vol.70 , pp. 1866-1873
    • Niederer, F.1    Ospelt, C.2    Brentano, F.3    Hottiger, M.O.4    Gay, R.E.5    Gay, S.6
  • 34
    • 70349385423 scopus 로고    scopus 로고
    • Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis
    • Saouaf SJ, Li B, Zhang G, Shen Y, Furuuchi N, HancockWW, et al. Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp Mol Pathol. 2009;87:99-104
    • (2009) Exp Mol Pathol , vol.87 , pp. 99-104
    • Saouaf, S.J.1    Li, B.2    Zhang, G.3    Shen, Y.4    Furuuchi, N.5    Hancock, W.W.6
  • 37
    • 68849105560 scopus 로고    scopus 로고
    • Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts
    • HoriuchiM,Morinobu A, Chin T, Sakai Y, KurosakaM, Kumagai S. Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts. J Rheumatol. 2009;36:1580-9
    • (2009) J Rheumatol , vol.36 , pp. 1580-1589
    • Horiuchi, M.1    Morinobu, A.2    Chin, T.3    Sakai, Y.4    Kurosaka, M.5    Kumagai, S.6
  • 38
    • 77954286123 scopus 로고    scopus 로고
    • Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor- alpha in synovial tissue of rheumatoidarthritis
    • Kawabata T, Nishida K, Takasugi K, Ogawa H, Sada K, Kadota Y, et al. Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor- alpha in synovial tissue of rheumatoidarthritis. Arthritis Res Ther. 2010;12:R133
    • (2010) Arthritis Res Ther , vol.12
    • Kawabata, T.1    Nishida, K.2    Takasugi, K.3    Ogawa, H.4    Sada, K.5    Kadota, Y.6
  • 39
    • 84880493174 scopus 로고    scopus 로고
    • The role of histone deacetylases in rheumatoid arthritis fibroblast-like synoviocytes
    • Hawtree S,MuthanaM,Wilson AG. The role of histone deacetylases in rheumatoid arthritis fibroblast-like synoviocytes. Biochem Soc Trans. 2013;41:783-8
    • (2013) Biochem Soc Trans. , vol.41 , pp. 783-788
    • Hawtree, S.1    Muthana, M.2    Wilson, A.G.3
  • 40
    • 79959788025 scopus 로고    scopus 로고
    • Expression and function of EZH2 in synovial fibroblasts: Epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis
    • Trenkmann M, Brock M, Gay RE, Kolling C, Speich R, Michel BA, et al. Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis. Ann Rheum Dis. 2011;70:1482-8
    • (2011) Ann Rheum Dis , vol.70 , pp. 1482-1488
    • Trenkmann, M.1    Brock, M.2    Gay, R.E.3    Kolling, C.4    Speich, R.5    Michel, B.A.6
  • 41
    • 43049183658 scopus 로고    scopus 로고
    • Antiarthritic effects of combined treatment with histone deacetylase inhibitorand low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells
    • Nakamura C, Matsushita I, Kosaka E, Kondo T, Kimura T. Antiarthritic effects of combined treatment with histone deacetylase inhibitorand low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. Rheumatology (Oxford). 2008;47:418-24
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 418-424
    • Nakamura, C.1    Matsushita, I.2    Kosaka, E.3    Kondo, T.4    Kimura, T.5
  • 42
    • 77954752923 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF-kappaB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells
    • Choo QY, Ho PC, Tanaka Y, Lin HS. Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF-kappaB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells. Rheumatology (Oxford). 2010;49:1447-60
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 1447-1460
    • Choo, Q.Y.1    Ho, P.C.2    Tanaka, Y.3    Lin, H.S.4
  • 43
    • 0346873023 scopus 로고    scopus 로고
    • A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis
    • Chung YL, Lee MY, Wang AJ, Yao LF. A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. Mol Ther. 2003;8:707-17
    • (2003) Mol Ther , vol.8 , pp. 707-717
    • Chung, Y.L.1    Lee, M.Y.2    Wang, A.J.3    Yao, L.F.4
  • 45
    • 79957958931 scopus 로고    scopus 로고
    • Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis
    • Preclinical validation of HDACi in models of RA
    • Joosten LA, Leoni F, Meghji S, Mascagni P. Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis. Mol Med. 2011;17:391-6. Preclinical validation of HDACi in models of RA
    • (2011) Mol Med. , vol.17 , pp. 391-396
    • Joosten, L.A.1    Leoni, F.2    Meghji, S.3    Mascagni, P.4
  • 46
    • 79955552937 scopus 로고    scopus 로고
    • Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
    • The only published clinical trial of HDACi for human arthritis
    • Vojinovic J, Damjanov N, D'Urzo C, Furlan A, Susic G, Pasic S, et al. Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2011;63:1452-8. The only published clinical trial of HDACi for human arthritis
    • (2011) Arthritis Rheum , vol.63 , pp. 1452-1458
    • Vojinovic, J.1    Damjanov, N.2    D'Urzo, C.3    Furlan, A.4    Susic, G.5    Pasic, S.6
  • 47
    • 66049112958 scopus 로고    scopus 로고
    • MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Nakamachi Y, Kawano S, Takenokuchi M, Nishimura K, Sakai Y, Chin T, et al. MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2009;60:1294-304
    • (2009) Arthritis Rheum , vol.60 , pp. 1294-1304
    • Nakamachi, Y.1    Kawano, S.2    Takenokuchi, M.3    Nishimura, K.4    Sakai, Y.5    Chin, T.6
  • 48
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR- 146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK. Upregulated miR- 146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 2008;10: R101
    • (2008) Arthritis Res Ther , vol.10
    • Pauley, K.M.1    Satoh, M.2    Chan, A.L.3    Bubb, M.R.4    Reeves, W.H.5    Chan, E.K.6
  • 49
    • 79953023325 scopus 로고    scopus 로고
    • MicroRNAs in rheumatoid arthritis: Midget RNAs with a giant impact
    • Wittmann J, Jack HM. microRNAs in rheumatoid arthritis: midget RNAs with a giant impact. Ann RheumDis. 2011;70 Suppl 1:i92-96
    • (2011) Ann RheumDis , vol.70 , Issue.SUPPL. 1
    • Wittmann, J.1    Jack, H.M.2
  • 51
    • 84858703918 scopus 로고    scopus 로고
    • Novel regulatory mechanisms in inflammatory arthritis: A role for microRNA
    • Baxter D, McInnes IB, Kurowska-Stolarska M. Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunol Cell Biol. 2012;90:288-92
    • (2012) Immunol Cell Biol , vol.90 , pp. 288-292
    • Baxter, D.1    McInnes, I.B.2    Kurowska-Stolarska, M.3
  • 52
    • 77958495102 scopus 로고    scopus 로고
    • MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    • O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA, et l.MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity. 2010;33:607-19
    • (2010) Immunity , vol.33 , pp. 607-619
    • O'connell, R.M.1    Kahn, D.2    Gibson, W.S.3    Round, J.L.4    Scholz, R.L.5    Chaudhuri, A.A.6
  • 53
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice
    • Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N, et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A. 2006;103:7024-9
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7024-7029
    • Costinean, S.1    Zanesi, N.2    Pekarsky, Y.3    Tili, E.4    Volinia, S.5    Heerema, N.6
  • 56
    • 84866111542 scopus 로고    scopus 로고
    • Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model
    • Pandis I, Ospelt C, Karagianni N, Denis MC, Reczko M, Camps C, et al. Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Ann Rheum Dis. 2012;71:1716-23
    • (2012) Ann Rheum Dis , vol.71 , pp. 1716-1723
    • Pandis, I.1    Ospelt, C.2    Karagianni, N.3    Denis, M.C.4    Reczko, M.5    Camps, C.6
  • 57
    • 79960595150 scopus 로고    scopus 로고
    • MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
    • Preclinical validation of mIR155 as a target for RA and determination of the mechanism of action of mIR155 in the CIA model supporting a role in innate immunity
    • Kurowska-Stolarska M, Alivernini S, Ballantine LE, Asquith DL, Millar NL, Gilchrist DS, et al. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci U S A. 2011;108:11193-8. Preclinical validation of mIR155 as a target for RA and determination of the mechanism of action of mIR155 in the CIA model supporting a role in innate immunity
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 11193-11198
    • Kurowska-Stolarska, M.1    Alivernini, S.2    Ballantine, L.E.3    Asquith, D.L.4    Millar, N.L.5    Gilchrist, D.S.6
  • 58
    • 79955561084 scopus 로고    scopus 로고
    • Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice
    • Preclinical validation of mIR155 as a target for RA and determination of the mechanism of action of mIR155 in the CIA model supporting a role in adaptive immunity and osteoclasts
    • Bluml S, Bonelli M, Niederreiter B, Puchner A,Mayr G, Hayer S, et al. Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum. 2011;63:1281-8. Preclinical validation of mIR155 as a target for RA and determination of the mechanism of action of mIR155 in the CIA model supporting a role in adaptive immunity and osteoclasts
    • (2011) Arthritis Rheum , vol.63 , pp. 1281-1288
    • Bluml, S.1    Bonelli, M.2    Niederreiter, B.3    Puchner, A.4    Mayr, G.5    Hayer, S.6
  • 61
    • 79958053053 scopus 로고    scopus 로고
    • The inhibitory effect of microRNA- 146a expression on bone destruction in collagen-induced arthritis
    • Nakasa T, Shibuya H, Nagata Y, Niimoto T, Ochi M. The inhibitory effect of microRNA- 146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum. 2011;63:1582-90
    • (2011) Arthritis Rheum , vol.63 , pp. 1582-1590
    • Nakasa, T.1    Shibuya, H.2    Nagata, Y.3    Niimoto, T.4    Ochi, M.5
  • 62
    • 77951973193 scopus 로고    scopus 로고
    • Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis
    • Li J, Wan Y, Guo Q, Zou L, Zhang J, Fang Y, et al. Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res Ther. 2010;12:R81
    • (2010) Arthritis Res Ther , vol.12
    • Li, J.1    Wan, Y.2    Guo, Q.3    Zou, L.4    Zhang, J.5    Fang, Y.6
  • 63
    • 84866605611 scopus 로고    scopus 로고
    • MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients
    • Jimenez-Morales S, Gamboa-Becerra R, Baca V, Del Rio-Navarro BE, Lopez-Ley DY, elazquez-Cruz R, et al. MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients. Tissue Antigens. 2012;80:317-21
    • (2012) Tissue Antigens , vol.80 , pp. 317-321
    • Jimenez-Morales, S.1    Gamboa-Becerra, R.2    Baca, V.3    Del Rio-Navarro, B.E.4    Lopez-Ley, D.Y.5    Velazquez-Cruz, R.6
  • 64
    • 84355161620 scopus 로고    scopus 로고
    • Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population
    • Yang B, Chen J, Li Y, Zhang J, Li D, Huang Z, et al. Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population. Hum Immunol. 2012;73:101-6
    • (2012) Hum Immunol , vol.73 , pp. 101-106
    • Yang, B.1    Chen, J.2    Li, Y.3    Zhang, J.4    Li, D.5    Huang, Z.6
  • 65
    • 77957873680 scopus 로고    scopus 로고
    • A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility
    • Chatzikyriakidou A, Voulgari PV, Georgiou I, Drosos AA. A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility. Joint, bone, spine : Revue du Rhumatisme. 2010;77:411-3
    • (2010) Joint, Bone, Spine : Revue du Rhumatisme , vol.77 , pp. 411-413
    • Chatzikyriakidou, A.1    Voulgari, P.V.2    Georgiou, I.3    Drosos, A.A.4
  • 66
    • 84855384226 scopus 로고    scopus 로고
    • TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes
    • Basal expression of mIR19 prevents innate responses in RA FLS
    • Philippe L, AlsalehG, Suffert G,MeyerA,Georgel P, Sibilia J, et al. TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes. J Immunol. 2012;188:454-61. Basal expression of mIR19 prevents innate responses in RA FLS
    • (2012) J Immunol , vol.188 , pp. 454-461
    • Philippe, L.1    Alsaleh, G.2    Suffert, G.3    Meyer, A.4    Georgel, P.5    Sibilia, J.6
  • 67
    • 84867898027 scopus 로고    scopus 로고
    • A miR-19 regulon that controls NFkappaB signaling
    • mIR19 is part of a positive feedback loop that promotes NFkB signaling in RA FLS
    • Gantier MP, Stunden HJ, McCoy CE, Behlke MA, Wang D, Kaparakis-Liaskos M, et al. A miR-19 regulon that controls NFkappaB signaling. Nucleic Acids Res. 2012;40:8048-58. mIR19 is part of a positive feedback loop that promotes NFkB signaling in RA FLS
    • (2012) Nucleic Acids Res , vol.40 , pp. 8048-8058
    • Gantier, M.P.1    Stunden, H.J.2    McCoy, C.E.3    Behlke, M.A.4    Wang, D.5    Kaparakis-Liaskos, M.6
  • 68
    • 84875721809 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NFkappaB signaling
    • Trenkmann M, Brock M, Gay RE, Michel BA, Gay S, Huber LC. Tumor necrosis factor alpha-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NFkappaB signaling. Arthritis Rheum. 2013;65:916-27
    • (2013) Arthritis Rheum , vol.65 , pp. 916-927
    • Trenkmann, M.1    Brock, M.2    Gay, R.E.3    Michel, B.A.4    Gay, S.5    Huber, L.C.6
  • 70
    • 84869063724 scopus 로고    scopus 로고
    • Brief report: Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223
    • Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM, et al. Brief report: amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223. Arthritis Rheum. 2012;64:3240-5
    • (2012) Arthritis Rheum , vol.64 , pp. 3240-3045
    • Li, Y.T.1    Chen, S.Y.2    Wang, C.R.3    Liu, M.F.4    Lin, C.C.5    Jou, I.M.6
  • 71
    • 77952086523 scopus 로고    scopus 로고
    • Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis
    • Murata K, Yoshitomi H, Tanida S, Ishikawa M, Nishitani K, Ito H, et al. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2010;12: R86
    • (2010) Arthritis Res Ther , vol.12
    • Murata, K.1    Yoshitomi, H.2    Tanida, S.3    Ishikawa, M.4    Nishitani, K.5    Ito, H.6
  • 72
    • 79551655444 scopus 로고    scopus 로고
    • Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
    • Stanczyk J, Ospelt C, Karouzakis E, Filer A, Raza K, Kolling C, et al. Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum. 2011;63:373-81
    • (2011) Arthritis Rheum , vol.63 , pp. 373-381
    • Stanczyk, J.1    Ospelt, C.2    Karouzakis, E.3    Filer, A.4    Raza, K.5    Kolling, C.6
  • 73
    • 84857887315 scopus 로고    scopus 로고
    • Down-Regulation of microRNA-34a*in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance
    • Niederer F, Trenkmann M, Ospelt C, Karouzakis E, Neidhart M, Stanczyk J, et al. Down-regulation of microRNA-34a*in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum. 2012;64:1771-9
    • (2012) Arthritis Rheum , vol.64 , pp. 1771-1779
    • Niederer, F.1    Trenkmann, M.2    Ospelt, C.3    Karouzakis, E.4    Neidhart, M.5    Stanczyk, J.6
  • 74
    • 84863686039 scopus 로고    scopus 로고
    • ThemicroRNA miR-23b suppresses IL- 17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha
    • Identification of mIR23b as promoter IL-17 stimulated NFkB activation in RA and extensive characterization of its mechanism of action
    • Zhu S, PanW, SongX, LiuY, ShaoX, TangY, et al. ThemicroRNA miR-23b suppresses IL- 17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha. Nat Med. 2012;18:1077-86. Identification of mIR23b as promoter IL-17 stimulated NFkB activation in RA and extensive characterization of its mechanism of action
    • (2012) Nat Med. , vol.18 , pp. 1077-1086
    • Zhu, S.1    Pan, W.2    Song, X.3    Liu, Y.4    Shao, X.5    Tang, Y.6
  • 75
    • 65249088074 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes
    • Alsaleh G, Suffert G, Semaan N, Juncker T, Frenzel L, Gottenberg JE, et al. Bruton's tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes. J Immunol. 2009;182:5088-97
    • (2009) J Immunol , vol.182 , pp. 5088-5097
    • Alsaleh, G.1    Suffert, G.2    Semaan, N.3    Juncker, T.4    Frenzel, L.5    Gottenberg, J.E.6
  • 76
    • 79956089534 scopus 로고    scopus 로고
    • MiR-346 controls release of TNF-alpha protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization
    • Semaan N, Frenzel L, Alsaleh G, Suffert G, Gottenberg JE, Sibilia J, et al. miR-346 controls release of TNF-alpha protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization. PLoS One. 2011;6:e19827
    • (2011) PLoS One , vol.6
    • Semaan, N.1    Frenzel, L.2    Alsaleh, G.3    Suffert, G.4    Gottenberg, J.E.5    Sibilia, J.6
  • 77
    • 69449094454 scopus 로고    scopus 로고
    • Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a
    • Nagata Y, Nakasa T, Mochizuki Y, Ishikawa M, Miyaki S, Shibuya H, et al. Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a. Arthritis Rheum. 2009;60:2677-83
    • (2009) Arthritis Rheum , vol.60 , pp. 2677-2683
    • Nagata, Y.1    Nakasa, T.2    Mochizuki, Y.3    Ishikawa, M.4    Miyaki, S.5    Shibuya, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.