The interplay between hypoxia, endothelial and melanoma cells regulates vascularization and cell motility through endothelin-1 and vascular endothelial growth factor

Carcinogenesis

Volumn 35, Issue 4, 2014, Pages 840-848

  Spinella, Francesca ^a   Caprara, Valentina ^a   Cianfrocca, Roberta ^a   Rosanò, Laura ^a   Di Castro, Valeriana ^a   Garrafa, Emirena ^b   Natali, Pier Giorgio ^a,c   Bagnato, Anna ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; SMALL INTERFERING RNA; VASCULOTROPIN A; VASCULOTROPIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CELL CULTURE; CELL MIGRATION; CELL MOTILITY; CHANNEL GATING; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYPOXIA; LYMPH VESSEL; MELANOMA CELL; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION;

ANIMALS; CELL HYPOXIA; CELL MOVEMENT; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MELANOMA; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; REAL-TIME POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84898666129     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu018     Document Type: Article

References (46)

1. Cao, Y. (2008) Molecular mechanisms and therapeutic development of angiogenesis inhibitors. Adv. Cancer Res., 100, 113-131.
2. Alitalo, A.K. et al. (2013) VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis. Cancer Res., 73, 4212-4221.
3. Carmeliet, P. et al. (2000) Angiogenesis in cancer and other diseases. Nature, 407, 249-257.
4. Korah, R.M. et al. (2000) Basic fibroblast growth factor confers a less malignant phenotype in MDA-MB-231 human breast cancer cells. Cancer Res., 60, 733-740.
5. Metheny-Barlow, L.J. et al. (2003) The enigmatic role of angiopoietin-1 in tumor angiogenesis. Cell Res., 13, 309-317.
6. Tait, C.R. et al. (2004) Angiopoietins in tumours: the angiogenic switch. J. Pathol., 204, 1-10.
7. Joyce, J.A. (2005) Therapeutic targeting of the tumor microenvironment. Cancer Cell, 7, 513-520.
8. Nikitenko, L.L. (2009) Vascular endothelium in cancer. Cell Tissue Res., 335, 223-240.
9. Bagnato, A. et al. (2003) Emerging role of endothelin-1 in tumor angiogenesis. Trends Endocrinol. Metab., 14, 44-50.
10. Butler, J.M. et al. (2010) Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat. Rev. Cancer, 10, 138-146.
11. Rosanò, L. et al. (2013) Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer, 13, 637-651.
12. Lahav, R. et al. (1999) An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc. Natl Acad. Sci. USA, 96, 11496-11500.
13. Bagnato, A. et al. (2004) Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression. Cancer Res., 64, 1436-1443.
14. Spinella, F. et al. (2009) Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade. Cancer Res., 69, 2669-2676.
15. Spinella, F. et al. (2007) Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells. Cancer Res., 67, 1725-1734.
16. Bittner, M. et al. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature, 406, 536-540.
17. Clasper, S. et al. (2008) A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis. Cancer Res., 68, 7293-7303.
18. Spinella, F. et al. (2013) Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells. J. Mol. Med., 91, 395-405.
19. Cueni, L.N. et al. (2010) Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood, 116, 4376-4384.
20. Salani, D. et al. (2000) Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am. J. Pathol., 157, 1703-1711.
21. Morbidelli, L. et al. (1995) Proliferation and migration of endothelial cells is promoted by endothelins via activation of ETB receptors. Am. J. Physiol., 269, H686-H695.
22. Knowles, J. et al. (2005) Endothelin-1 and angiogenesis in cancer. Curr. Vasc. Pharmacol., 3, 309-314.
23. Semenza, G.L. (2012) Hypoxia-inducible factors in physiology and medicine. Cell, 148, 399-408.
24. Garrafa, E. et al. (2012) Endothelin-1 cooperates with hypoxia to induce vascular-like structures through vascular endothelial growth factor-C, -D and -A in lymphatic endothelial cells. Life Sci., 91, 638-643.
25. Patel, N. et al. (2008) Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood, 112, 856-865.
26. Maniotis, A.J. et al. (1999) Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am. J. Pathol., 155, 739-752.
27. Spinella, F. et al. (2010) Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells. PLoS One, 5, e11241.
28. Talmadge, J.E. et al. (2010) AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res., 70, 5649-5669.
29. Liang, X. et al. (2008) Hypoxia inducible factor-alpha expression correlates with vascular endothelial growth factor-C expression and lymphangiogenesis/angiogenesis in oral squamous cell carcinoma. Anticancer Res., 28, 1659-1666.
30. Schoppmann, S.F. et al. (2006) Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res. Treat., 99, 135-141.
31. Cao, Y. (2005) Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat. Rev. Cancer, 5, 735-743.
32. Folkman, J. (1971) Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 285, 1182-1186.
33. Petrova, T.V. et al. (2002) Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J., 21, 4593-4599.
34. Brantley-Sieders, D.M. et al. (2011) Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium. Cancer Res., 71, 976-987.
35. van Akkooi, A.C. et al. (2010) Importance of tumor load in the sentinel node in melanoma: clinical dilemmas. Nat. Rev. Clin. Oncol., 7, 446-454.
36. Harrell, M.I. et al. (2007) Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am. J. Pathol., 170, 774-786.
37. Wu, M.H. et al. (2013) Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells. doi: 10.1038/onc.2013.109.
38. Wong, C.C. et al. (2011) Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc. Natl Acad. Sci. USA, 108, 16369-16374.
39. Chaturvedi, P. et al. (2013) Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J. Clin. Invest., 123, 189-205.
40. Paulis, Y.W. et al. (2010) Signalling pathways in vasculogenic mimicry. Biochim. Biophys. Acta, 1806, 18-28.
41. Lai, C.Y. et al. (2012) CD133+ melanoma subpopulations contribute to perivascular niche morphogenesis and tumorigenicity through vasculogenic mimicry. Cancer Res., 72, 5111-5118.
42. Liu, Q. et al. (2009) Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors. J. Neurooncol., 94, 1-19.
43. Liu, Y. et al. (2011) Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol. Cancer Res., 9, 1668-1685.
44. Puglisi, M.A. et al. (2011) Identification of endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells. J. Pathol., 225, 305-314.
45. Seftor, R.E. et al. (2012) Tumor cell vasculogenic mimicry: from controversy to therapeutic promise. Am. J. Pathol., 181, 1115-1125.
46. Buckanovich, R.J. et al. (2008) Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat. Med., 14, 28-36.