Basic fibroblast growth factor confers a less malignant phenotype in MDA-MB-231 human breast cancer cells

Cancer Research

Volumn 60, Issue 3, 2000, Pages 733-740

  Korah, Reju M ^a   Sysounthone, Vilayvanh ^a   Golowa, Yosef ^a   Wieder, Robert ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COLLAGENASE; MATRIX METALLOPROTEINASE; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR;

ARTICLE; BREAST CANCER; CANCER INVASION; COLONY FORMATION; CONTROLLED STUDY; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BREAST NEOPLASMS; CELL DIVISION; FEMALE; HUMANS; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; NEOPLASM INVASIVENESS; PHENOTYPE; RECEPTORS, FIBROBLAST GROWTH FACTOR; TRANSFECTION;

EID: 0033965233     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Meyer, T., and Hart, I. R. Mechanisms of tumour metastasis. Eur. J. Cancer, 34: 214-221, 1998.
2. Lai, L. C., Sirah, A. K., Erbas, H., and Lennard, T. W. J. Relationship between basic fibroblast growth factor and transforming growth factor-β2 in breast cyst fluid. J. Clin. Endocrinol. Metab., 80: 711-714, 1995.
3. Luqmani, Y. A., Graham, M., and Coombes, R. C. Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues. Br. J. Cancer, 66: 273-280, 1992.
4. Anandappa, S. Y., Winstanley, J. H. R., Leinster, S., Green, B., Rudland, P. S., and Barraclough, R. Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease. Br. J. Cancer, 69: 772-776, 1994.
5. Gomm, J. J., Smith, J., Ryall, G. K., Baille, R., Turnbull, L., and Coombes, R. C. Localization of basic fibroblast growth factor and transforming growth factor β1 in the human mammary gland. Cancer Res., 51: 4685-4692, 1991.
6. Yiangou, C., Gomm, J. J., Coope, R. C., Law, M., Luqmani, Y. A., Shousha, S., Coombes, R. C., and Johnston, C. L. Fibroblast growth factor 2 in breast cancer: occurrence and prognostic significance. Br. J. Cancer, 75: 28-33, 1997.
7. Colomer, R., Aparicio, J., Montero, S., Guzman, C., Larrodera, L., and Cortes-Funes, H. Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma. Br. J. Cancer, 76: 1215-1220, 1997.
8. Rogelj, S., Weinberg, R. A., Fanning, P., and Klagsbbrun, M. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature (Lond.), 331: 173-175, 1988.
9. Blam, S. B., Mitchell, R., Tischer, E., Rubin, J. S., Silva, M., Silver, S., Fiddes, J. C., Abraham, J. A., and Aaronson, S. A. Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein. Oncogene, 3: 129-136, 1988.
10. Quarto, N., Talarico, D., Sommer, A., Florkiewitz, R., Basilico, C., and Rifkin, D. B. Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/K-fgf. Oncogene Res., 5: 101-110, 1989.
11. Wieder, R., Wang, H., Shirke, S., Wang, Q., Menzel, T., Feirt, N., Jakubowski, A. A., and Gabrilove, J. L. Low level expression of basic FGF upregulates Bcl-2 and delays apoptosis, but high intracellular levels are required to induce transformation in NIH 3T3 cells. Growth Factors, 15: 41-60, 1997.
12. Mignatti, P., Morimoto, T., and Rifkin, D. B. Basic fibroblast growth factor released by single, isolated cell stimulates their migration in an autocrine manner. Proc. Natl. Acad. Sci. USA, 88: 11007-11011, 1991.
13. Taylor, W. R., Greenberg, A. H., Turley, E. A., and Wright, J. A. Cell motility, invasion, and malignancy induced by overexpression of K-FGF or bFGF. Exp. Cell Res., 204: 295-301, 1993.
14. Gately, S., Tsanaclis, A. M. C., Takanao, S., Klagsbrun, M., and Brem, S. Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain. Neurosurgery, 36: 780-788, 1995.
15. Corin, S. J., Chen, L. C., and Hamburger, A. W. Enhancement of anchorage-independent growth of a human adrenal carcinoma cell line by endogenously produced basic fibroblast growth factor. Int. J. Cancer, 46: 516-521, 1990.
16. Ropiquet, F., Berthon, P., Villette, J-M., Le Brun, G., Maitland, N. J., Cussenot, O., and Fiet, J. Constitutive expression of FGF2/bFGF in non-tumorigenic human prostatic epithelial cells results in the acquisition of a partial neoplastic phenotype. Int. J. Cancer, 72: 543-547, 1997.
17. Holland, E. C., and Varmus, H. E. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc. Natl. Acad. Sci. USA, 95: 1218-1222, 1998.
18. Jouanneau, J., Plouet, J., Moens, G., and Thiery, J. P. FGF-2 and FGF-1 expressed in rat bladder carcinoma cells have similar angiogenic potential but different tumorigenic properties in vivo. Oncogene, 14: 671-676, 1997.
19. Davies, B. R., Fernig, D. G., Barraclough, R., and Rudland, P. S. Effect on tumorigenicity and metastasis of transfection of a diploid benign rat mammary epithelial cell line with DNA corresponding to the mRNA for basic fibroblast growth factor. Int. J. Cancer, 65: 104-111, 1996.
20. Fenig, E., Wieder, R., Paglin, S., Wang, H., Persaud, R., Haimovitz-Friedman, A., Fuks, Z., and Yahalom, J. Basic fibroblast growth factor confers growth inhibition and mitogen-activated protein kinase activation in human breast cancer cells. Clin. Cancer Res., 3: 135-142, 1997.
21. 1 events. Cancer Res., 57: 1750-1757, 1997.
22. Johnson, M. R., Valentine, C., Basilico, C., and Mansukhani, A. FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells. Oncogene, 16: 2647-2656, 1998.
23. Wang, Q., Maloof, P., Wang, H., Fenig, E., Stein, D., Nichols, G., Denny, T. N., Yahalom, J., and Wieder, R. Basic fibroblast growth factor (bFGF) downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. Exp. Cell Res., 238: 177-187, 1998.
24. Maloof, P., Wang, Q., Wang, H., Stein, D., Denny, T. N, Yahalom, J., and Wieder, R. Overexpression of retrovirally transduced basic FGF in MCF-7 human breast cancer cells downregulates Bcl-2 and sensitizes cells to chemotherapy-induced apoptosis. Breast Cancer Res. Treat., 56: 153-167, 1999.
25. Bugler, B., Amalric, F., and Prats, H. Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor. Mol. Cell. Biol., 11: 573-577, 1991.
26. Couderc, B., Prats, H., Bayard, F., and Amalric, F. Potential oncogenic effects of basic fibroblast growth factor requires cooperation between CUG and AUG-initiated forms. Cell Regul., 2: 709-718, 1991.
27. Wieder, R., Fenig, E., Wang, H., Wang, Q., Paglin, S., Menzel, T., Gabrilove, J., Fuks, Z., and Yahalom, J. Overexpression of basic fibroblast growth factor in MCF-7 human breast cancer cells: lack of correlation between inhibition of cell growth and MAP kinase activation. J. Cell. Physiol., 177: 411-425, 1998.
28. Tamura, M., Gu, J., Matsumoto, K., Parsons, R., and Yamada, K. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (Washington DC), 280: 1614-1617, 1998.
29. Lochter, A., Srebrow, A., Sympson, C. J., Terracio, N., Werb, Z., and Bissell, M. J. Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. J. Biol. Chem., 272: 5007-5015, 1997.
30. Light, B. J., Yu, W-D., McElwain, M. C., Russell, D. M., Trump, D. L., and Johnson, C. S. Potentiation of cisplatin tumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system. Cancer Res., 57: 3759-3764, 1997.
31. Drabkin, H. J., and Raj Bhandary, U. L. Initiation of protein synthesis in mammalian cells with codons other than AUG and amino acids other than methionine. Mol. Cell. Biol., 18: 5140-5147, 1998.
32. Delehedde, M., Deudon, E., Boilly, B., and Hondermarck, H. Production of sulfated proteoglycans by human breast cancer cell lines: binding to fibroblast growth factor-2. J. Cell. Biochem., 64: 605-617, 1997.
33. Wieder, R. Selection of methods for measuring proliferation. In: G. Studzinski (ed.), Cell Growth, Differentiation and Senescence: A Practical Approach, pp. 1-32. New York: Oxford University Press, 1999.
34. Florkiewicz, R. Z., Majack, R. A., Buechler, R. D., and Florkiewicz, E. Quantitative export of FGF-2 occurs through an alternative, energy-dependent, non-ER/Golgi pathway. J. Cell. Physiol., 162: 388-399, 1995.
35. +-ATPase. J. Biol. Chem., 273: 544-551, 1998.
36. Kester, H. A., van der Leede, B. M., van der Saag, P. T., and van der Burg, B. Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation. J. Biol. Chem., 272: 16637-16643, 1997.
37. Miyagi, N., Kato, S., Terasaki, M., Shigemori, M., and Morimatsu, M. Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas. Int. J. Oncol., 12: 1085-1090, 1998.
38. Pickering, J. G., Ford, C. M., Tang, B., and Chow, L. H. Coordinated effects of fibroblast growth factor-2 on expression of fibrillar collagens, matrix metalloproteinases, and tissue inhibitors of matrix metalloproteinases by human vascular smooth muscle cells. Evidence for repressed collagen production and activated degradative capacity. Arterioscler. Thromb. Vasc. Biol., 17: 475-482, 1997.
39. Miyake, H., Hara, I., Yoshimura, K., Eto, H., Arakawa, S., Wada, S., Chihara, K., and Kamidono, S. Introduction of basic fibroblast growth factor gene into mouse renal cell carcinoma cell line enhances its metastatic potential. Cancer Res., 56: 2440-2445, 1996.
40. Uria, J. A., Balbin, M., Lopez, J. M., Alvarez, J., Vizoso, F., Takigawa, M., and Lopez-Otin, C. Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor. Am. J. Pathol., 153: 91-101, 1998.
41. Newberry, E. P., Willis, D., Latifi, T., Bourdreaux, J. M., and Towler, D. A. Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-Apl element. Mol. Endocrinol., 11: 1129-1144, 1997.
42. Puyraimond, A., Weitzman, J. B., Babiole, E., and Menashi, S. Examining the relationship between the gelatinolytic balance and the invasive capacity of endothelial cells. J. Cell Sci., 112: 1283-1290, 1999.
43. Osterhout, D. J., Ebner, S., Xu, J., Ornitz, D. M., Zazanis, G. A., and McKinnon, R. D. Transplanted oligodendrocyte progenitor cells expressing a dominant negative FGF receptor transgene fail to migrate in vivo. J. Neurosci., 17: 9122-9132, 1997.
44. Landgren, E., Klint, P., Yokote, K., and Claesson-Welsh, L. Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding. Oncogene, 17: 283-291, 1998.
45. Cavallaro, U., Wu, Z., Di Palo, A., Montesano, R., Pepper, M. S., Maier, J. A., and Soria, M. R. FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor. FASEB J., 12: 1027-1034, 1998.
46. LaVallee, T. M., Prudovsky, I. A., McMahon, G. A., Hu, X., and Maciag, T. Activation of the MAP kinase pathway by FGF-1 correlates with cell proliferation induction while activation of the Src pathway correlates with migration. J. Cell Biol., 141: 1647-1658, 1998.
47. 1 integrin and disassembly of actin filaments. Circ. Res., 80: 627-637, 1997.
48. Lauffenburger, D. A., and Horwitz, A. F. Cell migration: a physically integrated molecular process. Cell, 84: 359-369, 1996.
49. Klein, S., Giancotti, F. G., Presta, M., Albelda, S. M., Buck, C. A., and Rifkin, D. B. Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol. Biol. Cell, 4: 973-982, 1993.
50. Klein, S., Bikfalvi, A., Birkenmeier, T. M., Giancotti, F. P., and Rifkin, D. B. Integrin regulation by endogenous expression of 18-kDa fibroblast growth factor-2. J. Biol. Chem., 271: 22583-22590, 1996.
51. 2 integrin mRNA in mammary cells. J. Cell Sci. (Washington DC), 108: 595-607, 1995.
52. DiMilla, P. A., Stone, J. A., Quinn, J. A., Albeda, S. M., and Lauffenburger, D. A. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J. Cell Biol., 122: 729-737, 1993.
53. 1 integrins. A tool for studying the roles of substratum molecular avidity and density in migration. J. Cell Sci., 98: 517-532, 1991.