β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway

Oncology Reports

Volumn 31, Issue 5, 2014, Pages 2131-2138

  Yao, Cheng Cai ^a,b   Tu, Yuan Rong ^a   Jiang, Jie ^c   Ye, Sheng Fang ^d   Du, Hao Xin ^b   Zhang, Yi ^b  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b Department of Thoracic Surgery Xiamen Traditional Chinese Medicine (TCM) Hospital of Fujian University of TCM   (China)

^c THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^d XIAMEN UNIVERSITY   (China)

Author keywords

A549 DDP cells; Apoptosis; Drug resistance; Glutathione; Lung neoplasms; Mitochondrial membrane potential; Reactive oxygen species; elemene

Indexed keywords

BETA ELEMENE; CASPASE 3; CISPLATIN; CYTOCHROME C; GLUTATHIONE; PROCASPASE 3; PROTEIN BAD; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; BAD PROTEIN, HUMAN; BETA-ELEMENE; CYCLOSPORIN; SESQUITERPENE;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; LUNG CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; LUNG NEOPLASMS; METABOLISM; MITOCHONDRION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CYCLOSPORINE; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; GLUTATHIONE; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84898657122     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3083     Document Type: Article

References (35)

1. Cicenas S, Zaliene A and Atkocius V: Treatment outcome of locally advanced stage IIIA/B lung cancer. Medicina (Kaunas) 45: 452-459, 2009 (In Lithuanian)
2. Szkorupa M, Klein J, Bohanes T, et al: Neoadjuvant chemotherapy and surgical treatment in advanced stages of non-small cell lung cancer. Rozhl Chir 90: 433-439, 2011 (In Czech)
3. Spásová I: The position of neoadjuvant chemotherapy in the treatment of non-small-cell lung carcinoma. Vnitr Lek 53: 715-723, 2007 (In Czech)
4. Lee Y, Kim HY, Lee SH, et al: Clinical significance of heterogeneity in response to retreatment with epidermal growth factor receptor tyrosine kinase inhibitors in patients with lung cancer acquiring secondary resistance to the drug. Clin Lung Cancer 15: 145-151, 2014
5. Goldberg SB, Oxnard GR, Digumarthy S, et al: Chemotherapy with erlotinib or chemotherapy alone in advanced non-small cell lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors. Oncologist 18: 1214-1220, 2013
6. Ju JF, Yu WP, Fu CS and Ma LM: Modern research and clinical application of ?-elemene. Qilu Pharm Affairs 27: 546-548, 2008
7. Guo HQ, Zhang GN, Wang YJ, et al: ?-elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter. Oncol Rep 31: 858-866, 2014
8. Hao SH, Zhang J and Zhang T: A study of elemene emulsion treated advanced non small cell lung cancer on platinum based chemotherapy. Clin Focus 27: 1529-1531, 2012 (?n Chinese)
9. Zhao C, Zhang YC, Sun YY, et al: A study of elemene injection combined with interventional chemotherapy treated primary liver cancer. Chin J Diffic Compl Cas 11: 882-883, 2012 (?n Chinese)
10. Cheng HD, Yang Z, Zhang MJ, et al: Clinical observation of elemene combined with paclitaxel/tegafur in the treatment of advanced esophageal carcinoma. J Anhui Med Pharm 16: 1679-1681, 2012 (?n Chinese)
11. Ren W and Du SK: Different effect of elemene and BCG on preventing the recurrence of postoperative superficial bladder. J Shaanxi Med 41: 1151-1152, 2012 (?n Chinese)
12. Li QQ, Lee RX, Liang H, Zhong Y and Reed E: Enhancement of cisplatin-induced apoptosis by ?-elemene in resistant human ovarian cancer cells. Med Oncol 30: 424-444, 2013
13. Zhang Y, Mu XD, Li EZ, et al: The role of E3 ubiquitin ligase cbl proteins in reversing multi-drug resistance of ?-elemene human gastric adenocarcinoma cells. Int J Mol Sci 14: 10075-10089, 2013
14. Miedlich SU, Zalutskaya A, Zhu ED, et al: Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1/2 phosphorylation. J Biol Chem 285: 18270-18275, 2010
15. Hong J, Samudio I, Chintharlapalli S, et al: 1,1-bis (3'-indolyl)-1- (p-substituted phenyl) methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Mol Carcinog 47: 492-507, 2008
16. Zuo L and Motherwell MS: The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease. Gene 532: 18-23, 2013
17. Circu ML and Aw TY: Glutathione and modulation of cell apoptosis. Biochim Biophys Acta 1823: 1767-1777, 2012
18. Park HJ, Jeon YK, You DH, et al: Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. Food Chem Toxicol 60: 542-549, 2013
19. Brentnall M, Rodriguez-Menocal L, De Guevara RL, et al: Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol 9: 32-40, 2013
20. Gyulkhandanyan AV, Mutlu A, Freedman J, et al: Markers of platelet apoptosis: Methodology and applications. J Thromb Thrombolysis 33: 397-411, 2012
21. Pucci B, Kasten M and Giordano A: Cell cycle and apoptosis. Neoplasia 2: 291-299, 2000
22. Robertson JD, Orrenius S and Zhivotovsky B: Review: Nuclear events in apoptosis. J Struct Biol 129: 346-358, 2000
23. Tait JF: Imaging of apoptosis. J Nucl Med 49: 1573-1576, 2008
24. Radovi? N, Cuci? S and Altarac S: Molecular aspects of apoptosis. Acta Med Croatica 62: 249-256, 2008 (In Croatian)
25. Prosperini A, Juan-García A, Font G, et al: Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells. Toxicol Lett 222: 204-211, 2013
26. Yan F, Yang WK, Li XY, et al: A trifunctional enzyme with glutathione S-transferase, glutathione peroxidase and superoxide dismutase activity. Biochim Biophys Acta 1780: 869-872, 2008
27. Yang L, Wang P, Wang H, et al: Fucoidan derived from Undaria pinnatifida induces apoptosis in human hepatocellular carcinoma SMMC-7721 cells via the ROS-mediated mitochondrial pathway. Mar Drugs 11: 1961-1976, 2013
28. Liu XT, Wang YR and Zhang M: Mitochondria-mediated apoptosis: A review of recent studies. J Environ Health 30: 182-184, 2013
29. Zhao D, Huo LF, Liu H, et al: Mitochondria, cytochrome c, caspase and cell apoptosis. J Med Pest Control 28: 1337-1340, 2012
30. Ng KB, Bustamam A, Sukari MA, et al: Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from Boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest. BMC Complement Altern Med 13: 41-68, 2013
31. Ning Y, Riggins RB, Mulla JE, et al: Interferon ? restores breast cancer sensitivity to fulvestrant by regulating STAT1, IRF1, NF-?B, BCL2 family members, and signaling to caspase-dependent apoptosis. Mol Cancer Ther 9: 1274-1285, 2010
32. Liang Y and Sundberg JP: SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes. J Dermatol Sci 63: 148-153, 2011
33. Joshi S, Braithwaite AW, Robinson PJ and Chircop M: Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. Mol Cancer 10: 78-103, 2011
34. Favaloro B, Allocati N, Graziano V, et al: Role of apoptosis in disease. Aging 4: 330-349, 2012
35. Merhi F, Tang R, Piedfer M, et al: Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells. PLoS One 6: E25963, 2011