SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes

Journal of Dermatological Science

Volumn 63, Issue 3, 2011, Pages 148-153

  Liang, Yanhua ^a,b   Sundberg, John P ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

Apoptosis; Keratinocyte; Mice; Mitochondria; Sharpin

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; PROTEIN BAX; PROTEIN BCL 2; SHARPIN PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DISRUPTION; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; KERATINOCYTE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARRIER PROTEINS; CASPASES; CELL PROLIFERATION; DERMATITIS; FEMALE; KERATINOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MUTATION; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 79960905833     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.04.012     Document Type: Article

References (31)

1. Feldman S., Behnam S.M., Behnam S.E., et al. Involving the patient: impact of inflammatory skin disease and patient-focused care. J Am Acad Dermatol 2005, 53:S78-S85.
2. Thind C.K., Ormerod A.D. Recent advances in inflammatory skin diseases. Scott Med J 2008, 53:30-34. quiz 4, 66.
3. HogenEsch H., Gijbels M.J., Offerman E., et al. A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am J Pathol 1993, 143:972-982.
4. HogenEsch H., Janke S., Boggess D., et al. Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice. J Immunol 1999, 162:3890-3896.
5. Seymour R., Sundberg J.P., Hogenesch H. Abnormal lymphoid organ development in immunodeficient mutant mice. Vet Pathol 2006, 43:401-423.
6. Gudjonsson J.E., Johnston A., Dyson M., et al. Mouse models of psoriasis. J Invest Dermatol 2007, 127:1292-1308.
7. Schon M.P. Animal models of psoriasis - what can we learn from them?. J Invest Dermatol 1999, 112:405-410.
8. Schon M.P. Animal models of psoriasis: a critical appraisal. Exp Dermatol 2008, 17:703-712.
9. HogenEsch H., Boggess D., Sundberg J.P. Changes in keratin and filaggrin expression in the skin of chronic proliferative dermatitis (cpdm) mutant mice. Pathobiology 1999, 67:45-50.
10. HogenEsch H., Torregrosa S.E., Boggess D., et al. Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12. Eur J Immunol 2001, 31:734-742.
11. Seymour R.E., Hasham M.G., Cox G.A., et al. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun 2007, 8:416-421.
12. Lim S., Sala C., Yoon J., et al. Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Mol Cell Neurosci 2001, 17:385-397.
13. Marchler-Bauer A., Anderson J.B., Derbyshire M.K., et al. CDD: a conserved domain database for interactive domain family analysis. Nucleic Acids Res 2007, 35:D237-D240.
14. Gijbels M.J., HogenEsch H., Blauw B., et al. Ultrastructure of epidermis of mice with chronic proliferative dermatitis. Ultrastruct Pathol 1995, 19:107-111.
15. Behne M.J., Barry N.P., Hanson K.M., et al. Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. J Invest Dermatol 2003, 120:998-1006.
16. Lippens S., Denecker G., Ovaere P., et al. Death penalty for keratinocytes: apoptosis versus cornification. Cell Death Differ 2005, 12(Suppl. 2):1497-1508.
17. Polakowska R.R., Haake A.R. Apoptosis: the skin from a new perspective. Cell Death Differ 1994, 1:19-31.
18. Lippens S., Kockx M., Knaapen M., et al. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. Cell Death Differ 2000, 7:1218-1224.
19. Lowe S.W., Cepero E., Evan G. Intrinsic tumour suppression. Nature 2004, 432:307-315.
20. Peter M.E., Krammer P.H. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 2003, 10:26-35.
21. Riedl S.J., Salvesen G.S. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 2007, 8:405-413.
22. Medema J.P., Scaffidi C., Kischkel F.C., et al. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 1997, 16:2794-2804.
23. Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
24. Lichti U., Anders J., Yuspa S.H. Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc 2008, 3:799-810.
25. Robertson J.D., Orrenius S., Zhivotovsky B. Review: nuclear events in apoptosis. J Struct Biol 2000, 129:346-358.
26. Gosselin K., Deruy E., Martien S., et al. Senescent keratinocytes die by autophagic programmed cell death. Am J Pathol 2009, 174:423-435.
27. Tinari A., Giammarioli A.M., Manganelli V., et al. Analyzing morphological and ultrastructural features in cell death. Methods Enzymol 2008, 442:1-26.
28. Raj D., Brash D.E., Grossman D. Keratinocyte apoptosis in epidermal development and disease. J Invest Dermatol 2006, 126:243-257.
29. Nair R.P., Duffin K.C., Helms C., et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 2009, 41:199-204.
30. Zhang X.J., Huang W., Yang S., et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 2009, 41:205-210.
31. Doonan F., Cotter T.G. Morphological assessment of apoptosis. Methods 2008, 44:200-204.