Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1/2 phosphorylation

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18270-18275

  Miedlich, Susanne U ^a   Zalutskaya, Alena ^a   Zhu, Eric D ^a   Demay, Marie B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC PATHWAYS; CHONDROCYTES; GROWTH PLATE; HYPERTROPHIC CHONDROCYTES; IMMUNOREACTIVITIES; IN-VIVO; INDUCED APOPTOSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MRNA EXPRESSION; PARATHYROID HORMONES; PHOSPHATE LEVELS; POST TREATMENT; PROTEIN SIGNALING; SIGNALING PATHWAYS; VITAMIN-D;

ANIMALS; CELL CULTURE; CELL DEATH; CELL MEMBRANES; MAGNESIUM PRINTING PLATES; PHOSPHORYLATION; PROTEINS; SIGNALING;

BODY FLUIDS;

GELATINASE B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATE; VASCULOTROPIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; GROWTH PLATE; IMMUNOREACTIVITY; IN VIVO STUDY; KIDNEY TUBULE ABSORPTION; METATARSAL BONE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; FLOW CYTOMETRY; HYPERTROPHY; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHATES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA; MURINAE; MUS;

EID: 77953317000     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.098616     Document Type: Article

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