High-energy ball milling of saquinavir increases permeability across the buccal mucosa

Drug Development and Industrial Pharmacy

Volumn 40, Issue 5, 2014, Pages 639-648

  Rambharose, Sanjeev ^a   Ojewole, Elizabeth ^a   Branham, Michael ^a   Kalhapure, Rahul ^a   Govender, Thirumala ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Ball milling; Buccal permeability; Histology; Permeation enhancer; Saquinavir

Indexed keywords

SAQUINAVIR; DODECYL SULFATE SODIUM; DRUG DOSAGE FORM; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; SURFACTANT;

ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CHEEK MUCOSA; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG SOLUBILITY; LAMINA PROPRIA; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; STEADY STATE; SWINE; SYSTEMIC CIRCULATION; TIGHT JUNCTION; ANATOMY AND HISTOLOGY; ANIMAL; BUCCAL DRUG ADMINISTRATION; DRUG DOSAGE FORM; DRUG EFFECTS; GASTROINTESTINAL ABSORPTION; HIV INFECTIONS; MEDICINAL CHEMISTRY; METABOLISM; MOUTH MUCOSA; PERMEABILITY; PIG; SOLUBILITY; TRANSMISSION ELECTRON MICROSCOPY;

ADMINISTRATION, BUCCAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; HIV INFECTIONS; HIV PROTEASE INHIBITORS; MICROSCOPY, ELECTRON, TRANSMISSION; MOUTH MUCOSA; ORAL MUCOSAL ABSORPTION; PERMEABILITY; SAQUINAVIR; SODIUM DODECYL SULFATE; SOLUBILITY; SURFACE-ACTIVE AGENTS; SUS SCROFA;

EID: 84898646867     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2014.884120     Document Type: Article

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