Investigating the effect of Aloe vera gel on the buccal permeability of didanosine

Planta Medica

Volumn 78, Issue 4, 2012, Pages 354-361

  Ojewole, Elizabeth ^a   Mackraj, Irene ^a   Akhundov, Kamil ^b   Hamman, Josias ^c   Viljoen, Alvaro ^c   Olivier, Eugene ^c   Wesley Smith, James ^a   Govender, Thirumala ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c TSHWANE UNIVERSITY OF TECHNOLOGY   (South Africa)

Author keywords

Aloe barbadensis Miller; Aloe vera (L.) Burm. F.; Asphodelaceae; buccal; didanosine; histomorphology; permeation enhancer

Indexed keywords

DIDANOSINE; PHOSPHATE BUFFERED SALINE;

ALOE VERA; ALOE VERA GEL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CHEEK MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRISTAE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG PENETRATION; DRUG TRANSPORT; GEL; HISTOLOGY; MEMBRANE PERMEABILITY; NONHUMAN;

ADMINISTRATION, BUCCAL; ALOE; ANIMALS; CELL MEMBRANE PERMEABILITY; DIDANOSINE; GELS; MOUTH MUCOSA; PLANT EXTRACTS; SWINE;

ALOE VERA; ASPHODELACEAE;

EID: 84858154994     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280431     Document Type: Article

References (34)

1. Rathbun RC, Lockhart SM, Stephens JR. Current HIV treatment guidelines - an overview. Curr Pharm Des 2006; 12: 1045-1063
2. Heyer A, Ogunbanjo GA. Adherence to HIVantiretroviral therapy Part II: which interventions are effective in improving adherence? SA Fam Pract 2006; 48: 6-10 (Pubitemid 44947082)
3. Xiang J, Fang X, Li X. Transbuccal delivery of 2′,3′- dideoxycytidine: in vitro permeation study and histological investigation. Int J Pharm 2002; 231: 57-66 (Pubitemid 33086819)
4. Li X, Chan WK. Transport, metabolism and elimination mechanisms of anti-HIV agents. Adv Drug Deliv Rev 1999; 39: 81-103 (Pubitemid 29430231)
5. Pather SI, Rathbone MJ, Senel S. Current status and the future of buccal drug delivery systems. Expert Opin Drug Deliv 2008; 5: 531-542 (Pubitemid 351877432)
6. Rossi S, Sandri G, Caramella CM. Buccal drug delivery: A challenge already won? Drug Discov Today Technol 2005; 2: 59-65 (Pubitemid 40946309)
7. Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005; 57: 1666-1691 (Pubitemid 41443474)
8. Narishetty STK, Panchagnula R. Effect of L-menthol and 1,8-cineole on phase behaviour and molecular organization of SC lipids and skin permeation of zidovudine. J Control Release 2005; 102: 59-70 (Pubitemid 40093776)
9. Mukherji E, Millenbaugh NJ, Au JL. Percutaneous absorption of 2′,3′-dideoxyinosine in rats. Pharm Res 1994; 11: 809-815
10. Giannola LI, De Caro V, Giandalia G, Siragusa MG, Tripodo C, Florena AM, Campisi G. Release of naltrexone on buccal mucosa: permeation studies, histological aspects and matrix system design. Eur J Pharm Biopharm 2007; 67: 425-433 (Pubitemid 47211903)
11. Senel S, Hincal AA. Drug permeation enhancement via buccal route: possibilities and limitations. J Control Release 2001; 72: 133-144
12. Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr Polym 1999; 39: 109-117
13. Chen W, Lu Z, Viljoen A, Hamman J. Intestinal drug transport enhancement by Aloe vera. Planta Med 2009; 75: 587-595
14. Reynolds T, Dweck AC. Aloe vera leaf gel: a review update. J Ethnopharmacol 1999; 68: 3-37 (Pubitemid 29502456)
15. Boudreau MD, Beland FA. An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera. J Environ Sci Health C 2006; 24: 103-154
16. Pugh N, Ross SA, ElSohly MA, Pasco DS. Characterization of aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem 2001; 49: 1030-1034 (Pubitemid 32172665)
17. Cole L, Heard C. Skin permeation enhancement potential of Aloe vera and a proposed mechanism of action based upon size exclusion and pull effect. Int J Pharm 2007; 333: 10-16 (Pubitemid 46283265)
18. Jani GK, Shah DP, Jain VC, Patel MJ, Vithalan DA. Evaluating mucilage from Aloe barbadensis Miller as a pharmaceutical excipient for sustained- release matrix tablets. Pharm Technol 2007; 31: 90-98
19. Giannola LI, De Caro V, Giandalia G, SiragusaMG, Campisi G, Florena AM, Ciach T. Diffusion of naltrexone across reconstituted human oral epithelium and histomorphological features. Eur J Pharm Biopharm 2007; 65: 238-246 (Pubitemid 46038078)
20. Koland M, Sandeep VP, Charyulu NR. Fast dissolving sublingual films of ondansetron hydrochloride: effect of additives on in vitro drug release and mucosal permeation. J Young Pharm 2010; 2: 216-222
21. Shojaei AH, Khan M, Lim G, Khosravan R. Transbuccal permeation of a nucleoside analog, dideoxycytidine: effects of menthol as a permeation enhancer. Int J Pharm 1999; 192: 139-146 (Pubitemid 29531548)
22. Karnovsky MJ. A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J Cell Biol 1965; 27: 137A-138A
23. Mahalingam R, Ravivarapu H, Redhkar S, Li X, Jasti BR. Transbuccal delivery of 5-aza-2-deoxycytidine: effects of drug concentration, buffer solution, and bile salts on permeation. AAPS PharmSciTech 2007; 8 (55): E1-E6 (Pubitemid 47103045)
24. Heemstra LB, Finnin BC, Nicolazzo JA. Buccal mucosa as an alternative route for the systemic delivery of risperidone. J Pharm Sci 2010; 99: 4584-4592
25. Hassan N, Ahad A, Ali M, Ali J. Chemical permeation enhancers for transbuccal drug delivery. Expert Opin Drug Deliv 2010; 7: 97-112
26. Sandri G, Poggi P, Bonferoni MC, Rossi S, Ferrari F, Caramella C. Histological evaluation of buccal penetration enhancement properties of chitosan and trimethyl chitosan. J Pharm Pharmacol 2006; 58: 1327-1336 (Pubitemid 44596129)
27. Hu L, Damaj BB, Martin R, Michniak-Kohn BB. Enhanced in vitro transbuccal drug delivery of ondansetron HCl. Int J Pharm 2011; 404: 66-74
28. Sandri G, Rossi S, Bonferoni MC, Ferrari F, Zambito Y, Di Colo G. Buccal penetration enhancement properties of N-trimethyl chitosan: Influence of quaternization degree on absorption of a high molecular weight molecule. Int J Pharm 2005; 297: 146-155 (Pubitemid 40720274)
29. Shin S, Cho C, Oh I. Enhanced efficacy by percutaneous absorption of piroxicam from the ploxamer gel in rats. Int J Pharm 2000; 193: 213-218 (Pubitemid 30001864)
30. Shin S, Kim J. Enhanced permeation of triamcinolone acetonide through the buccal mucosa. Eur J Pharm Biopharm 2000; 50: 217-220
31. Figueiras A, Hombach J, Veiga F, Bernkop-Schnürch A. In vitro evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery. Eur J Pharm Biopharm 2009; 71: 339-345
32. de Vries ME, Boddé HE, Verhoef JC, Ponee M, Craane WIHM, Junginger HE. Localization of the permeability barrier inside porcine buccal mucosa: a combined in vitro study of drug permeability, electrical resistance and tissue morphology. Int J Pharm 1991; 76: 25-35
33. Madhav NVS, Shakya AK, Shakya P, Singh K. Orotransmucosal drug delivery systems: a review. J Control Release 2009; 140: 2-11
34. Dorr W, Jacubek A, Kummermehr J, Herrmann T, Dolling-Jochem I, Eckelt U. Effects of stimulated repopulation on oral mucositis during conventional radiotherapy. Radiother Oncol 1995; 37: 100-107