메뉴 건너뛰기




Volumn 15, Issue 4, 2014, Pages 5952-5969

Leucyl-tRNA synthetase regulates lactation and cell proliferation via mTOR signaling in dairy cow mammary epithelial cells

Author keywords

Cell proliferation; Dairy cow mammary epithelial cells; Lactation; Leucine; LeuRS; MTOR

Indexed keywords

BETA CASEIN; CYCLIN D1; GLUCOSE TRANSPORTER 1; LACTOSE; LEUCINE TRANSFER RNA LIGASE; MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; CASEIN; LEUCINE; MESSENGER RNA; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TARGET OF RAPAMYCIN KINASE;

EID: 84898614103     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15045952     Document Type: Article
Times cited : (58)

References (56)
  • 1
    • 0022016567 scopus 로고
    • Glucagon, insulin, growth hormone, and glucose concentrations in blood plasma of lactating dairy cows
    • Herbein, J.H.; Aiello, R.J.; Eckler, L.I.; Pearson, R.E.; Akers, R.M. Glucagon, insulin, growth hormone, and glucose concentrations in blood plasma of lactating dairy cows. J. Dairy Sci. 1985, 68, 320-325.
    • (1985) J. Dairy Sci , vol.68 , pp. 320-325
    • Herbein, J.H.1    Aiello, R.J.2    Eckler, L.I.3    Pearson, R.E.4    Akers, R.M.5
  • 2
    • 0013894914 scopus 로고
    • Effect of insulin on yield and composition of milk of dairy cows
    • Schmidt, G.H. Effect of insulin on yield and composition of milk of dairy cows. J. Dairy Sci. 1966, 9, 381-385.
    • (1966) J. Dairy Sci , vol.9 , pp. 381-385
    • Schmidt, G.H.1
  • 3
    • 0020095034 scopus 로고
    • Amino acid utilization by lactating mammary gland
    • Mepham, T.B. Amino acid utilization by lactating mammary gland. J. Dairy Sci. 1982, 65, 87-98.
    • (1982) J. Dairy Sci , vol.65 , pp. 87-98
    • Mepham, T.B.1
  • 4
    • 0034202828 scopus 로고    scopus 로고
    • Evaluation of whole blood and plasma in the interorgan supply of free amino acids for the mammary gland of lactating dairy cows
    • Mackle, T.R.; Dwyer, D.A.; Ingvartsen, K.L.; Chouinard, P.Y.; Ross, D.A.; Bauman, D.E. Evaluation of whole blood and plasma in the interorgan supply of free amino acids for the mammary gland of lactating dairy cows. J. Dairy Sci. 2000, 83, 1300-1309.
    • (2000) J. Dairy Sci , vol.83 , pp. 1300-1309
    • Mackle, T.R.1    Dwyer, D.A.2    Ingvartsen, K.L.3    Chouinard, P.Y.4    Ross, D.A.5    Bauman, D.E.6
  • 5
    • 33646178144 scopus 로고    scopus 로고
    • Major advances associated with the biosynthesis of milk
    • Bauman, D.E.; Mather, I.H.; Wall, R.J.; Lock, A.L. Major advances associated with the biosynthesis of milk. J. Dairy Sci. 2006, 89, 1235-1243.
    • (2006) J. Dairy Sci , vol.89 , pp. 1235-1243
    • Bauman, D.E.1    Mather, I.H.2    Wall, R.J.3    Lock, A.L.4
  • 6
    • 33646188810 scopus 로고    scopus 로고
    • Major advances in nutrition: Impact on milk composition
    • Jenkins, T.C.; McGuire, M.A. Major advances in nutrition: Impact on milk composition. J. Dairy Sci. 2006, 89, 2-10.
    • (2006) J. Dairy Sci , vol.89 , pp. 2-10
    • Jenkins, T.C.1    McGuire, M.A.2
  • 9
    • 79958795394 scopus 로고    scopus 로고
    • Frontier of epilepsy research-mTOR signaling pathway
    • Cho, C.H. Frontier of epilepsy research-mTOR signaling pathway. Exp. Mol. Med. 2011, 43, 231-274.
    • (2011) Exp. Mol. Med , vol.43 , pp. 231-274
    • Cho, C.H.1
  • 10
    • 84884676252 scopus 로고    scopus 로고
    • Nutrient signaling to mTOR and cell growth
    • Jewell, J.L; Guan, K.L. Nutrient signaling to mTOR and cell growth. Trends Biochem. Sci. 2013, 38, 233-242.
    • (2013) Trends Biochem. Sci , vol.38 , pp. 233-242
    • Jewell, J.L.1    Guan, K.L.2
  • 11
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak, Y.; Bar-Peled, L.; Zoncu, R.; Markhard, A.L.; Nada, S.; Sabatini, D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141, 290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 12
    • 84873469666 scopus 로고    scopus 로고
    • Nutrient sensing, metabolism, and cell growth control
    • Yuan, H.X.; Xiong, Y.; Guan, K.L. Nutrient sensing, metabolism, and cell growth control. Mol. Cell 2013, 49, 379-387.
    • (2013) Mol. Cell , vol.49 , pp. 379-387
    • Yuan, H.X.1    Xiong, Y.2    Guan, K.L.3
  • 13
    • 31344482641 scopus 로고    scopus 로고
    • Metabolism of branched-chain amino acids in maple syrup urine disease
    • Schadewaldt, P.; Wendel, U. Metabolism of branched-chain amino acids in maple syrup urine disease. Eur. J. Pediatr. 1997, 156, 62-66.
    • (1997) Eur. J. Pediatr , vol.156 , pp. 62-66
    • Schadewaldt, P.1    Wendel, U.2
  • 14
    • 36749047009 scopus 로고    scopus 로고
    • Amino acids and mTOR signalling in anabolic function
    • Proud, C.G. Amino acids and mTOR signalling in anabolic function. Biochem. Soc. Trans. 2007, 35, 1187-1190.
    • (2007) Biochem. Soc. Trans , vol.35 , pp. 1187-1190
    • Proud, C.G.1
  • 15
    • 34247573364 scopus 로고    scopus 로고
    • Leucine and protein synthesis: MTOR and beyond
    • Stipanuk, M.H. Leucine and protein synthesis: mTOR and beyond. Nutr. Rev. 2007, 65, 122-129.
    • (2007) Nutr. Rev , vol.65 , pp. 122-129
    • Stipanuk, M.H.1
  • 16
    • 66849131401 scopus 로고    scopus 로고
    • Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling
    • Kim, M.S.; Wu, K.Y.; Auyeung, V.; Chen, Q.; Gruppuso, P.A.; Phornphutkul, C. Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling. Am. J. Physiol. Endocrinol. Metab. 2009, 296, 1374-1382.
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.296 , pp. 1374-1382
    • Kim, M.S.1    Wu, K.Y.2    Auyeung, V.3    Chen, Q.4    Gruppuso, P.A.5    Phornphutkul, C.6
  • 17
    • 84865041393 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase: Double duty in amino acid sensing
    • Durán, R.V.; Hall, M.N. Leucyl-tRNA synthetase: Double duty in amino acid sensing. Cell Res. 2012, 68, 1207-1209.
    • (2012) Cell Res , vol.68 , pp. 1207-1209
    • Durán, R.V.1    Hall, M.N.2
  • 19
    • 84862777407 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    • Han, J.M.; Jeong, S.J.; Park, M.C.; Kim, G.; Kwon, N.H.; Kim, H.K.; Ha, S.H.; Ryu, S.H.; Kim, S. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012, 149, 410-424.
    • (2012) Cell , vol.149 , pp. 410-424
    • Han, J.M.1    Jeong, S.J.2    Park, M.C.3    Kim, G.4    Kwon, N.H.5    Kim, H.K.6    Ha, S.H.7    Ryu, S.H.8    Kim, S.9
  • 20
    • 4344599587 scopus 로고    scopus 로고
    • Cell Adhesion in manlmary gland biology and neoplasia
    • Charles, H.S. Cell Adhesion in manlmary gland biology and neoplasia. J. Mammary Gland Biol. Neoplasia 2003, 8, 375-381.
    • (2003) J. Mammary Gland Biol. Neoplasia , vol.8 , pp. 375-381
    • Charles, H.S.1
  • 22
    • 84890923299 scopus 로고    scopus 로고
    • Modulation of lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes by sophoricoside
    • Wu, C.; Luan, H.; Wang, S.; Zhang, X.; Wang, R.; Jin, L.; Guo, P.; Chen, X. Modulation of lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes by sophoricoside. Molecules 2013, 18, 15624-15635.
    • (2013) Molecules , vol.18 , pp. 15624-15635
    • Wu, C.1    Luan, H.2    Wang, S.3    Zhang, X.4    Wang, R.5    Jin, L.6    Guo, P.7    Chen, X.8
  • 25
    • 31544466776 scopus 로고    scopus 로고
    • Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis
    • Kimball, S.R.; Jefferson, L.S. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J. Nutr. 2006, 136, 227S-231S.
    • (2006) J. Nutr , vol.136
    • Kimball, S.R.1    Jefferson, L.S.2
  • 28
    • 66349138676 scopus 로고    scopus 로고
    • Nutrient control of TORC1, a cell-cycle regulator
    • Wang, X.; Proud, C.G. Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol. 2009, 19, 260-267.
    • (2009) Trends Cell Biol , vol.19 , pp. 260-267
    • Wang, X.1    Proud, C.G.2
  • 29
    • 84856249448 scopus 로고    scopus 로고
    • How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal
    • Ktistakis, N.T.; Manifava, M.; Schoenfelder, P.; Rotondo, S. How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal. Biochem. Soc. Trans. 2012, 40, 37-43.
    • (2012) Biochem. Soc. Trans , vol.40 , pp. 37-43
    • Ktistakis, N.T.1    Manifava, M.2    Schoenfelder, P.3    Rotondo, S.4
  • 31
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • Um, S.H.; D'Alessio, D.; Thomas, G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 2006, 3, 393-402.
    • (2006) Cell Metab , vol.3 , pp. 393-402
    • Um, S.H.1    D'Alessio, D.2    Thomas, G.3
  • 32
    • 34249679614 scopus 로고    scopus 로고
    • mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
    • Dann, S.G; Selvaraj, A; Thomas, G. mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer. Trends Mol. Med. 2007, 13, 252-259.
    • (2007) Trends Mol. Med , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 35
    • 36649025517 scopus 로고    scopus 로고
    • Translational regulation of milk protein synthesis at secretory activation
    • Rhoads, E.R.; Grudzien-Nogalska, E. Translational regulation of milk protein synthesis at secretory activation. J. Mammary Gland Biol. Neoplasia 2007, 12, 283-292.
    • (2007) J. Mammary Gland Biol. Neoplasia , vol.12 , pp. 283-292
    • Rhoads, E.R.1    Grudzien-Nogalska, E.2
  • 36
    • 74949103559 scopus 로고    scopus 로고
    • Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signalling pathway
    • Burgos, S.A.; Dai, M.; Cant, J.P. Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signalling pathway. J. Dairy Sci. 2010, 93, 153-161.
    • (2010) J. Dairy Sci , vol.93 , pp. 153-161
    • Burgos, S.A.1    Dai, M.2    Cant, J.P.3
  • 37
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • Byfield, M.P.; Murray, J.T.; Backer, J.M. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 2005, 280, 33076-33082.
    • (2005) J. Biol. Chem , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 40
    • 79958116645 scopus 로고    scopus 로고
    • Gene networks driving bovine mammary protein synthesis during the lactation cycle
    • Bionaz, M.; Loor, J.J. Gene networks driving bovine mammary protein synthesis during the lactation cycle. Bioinform. Biol. Insights 2011, 5, 83-98.
    • (2011) Bioinform. Biol. Insights , vol.5 , pp. 83-98
    • Bionaz, M.1    Loor, J.J.2
  • 41
    • 84892997710 scopus 로고    scopus 로고
    • MiR-103 Controls Milk fat accumulation in goat (Capra hircus) mammary gland during lactation
    • Lin, X.; Luo, J.; Zhang, L.; Wang, W.; Gou, D. MiR-103 Controls Milk fat accumulation in goat (Capra hircus) mammary gland during lactation. PLoS One 2013, 11, e79258.
    • (2013) PLoS One , vol.11
    • Lin, X.1    Luo, J.2    Zhang, L.3    Wang, W.4    Gou, D.5
  • 44
    • 0028052991 scopus 로고
    • High and polarized expression of GLUT1 glucose transporters inepithelial cells from mammary gland: Acute down regulation of GLUT1 carriers by weaning
    • Camps, M.; Vilaro, S.; Testar, X.; Palacín, M.; Zorzano, A. High and polarized expression of GLUT1 glucose transporters inepithelial cells from mammary gland: Acute down regulation of GLUT1 carriers by weaning. Endocrinology 1994, 134, 924-934.
    • (1994) Endocrinology , vol.134 , pp. 924-934
    • Camps, M.1    Vilaro, S.2    Testar, X.3    Palacín, M.4    Zorzano, A.5
  • 45
    • 52249089184 scopus 로고    scopus 로고
    • Gene networks driving bovine milk fat synthesis during the lactation cycle
    • Bionaz, M.; Loor, J.J. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Gen. 2008, 9, 83-98.
    • (2008) BMC Gen , vol.9 , pp. 83-98
    • Bionaz, M.1    Loor, J.J.2
  • 47
    • 84861043736 scopus 로고    scopus 로고
    • Connecting mTORC1 signaling to SREBP-1 activation
    • Bakan, I.; Laplante, M. Connecting mTORC1 signaling to SREBP-1 activation. Curr. Opin. Lipidol. 2012, 23, 226-234.
    • (2012) Curr. Opin. Lipidol , vol.23 , pp. 226-234
    • Bakan, I.1    Laplante, M.2
  • 48
    • 79960319519 scopus 로고    scopus 로고
    • Metabolic regulation of mammary gland epithelial cells of dairy cow by galactopoietic compound isolated from Vaccariae segetalis
    • Tong, H.L.; Gao, X.J.; Li, Q.Z. Metabolic regulation of mammary gland epithelial cells of dairy cow by galactopoietic compound isolated from Vaccariae segetalis. Agric. Sci. China 2011, 10, 1106-1116.
    • (2011) Agric. Sci. China , vol.10 , pp. 1106-1116
    • Tong, H.L.1    Gao, X.J.2    Li, Q.Z.3
  • 49
    • 84868108262 scopus 로고    scopus 로고
    • MiR-15a decreases bovine mammary epithelial cell viability and lactation and regulates growth hormone receptor expression
    • Li, H.-M.; Wang, C.-M.; Li, Q.-Z.; Gao, X.-J. MiR-15a decreases bovine mammary epithelial cell viability and lactation and regulates growth hormone receptor expression. Molecules 2012, 17, 12037-12048.
    • (2012) Molecules , vol.17 , pp. 12037-12048
    • Li, H.-M.1    Wang, C.-M.2    Li, Q.-Z.3    Gao, X.-J.4
  • 51
    • 84875101911 scopus 로고    scopus 로고
    • Expression and functions of fibroblast growth factor 10 in the mou semammary gland
    • Cui, Y.-J.; Li, Q.-Z.H. Expression and functions of fibroblast growth factor 10 in the mou semammary gland. Int. J. Mol. Sci. 2013, 14, 4094-4105.
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 4094-4105
    • Cui, Y.-J.1    Li, Q.-Z.H.2
  • 52
    • 77649341620 scopus 로고    scopus 로고
    • PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development
    • Chan, C.-B.; Liu, X.; Ensslin, M.A.; Dillehay, D.L.; Ormandy, C.J.; Sohn, P.; Serra, R.; Ye, K. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J. 2010, 29, 956-968.
    • (2010) EMBO J , vol.29 , pp. 956-968
    • Chan, C.-B.1    Liu, X.2    Ensslin, M.A.3    Dillehay, D.L.4    Ormandy, C.J.5    Sohn, P.6    Serra, R.7    Ye, K.8
  • 53
    • 84872864944 scopus 로고    scopus 로고
    • Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis
    • Lu, L.M.; Li, Q.Z.; Huang, J.G.; Gao, X.J. Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis. Molecules 2013, 18, 263-275.
    • (2013) Molecules , vol.18 , pp. 263-275
    • Lu, L.M.1    Li, Q.Z.2    Huang, J.G.3    Gao, X.J.4
  • 54
    • 84886606236 scopus 로고    scopus 로고
    • SOCS3-Mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitro
    • Huang, Y.-L.; Zhao, F.; Luo, C.-C.; Zhang, X.; Si, Y.; Sun, Z.; Zhang, L.; Li, Q.-Z.; Gao, X.-J. SOCS3-Mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitro. Molecules 2013, 18, 12987-13002.
    • (2013) Molecules , vol.18 , pp. 12987-13002
    • Huang, Y.-L.1    Zhao, F.2    Luo, C.-C.3    Zhang, X.4    Si, Y.5    Sun, Z.6    Zhang, L.7    Li, Q.-Z.8    Gao, X.-J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.