Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 6, 2009, Pages

  Kim, Mimi S ^a   Ke, Ying Wu ^a   Auyeung, Valerie ^a   Chen, Qian ^a   Gruppuso, Philip A ^a   Phornphutkul, Chanika ^a,b  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

Author keywords

Gene expression; Mammalian target of rapamycin; Rapamycin

Indexed keywords

COLLAGEN TYPE 10; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN S6; PROTEOGLYCAN; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPLANT; FEMALE; FETUS; GROWTH INHIBITION; GROWTH PLATE; HYPERTROPHY; METATARSAL BONE; MICROARRAY ANALYSIS; NONHUMAN; NUTRIENT LIMITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CHONDROCYTES; FEMALE; GENE EXPRESSION REGULATION; LEUCINE; METATARSAL BONES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN CULTURE TECHNIQUES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PREGNANCY; RATS; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 66849131401     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.91018.2008     Document Type: Article

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