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Volumn 22, Issue 3, 2014, Pages 147-151

Inflammation and atherosclerosis: A review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy

Author keywords

atherosclerosis; coronary heart disease; interleukin 6; tocilizumab

Indexed keywords

ACUTE PHASE PROTEIN; CANAKINUMAB; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; METHOTREXATE; PLACEBO; TOCILIZUMAB; MONOCLONAL ANTIBODY;

EID: 84898601092     PISSN: 10615377     EISSN: 15384683     Source Type: Journal    
DOI: 10.1097/CRD.0000000000000021     Document Type: Review
Times cited : (329)

References (58)
  • 2
    • 84898599202 scopus 로고    scopus 로고
    • Preventing chronic disease: a vital investment Accessed 2/27/14
    • Preventing chronic disease: a vital investment. WHO Global Report. 2005. www.who.int/entity/chp/chronic-disease-report/en/-30K. Accessed 2/27/14.
    • (2005) WHO Global Report.
  • 3
    • 79952444246 scopus 로고    scopus 로고
    • Forecasting the future of cardiovascular disease in the United States: A policy statement from the American Heart Association
    • American Heart Association Advocacy Coordinating Committee; Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Arteriosclerosis; Thrombosis and Vascular Biology; Council on Cardiopulmonary; Critical Care; Perioperative and Resuscitation; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research
    • Heidenreich PA, Trogdon JG, Khavjou OA, et al; American Heart Association Advocacy Coordinating Committee; Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Arteriosclerosis; Thrombosis and Vascular Biology; Council on Cardiopulmonary; Critical Care; Perioperative and Resuscitation; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123:933-944.
    • (2011) Circulation. , vol.123 , pp. 933-944
    • Heidenreich, P.A.1    Trogdon, J.G.2    Khavjou, O.A.3
  • 4
    • 0026541706 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes (2)
    • Fuster V, Badimon L, Badimon JJ, et al. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med. 1992;326:310-318.
    • (1992) N Engl J Med. , vol.326 , pp. 310-318
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3
  • 5
  • 6
    • 0017305294 scopus 로고
    • The pathogenesis of atherosclerosis (frst of two parts)
    • Ross R, Glomset JA. The pathogenesis of atherosclerosis (frst of two parts). N Engl J Med. 1976;295:369-377.
    • (1976) N Engl J Med. , vol.295 , pp. 369-377
    • Ross, R.1    Glomset, J.A.2
  • 7
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an infammatory disease
    • Ross R. Atherosclerosis-an infammatory disease. N Engl J Med. 1999;340: 115-126.
    • (1999) N Engl J Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 9
    • 0032501738 scopus 로고    scopus 로고
    • Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men
    • Ridker PM, Hennekens CH, Roitman-Johnson B, et al. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet. 1998;351:88-92.
    • (1998) Lancet. , vol.351 , pp. 88-92
    • Ridker, P.M.1    Hennekens, C.H.2    Roitman-Johnson, B.3
  • 10
    • 0035010184 scopus 로고    scopus 로고
    • A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    • Cybulsky MI, Iiyama K, Li H, et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001;107:1255-1262.
    • (2001) J Clin Invest. , vol.107 , pp. 1255-1262
    • Cybulsky, M.I.1    Iiyama, K.2    Li, H.3
  • 11
    • 0035908941 scopus 로고    scopus 로고
    • Circulating cell adhesion molecules and death in patients with coronary artery disease
    • Blankenberg S, Rupprecht HJ, Bickel C, et al. Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation. 2001;104:1336-1342.
    • (2001) Circulation. , vol.104 , pp. 1336-1342
    • Blankenberg, S.1    Rupprecht, H.J.2    Bickel, C.3
  • 12
    • 0032134003 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-defcient mice
    • Gu L, Okada Y, Clinton SK, et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-defcient mice. Mol Cell. 1998;2:275-281.
    • (1998) Mol Cell. , vol.2 , pp. 275-281
    • Gu, L.1    Okada, Y.2    Clinton, S.K.3
  • 13
    • 17644412023 scopus 로고    scopus 로고
    • Infammation, atherosclerosis, and coronary artery disease
    • Hannson GK. Infammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685-95.
    • (2005) N Engl J Med. , vol.352 , pp. 1685-1695
    • Hannson, G.K.1
  • 14
    • 0000256847 scopus 로고    scopus 로고
    • The role of the lymphocyte
    • Fuster V Ross R Topol E eds New York NY: Lippincott-Raven
    • Hansson G, Libby P. The role of the lymphocyte. In: Fuster V, Ross R, Topol E, eds. Atherosclerosis and Coronary Artery Disease. New York, NY: Lippincott-Raven; 1996:557-568.
    • (1996) Atherosclerosis and Coronary Artery Disease , pp. 557-568
    • Hansson, G.1    Libby, P.2
  • 15
    • 34250014988 scopus 로고    scopus 로고
    • Mast cells promote atherosclerosis by releasing proinfammatory cytokines
    • Sun J, Sukhova GK, Wolters PJ, et al. Mast cells promote atherosclerosis by releasing proinfammatory cytokines. Nat Med. 2007;13:719-724.
    • (2007) Nat Med. , vol.13 , pp. 719-724
    • Sun, J.1    Sukhova, G.K.2    Wolters, P.J.3
  • 16
    • 34250014988 scopus 로고    scopus 로고
    • Mast cells promote atherosclerosis by releasing proinfammatory cytokines
    • Sun J, Sukhova GK, Wolters PJ, et al. Mast cells promote atherosclerosis by releasing proinfammatory cytokines. Nat Med. 2007;13:719-724.
    • (2007) Nat Med. , vol.13 , pp. 719-724
    • Sun, J.1    Sukhova, G.K.2    Wolters, P.J.3
  • 17
    • 0033984744 scopus 로고    scopus 로고
    • Infammation, obesity, stress and coronary heart disease: Is interleukin-6 the link?
    • Yudkin JS, Kumari M, Humphries SE, et al. Infammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 2000;148:209-214.
    • (2000) Atherosclerosis. , vol.148 , pp. 209-214
    • Yudkin, J.S.1    Kumari, M.2    Humphries, S.E.3
  • 18
    • 58149314083 scopus 로고    scopus 로고
    • Vaccines in development to prevent and treat atherosclerotic disease
    • Riley E, Dasari V, Frishman WH, et al. Vaccines in development to prevent and treat atherosclerotic disease. Cardiol Rev. 2008;16:288-300.
    • (2008) Cardiol Rev. , vol.16 , pp. 288-300
    • Riley, E.1    Dasari, V.2    Frishman, W.H.3
  • 19
    • 0029807088 scopus 로고    scopus 로고
    • Macrophages and atherosclerotic plaque stability
    • Libby P, Geng YJ, Aikawa M, et al. Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol. 1996;7:330-335.
    • (1996) Curr Opin Lipidol. , vol.7 , pp. 330-335
    • Libby, P.1    Geng, Y.J.2    Aikawa, M.3
  • 20
    • 0035902456 scopus 로고    scopus 로고
    • Current concepts of the pathogenesis of the acute coronary syndromes
    • Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 2001;104:365-372.
    • (2001) Circulation. , vol.104 , pp. 365-372
    • Libby, P.1
  • 21
    • 0035799341 scopus 로고    scopus 로고
    • Infammation and thrombosis: The clot thickens
    • Libby P, Simon DI. Infammation and thrombosis: the clot thickens. Circulation. 2001;103:1718-1720.
    • (2001) Circulation. , vol.103 , pp. 1718-1720
    • Libby, P.1    Simon, D.I.2
  • 22
    • 43249118045 scopus 로고    scopus 로고
    • Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review
    • Danesh J, Kaptoge S, Mann AG, et al. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med. 2008;5:e78.
    • (2008) PLoS Med. , vol.5
    • Danesh, J.1    Kaptoge, S.2    Mann, A.G.3
  • 23
    • 0029810933 scopus 로고    scopus 로고
    • Relation of C-reactive protein and coronary heart disease in MRFIT nested case-control study
    • MRFIT Research Group
    • Kuller LH, Tracey R P, Shaten J, et al; MRFIT Research Group. Relation of C-reactive protein and coronary heart disease in MRFIT nested case-control study. Am J Epidemiol. 1996;144:537-547
    • (1996) Am J Epidemiol. , vol.144 , pp. 537-547
    • Kuller, L.H.1    Tracey, R.P.2    Shaten, J.3
  • 24
    • 73449130797 scopus 로고    scopus 로고
    • C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta analysis
    • Emerging Risk Factors Collaboration
    • Emerging Risk Factors Collaboration. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta analysis. Lancet. 2010;375:132-140.
    • (2010) Lancet. , vol.375 , pp. 132-140
  • 25
    • 84926426742 scopus 로고    scopus 로고
    • Plasma fbrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: An individual participant meta-analysis
    • Fibrinogen Studies Collaboration.
    • Fibrinogen Studies Collaboration. Plasma fbrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294:1799-1809.
    • (2005) JAMA. , vol.294 , pp. 1799-1809
  • 26
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of infammation in the prediction of cardiovascular disease in women
    • Ridker PM, Hennekens CH, Buring JE, et al. C-reactive protein and other markers of infammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836-843.
    • (2000) N Engl J Med. , vol.342 , pp. 836-843
    • Ridker, P.M.1    Hennekens, C.H.2    Buring, J.E.3
  • 27
    • 84871415707 scopus 로고    scopus 로고
    • Mendelian randomization: How genetics is pushing the boundaries of epidemiology to identify new causes of heart disease
    • Thanassoulis G. Mendelian randomization: how genetics is pushing the boundaries of epidemiology to identify new causes of heart disease. Can J Cardiol. 2013;29:30-36
    • (2013) Can J Cardiol. , vol.29 , pp. 30-36
    • Thanassoulis, G.1
  • 28
    • 79951990503 scopus 로고    scopus 로고
    • Association between C-reactive protein and coronary heart disease: Mendelian randomization analysis based on individual participant data
    • CRP Coronary Hearth Disease Genetics Collaboration
    • CRP Coronary Hearth Disease Genetics Collaboration. Association between C-reactive protein and coronary heart disease: mendelian randomization analysis based on individual participant data. BMJ. 2011;342:d548.
    • (2011) BMJ. , vol.342
  • 29
    • 33748438338 scopus 로고    scopus 로고
    • Fibrinogen and coronary heart disease: Test of causality by 'Mendelian randomization'
    • Keavney B, Danesh J, Parish S, et al. Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'. Int J Epidemiol. 2006;35:935-943.
    • (2006) Int J Epidemiol. , vol.35 , pp. 935-943
    • Keavney, B.1    Danesh, J.2    Parish, S.3
  • 30
    • 0030008326 scopus 로고    scopus 로고
    • Effect of endotoxin in IL-1 beta-defcient mice
    • Fantuzzi G, Zheng H, Faggioni R, et al. Effect of endotoxin in IL-1 beta-defcient mice. J Immunol. 1996;157:291-296.
    • (1996) J Immunol. , vol.157 , pp. 291-296
    • Fantuzzi, G.1    Zheng, H.2    Faggioni, R.3
  • 31
    • 0345609037 scopus 로고    scopus 로고
    • Characterization of tumor necrosis factor-defcient mice
    • Marino MW, Dunn A, Grail D, et al. Characterization of tumor necrosis factor-defcient mice. Proc Natl Acad Sci USA. 1997;94:8093-8098.
    • (1997) Proc Natl Acad Sci USA. , vol.94 , pp. 8093-8098
    • Marino, M.W.1    Dunn, A.2    Grail, D.3
  • 32
    • 0033134682 scopus 로고    scopus 로고
    • Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
    • Harris TB, Ferrucci L, Tracy R P, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106:506-512.
    • (1999) Am J Med. , vol.106 , pp. 506-512
    • Harris, T.B.1    Ferrucci, L.2    Tracy, R.P.3
  • 33
    • 0030891228 scopus 로고    scopus 로고
    • Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    • Romano M, Sironi M, Toniatti C, et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity. 1997;6:315-325.
    • (1997) Immunity. , vol.6 , pp. 315-325
    • Romano, M.1    Sironi, M.2    Toniatti, C.3
  • 34
    • 0028114494 scopus 로고
    • Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man
    • Späth-Schwalbe E, Born J, Schrezenmeier H, et al. Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man. J Clin Endocrinol Metab. 1994;79:1212-1214.
    • (1994) J Clin Endocrinol Metab. , vol.79 , pp. 1212-1214
    • Späth-Schwalbe, E.1    Born, J.2    Schrezenmeier, H.3
  • 35
    • 0031735267 scopus 로고    scopus 로고
    • Peripheral corticotropin-releasing factor mediates the elevation of plasma IL-6 by immobilization stress in rats
    • Ando T, Rivier J, Yanaihara H, et al. Peripheral corticotropin-releasing factor mediates the elevation of plasma IL-6 by immobilization stress in rats. Am J Physiol. 1998;275(5 pt 2):R1461-R1467.
    • (1998) Am J Physiol. , vol.275 , Issue.5 PART 2
    • Ando, T.1    Rivier, J.2    Yanaihara, H.3
  • 37
    • 63849275584 scopus 로고    scopus 로고
    • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    • Eddahri F, Denanglaire S, Bureau F, et al. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood. 2009;113:2426-2433.
    • (2009) Blood. , vol.113 , pp. 2426-2433
    • Eddahri, F.1    Denanglaire, S.2    Bureau, F.3
  • 38
    • 0031472637 scopus 로고    scopus 로고
    • Effects of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity
    • Neumann FJ, Ott I, Marx N, et al. Effects of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity. Arter Throm Vasc Biol. 1997;17:3399-3405.
    • (1997) Arter Throm Vasc Biol. , vol.17 , pp. 3399-3405
    • Neumann, F.J.1    Ott, I.2    Marx, N.3
  • 39
    • 0028323245 scopus 로고
    • Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees
    • van der Poll T, Levi M, Hack CE, et al. Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees. J Exp Med. 1994;179:1253-1259.
    • (1994) J Exp Med. , vol.179 , pp. 1253-1259
    • Van Der Poll, T.1    Levi, M.2    Hack, C.E.3
  • 40
    • 0026575846 scopus 로고
    • Cytokine serum level during severe sepsis in human IL-6 as a marker of severity
    • Damas P, Ledoux D, Nys M, et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg. 1992;215:356-362.
    • (1992) Ann Surg. , vol.215 , pp. 356-362
    • Damas, P.1    Ledoux, D.2    Nys, M.3
  • 41
    • 10344265934 scopus 로고    scopus 로고
    • Risk of myocardial infarction and stroke after acute infection or vaccination
    • Smeeth L, Thomas SL, Hall AJ, et al. Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med. 2004;351: 2611-2618.
    • (2004) N Engl J Med. , vol.351 , pp. 2611-2618
    • Smeeth, L.1    Thomas, S.L.2    Hall, A.J.3
  • 42
    • 0027448539 scopus 로고
    • Detection of Chlamydia pneumoniae in aortic lesions of atherosclerosis by immunocytochemical stain
    • Kuo CC, Gown AM, Benditt E P, et al. Detection of Chlamydia pneumoniae in aortic lesions of atherosclerosis by immunocytochemical stain. Arterioscler Thromb. 1993;13:1501-1504.
    • (1993) Arterioscler Thromb. , vol.13 , pp. 1501-1504
    • Kuo, C.C.1    Gown, A.M.2    Benditt, E.P.3
  • 43
    • 52949144863 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in rheumatoid arthritis
    • Gabriel SE. Cardiovascular morbidity and mortality in rheumatoid arthritis. Am J Med. 2008;121(10 suppl 1):S9-S14.
    • (2008) Am J Med. , vol.121 , Issue.10 SUPPL. 1
    • Gabriel, S.E.1
  • 44
    • 0023942493 scopus 로고
    • Interleukin-6 in synovial fuid and serum of patients with rheumatoid arthritis and other infammatory arthritides
    • Houssiau FA, Devogelaer J P, Van Damme J, et al. Interleukin-6 in synovial fuid and serum of patients with rheumatoid arthritis and other infammatory arthritides. Arthritis Rheum. 1988;31:784-788.
    • (1988) Arthritis Rheum. , vol.31 , pp. 784-788
    • Houssiau, F.A.1    Devogelaer, J.P.2    Van Damme, J.3
  • 45
    • 0020533259 scopus 로고
    • Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study
    • Hubert HB, Feinleib M, McNamara PM, et al. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67:968-977.
    • (1983) Circulation. , vol.67 , pp. 968-977
    • Hubert, H.B.1    Feinleib, M.2    McNamara, P.M.3
  • 46
    • 0030735542 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
    • Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997;82:4196-4200.
    • (1997) J Clin Endocrinol Metab. , vol.82 , pp. 4196-4200
    • Mohamed-Ali, V.1    Goodrick, S.2    Rawesh, A.3
  • 48
    • 84859210770 scopus 로고    scopus 로고
    • Interleukin-6 receptor pathways in coronary heart disease: A collaborative meta-analysis of 82 studies
    • IL6R Genetics Consortium and Emerging Risk Factor Collaboration
    • IL6R Genetics Consortium and Emerging Risk Factor Collaboration. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 2012;379:1205-1213.
    • (2012) Lancet. , vol.379 , pp. 1205-1213
  • 49
    • 64949203166 scopus 로고    scopus 로고
    • Tocilizumab: A review of its use in the management of rheumatoid arthritis
    • Oldfeld V, Dhillon S, Plosker GL. Tocilizumab: a review of its use in the management of rheumatoid arthritis. Drugs. 2009;69:609-632.
    • (2009) Drugs. , vol.69 , pp. 609-632
    • Oldfeld, V.1    Dhillon, S.2    Plosker, G.L.3
  • 50
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocili-zumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocili-zumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008;58:2968-2980.
    • (2008) Arthritis Rheum. , vol.58 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 51
    • 82955198418 scopus 로고    scopus 로고
    • A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis
    • Protogerou AD, Zampeli E, Fragiadaki K, et al. A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis. Atherosclerosis. 2011;219:734-736
    • (2011) Atherosclerosis. , vol.219 , pp. 734-736
    • Protogerou, A.D.1    Zampeli, E.2    Fragiadaki, K.3
  • 52
    • 84859215358 scopus 로고    scopus 로고
    • The interleukin-6 receptor as a target for pre vention of coronary heart disease: A mendelian randomization analysis
    • The Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6 MR) Consortium
    • The Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6 MR) Consortium. The interleukin-6 receptor as a target for pre vention of coronary heart disease: a mendelian randomization analysis. Lancet. 2012; 379:1214-1224.
    • (2012) Lancet. , vol.379 , pp. 1214-1224
  • 53
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • OPTION Investigators
    • Smolen JS, Beaulieu A, Rubbert-Roth A, et al; OPTION Investigators. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet. 2008;371:987-997.
    • (2008) Lancet. , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 54
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
    • ADACTA Study Investigators
    • Gabay C, Emery P, van Vollenhoven R, et al; ADACTA Study Investigators. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet. 2013;381:1541-1550.
    • (2013) Lancet. , vol.381 , pp. 1541-1550
    • Gabay, C.1    Emery, P.2    Van Vollenhoven, R.3
  • 55
    • 84879414277 scopus 로고    scopus 로고
    • Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis
    • Strang AC, Bisoendial RJ, Kootte RS, et al. Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis. Atherosclerosis. 2013;229:174-181.
    • (2013) Atherosclerosis. , vol.229 , pp. 174-181
    • Strang, A.C.1    Bisoendial, R.J.2    Kootte, R.S.3
  • 56
    • 67949124665 scopus 로고    scopus 로고
    • Testing the infammatory hypothesis of atherothrombosis: Sci-entifc rationale for the cardiovascular infammation reduction trial (CIRT)
    • Ridker PM. Testing the infammatory hypothesis of atherothrombosis: sci-entifc rationale for the cardiovascular infammation reduction trial (CIRT). J Thromb Haemost. 2009;7(suppl 1):332-339.
    • (2009) J Thromb Haemost. , vol.7 , Issue.SUPPL. 1 , pp. 332-339
    • Ridker, P.M.1
  • 57
    • 84880918511 scopus 로고    scopus 로고
    • Rationale and design of the Cardiovascular Infammation Reduction Trial: A test of the infammatory hypothesis of atherothrombosis
    • Everett BM, Pradhan AD, Solomon DH, et al: Rationale and design of the Cardiovascular Infammation Reduction Trial: a test of the infammatory hypothesis of atherothrombosis. Am Heart J. 2013;166:199-207.
    • (2013) Am Heart J. , vol.166 , pp. 199-207
    • Everett, B.M.1    Pradhan, A.D.2    Solomon, D.H.3
  • 58
    • 80053644777 scopus 로고    scopus 로고
    • Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and design of the Canakinumab Anti-infammatory Thrombosis Outcomes Study (CANTOS)
    • Ridker PM, Thuren T, Zalewski A, et al. Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-infammatory Thrombosis Outcomes Study (CANTOS). Am Heart J. 2011;162:597-605.
    • (2011) Am Heart J. , vol.162 , pp. 597-605
    • Ridker, P.M.1    Thuren, T.2    Zalewski, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.