Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

Journal of Molecular Medicine

Volumn 92, Issue 4, 2014, Pages 373-386

  Lonskaya, Irina ^a   Hebron, Michaeline L ^a   Desforges, Nicole M ^a   Schachter, Joel B ^b   Moussa, Charbel E H ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Alzheimer's; Amyloid; Autophagy; Parkin; Tau; Ubiquitination

Indexed keywords

AMYLOID; BECLIN 1; NILOTINIB; PARKIN; PROTEASOME; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYSOSOME; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; UBIQUITINATION; WILD TYPE; ALZHEIMER DISEASE; ANIMAL; C57BL MOUSE; DRUG EFFECTS; ENZYME STABILITY; ENZYMOLOGY; HIPPOCAMPUS; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; ENZYME STABILITY; HIPPOCAMPUS; HUMANS; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RATS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84898487614     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-1112-3     Document Type: Article

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