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Volumn 7, Issue 6, 2014, Pages 1635-1638

3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition

Author keywords

3,3 diindolylmethane; Epithelial mesenchymal transition; Invasion; Metastasis; Nasopharyngeal carcinoma cell

Indexed keywords

3, 3' DIINDOLYLMETHANE; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 84898450647     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1649     Document Type: Article
Times cited : (10)

References (38)
  • 1
    • 2442540470 scopus 로고    scopus 로고
    • Focus on nasopharyngeal carcinoma
    • Lo KW, To KF and Huang DP: Focus on nasopharyngeal carcinoma. Cancer Cell 5: 423-428, 2004.
    • (2004) Cancer Cell , vol.5 , pp. 423-428
    • Lo, K.W.1    To, K.F.2    Huang, D.P.3
  • 2
    • 84857781938 scopus 로고    scopus 로고
    • Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches
    • Lo KW, Chung GT and To KF: Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches. Semin Cancer Biol 22: 79-86, 2012.
    • (2012) Semin Cancer Biol , vol.22 , pp. 79-86
    • Lo, K.W.1    Chung, G.T.2    To, K.F.3
  • 4
    • 20044378115 scopus 로고    scopus 로고
    • Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience
    • Lee AW, Sze WM, Au JS, et al: Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int J Radiat Oncol Biol Phys 61: 1107-1116, 2005.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 1107-1116
    • Lee, A.W.1    Sze, W.M.2    Au, J.S.3
  • 5
    • 84869499334 scopus 로고    scopus 로고
    • Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma
    • He JR, Shen GP, Ren ZF, et al: Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma. Head Neck 34: 1769-1776, 2012.
    • (2012) Head Neck , vol.34 , pp. 1769-1776
    • He, J.R.1    Shen, G.P.2    Ren, Z.F.3
  • 6
    • 84876694138 scopus 로고    scopus 로고
    • Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: Findings from a randomised trial
    • Huang PY, Wang CT, Cao KJ, et al: Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: findings from a randomised trial. Eur J Cancer 49: 1923-1931, 2013.
    • (2013) Eur J Cancer , vol.49 , pp. 1923-1931
    • Huang, P.Y.1    Wang, C.T.2    Cao, K.J.3
  • 7
    • 0026720425 scopus 로고
    • Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: Overall survival and patterns of failure
    • Lee AW, Poon YF, Foo W, et al: Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys 23: 261-270, 1992.
    • (1992) Int J Radiat Oncol Biol Phys , vol.23 , pp. 261-270
    • Lee, A.W.1    Poon, Y.F.2    Foo, W.3
  • 8
    • 67650667501 scopus 로고    scopus 로고
    • Molecular targets for tumor radiosensitization
    • Tofilon PJ and Camphausen K: Molecular targets for tumor radiosensitization. Chem Rev 109: 2974-2988, 2009.
    • (2009) Chem Rev , vol.109 , pp. 2974-2988
    • Tofilon, P.J.1    Camphausen, K.2
  • 9
    • 84862826612 scopus 로고    scopus 로고
    • Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: A meta-analysis of clinical evidence
    • Ho FC, Tham IW, Earnest A, Lee KM and Lu JJ: Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 12: 98, 2012.
    • (2012) BMC Cancer , vol.12 , pp. 98
    • Ho, F.C.1    Tham, I.W.2    Earnest, A.3    Lee, K.M.4    Lu, J.J.5
  • 10
    • 84863281650 scopus 로고    scopus 로고
    • Lee JS and Kim SM: 3,3′-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest
    • Kim SJ, Lee JS and Kim SM: 3,3′-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest. Oncol Rep 27: 1669-1673, 2012.
    • (2012) Oncol Rep , vol.27 , pp. 1669-1673
    • Kim, S.J.1
  • 11
    • 84859732024 scopus 로고    scopus 로고
    • Dashwood RH and Benninghoff AD: 3,3′-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells
    • Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH and Benninghoff AD: 3,3′-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One 7: e34975, 2012.
    • (2012) PLoS One , vol.7
    • Shorey, L.E.1    Hagman, A.M.2    Williams, D.E.3    Ho, E.4
  • 12
    • 84861009528 scopus 로고    scopus 로고
    • A selective aryl hydrocarbon receptor modulator 3,3′-Diindolylmethane inhibits gastric cancer cell growth
    • Yin XF, Chen J, Mao W, Wang YH and Chen MH: A selective aryl hydrocarbon receptor modulator 3,3′-Diindolylmethane inhibits gastric cancer cell growth. J Exp Clin Cancer Res 31: 46, 2012.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 46
    • Yin, X.F.1    Chen, J.2    Mao, W.3    Wang, Y.H.4    Chen, M.H.5
  • 13
    • 84865312769 scopus 로고    scopus 로고
    • Anti-proliferative and pro-apoptotic effects of 3,3′-diindolylmethane in human cervical cancer cells
    • Zhu J, Li Y, Guan C and Chen Z: Anti-proliferative and pro-apoptotic effects of 3,3′-diindolylmethane in human cervical cancer cells. Oncol Rep 28: 1063-1068, 2012.
    • (2012) Oncol Rep , vol.28 , pp. 1063-1068
    • Zhu, J.1    Li, Y.2    Guan, C.3    Chen, Z.4
  • 14
    • 84881524388 scopus 로고    scopus 로고
    • In vivo and in vitro study on the role of 3,3′-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma
    • Chen C, Chen SM, Xu B, et al: In vivo and in vitro study on the role of 3,3′-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma. Carcinogenesis 34: 1815-1821, 2013.
    • (2013) Carcinogenesis , vol.34 , pp. 1815-1821
    • Chen, C.1    Chen, S.M.2    Xu, B.3
  • 15
    • 84866859568 scopus 로고    scopus 로고
    • Targeting Jab1/CSN5 in nasopharyngeal carcinoma
    • Pan Y and Claret FX: Targeting Jab1/CSN5 in nasopharyngeal carcinoma. Cancer Lett 326: 155-160, 2012.
    • (2012) Cancer Lett , vol.326 , pp. 155-160
    • Pan, Y.1    Claret, F.X.2
  • 16
    • 0034565923 scopus 로고    scopus 로고
    • Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy
    • Cheng SH, Jian JJ, Tsai SY, et al: Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys 48: 1323-1330, 2000.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 1323-1330
    • Cheng, S.H.1    Jian, J.J.2    Tsai, S.Y.3
  • 17
    • 79952103326 scopus 로고    scopus 로고
    • Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: Combined analyses of NPC-9901 and NPC-9902 Trials
    • Lee AW, Tung SY, Ngan RK, et al: Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials. Eur J Cancer 47: 656-666, 2011.
    • (2011) Eur J Cancer , vol.47 , pp. 656-666
    • Lee, A.W.1    Tung, S.Y.2    Ngan, R.K.3
  • 18
    • 79955435781 scopus 로고    scopus 로고
    • Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: Long-term results of a phase 2 study
    • Xiao WW, Huang SM, Han F, et al: Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study. Cancer 117: 1874-1883, 2011.
    • (2011) Cancer , vol.117 , pp. 1874-1883
    • Xiao, W.W.1    Huang, S.M.2    Han, F.3
  • 19
    • 84870254016 scopus 로고    scopus 로고
    • A phase III study of late course accelerated hyperfractionated radiotherapy versus conventionally fractionated radiotherapy in patients with nasopharyngeal carcinoma
    • Pan ZQ, He XY, Guo XM, et al: A phase III study of late course accelerated hyperfractionated radiotherapy versus conventionally fractionated radiotherapy in patients with nasopharyngeal carcinoma. Am J Clin Oncol 35: 600-605, 2012.
    • (2012) Am J Clin Oncol , vol.35 , pp. 600-605
    • Pan, Z.Q.1    He, X.Y.2    Guo, X.M.3
  • 20
    • 84867048784 scopus 로고    scopus 로고
    • A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma
    • Peng G, Wang T, Yang KY, et al: A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol 104: 286-293, 2012.
    • (2012) Radiother Oncol , vol.104 , pp. 286-293
    • Peng, G.1    Wang, T.2    Yang, K.Y.3
  • 21
    • 84872357296 scopus 로고    scopus 로고
    • Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for T4 nasopharyngeal carcinoma
    • Cao CN, Luo JW, Gao L, et al: Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for T4 nasopharyngeal carcinoma. Oral Oncol 49: 175-181, 2013.
    • (2013) Oral Oncol , vol.49 , pp. 175-181
    • Cao, C.N.1    Luo, J.W.2    Gao, L.3
  • 22
    • 84878567392 scopus 로고    scopus 로고
    • Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China
    • Chen Y, Sun Y, Liang SB, et al: Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China. Cancer 119: 2230-2238, 2013.
    • (2013) Cancer , vol.119 , pp. 2230-2238
    • Chen, Y.1    Sun, Y.2    Liang, S.B.3
  • 23
    • 84878707856 scopus 로고    scopus 로고
    • Concurrent chemoradiotherapy with or without adjuvant chemotherapy in intermediate and locoregionally advanced nasopharyngeal carcinoma
    • Zhang W, Dou H, Lam C, et al: Concurrent chemoradiotherapy with or without adjuvant chemotherapy in intermediate and locoregionally advanced nasopharyngeal carcinoma. Tumour Biol 34: 1729-1736, 2013.
    • (2013) Tumour Biol , vol.34 , pp. 1729-1736
    • Zhang, W.1    Dou, H.2    Lam, C.3
  • 24
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber MA, Kraut N and Beug H: Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17: 548-558, 2005.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 25
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • Lee JM, Dedhar S, Kalluri R and Thompson EW: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172: 973-981, 2006.
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 26
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J and Weinberg RA: Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829, 2008.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 27
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S and Yang J: Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22: 725-736, 2012.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 28
    • 0043172396 scopus 로고    scopus 로고
    • Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    • Grünert S, Jechlinger M and Beug H: Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4: 657-665, 2003.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 657-665
    • Grünert, S.1    Jechlinger, M.2    Beug, H.3
  • 29
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 30
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    • Onder TT, Gupta PB, Mani SA, Yang J, Lander ES and Weinberg RA: Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68: 3645-3654, 2008.
    • (2008) Cancer Res , vol.68 , pp. 3645-3654
    • Onder, T.T.1    Gupta, P.B.2    Mani, S.A.3    Yang, J.4    Lander, E.S.5    Weinberg, R.A.6
  • 31
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B and Berx G: Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 13: 97-110, 2013.
    • (2013) Nat Rev Cancer , vol.13 , pp. 97-110
    • de Craene, B.1    Berx, G.2
  • 32
    • 84872416422 scopus 로고    scopus 로고
    • Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma
    • Scanlon CS, Van Tubergen EA, Inglehart RC and D'Silva NJ: Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J Dent Res 92: 114-121, 2013.
    • (2013) J Dent Res , vol.92 , pp. 114-121
    • Scanlon, C.S.1    van Tubergen, E.A.2    Inglehart, R.C.3    D'Silva, N.J.4
  • 33
    • 84872267912 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance
    • Shirkoohi R: Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance. Cancer Sci 104: 28-35, 2013.
    • (2013) Cancer Sci , vol.104 , pp. 28-35
    • Shirkoohi, R.1
  • 34
    • 77955822805 scopus 로고    scopus 로고
    • Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin
    • Wong TS, Chan WS, Li CH, et al: Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin. Anticancer Res 30: 2851-2856, 2010.
    • (2010) Anticancer Res , vol.30 , pp. 2851-2856
    • Wong, T.S.1    Chan, W.S.2    Li, C.H.3
  • 35
    • 84879202537 scopus 로고    scopus 로고
    • Aberrant expression of β-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer
    • Xu L, Jiang Y, Zheng J, et al: Aberrant expression of β-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer. Hum Pathol 44: 1357-1364, 2013.
    • (2013) Hum Pathol , vol.44 , pp. 1357-1364
    • Xu, L.1    Jiang, Y.2    Zheng, J.3
  • 36
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors
    • Nieto MA: The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3: 155-166, 2002.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 37
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Pérez-Moreno MA, Rodrigo I, et al: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83, 2000.
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Pérez-Moreno, M.A.2    Rodrigo, I.3
  • 38
    • 84865346897 scopus 로고    scopus 로고
    • Aberrant expression of nuclear vimentin and related epithelial-mesenchymal transition markers in nasopharyngeal carcinoma
    • Luo W, Fang W, Li S and Yao K: Aberrant expression of nuclear vimentin and related epithelial-mesenchymal transition markers in nasopharyngeal carcinoma. Int J Cancer 131: 1863-1873, 2012.
    • (2012) Int J Cancer , vol.131 , pp. 1863-1873
    • Luo, W.1    Fang, W.2    Li, S.3    Yao, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.