Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma

Head and Neck

Volumn 34, Issue 12, 2012, Pages 1769-1776

  He, Jian Rong ^a,b,c   Shen, Guo Ping ^a,b   Ren, Ze Fang ^a,b   Qin, Han ^b   Cui, Cui ^a   Zhang, Ying ^a   Zeng, Yi Xin ^a   Jia, Wei Hua ^a,b  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

lymphocytes; nasopharyngeal carcinoma; neutrophils; prognostic factor; survival

Indexed keywords

BIOLOGICAL MARKER;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PROGNOSIS; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; NEUTROPHIL COUNT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL;

ADOLESCENT; ADULT; AGED; FEMALE; HUMANS; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEUTROPHILS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 84869499334     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.22008     Document Type: Article

References (41)

1. Yu MC, Yuan JM,. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol 2002; 12: 421-429.
2. Parkin DM, Bray F, Ferlay J, Pisani P,. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
3. Chua DT, Sham JS, Au GK, Choy D,. Concomitant chemoirradiation for stage III-IV nasopharyngeal carcinoma in Chinese patients: results of a matched cohort analysis. Int J Radiat Oncol Biol Phys 2002; 53: 334-343.
4. Lo YM, Chan AT, Chan LY, et al. Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA. Cancer Res 2000; 60: 6878-6881.
5. Lin JC, Wang WY, Chen KY, et al. Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma. N Engl J Med 2004; 350: 2461-2470.
6. Paesmans M, Sculier JP, Libert P, et al. Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. The European Lung Cancer Working Party. J Clin Oncol 1995; 13: 1221-1230.
7. Teramukai S, Kitano T, Kishida Y, et al. Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer 2009; 45: 1950-1958.
8. Paesmans M, Sculier JP, Lecomte J, et al. Prognostic factors for patients with small cell lung carcinoma: analysis of a series of 763 patients included in 4 consecutive prospective trials with a minimum follow-up of 5 years. Cancer 2000; 89: 523-533.
9. Negrier S, Escudier B, Gomez F, et al. Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Francais d'Immunotherapie. Ann Oncol 2002; 13: 1460-1468.
10. Atzpodien J, Royston P, Wandert T, Reitz M,. Metastatic renal carcinoma comprehensive prognostic system. Br J Cancer 2003; 88: 348-353.
11. Donskov F, von der Maase H,. Impact of immune parameters on long-term survival in metastatic renal cell carcinoma. J Clin Oncol 2006; 24: 1997-2005.
12. Schmidt H, Bastholt L, Geertsen P, et al. Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Br J Cancer 2005; 93: 273-278.
13. Schmidt H, Suciu S, Punt CJ, et al. Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee on Cancer Stage IV Melanoma: results of the EORTC 18951 Biochemotherapy Trial. J Clin Oncol 2007; 25: 1562-1569.
14. Cho H, Hur HW, Kim SW, et al. Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother 2009; 58: 15-23.
15. Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ,. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91: 181-184.
16. Halazun KJ, Aldoori A, Malik HZ, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 2008; 34: 55-60.
17. Kishi Y, Kopetz S, Chun YS, Palavecino M, Abdalla EK, Vauthey JN,. Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol 2009; 16: 614-622.
18. Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagal Y, Fukushima M,. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 73: 215-220.
19. Gomez D, Farid S, Malik HZ, et al. Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 2008; 32: 1757-1762.
20. Halazun KJ, Hardy MA, Rana AA, et al. Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg 2009; 250: 141-151.
21. Bhatti I, Peacock O, Lloyd G, Larvin M, Hall RI,. Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil-lymphocyte versus platelet-lymphocyte ratio. Am J Surg 2010; 200: 197-203.
22. Clark EJ, Connor S, Taylor MA, Madhavan KK, Garden OJ, Parks RW,. Preoperative lymphocyte count as a prognostic factor in resected pancreatic ductal adenocarcinoma. HPB (Oxford) 2007; 9: 456-460.
23. Sasaki A, Iwashita Y, Shibata K, Matsumoto T, Ohta M, Kitano S,. Prognostic value of preoperative peripheral blood monocyte count in patients with hepatocellular carcinoma. Surgery 2006; 139: 755-764.
24. An X, Ding PR, Wang FH, Jiang WQ, Li YH,. Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma. Tumour Biol 2010; 32: 317-324.
25. Goicoechea M, Haubrich R,. CD4 lymphocyte percentage versus absolute CD4 lymphocyte count in predicting HIV disease progression: an old debate revisited. J Infect Dis 2005; 192: 945-947.
26. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual. New York: Springer-Verlag; 2002.
27. Kitayama J, Yasuda K, Kawai K, Sunami E, Nagawa H,. Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer. Radiat Oncol 2010; 5: 47.
28. Kuwae N, Kopple JD, Kalantar-Zadeh K,. A low lymphocyte percentage is a predictor of mortality and hospitalization in hemodialysis patients. Clin Nephrol 2005; 63: 22-34.
29. Mantovani A, Allavena P, Sica A, Balkwill F,. Cancer-related inflammation. Nature 2008; 454: 436-444.
30. Coussens LM, Werb Z,. Inflammation and cancer. Nature 2002; 420: 860-867.
31. Moore MM, Chua W, Charles KA, Clarke SJ,. Inflammation and cancer: causes and consequences. Clin Pharmacol Ther 2010; 87: 504-508.
32. Fondevila C, Metges JP, Fuster J, et al. p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer. Br J Cancer 2004; 90: 206-215.
33. Kusumanto YH, Dam WA, Hospers GA, Meijer C, Mulder NH,. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis 2003; 6: 283-287.
34. Ulich TR, del Castillo J, Keys M, Granger GA, Ni RX,. Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes. J Immunol 1987; 139: 3406-3415.
35. Ulich TR, del Castillo J, Guo KZ,. In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood 1989; 73: 108-110.
36. Di Carlo E, Forni G, Lollini P, Colombo MP, Modesti A, Musiani P,. The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood 2001; 97: 339-345.
37. Rabinowich H, Cohen R, Bruderman I, Steiner Z, Klajman A,. Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Res 1987; 47: 173-177.
38. Petrie HT, Klassen LW, Kay HD,. Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J Immunol 1985; 134: 230-234.
39. el-Hag A, Clark RA,. Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J Immunol 1987; 139: 2406-2413.
40. Shau HY, Kim A,. Suppression of lymphokine-activated killer induction by neutrophils. J Immunol 1988; 141: 4395-4402.
41. Fitzmaurice G,. The meaning and interpretation of interaction. Nutrition 2000; 16: 313-314.