In vivo and in vitro study on the role of 3,3'-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma

Carcinogenesis

Volumn 34, Issue 8, 2013, Pages 1815-1821

  Chen, Chen ^a   Chen, Shi Ming ^a   Xu, Bin ^a   Chen, Zhe ^a   Wang, Fei ^a   Ren, Jie ^a   Xu, Yong ^a   Wang, Yan ^a   Xiao, Bo Kui ^a   Tao, Ze Zhang ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3,3' DIINDOLYLMETHANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CANCER GROWTH; CANCER INHIBITION; CELL DAMAGE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EPITHELIUM CELL; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HEART; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; LIVER CELL; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR VOLUME; WESTERN BLOTTING;

EID: 84881524388     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt122     Document Type: Article

References (28)

1. Cheng, S.H. et al. (2000) Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy. Int. J. Radiat. Oncol. Biol. Phys., 48, 1323-1330.
2. Yamashita, S. et al. (1985) Squamous cell carcinoma of the nasopharynx. An analysis of failure patterns after radiation therapy. Acta Radiol. Oncol., 24, 315-320.
3. Safe, S. et al. (2008) Cancer chemotherapy with indole-3-carbinol, bis(3'- indolyl)methane and synthetic analogs. Cancer Lett., 269, 326-338.
4. Weng, J.R. et al. (2008) Indole-3-carbinol as a chemopreventive and anticancer agent. Cancer Lett., 262, 153-163.
5. Vivar, O.I. et al. (2009) 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Biochem. Pharmacol., 78, 469-476.
6. Rahman, K.M. et al. (2009) 3,3'-Diindolylmethane enhances taxotereinduced apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation. Cancer Res., 69, 4468-4475.
7. Chen, C.C. et al. (2010) Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathways. Cell. Signal., 22, 1132-1142.
8. Ding, L. et al. (2005) Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int. J. Biochem. Cell Biol., 37, 1881-1889.
9. Wang, Z. et al. (2010) STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 and ERK signaling. Eur. J. Cancer, 46, 2996-3006.
10. Han, J.B. et al. (2011) Adenovirus-mediated transfer of tris-shRNAs induced apoptosis of nasopharyngeal carcinoma cell in vitro and in vivo. Cancer Lett., 309, 162-169.
11. Wang, Y. et al. (2008) Application of combination of short hairpin RNA segments for silencing VEGF, TERT and Bcl-xl expression in laryngeal squamous carcinoma. Cancer Biol. Ther., 7, 896-901.
12. Wong, V.C. et al. (2012) Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype. Int. J. Cancer, 130, 83-95.
13. Koon, H.K. et al. (2009) Targeted inhibition of the EGFR pathways enhances Zn-BC-AM PDT-induced apoptosis in well-differentiated nasopharyngeal carcinoma cells. J. Cell. Biochem., 108, 1356-1363.
14. Qu, C. et al. (2012) MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell Cycle, 11, 785-796.
15. Sun, W. et al. (2012) Id-1 and the p65 subunit of NF-κB promote migration of nasopharyngeal carcinoma cells and are correlated with poor prognosis. Carcinogenesis, 33, 810-817.
16. Li, S.S. et al. (2012) Simultaneously targeting bcl-2 and Akt pathways sensitizes nasopharyngeal carcinoma to tumor necrosis factor-related apoptosis- inducing ligand. Cancer Biother. Radiopharm., 27, 88-95.
17. Jiang, H., et al. (2010) Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo. J. Exp. Clin. Cancer Res., 29, 34.
18. Liu, S.F. et al. (2008) NF-kappaB inhibitors induce lytic cytotoxicity in Epstein-Barr virus-positive nasopharyngeal carcinoma cells. Cell Biol. Int., 32, 1006-1013.
19. Wong, F.C. et al. (2010) Whole-field simultaneous integrated-boost intensity- modulated radiotherapy for patients with nasopharyngeal carcinoma. Int. J. Radiat. Oncol. Biol. Phys., 76, 138-145.
20. Heath, E.I. et al. (2010) A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'-Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am. J. Transl. Res., 2, 402-411.
21. Reed, G.A. et al. (2008) Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol. Biomarkers Prev., 17, 2619-2624.
22. Jin, Y. et al. (2010) 3,3'-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells. Anticancer. Drugs, 21, 814-822.
23. Bhatnagar, N. et al. (2009) 3,3'-Diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. Cancer Prev. Res. (Phila)., 2, 581-589.
24. Rahimi, M. et al. (2010) 3,3'-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutants. Cancer Lett., 295, 59-68.
25. Ali, S. et al. (2008) Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol. Cancer Ther., 7, 1708-1719.
26. Cho, H.J. et al. (2011) 3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model. Mol. Carcinog., 50, 100-112.
27. Howells, L.M. et al. (2007) Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. Acta Pharmacol. Sin., 28, 1274-1304.
28. Manach, C. et al. (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr., 81(1 Suppl), 230S-242S.